Author Name Research Articles

FP5.12 - Write what you know: A retrospective documentation audit

Abstract Aims The Royal College of Physicians (RCP) stipulates that every patient entry in the notes should be; dated, timed and signed by the author (name and designation included). Additionally, the content should have a standardised structure and layout with a chronological order to reflect a continuum of patient care. This audit aimed to assess the percentage of patient documentations that were compliant with these standards. Methods We retrospectively evaluated inpatient documentations for general, colorectal and vascular surgery for one week within a district general hospital setting. The data was obtained from electronic documentations. We assessed inpatient documentation for all relevant criteria as per RCP guidelines. Inpatient documentation included; the admission notes, post take ward round, daily ward rounds and inter-speciality discussions. Results A total of 88 patient related entries were reviewed. Of these 89.8% were dated. 42.0% of the entries were timed, with inter-specialty discussion having the highest percentage of recorded times. 93.2% had a standardised structure. The structure of admission entries was the most consistent with standards. 6.8% and 3.4% had the authors designation and signature respectively. Conclusion Clear informative documentation is pivotal for safe and effective patient care. Failure of patient documentation to meet the stipulated standards was established in this audit. Factors including inadequate junior doctor training, pace of ward rounds and reliance on electronic noting systems are potential reasons for poor compliance. Capitalising on opportunities to educate junior doctors is paramount in improving patient care.

Pengaruh Disiplin Kerja dan Lingkungan Kerja terhadap Kinerja Karyawan dengan Kompensasi sebagai Variabel Intervening pada PT Jayamandiri Gemasejati Bogor

This is a new author's manual and a template for Jurnal Dirosah Islamiyah. Published every May and November since 2019. Articles must start with Article Title followed by Author Name and Affiliate Address and abstract. This part of the abstract must be typed in 150-250 word counts. Especially for the abstract, use the Cambria font, measuring 10 pt. Single space per line in this article. If the article is written in Indonesian, the abstract should be typed in English and Indonesian. Meanwhile, if the article is written in English, the abstract must be typed in English only. The abstract is typed as concisely as possible and consists of: research objectives, methods, results and discussion and brief conclusions. 250 words maximum. Abstract should only be typed in one paragraph and in one column format.

Gender Distribution of Course Material Authors in a Doctor of Veterinary Medicine Program.

The gender distribution of authors in the health sciences literature has been well documented. We explored whether this distribution persists among library course reserves for a Doctor of Veterinary Medicine program, as course reserves are veterinary faculty members' own teaching materials. Such a bibliometric analysis of course reserves provides a novel method of examining curricular materials. In the Fall of 2022, researchers collected the library's current course reserve metadata, including fields, such as author names and material types. Binary gender was determined based on a variety of sources: traditional naming conventions, gender presentation in photographs, pronouns in signatures, and biographies. Of the 167 exported authors, 162 were included for further analysis in SPSS. Course reserves' authors were analyzed by collaborators and media type. The dichotomous gender distribution of first authors was 76% male/ 24% female. Female first authors were more likely to have collaborators than male first authors (39% vs 26%). When collaborations did occur, first and second authors had the same gender at a significantly higher rate. Exploring author gender across material type, we found that generally, the first author gender ratio remained 3 males to every female. Contextualizing these results in the framework of contemporary health sciences literature, we found that the gender disparities in course reserves to be unsurprising, while still disappointing.

SciScribe: Automating and contextualizing literature reviews in cardiac surgery

BackgroundThe task of writing structured content reviews and guidelines has grown stronger and more complex. We propose to go beyond search tools and toward curation tools by automating time-consuming and repetitive steps of extracting and organizing information. MethodsSciScribe is built as an extension of IBM's Deep Search platform, which provides document processing and search capabilities. This platform was used to ingest and search full-content publications from PubMed Central (PMC) and official, structured records from the ClinicalTrials and OpenPayments databases. Author names and NCT numbers, mentioned within the publications, were used to link publications to these official records as context. Search strategies involve traditional keyword-based search as well as natural language question and answering via large language models (LLMs). ResultsSciScribe is a web-based tool that helps accelerate literature reviews through key features: (1) accumulating a personal collection from publication sources, such as PMC or other sources; (2) incorporating contextual information from external databases into the presented papers, promoting a more informed assessment by readers; (3) semantic questioning and answering of documents to quickly assess relevance and hierarchical organization; and (4) semantic question answering for each document within a collection, collated into tables. ConclusionsEmergent language processing techniques are opening new avenues to accelerate and enhance the literature review process, for which we have demonstrated a use case implementation in cardiac surgery. SciScribe automates and accelerates this process, mitigates errors associated with repetition and fatigue, and contextualizes results by linking relevant external data sources instantaneously.

JournalADE: Creation and validation of a novel program for automated data extraction (ADE) to assess authorship gender representation

Background: Analyses of gender in academic authorship are key to characterizing representation in surgical fields, but current methods of manual data collection are time-consuming and error prone. The purpose of this study was to design a program to automatically extract publication data and verify the accuracy of this program in comparison to manually-collected data in a pilot study of three orthopaedic surgery journals. Methods: Publications from three orthopaedic subspecialty journals between January 2019 and June 2021 were identified via PubMed search. For each publication, online publication date, journal issue month, first author name, and senior author name were collected from PubMed listings by hand and programmatically in a Python script (JournalADE). Gender was determined using Gender API. Results: The percent of publications for which manually- and program-collected online publication dates were within 14 days of each other was above 95% for all journals. There was 98.3% (95% CI=97.84-98.76%) agreement for online publication date, with a mean difference of 6.43 (SD 0.87) days. Journal issue month agreement was 99.6% (95% CI=99.37-99.83%). Agreement for first author gender was 97.33% (95% CI=96.75-97.91%) and for senior author gender was 96.77% (95% CI=96.14-97.4%). Estimated labor time for manual collection was 100 hr, compared to 15 min for JournalADE. Conclusions: When comparing the JournalADE- and manually-collected data, rates of agreement were high at a fraction of the time. This supports the efficacy of JournalADE and sets the stage for its use in future studies of gender in authorship.

Comparing the Efficacy of Robotic Versus Laparoscopic Sleeve Gastrectomy: A Systematic Review and Meta-Analysis.

Laparoscopic sleeve gastrectomy (LSG) has emerged as the predominant metabolic bariatric surgery. With a growing number of studies evaluating the feasibility of robotic sleeve gastrectomy (RSG), it becomes imperative to ascertain whether the outcomes of both techniques are comparable. This study endeavors to synthesize existing evidence and juxtapose the surgical outcomes of LSG and RSG. We collected articles comparing LSG and RSG published between 2011 and 2024. The compiled data included author names, study duration, sample size, average age, gender distribution, geographical location, preoperative body mass index (BMI), bougie diameter, duration of hospitalization, surgical duration, readmission rates, conversion rates, costs, postoperative percentage of excess weight loss (%EWL), postoperative BMI, mortality rates, and complications. We incorporated 21 articles. Both the RSG and LSG cohorts exhibited comparable rates of readmission, conversion, mortality, and incidence of complications (p > 0.05). Moreover, the efficacy of weight loss was similar between RSG and LSG. Nonetheless, RSG was linked to longer operative duration (WMD, -27.50 minutes; 95% confidence interval [CI], -28.82 to -26.18; p < 0.0001), prolonged hospitalization (WMD, -0.15 days; 95% CI, -0.25 to -0.04; p = 0.006), and elevated expenses (WMD, -5830.9 dollars; 95% CI, -8075.98 to -3585.81; p < 0.0001). While both RSG and LSG demonstrated positive postoperative clinical outcomes, RSG patients experienced extended hospital stays, longer operative times, and increased hospitalization costs compared to LSG patients. Using the robotic platform for sleeve gastrectomy (SG) in patients with obesity did not appear to offer any clear benefits.

Efficacy and safety of Ibalizumab for the treatment of HIV-1 infected patients: A systematic review

Objectives: Human immunodeficiency virus (HIV) infection is a significant global health concern, due to the emerging complexity in the management of infection. The emergence of novel therapeutic agents, such as ibalizumab, has provided a ray of hope for individuals living with HIV. This systematic review provides a comprehensive analysis of the efficacy and safety of ibalizumab for the treatment of HIV-1-infected patients. Material and Methods: Using online medical literature databases and the preferred reporting items for systematic reviews and meta-analysis (PRISMA) guidelines, four of the 86 articles met the acceptance criteria to be analyzed. Details such as author name, year of publication, demographic characteristics, mode, and dose of drug administration, duration of treatment, comparator if any, baseline CD4 counts, and viral load, change in CD4 count and viral load, and the adverse events were noted in the studies. Results: The total number of patients enrolled in each study ranged from 22 to 82 with a median age ranging from 39 to 53. Except for the open-label dose-ranging cohort study, baseline CD4 counts and post-intervention CD4 counts were assessed in all the studies. The patients who received a higher dose of ibalizumab showed an early significant rise in CD4+T-cell count at week 16 and week 48. Although the viral reduction after ibalizumab injection increases from the dose of 3 mg/kg, it was noted that beyond 10mg/kg the viral load reduction was not increasing proportionately with 25 mg/kg. The adverse effects encountered among the four studies ranged from 45% to 91%. The commonly observed adverse effects were headache, diarrhea, nausea, fatigue, somnolence, and rash. Conclusion: Ibalizumab demonstrates promise as a therapeutic option for individuals with multidrug-resistant HIV-1. Its unique mechanism of action and positive impact on viral load reduction and CD4 cell counts make it a valuable addition to the armamentarium of HIV treatment options.

Nutritional Strategies for Maintaining Optimal Hemoglobin Levels in Soccer Players: A Review of Health Implications

This study uses a literature review-based qualitative descriptive research model to explore nutritional strategies in maintaining optimal hemoglobin levels in football players. The research process begins with the collection of literature from reliable sources, by accessing scientific databases such as Scopus, Science Direct, and Google Scholar using keywords such as "Nutrition Strategies," "Hemoglobin Levels," and "Soccer Players." After gathering the relevant literature, the authors reviewed important terms related to hemoglobin and their application to football players. Furthermore, data from the relevant literature is collected and analyzed. The data includes the author's name, year of publication, research design, research objectives, samples, instruments, and a summary of the findings. Articles that met the criteria were then filtered for further analysis. The documentation method is used to collect data by searching and extracting information from related literature. The collected data is then compiled into a comprehensive document to answer the research questions. Content analysis was conducted to evaluate the relevance and contribution of the study to nutritional strategies in maintaining hemoglobin levels. The conclusions of this analysis provide evidence-based recommendations regarding effective nutrition strategies to maintain optimal hemoglobin levels in soccer players.

Current trends and hotspots of depressive disorders with colorectal cancer: A bibliometric and visual study

BACKGROUND Depression is strongly associated with colorectal cancer (CRC). Few bibliometric analyses have systematically summarized the research focus and recent progress in this field. AIM To determine the research status and hotspots by bibliometric analysis of relevant publications on the relationship between CRC and depression. METHODS Articles on depression in CRC patients were collected from the Web of Science Core Collection. CiteSpace and VOSviewer software were used to visualize bibliometric networks. RESULTS From 2001 to 2022, Supportive Care in Cancer , the United States, Tilburg University, and Mols were the most productive and influential journal, country, institution, and author name. Co-occurrence cluster analysis of keywords placed quality of life, anxiety, and psychological stress in the center of the visual network diagram. Further clustering was performed for the clusters with studies of the relevant mechanism of action, which showed that: (1) Cytokines have a role essential for the occurrence and development of depressive disorders in CRC; (2) MicroRNAs have a role essential for the development of depressive disorders in CRC; (3) Some anticancer drugs have pro-depressant activity; and (4) Selective serotonin reuptake inhibitors have both antitumor and antidepressant activity. CONCLUSION Life quality and psychological nursing of the cancer population were key topics. The roles of cytokines and microRNAs, the pro-depression activity of anticancer drugs and their antitumor properties deserve in-depth study.

Publication Rates for Oral Manuscript and Poster Presentations From the American College of Foot and Ankle Surgeons: 2015 to 2019

The quality of national society conferences is often assessed indirectly by analyzing the journal publication rate of the abstracts presented. The conversion rate of abstracts presented at the annual American College of Foot and Ankle Surgeons conference is currently the highest reported (76.9%) for any foot and ankle society to date. The purpose of the present retrospective study was to re-assess the journal publication rate for abstracts (oral manuscript, poster) accepted for presentation at the annual meeting, this time from 2015 to 2019. All accepted abstracts from this period were compiled in a database. PubMed, Google Scholar, and Scopus searches were performed using abstract titles, and author names. The journal publication rate was 80.7% (92/114) for oral manuscripts, and 23.1% (287/1240) for poster abstracts. The mean time to publication was 18.7 months (0 to 75), and 19.1 months (0 to 88) for oral manuscript and posters, respectively. The most common journal for abstract publication was The Journal of Foot and Ankle Surgery. The American College of Foot and Ankle Surgeons oral manuscript publication rate from 2015 to 2019 (80.7%) exceeded the previous reported rate from 2010 to 2014 (76.9%), and is now the highest reported for any national foot and ankle society to date. Attendees of the oral presentations, and readers of the Journal of Foot and Ankle Surgery may remain confident in the quality, and clinical significance of the research presented.

Utilization of patient reported outcomes measurement information system in plastic and reconstructive surgery research

BackgroundThe Patient-Reported Outcomes Measurement Information System (PROMIS) was developed by investigators funded by the National Institutes of Health as a standardized means of directly assessing patients’ perspectives across domains. PROMIS domains include physical function, pain, fatigue, emotional distress, and social health. Various studies have reported increased utilization of PROMIS in research articles in specific specialties; however, the extent to which PROMIS has been employed in the field of plastic and reconstructive surgery remains unclear. The goal of the present study is to characterize the prevalence and trends of PROMIS within plastic and reconstructive surgery articles. MethodsLiterature search was conducted across multiple databases for PROMIS studies within plastic surgery literature. 136 were identified and the following data was extracted: author name, journal, impact factor, country of origin, year of publication, publication type, subspecialty, study size, and PROMIS measures used. Results136 studies met inclusion criteria. There was an overall increasing trend in the number of PROMIS studies published. The most common subspecialties that utilized PROMIS measures were General Reconstruction (n=24), Hand (n=9), and Burn (n=5). The most used PROMS measures were Pain Interference (n=26), Pain Intensity (n=15), and Depression (n=13). There was a total of 24 journals that included PROMIS studies with a mean impact factor of 3.73 (SD = 3.2). The most common country of origin was the United States (n=42). ConclusionThe data demonstrates an increasing use of PROMIS within plastic surgery across a wide variety of subspecialities and study designs. The characterization of these trends allows researchers and clinicians alike a greater understanding of a powerful tool in measuring patient care.

A bidirectional free space optical link for last-mile terrestrial access links employing a novel wavelength shift keying technique

In this study, we propose a novel wavelength shift keying (WSK) technique that is combined with the conventional intensity modulation scheme for the transmission of point-to-point bidirectional data at the rate of 10 Gbps in each direction. We observe that WSK technique has not been investigated for implementation in point-to-point free space optical (FSO) links. Therefore, to the best of our knowledge, our study is the first one to perform this investigation. Our proposed link uses WSK in the downlink direction while we re-use the optical carriers for the transmission of uplink data. The use of WSK in the downlink direction enables us to perform balanced detection at the receiver, resulting in 3 dB improvement in receiver sensitivity compared to simple direct detection. We present bit error rate (BER) results for the signals transmitted in both the directions under different turbulence conditions and FSO link lengths. It was observed that the downlink signals generally perform better compared to the uplink due to the use of balanced detection and higher intensity fluctuations induced over the re-used optical carrier transmitted in the uplink direction.Please check and confirm that all the author names (given name, family name) and initials are correctly identified. The author names and initials are CORRECT.

Creating, publishing, and spreading processes of health-related contents in internet news sites: evaluation of the opinions of actors in health communication.

The accuracy and reliability of health information disseminated through news is crucial, as it directly impacts both individual and societal health outcomes. This study aims to analyze the publication process of health content in Türkiye and its implications for public health. By examining the perspectives of various health communication stakeholders, the study seeks to identify existing issues and propose potential solutions. The research uses a mixed-methods approach, including baseline content analysis of 846 news by 133 criteria, quantitative research with 78 participants encompassing bureaucrats, academics, journalists, and health association members, and 15 in-depth interviews for comprehensive insights. The content analysis indicated that 23.2% of the analyzed news articles lacked credible sources, while 63% did not mention the author's name. A striking 96.2% of respondents stated that inaccurate health news poses a risk to public health, emphasizing the urgent need for standardized reporting practices. The majority (90.9%) pinpointed the media as the primary catalysts for infodemic spread, with 93.5% citing gatekeepers as barriers to accurate information. Eroding trust in media, fueled by unethical practices, harms both media credibility and effective public health interventions. The study underscores the necessity for a collaborative approach among public institutions, academia, and media, focusing on responsibility, regulation, and sanctions against the infodemic. The research advocates for a balanced approach that prioritizes health rights and press freedom within a stakeholder-driven framework, highlighting that legislation alone cannot fully enhance the digital information ecosystem.

Data set of fraction unbound values in the in vitro incubations for metabolic studies for better prediction of human clearance.

In vitro-in vivo extrapolation is a commonly applied technique for liver clearance prediction. Various in vitro models are available such as hepatocytes, human liver microsomes, or recombinant cytochromes P450. According to the free drug theory, only the unbound fraction (fu) of a chemical can undergo metabolic changes. Therefore, to ensure the reliability of predictions, both specific and nonspecific binding in the model should be accounted. However, the fraction unbound in the experiment is often not reported. The study aimed to provide a detailed repository of the literature data on the compound's fu value in various in vitro systems used for drug metabolism evaluation and corresponding human plasma binding levels. Data on the free fraction in plasma and different in vitro models were supplemented with the following information: the experimental method used for the assessment of the degree of drug binding, protein or cell concentration in the incubation, and other experimental conditions, if different from the standard ones, species, reference to the source publication, and the author's name and date of publication. In total, we collected 129 literature studies on 1425 different compounds. The provided data set can be used as a reference for scientists involved in pharmacokinetic/physiologically based pharmacokinetic modelling as well as researchers interested in Quantitative Structure-Activity Relationship models for the prediction of fraction unbound based on compound structure. Database URL: https://data.mendeley.com/datasets/3bs5526htd/1.

Features of management decisions in enforcement agencies

The article examines the features of managerial decision-making in such public authorities as enforcement agencies. The author considers management decisions in enforcement agencies from the point of view of the phonomena of their legal status, in particular, as a tool for ensuring the enforcement of an authoritative decision of a judge, judicial authority, other public authority, official in relation to a single legal entity: a citizen, an organization, a public authority. This proves the importance of the role of management decisions in ensuring human and civil rights as the highest value, authoritative publicly significant decisions on the scale of the entire state. Adhering to a broad interpretation of the definitions of the concepts of “public administration”, “act”, the author comes to the conclusion that the management decision — this is a process that requires formalization, and which permeates the entire activity of the enforcement authority, in particular and mainly, illustrating the process of enforcement proceedings, asserts that a management decision accompanies it from the moment of receipt of the enforcement document to its completion, says that as long as the state exists, it will need tools for the enforcement of authority decisions, and therefore in a management decision. According to the author, a legally significant managerial decision of the enforcement body, its official, is based on a triad of conditions on the basis of which it is made: legislative, jurisdictional, competent; it takes the form of a legal act of management, the main of which is a resolution. In addition to resolutions, the author names such forms of management decisions as a request, a bilateral act and others, arguing his position from the point of view of a broad understanding of the term “act”. The author comes to the conclusion that the adoption of a managerial decision in enforcement proceedings is a vivid example of a combination of administrative procedure and specific administrative and jurisdictional proceedings, characteristic only of a bailiff conducting enforcement proceedings, in the unity of conditionally allocated types of administrative procedural activities.

Carbapenem-resistant Enterobacteriaceae in the livestock, humans and environmental samples around the globe: a systematic review and meta-analysis

Carbapenem-resistant Enterobacteriaceae (CRE) have diminished treatment options causing serious morbidities and mortalities. This systematic review and meta-analysis assessed the prevalence and associated factors of Enterobacteriaceae infections in clinical, livestock and environmental settings globally. The population intervention comparison and outcome strategy was used to enroll studies using the preferred reporting system for systematic review and meta-analysis to include only cross-sectional studies. Search engines used to retrieve articles included journal author name estimator, PubMed, Google Scholar and African Journals Online (AJOL). The Newcastle–Ottawa scale was used to assess the quality of studies. Sixteen articles from 2013 to 2023 in Africa, Asia, Europe and South America were studied. The pooled prevalence of CRE was 43.06% (95% CI 21.57–66.03). Klebsiella pneumoniae (49.40%), Escherichia coli (26.42%), and Enterobacter cloacae (14.24%) were predominant. Klebsiella pneumoniae had the highest resistance with the blaKPC-2 in addition to blaNDM, blaOXA-48, blaIMP and blaVIM. The blaKPC-2 genes occurrence was associated with environmental (P-value < 0.0001) and South American studies (P-value < 0.0001), but there was no difference in the trends over time (P-value = 0.745). This study highlights the high rates of CRE infections, particularly within blaKPC production. Monitoring and surveillance programs, research and infection control measures should be strengthened. Additionally, further studies are needed to explore the mechanisms driving the predominance of specific bacterial species and the distribution of resistance genes within this bacterial family.

Levator palpebralis superioris histopathologic findings in congenital ptosis and surgical outcome after its resection: Is there any association?

To evaluate the histopathologic findings of Levator palpebralis superioris (LPS) muscle biopsy after LPS resection for treatment of congenital ptosis and its possible relation with surgical outcomes.Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Author 4 Given name: [Seyed Mohsen] Last name [Rafizadeh]. Author 6 Given name: [Seyed Ali] Last name [Sonbolestan].Also, kindly confirm the details in the metadata are correct.The author names and the sequence are correct. Congenital ptosis patients were enrolled in this retrospective study. All of them underwent full ophthalmologic examination included of Margin-reflex distance 1 (MRD-1) and LPS function measurement preoperatively. The patients were followed for 3months for the postoperative period and after that the measurements were repeated. Histologic parameters including percentages of fat, striated and smooth muscle, and fibrous tissue. The histopathologic findings and their possible correlation with the measurements are analyzed. Sixty-seven patients with unilateral congenital ptosis were enrolled. 45 patients (67.2%) were males. The mean age of patients was 16.10 ± 11.18years. The patients' MRD-1 was improved significantly from 0.82 ± 1.26mm to 3.85 ± 1.25mm after LPS resection (P = 0.000). The success rate was 80.3%. There were no correlations between MRD change and histopathologic tissue percentages but significant correlation was found between success of surgery and fibrous tissue percentage of resected sample (P = 0.033). The histopathology of the LPS may be useful in prediction of surgical outcome after LPS resection in congenital ptosis patients. The percentage of fibrous tissue play an important role.

Gender Diversity Among Reconstructive Microsurgery Studies Based on the Relative Citation Ratio: An 18-Year Analysis.

Gender disparities in plastic surgery authorship have been previously described in the literature. The relative citation ratio (RCR) index is a new metric that normalizes citation rates for field and time, which can be utilized to compare authors. This study aims to evaluate differences in gender authorship in reconstructive microsurgery (RM) papers, as well as the impact of gender on the RCR index. A PubMed query isolated RM studies between 2002 and 2020 across the 3 highest impact PS journals. Author names and RCR information were collected from NIH iCite. The likely gender was adjudicated by using NamSor-Software. Unpaired Wilcoxon rank-sum and chi-square tests were used to assess differences between groups. Of 1146 articles (2172 authors), there was a significant difference between the proportion of females as senior authors compared to first authors ( P < 0.001). Overall, females represented 15.4% of all authors, 19.7% of first authors, and 11.3% of senior authors. Males had a significantly higher weighted RCR ( P < 0.0001) and number of publications ( P < 0.0001), which remained significant when stratified by first and senior author. Female authors collectively had a higher mean RCR ( P = 0.008) and among first authors ( P < 0.0001), with no significant difference among senior authors ( P = 0.47). A considerably greater number of males are publishing in reconstructive microsurgery compared to females, with significantly more males being senior authors compared to first authors. Males had higher weighted RCR scores and publications compared to females. This study suggests that equity in gender authorship within the field is yet to be achieved.

Characterizing Enoxaparin's Population Pharmacokinetics to Guide Dose Individualization in the Pediatric Population.

Pediatric dosing of enoxaparin was derived based on extrapolation of the adult therapeutic range to children. However, a large fraction of children do not achieve therapeutic anticoagulation with initial dosing. We aim to use real-world anti-Xa data obtained from children receiving enoxaparin per standard of care to characterize the population pharmacokinetics (PopPK).Author names: Please confirm if the author names are presented accurately and in the correct sequence (given name, middle name/initial, family name). Also, kindly confirm the details in the metadata are correct.The author names are accurately presented and the metadata are correct. METHODS: A PopPK analysis was performed using NONMEM, and a stepwise covariate modeling approach was applied for the covariate selection. The final PopPK model, developed with data from 1293 patients ranging in age from 1 day to 18 years, was used to simulate enoxaparin subcutaneous dosing for prophylaxis and treatment based on total body weight (0-18 years, TBW) or fat-free mass (2-18 years, FFM). Simulated exposures in children with obesity (body mass index percentile ≥95th percentile) were compared with those without obesity. A linear, one-compartment PopPK model that included allometric scaling using TBW (<2 years) or FFM (≥2 years) characterized the enoxaparin pharmacokinetic data. In addition, serum creatinine was identified as a significant covariate influencing clearance. Simulations indicated that in patients aged <2 years, the recommended 1.5 mg/kg TBW-based dosing achieves therapeutic simulated concentrations. In pediatric patients aged ≥2 years, the recommended 1.0 mg/kg dose resulted in exposures more comparable in children with and without obesity when FFM weight-based dosing was applied. Using real-world data and PopPK modeling, enoxaparin's pharmacokinetics were characterized in pediatric patients. Using FFM and twice-daily dosing might reduce the risk of overdosing, especially in children with obesity.

Penerapan Metode Association Rule Menggunakan Apriori untuk Rekomendasi Penyusunan Rak Buku di Perpustakaan Universitas Muhammadiyah Bengkulu

The library is one of the facilities provided by Muhammadiyah University. The Muhammadiyah University Library can provide various kinds of library materials such as textbooks, text books, literature for practicums, general magazines and various other collections. Some book collections can be borrowed or can only be accessed on site. Apriori is an algorithm that is well known for searching frequent item sets using association rule techniques. The a priori algorithm uses knowledge about previously known frequent itemsets to process further information. In the a priori algorithm, to determine the candidates that may appear, it is done by paying attention to the minimum support. The data collection techniques used by the author in this research are interview techniques, observation and literature study. To carry out a bookshelf search application in a library, it begins with the process of inputting the book title, author's name, and publisher through inputting search data. Next, the system will look for a match string which will be processed by the application. If each string is found it will display it as a whole and will provide bookshelf information. The conclusion that can be drawn from the application of the association rule method using a priori for recommendations for arranging bookshelves in the Muhammadiyah University of Bengkulu library, is that you can find the placement of books in the library by applying the association rule method, can distribute books grouped according to scientific discipline categories, and the rapid miner application By using the association rule method, you can also read scientific discipline categories from the same book and the title entered contains the same characters but different writing.