Autism Research Research Articles

The Brunswik Lens Model: a theoretical framework for advancing understanding of deceptive communication in autism.

Due to differences in social communication and cognitive functioning, autistic adults may have greater difficulty engaging in and detecting deception compared to neurotypical adults. Consequently, autistic adults may experience strained social relationships or face increased risk of victimization. It is therefore crucial that research investigates the psychological mechanisms that are responsible for autistic adults' difficulties in the deception process in order to inform interventions required to reduce risk. However, weaknesses of extant research exploring deception in autism include a heavy focus on children and limited theoretical exploration of underlying psychological mechanisms. To address these weaknesses, this review aims to introduce a system-level theoretical framework to the study of deception in autistic adulthood: The Brunswik Lens Model of Deception. Here, we provide a comprehensive account of how autism may influence all processes involved in deception, including: Choosing to Lie (1), Producing Deception Cues (2), Perceiving Deception Cues (3), and Making the Veracity Decision (4). This review also offers evidence-based, theoretical predictions and testable hypotheses concerning how autistic and neurotypical adults' behavior may differ at each stage in the deception process. The call to organize future research in relation to a joint theoretical perspective will encourage the field to make substantive, theoretically motivated progress toward the development of a comprehensive model of deception in autistic adulthood. Moreover, the utilization of the Brunswik Lens Model of Deception in future autism research may assist in the development of interventions to help protect autistic adults against manipulation and victimization.

Analysis of Hot Spots and Trends in China’s Social Work Intervention in Autism Research Based on CiteSpace

Analysis of Hot Spots and Trends in China’s Social Work Intervention in Autism Research Based on CiteSpace

Exploring the landscape of adult autism research in psychology: a bibliometric and network analysis.

The global prevalence of autism spectrum disorder (ASD) is increasing. ASD manifests with persistent social communication and interaction challenges, limited interests, and repetitive behaviors. As the scientific literature on ASD in adults varies greatly, mapping the recent global research becomes valuable for enhancing comprehension of this subject. This study aims to map recent global scientific publications on ASD in adults. Using the Preferred Reporting Items for Systematic Reviews and Meta-Analyses, bibliometrics, and network analyses, we assessed 850 articles indexed in the Web of Science Core Collection between 2013 and 2022 assigned to the research area of psychology. Findings indicate an annual average growth of 11.69%. Key keywords include Emotion, Anxiety, and Depression, with Anxiety, Depression, and Mental Health as central nodes in the network. Rehabilitation, Behavioral Sciences, and Psychiatry frequently co-occur, and Psychology, Psychiatry, and 'Neurosciences and Neurology' are central nodes in the network of research areas. The United States of America and the United Kingdom lead in publications, with the United Kingdom being the most central country in the network. King's College London and the University of California are the main research organizations, with King's College London as the central node in the network. The American Psychiatric Association's DSM-5-TR was the most cited reference in the period. This comprehensive analysis contributes to understanding the landscape of ASD research in adults, providing insights for future research and fostering collaborations.

Creating a more inclusive autism research community

Creating a more inclusive autism research community

Smart shirt and carpet for annotating child behaviour in autism research

This study presents a developmental solution for annotating events, eye-contact, in live interaction scenarios, such as autism research. The approach involves prototyping infrared light emitting diodes (IR LEDs) integrated into both a smart shirt and smart carpets. Leveraging the imperceptibility of IR LEDs to the human eye ensures minimal disturbance to the individuals under surveillance. During video analysis, researchers can identify instances of eye-contact through the activation of IR LEDs, aiding in the recognition of corresponding events. The prototyped smart shirt features a necklace-type design with embedded IR LEDs, while two distinct designs of smart carpets incorporate IR LEDs at varying vision angles and positions. Validation of the prototypes includes laboratory testing and real-world evaluations with the researchers. The assessment encompasses the observation of IR LEDs on the smart shirt and carpets from diverse perspectives, evaluating their light intensity, and assessing their operational synchronization. The findings contribute to the advancement of technology-assisted methodologies in capturing and analyzing interpersonal interactions, particularly in the context of autism research.

Autism research: Thank you to our 2023 reviewers

Autism research: Thank you to our 2023 reviewers

A Pilot Program for Teaching Sexuality and Relationships to Adults with Autism and Developmental Disabilities.

Background: People often have an innate interest in both platonic and romantic relationships. In fact, feelings toward sexuality and sexuality education do not differ between various individuals. Yet, autistic individuals have been shown to score significantly lower on measures of sexual awareness than their typically developing counterparts. Aims: The current project sought to investigate the benefits of a specially tailored socio-sexuality curriculum on the interpersonal relationship knowledge of 12 autistic young adults. Methods and Procedures: The eight-session sexuality education intervention was carefully tailored from an existing, online guide from the Organization for Autism Research. Pre- and post-test data were collected via the Assessment of Functional Living Skills Interpersonal Relationships domain. T-tests were conducted to determine significance. Outcomes and Results: Results from paired-sample t-tests indicated significant gains in interpersonal relationship knowledge from pre- to post-intervention. Conclusions and Implications: When provided with specifically tailored sexuality education, young autistic adults can experience socially valid, significant gains on interpersonal relationship knowledge.

Impact of Receiving Genetic Diagnoses on Parents' Perceptions of Their Children with Autism and Intellectual Disability.

To assess whether genetic test results identifying the cause of a child's autism, when accompanied by other neurodevelopmental disorders (NDD), including intellectual disability, alter how parents perceive and treat their child. 28 parents of 22 individuals with autism (mean age: 15years), usually with other NDDs, were interviewed after receiving genetic diagnoses indicating a de novo mutation through the Simons Foundation Powering Autism Research for Knowledge study. Diagnosis of a de novo genetic variant can alter parental perceptions of offspring with autism and other NDDs. Parents often blamed their child less, saw their child as less in control of symptoms, and developed more patience, framing expectations accordingly. Parents had mixed feelings about receiving genetic diagnoses, with sadness sometimes accompanying reframed expectations. Genetic diagnoses could change views of the child among extended family members, teachers, social service agencies, insurers, and broader communities and society. Genetic testing might also reduce delays in diagnoses of autism among African American, Latino and other children. These data, the first to examine several critical aspects of how parents and others view children with autism and other NDDs after receiving genetic diagnoses, highlight vital needs for education of multiple stakeholders (including geneticists, other physicians, genetic counselors, parents, individuals with autism, social service agencies, insurers, policymakers, and the broader public), research (to include perspectives of extended family members, insurers, social service agencies and teachers) and practice (to increase recognition and awareness of the potential benefits and effects of genetic testing for such children).

Do We Need Autistic Autism Researchers to Understand Autism?

The assumption that autistic individuals do not have the theory of mind – the social-cognitive ability to understand other people by attributing mental states to them – has been widespread in the psychological literature. However, the empirical evidence from the original research and its replications failed to prove and support autistic mind-blindness. Yet, it is still present in literature on autism spectrum. Meanwhile, convincing research, that has been conducted among autistic researchers and their allies, is often overlooked by non-autistic specialists. This paper focuses on how autistic autism researchers have been influencing their field of study and how academy can benefit from their work.

Receptive language and receptive-expressive discrepancy in minimally verbal autistic children and adolescents.

Among the approximately one-third of autistic individuals who experience considerable challenges in acquiring spoken language and are minimally verbal (MV), relatively little is known about the range of their receptive language abilities. This study included 1579 MV autistic children and adolescents between 5 and 18 years of age drawn from the National Database for Autism Research and the SFARI Base data repository. MV autistic children and adolescents demonstrated significantly lower receptive language compared to the norms on standardized language assessment and parent report measures. Moreover, their receptive language gap widened with age. Overall, our sample demonstrated significantly better receptive than expressive language. However, at the individual level, only about 25% of MV autistic children and adolescents demonstrated significantly better receptive language relative to their minimal expressive levels. Social skills explained a significant proportion of the variance in parent-reported receptive language skills, while motor skills were the most significant predictor of greater receptive-expressive discrepancy. Findings from this study revealed the heterogeneous language profiles in MV autistic children and adolescents, underscoring the importance of individualizing interventions to match their different communication strengths and needs and integrating multiple interconnected areas to optimize their overall development of language comprehension, socialization, and general motor skills.

AGEING WELL WITH AUTISM

Abstract Autism is characterized by patterns of neurological development that can cause differences in social interactions and sensory processing; restricted and repetitive patterns of behavior; and difficulties in identifying and describing feelings. The highly sociable and unpredictable environments typical of most societies are poorly suited to autistic people*, leading to disadvantage and exclusion. Despite increasing numbers of people aging with autism, little is known about the needs and experiences of middle-aged and older autistic adults. This is important given that autistic people experience higher rates of health and functional difficulties, and express a need for appropriate, accessible forms of support as they age. In this study, we interviewed seventeen autistic adults, aged from 46-72 years, about their views and experiences of aging, and how services could better support them to age well. The transcribed interviews were analyzed using inductive thematic analysis. The findings revealed several potential ways that autism affected people’s ability to age well. This included difficulties in accessing formal and informal supports; interactions between autism and health conditions; and negative attitudes and low understanding about autism encountered within services and society. Recommendations for supporting autistic adults to age well included involving autistic people in the design of services, and introducing specialized advocate/coordinator roles or ‘one-stop-shop’ hubs that could help autistic people navigate services more easily. * Our use of the terms ‘autistic people/adults’ is in-line with evidence-based guidance for writing about autism research, and is preferred by autistic people to ‘person-first’ terms like ‘person with autism’ (https://journals.sagepub.com/pb-assets/cmscontent/AUT/Autism-terminology-guidance-2021-1626860796.pdf)

A targeted long-read sequencing approach questions the association of OXTR methylation with high-functioning autism

BackgroundDNA sequence variation and altered epigenetic regulation of the oxytocin receptor gene (OXTR) have been implicated in autism and autistic-like behaviors. While previous studies have examined subsegments of OXTR, nanopore Cas9-targeted sequencing (nCATS) allows deep characterization of entire genes with simultaneous assessment of epigenetic 5-methylcytosine (5mC) modification and without the need for prior DNA amplification or bisulfite conversion. This pilot study uses an nCATS approach to sequence the entire OXTR gene and its regulatory construct and screen for 5mC modification to compare results between individuals with high-functioning autism (HFA) and neurotypical controls (NC).MethodsUsing DNA extracted from peripheral blood, OXTR (Hg38, chr3: 8750381–8770434, 20,054 base pairs) was analyzed by nCATS. 5mC modification probabilities were calculated and visualized across the gene and differential methylation analysis was performed.ResultsTwenty adults with HFA (10 males, 10 females) and 20 age- and sex-matched NC (± 5 years) were included. There were no apparent group differences in the entire OXTR gene sequence, except for the intron variant rs918316, which was clustered in the HFA group. However, differential methylation analysis did not reveal a single significant group-dependent differentially methylated site among the 412 CpG sites captured.LimitationsLimitations of this study include the small number of samples due to the pilot nature of the study, which particularly limits the relevance of the sequence variants found. It should also be noted that the use of peripheral blood material limits the ability to draw conclusions about central processes.ConclusionsPrevious findings of autism-associated OXTR epigenetic alterations were not reproducible with our method. In our opinion, this may lead to a reconsideration of the relevance of altered methylation at individual OXTR CpG positions in autism research. However, given the pilot nature of the study, these results need to be replicated in independent cohorts and with larger sample sizes.

Neurodiversity and double empathy: can empathy disconnects be mitigated to support autistic belonging?

Within disability studies in general, and autism research in particular, a neurodiverse perspective has been gaining traction. Since the 1990s, and with increasing intensity recently, the neurodiversity movement has reshaped narratives about autism, has refocused research priorities, as well as the ways supports are conceived and delivered. The neurodiversity movement has brought autistic-led theories to the center of research agendas including the Double Empathy theory. Most of the double empathy theory research to date has examined communication patterns between less familiar partners, but there is so much more to learn. The purpose of this paper is to (a) review the science relative to communication and social interaction, the double empathy theory, and belonging for autistic people, (b) consider the future of autistic wellbeing through prioritizing belonging, (c) examine intersubjectivity, meaning making, and empathy as factors in belonging, and (d) propose a framework for reducing empathy disconnects in cross-neurotype interactions.

Increased anticholinergic medication use in middle-aged and older autistic adults and its associations with self-reported memory difficulties and cognitive decline.

Many commonly used prescription and over-the-counter medicines have potent anticholinergic (AC) effects. Among older adults, AC medications are associated with cognitive impairment and risk for cognitive disorders, including Alzheimer's disease. Collectively, the impact of AC medications is known as anticholinergic cognitive burden (ACB). Because of the high rates of co-occurring medical and psychiatric conditions, autistic adults may have high AC exposure and, thus, may experience elevated ACB. However, no research has characterized AC exposure or examined its associations with cognitive outcomes in autistic adults. Autistic adults (40-83 years) recruited via Simons Powering Autism Research's (SPARK) Research Match service self-reported their medication use (N = 415) and memory complaints (N = 382) at Time (T)1. At T2, 2 years later, a subset of T1 participants (N = 197) self-reported on decline in cognition. Medications were coded using two scales of AC potency. A high proportion (48.2%-62.9%, depending upon the AC potency scale) of autistic adults reported taking at least one medication with AC effects, and 20.5% to 26.5% of autistic adults reported clinically-relevant levels of AC medication (potency ≥3). After controlling for birth-sex, and age, hierarchical linear regression models showed total ACB scores and AC potency values of ≥3 predicted greater memory complaints. Logistic regression models showed that AC medicines at T1 were associated with self-reported cognitive decline at follow-up 2 years later. Understanding AC medications-including potentially earlier AC polypharmacy-and their impacts on cognition (e.g., dementia risk) in autistic adults is warranted.

Wales and Autism: the impact of philanthropy matched by ambition

PurposeThe purpose of this paper is to place on record the impact made on government policy and research by Autism Cymru, a small charity that existed in Wales between 2001 and 2014. The success of Autism Cymru resulted directly from philanthropic funding, applied with strategic vision and genuine ambition.Design/methodology/approachA retrospective, chronological viewpoint highlighting the creative process, drawing upon records held by the charity.FindingsAutism Cymru initiated the concept and played a crucial role in steering the development of government policy for autism in Wales between 2001 and 2011. The charity also drove forward the initiative, which led to the establishment of the Wales Autism Research Centre at Cardiff University in 2010. This paper demonstrates that with astute philanthropic support, small learning disability/autism charities can elicit structural and sustainable change at the national level, leading to wide-ranging benefits for the communities they represent.Originality/valueThe strategic approach taken over 20 years ago in Wales by Autism Cymru, which led to the Welsh Government’s ASD Strategic Action Plan for Wales (Welsh Government, 2011), set in place a national policy model, which was then followed by The Scottish Strategy for Autism and the Northern Ireland Autism Strategy (Department of Health, 2013>; Scottish Government, 2011). The insightful and tenacious method used by Autism Cymru remains relevant today, demonstrating that any small charity supported by shrewd philanthropic funding can punch well above its weight by taking a planned, ambitious and strategic approach to policy, research and practice.

Commentary on “Wales and Autism: the impact of philanthropy matched with ambition”

PurposeThis paper is a commentary that aims to address themes arising from the article by Morgan titled “Wales and Autism: The Impact of Philanthropy Matched with Ambition”.Design/methodology/approachThis opinion piece considers the broader impact of stakeholder engagement in the field of autism, including how the dissemination of evidence-based support could be made more accessible for autistic people, their families and carers and philanthropists.FindingsThis paper highlights the link between stakeholder engagement and meaningful change in policy and practice in the field of autism. It highlights the need for philanthropists to invest in evidence-based support but highlights the difficulty in identifying and accessing such support. This piece supports the use of evidence and gap maps (EGMs) to increase the accessibility of autism research and evidence.Originality/valueWhile stakeholder engagement is encouragingly rising in this field, most of the evidence is held in academic journals, which are behind paywalls and, therefore, inaccessible to many autistic people, their families, carers and associated professionals. Displaying evidence using EGMs provides an accessible way for autistic people and those who support them to identify possible avenues of support quickly and allows philanthropists to direct research funding to areas of high priority.

Exploring Sleep in Caregivers of Children with Autism Spectrum Disorder (ASD) and the Relationship to Health-Related Quality of Life (HRQoL) and Family Quality of Life (FQoL).

Background and Objectives: To investigate (1) the prevalence of sleep disorder symptoms in caregivers of children with autism spectrum disorder (ASD) and (2) the relationships between caregiver sleep problems and their health-related quality of life and family quality of life. Materials and Methods: Descriptive cross-sectional study of caregivers (N = 62) of children aged 6 to 11 years old diagnosed with ASD and receiving care at a regional autism research and resource center. Results: Participants completed the Sleep Habits Questionnaire (SHQ), the Medical Outcomes Study (MOS) SF-12, and the Beach Center Family Quality of Life Scale (FQoL). Caregivers with longer sleep duration reported better mental health and better family quality of life. Caregivers who reported insomnia symptoms, non-restorative sleep, and insufficient sleep were more likely to report poorer mental health than caregivers who did not report these sleep disorder symptoms. Caregivers with obstructive sleep apnea and restless legs syndrome experienced worse physical quality of life. Conclusions: The physical and mental health of the primary caregiver is essential to the support of the child with ASD and to the functioning of the family. The study findings point to the importance of future research and interventions to enhance sleep health in order to improve quality of life for caregivers of children with ASD.

The use of eye-tracking technology as a tool to evaluate social cognition in people with an intellectual disability: a systematic review and meta-analysis

BackgroundRelatively little is known about social cognition in people with intellectual disability (ID), and how this may support understanding of co-occurring autism. A limitation of previous research is that traditional social-cognitive tasks place a demand on domain-general cognition and language abilities. These tasks are not suitable for people with ID and lack the sensitivity to detect subtle social-cognitive processes. In autism research, eye-tracking technology has offered an effective method of evaluating social cognition—indicating associations between visual social attention and autism characteristics. The present systematic review synthesised research which has used eye-tracking technology to study social cognition in ID. A meta-analysis was used to explore whether visual attention on socially salient regions (SSRs) of stimuli during these tasks correlated with degree of autism characteristics presented on clinical assessment tools.MethodSearches were conducted using four databases, research mailing lists, and citation tracking. Following in-depth screening and exclusion of studies with low methodological quality, 49 articles were included in the review. A correlational meta-analysis was run on Pearson’s r values obtained from twelve studies, reporting the relationship between visual attention on SSRs and autism characteristics.Results and conclusionsEye-tracking technology was used to measure different social-cognitive abilities across a range of syndromic and non-syndromic ID groups. Restricted scan paths and eye-region avoidance appeared to impact people’s ability to make explicit inferences about mental states and social cues. Readiness to attend to social stimuli also varied depending on social content and degree of familiarity. A meta-analysis using a random effects model revealed a significant negative correlation (r = −.28, [95% CI −.47, −.08]) between visual attention on SSRs and autism characteristics across ID groups. Together, these findings highlight how eye-tracking can be used as an accessible tool to measure more subtle social-cognitive processes, which appear to reflect variability in observable behaviour. Further research is needed to be able to explore additional covariates (e.g. ID severity, ADHD, anxiety) which may be related to visual attention on SSRs, to different degrees within syndromic and non-syndromic ID groups, in order to determine the specificity of the association with autism characteristics.

Cognitive Science Today, What is it to You?

In a paper from the late 1990s, Francisco Varela indicates that a science of inter-being is on the horizon. But how to envisage such a science? Here I propose that an enactive science of inter-being will benefit from engaging with recent innovative autism research that starts from autistic experience and intersubjectivity. Properly intersubjective autism research is both more ethically just and scientifically richer than cognitivist explanations that have dominated research, discourse, and practice for a long time, and which have tended to set people apart more than connect them. I discuss the work of Bervoets and Hens (2020), who show how autism research is unavoidably theorethical, and must be in order to move past the catch-22 they identify between autism and dysfunction. This kind of research exemplifies a participatory sense-making between subjects and scientists, and it is here that 'steps to a science of inter-being' (Varela, 1999a) are being taken.

THE IMPORTANCE OF EARLY INTERVENTION FOCUSED ON PARENT TRAINING FOR PRESCHOOL-AGED CHILDREN WITH AUTISM: A SYSTEMATIC LITERATURE REVIEW

Increased number of children with autism spectrum disorder (ASD) has also heightened interest in finding and providing appropriate interventions. Early intervention is implemented at the moment when deviations are noticed, without waiting for an official diagnosis. Parents are crucial participants in interventions carried out with children; therefore, this research considers interventions focused on training parents to work with children with ASD up to the age of six. For the purposes of this paper, we searched the following journals: Autism, Focus on Autism and Other Developmental Disabilities, and Research in Autism. The search was limited to editions from 2012 to 2022, and the following keywords were considered: parent training, early intervention, autism. References were searched manually. The initial search yielded a total of 992 articles. Twenty-four studies related to children up to six years old and involving parent training in early intervention were included in the analysis. Using a tool for assessing quantitative studies, the selected studies were evaluated, with each component assessed based on the information contained in the study as good, moderate, or weak. The overall rating for the paper can be strong, moderate, or weak. This paper highlights the importance of support to enhance parental competencies.