PurposeTo assess the impact of the automatic tube current modulation (ATCM) on virtual monoenergetic images (VMIs) quality in dual-source CT(DSCT). Materials and methodsAcquisitions were performed on DSCT using the Mercury phantom. The acquisition parameters for an abdomen-pelvic examination with single-energy CT(SECT) and dual-energy CT(DECT) imaging were used. Acquisitions were performed for each imaging mode using fixed mAs and ATCM. The mAs value was set to obtain a volume CT dose index of 11 mGy in fixed mAs acquisitions. This value was used as the reference mAs in ATCM acquisitions. The noise power spectrum and task-based transfer function at 40,50,60 and 70 keV levels were computed on VMIs and SECT images. The detectability index (d′) was calculated for a lesion with an iodine concentration of 10 mg/mL. ResultsThe noise magnitude on VMIs was higher with the ATCM system than with fixed mAs for all energy levels and section diameters of 21,26 and 31 cm. The noise texture and spatial resolution were similar between the fixed mAs and ATCM acquisitions for both imaging modes. The d’ values were lower for all energy levels with ATCM than with fixed mAs acquisitions for 21 and 26 cm diameters by −39.82 ± 9.32%, similar at 31 cm diameter −4.13 ± 0.24% and higher at 36 cm diameter 10.40 ± 6.69%. It was higher on VMIs at all energy levels compared to SECT images. ConclusionsThe ATCM system could be used with DECT imaging to optimize patient exposure without changing the noise texture and spatial resolution of VMIs compared to fixed mAs and SECT.