Auditory Domain Research Articles

Functional reorganization of brain regions supporting artificial grammar learning across the first half year of life.

Pre-babbling infants can track nonadjacent dependencies (NADs) in the auditory domain. While this forms a crucial prerequisite for language acquisition, the neurodevelopmental origins of this ability remain unknown. We applied functional near-infrared spectroscopy in neonates and 6- to 7-month-old infants to investigate the neural substrate supporting NAD learning and detection using tone sequences in an artificial grammar learning paradigm. Detection of NADs was indicated by left prefrontal activation in neonates while by left supramarginal gyrus (SMG), superior temporal gyrus (STG), and inferior frontal gyrus activation in 6- to 7-month-olds. Functional connectivity analyses further indicated that the neonate activation pattern during the test phase benefited from a brain network consisting of prefrontal regions, left SMG and STG during the rest and learning phases. These findings suggest a left-hemispheric learning-related functional brain network may emerge at birth and serve as the foundation for the later engagement of these regions for NAD detection, thus, providing a neural basis for language acquisition.

Introducing ART: A new method for testing auditory memory with circular reproduction tasks.

Theories of visual working memory have seen significant progress through the use of continuous reproduction tasks. However, these tasks have mainly focused on studying visual features, with limited examples existing in the auditory domain. Therefore, it is unknown to what extent newly developed memory models reflect domain-general limitations or are specific to the visual domain. To address this gap, we developed a novel methodology: the Auditory Reproduction Task (ART). This task utilizes Shepard tones, which create an infinite rising or falling tone illusion by dissecting pitch chroma and height, to create a 1-360° auditory circular space. In Experiment 1, we validated the perceptual circularity and uniformity of this auditory stimulus space. In Experiment 2, we demonstrated that auditory working memory shows similar set size effects to visual working memory-report error increased at a set size of 2 relative to 1, caused by swap errors. In Experiment 3, we tested the validity of ART by correlating reproduction errors with commonly used auditory and visual working memory tasks. Analyses revealed that ART errors were significantly correlated with performance in both auditory and visual working memory tasks, albeit with a stronger correlation observed with auditory working memory. While these experiments have only scratched the surface of the theoretical and computational constraints on auditory working memory, they provide a valuable proof of concept for ART. Further research with ART has the potential to deepen our understanding of auditory working memory, as well as to explore the extent to which existing models are tapping into domain-general constraints.

Influence of auditory-based cognitive training on auditory resolution, executive function, and working memory skills in individuals with mild cognitive impairment – a pilot randomized controlled study

Background Age-related central auditory processing disorder and mild cognitive impairment (MCI) can be concomitant in older adults, making it difficult to communicate, especially in challenging listening conditions. This preliminary study investigated the efficacy of auditory-based cognitive training on the auditory processing abilities and cognitive functions of older adults with MCI. Methods In this randomized controlled trial twenty-two older adults with mild cognitive impairment (MCI) were randomly assigned to either an experimental (n=11) or a control group (n=11). The experimental group received 15 cognitive training sessions through tasks involving the auditory domain. The outcome measures of this study included auditory resolution (Temporal gap detection, frequency discrimination, and modulation detection) and cognitive measures (Trail making tests and digit recall), which were administered at three-time points (before training, post-training, and follow-up). The linear mixed model computed the effects of training on the outcome measures. Results A significant improvement was observed in the modulation detection threshold between baseline and follow-up and between post-training and follow-up sessions. However, GDT and FD thresholds did not reveal any statistically significant difference. In the trail making test, Part B showed consistent significance across the time points, whereas Part A and the delayed recall task showed no significant difference. Conclusion Auditory-based cognitive training may improve auditory processing and executive function in older adults with mild cognitive impairment (MCI). Trial registration CTRI/2019/01/017073, registered on 14.01.2019

The influence of affective voice on sound distance perception.

Affective stimuli in our environment indicate reward or threat and thereby relate to approach and avoidance behavior. Previous findings suggest that affective stimuli may bias visual perception, but it remains unclear whether similar biases exist in the auditory domain. Therefore, we asked whether affective auditory voices (angry vs. neutral) influence sound distance perception. Two VR experiments (data collection 2021-2022) were conducted in which auditory stimuli were presented via loudspeakers located at positions unknown to the participants. In the first experiment (N = 44), participants actively placed a visually presented virtual agent or virtual loudspeaker in an empty room at the perceived sound source location. In the second experiment (N = 32), participants were standing in front of several virtual agents or virtual loudspeakers and had to indicate the sound source by directing their gaze toward the perceived sound location. Results in both preregistered experiments consistently showed that participants estimated the location of angry voice stimuli at greater distances than the location of neutral voice stimuli. We discuss that neither emotional nor motivational biases can account for these results. Instead, distance estimates seem to rely on listeners' representations regarding the relationship between vocal affect and acoustic characteristics. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Cortical-subcortical interactions underlie processing of auditory predictions measured with 7T fMRI.

Perception integrates both sensory inputs and internal models of the environment. In the auditory domain, predictions play a critical role because of the temporal nature of sounds. However, the precise contribution of cortical and subcortical structures in these processes and their interaction remain unclear. It is also unclear whether these brain interactions are specific to abstract rules or if they also underlie the predictive coding of local features. We used high-field 7T functional magnetic resonance imaging to investigate interactions between cortical and subcortical areas during auditory predictive processing. Volunteers listened to tone sequences in an oddball paradigm where the predictability of the deviant was manipulated. Perturbations in periodicity were also introduced to test the specificity of the response. Results indicate that both cortical and subcortical auditory structures encode high-order predictive dynamics, with the effect of predictability being strongest in the auditory cortex. These predictive dynamics were best explained by modeling a top-down information flow, in contrast to unpredicted responses. No error signals were observed to deviations of periodicity, suggesting that these responses are specific to abstract rule violations. Our results support the idea that the high-order predictive dynamics observed in subcortical areas propagate from the auditory cortex.

Exploring the relationship between manual dexterity and cognition in people with multiple sclerosis: 9-hole peg and multiple cognitive functions

Aim and RationaleProblems with manual dexterity and cognition impact the everyday performance of people with multiple sclerosis (PwMS). Accumulated findings point to the relationship between deficits in manual dexterity and auditory domains of cognition with a lack of evidence on visuospatial and verbal aspects of cognitive functioning. Therefore, this study explores the relationship between manual dexterity and cognition in a cohort of PwMS. MethodThis cross-sectional study collected data from 63 PwMS aged 22 to 55 through a convenient sampling method. Participants were diagnosed with relapsing-remitting multiple sclerosis (RRMS). Cognition was measured using a multi-domain computerized cognitive testing, NeuroTrax, and manual dexterity was measured using a 9-hole peg assessment. Spearman correlation was used to identify the correlation among cognition subtests as well as with manual dexterity. Linear regression analysis was also conducted to identify whether manual dexterity predicts cognitive functioning. ResultsA significant negative correlation was found between 9-hole peg scores and global cognitive scores (GCS), r = -0.34, p = 006. The manual dexterity scores were also shown to predict GCS, R2= 0.165, p = 0.001. ConclusionManual dexterity was found to not only predict cognitive dysfunction but was also associated with multiple cognitive domains. Understanding the relationship between manual dexterity and cognition and the inferred progression of deficits can assist clinicians to provide interventions at earlier stages of disease progression to potentially increase daily functioning and quality of life (QoL).

Systematic review and meta-analysis of the visual mismatch negativity in schizophrenia.

Mismatch negativity (MMN) is an event-related potential component automatically elicited by events that violate predictions based on prior events. To elicit this component, researchers use stimulus repetition to induce predictions, and the MMN is obtained by subtracting the brain response to rare or unpredicted stimuli from that of frequent stimuli. Under the Predictive Processing framework, one increasingly popular interpretation of the mismatch response postulates that MMN represents a prediction error. In this context, the reduced MMN amplitude to auditory stimuli has been considered a potential biomarker of Schizophrenia, representing a reduced prediction error and the inability to update the mental model of the world based on the sensory signals. It is unclear, however, whether this amplitude reduction is specific for auditory events or if the visual MMN reveals a similar pattern in schizophrenia spectrum disorder. This review and meta-analysis aimed to summarise the available literature on the vMMN in schizophrenia. A systematic literature search resulted in 10 eligible studies that resulted in a combined effect size of g = -.63, CI [-.86, -.41], reflecting lower vMMN amplitudes in patients. These results are in line with the findings in the auditory domain. This component offers certain advantages, such as less susceptibility to overlap with components generated by attentional demands. Future studies should use vMMN to explore abnormalities in the Predictive Processing framework in different stages and groups of the SSD and increase the knowledge in the search for biomarkers in schizophrenia.

Is there a bilingual advantage in auditory attention among children? A systematic review and meta-analysis of standardized auditory attention tests.

A wealth of research has investigated the associations between bilingualism and cognition, especially in regards to executive function. Some developmental studies reveal different cognitive profiles between monolinguals and bilinguals in visual or audio-visual attention tasks, which might stem from their attention allocation differences. Yet, whether such distinction exists in the auditory domain alone is unknown. In this study, we compared differences in auditory attention, measured by standardized tests, between monolingual and bilingual children. A comprehensive literature search was conducted in three electronic databases: OVID Medline, OVID PsycInfo, and EBSCO CINAHL. Twenty studies using standardized tests to assess auditory attention in monolingual and bilingual participants aged less than 18 years were identified. We assessed the quality of these studies using a scoring tool for evaluating primary research. For statistical analysis, we pooled the effect size in a random-effects meta-analytic model, where between-study heterogeneity was quantified using the I2 statistic. No substantial publication bias was observed based on the funnel plot. Further, meta-regression modelling suggests that test measure (accuracy vs. response times) significantly affected the studies' effect sizes whereas other factors (e.g., participant age, stimulus type) did not. Specifically, studies reporting accuracy observed marginally greater accuracy in bilinguals (g = 0.10), whereas those reporting response times indicated faster latency in monolinguals (g = -0.34). There was little difference between monolingual and bilingual children's performance on standardized auditory attention tests. We also found that studies tend to include a wide variety of bilingual children but report limited language background information of the participants. This, unfortunately, limits the potential theoretical contributions of the reviewed studies. Recommendations to improve the quality of future research are discussed.

Pupil diameter as an indicator of sound pair familiarity after statistically structured auditory sequence

Inspired by recent findings in the visual domain, we investigated whether the stimulus-evoked pupil dilation reflects temporal statistical regularities in sequences of auditory stimuli. We conducted two preregistered pupillometry experiments (experiment 1, n = 30, 21 females; experiment 2, n = 31, 22 females). In both experiments, human participants listened to sequences of spoken vowels in two conditions. In the first condition, the stimuli were presented in a random order and, in the second condition, the same stimuli were presented in a sequence structured in pairs. The second experiment replicated the first experiment with a modified timing and number of stimuli presented and without participants being informed about any sequence structure. The sound-evoked pupil dilation during a subsequent familiarity task indicated that participants learned the auditory vowel pairs of the structured condition. However, pupil diameter during the structured sequence did not differ according to the statistical regularity of the pair structure. This contrasts with similar visual studies, emphasizing the susceptibility of pupil effects during statistically structured sequences to experimental design settings in the auditory domain. In sum, our findings suggest that pupil diameter may serve as an indicator of sound pair familiarity but does not invariably respond to task-irrelevant transition probabilities of auditory sequences.

Age Impacts Speech-in-Noise Recognition Differently for Nonnative and Native Listeners.

The purpose of this study was to explore potential differences in suprathreshold auditory function among native and nonnative speakers of English as a function of age. Retrospective analyses were performed on three large data sets containing suprathreshold auditory tests completed by 5,572 participants who were self-identified native and nonnative speakers of English between the ages of 18-65 years, including a binaural tone detection test, a digit identification test, and a sentence recognition test. The analyses show a significant interaction between increasing age and participant group on tests involving speech-based stimuli (digit strings, sentences) but not on the binaural tone detection test. For both speech tests, differences in speech recognition emerged between groups during early adulthood, and increasing age had a more negative impact on word recognition for nonnative compared to native participants. Age-related declines in performance were 2.9 times faster for digit strings and 3.3 times faster for sentences for nonnative participants compared to native participants. This set of analyses extends the existing literature by examining interactions between aging and self-identified native English speaker status in several auditory domains in a cohort of adults spanning young adulthood through middle age. The finding that older nonnative English speakers in this age cohort may have greater-than-expected deficits on speech-in-noise perception may have clinical implications on how these individuals should be diagnosed and treated for hearing difficulties.

Towards sensory substitution and augmentation: Mapping visual distance to audio and tactile frequency.

Multimodal perception is the predominant means by which individuals experience and interact with the world. However, sensory dysfunction or loss can significantly impede this process. In such cases, cross-modality research offers valuable insight into how we can compensate for these sensory deficits through sensory substitution. Although sight and hearing are both used to estimate the distance to an object (e.g., by visual size and sound volume) and the perception of distance is an important element in navigation and guidance, it is not widely studied in cross-modal research. We investigate the relationship between audio and vibrotactile frequencies (in the ranges 47-2,764 Hz and 10-99 Hz, respectively) and distances uniformly distributed in the range 1-12 m. In our experiments participants mapped the distance (represented by an image of a model at that distance) to a frequency via adjusting a virtual tuning knob. The results revealed that the majority (more than 76%) of participants demonstrated a strong negative monotonic relationship between frequency and distance, across both vibrotactile (represented by a natural log function) and auditory domains (represented by an exponential function). However, a subgroup of participants showed the opposite positive linear relationship between frequency and distance. The strong cross-modal sensory correlation could contribute to the development of assistive robotic technologies and devices to augment human perception. This work provides the fundamental foundation for future assisted HRI applications where a mapping between distance and frequency is needed, for example for people with vision or hearing loss, drivers with loss of focus or response delay, doctors undertaking teleoperation surgery, and users in augmented reality (AR) or virtual reality (VR) environments.

Preliminary Evidence for Global Properties in Human Listeners During Natural Auditory Scene Perception.

Theories of auditory and visual scene analysis suggest the perception of scenes relies on the identification and segregation of objects within it, resembling a detail-oriented processing style. However, a more global process may occur while analyzing scenes, which has been evidenced in the visual domain. It is our understanding that a similar line of research has not been explored in the auditory domain; therefore, we evaluated the contributions of high-level global and low-level acoustic information to auditory scene perception. An additional aim was to increase the field's ecological validity by using and making available a new collection of high-quality auditory scenes. Participants rated scenes on 8 global properties (e.g., open vs. enclosed) and an acoustic analysis evaluated which low-level features predicted the ratings. We submitted the acoustic measures and average ratings of the global properties to separate exploratory factor analyses (EFAs). The EFA of the acoustic measures revealed a seven-factor structure explaining 57% of the variance in the data, while the EFA of the global property measures revealed a two-factor structure explaining 64% of the variance in the data. Regression analyses revealed each global property was predicted by at least one acoustic variable (R2 = 0.33-0.87). These findings were extended using deep neural network models where we examined correlations between human ratings of global properties and deep embeddings of two computational models: an object-based model and a scene-based model. The results support that participants' ratings are more strongly explained by a global analysis of the scene setting, though the relationship between scene perception and auditory perception is multifaceted, with differing correlation patterns evident between the two models. Taken together, our results provide evidence for the ability to perceive auditory scenes from a global perspective. Some of the acoustic measures predicted ratings of global scene perception, suggesting representations of auditory objects may be transformed through many stages of processing in the ventral auditory stream, similar to what has been proposed in the ventral visual stream. These findings and the open availability of our scene collection will make future studies on perception, attention, and memory for natural auditory scenes possible.

Facial cues to anger affect meaning interpretation of subsequent spoken prosody

Abstract In everyday life, visual information often precedes the auditory one, hence influencing its evaluation (e.g., seeing somebody’s angry face makes us expect them to speak to us angrily). By using the cross-modal affective paradigm, we investigated the influence of facial gestures when the subsequent acoustic signal is emotionally unclear (neutral or produced with a limited repertoire of cues to anger). Auditory stimuli spoken with angry or neutral prosody were presented in isolation or preceded by pictures showing emotionally related or unrelated facial gestures (angry or neutral faces). In two experiments, participants rated the valence and emotional intensity of the auditory stimuli only. These stimuli were created from acted speech from movies and delexicalized via speech synthesis, then manipulated by partially preserving or degrading their global spectral characteristics. All participants relied on facial cues when the auditory stimuli were acoustically impoverished; however, only a subgroup of participants used angry faces to interpret subsequent neutral prosody. Thus, listeners are sensitive to facial cues for evaluating what they are about to hear, especially when the auditory input is less reliable. These results extend findings on face perception to the auditory domain and confirm inter-individual variability in considering different sources of emotional information.

Auditory aversive generalization learning prompts threat-specific changes in alpha-band activity.

Pairing a neutral stimulus with aversive outcomes prompts neurophysiological and autonomic changes in response to the conditioned stimulus (CS+), compared to cues that signal safety (CS-). One of these changes-selective amplitude reduction of parietal alpha-band oscillations-has been reliably linked to processing of visual CS+. It is, however, unclear to what extent auditory conditioned cues prompt similar changes, how these changes evolve as learning progresses, and how alpha reduction in the auditory domain generalizes to similar stimuli. To address these questions, 55 participants listened to three sine wave tones, with either the highest or lowest pitch (CS+) being associated with a noxious white noise burst. A threat-specific (CS+) reduction in occipital-parietal alpha-band power was observed similar to changes expected for visual stimuli. No evidence for aversive generalization to the tone most similar to the CS+ was observed in terms of alpha-band power changes, aversiveness ratings, or pupil dilation. By-trial analyses found that selective alpha-band changes continued to increase as aversive conditioning continued, beyond when participants reported awareness of the contingencies. The results support a theoretical model in which selective alpha power represents a cross-modal index of continuous aversive learning, accompanied by sustained sensory discrimination of conditioned threat from safety cues.

Neurotopographical Transformations: Dissecting Cortical Reconfigurations in Auditory Deprivation.

Within the intricate matrices of cognitive neuroscience, auditory deprivation acts as a catalyst, propelling a cascade of neuroanatomical adjustments that have, until now, been suboptimally articulated in extant literature. Addressing this gap, our study harnesses high-resolution 3 T MRI modalities to unveil the multifaceted cortical transformations that emerge in tandem with congenital auditory deficits. We conducted a rigorous cortical surface analysis on a cohort of 90 congenitally deaf individuals, systematically compared with 90 normoacoustic controls. Our sample encompassed both male and female participants, ensuring a gender-inclusive perspective in our analysis. Expected alterations within prototypical auditory domains were evident, but our findings transcended these regions, spotlighting modifications dispersed across a gamut of cortical and subcortical structures, thereby epitomizing the cerebral adaptive dynamics to sensory voids. Crucially, the study's innovative methodology integrated two pivotal variables: the duration of auditory deprivation and the extent of sign language immersion. By intersecting these metrics with structural changes, our analysis unveiled nuanced layers of cortical reconfigurations, elucidating a more granulated understanding of neural plasticity. This intersectional approach bestows a unique advantage, allowing for a discerning exploration into how varying durations of sensory experience and alternative communication modalities modulate the brain's morphological terrain. In encapsulating the synergy of neuroimaging finesse and incisive scientific rigor, this research not only broadens the current understanding of adaptive neural mechanisms but also paves the way for tailored therapeutic strategies, finely attuned to individual auditory histories and communicative repertoires.

Auditory Ensemble Perception (Summary Statistics) for Music Scale Tones by Listeners with and without Absolute Pitch

ABSTRACT Ensemble perception refers to our ability to summarize complex information across individual items in a group. Ensemble perception of pitch in the auditory domain can be achieved remarkably well: listeners can accurately judge whether the pitch corresponding to the mean frequency of a set of six music scale tones is higher or lower than the pitch of a test tone presented after the set. Ensemble perception for music scale tones was performed by absolute pitch (AP) possessors (n = 16) and musically experienced non-AP listeners (n = 14). They performed a set averaging experiment (Experiment 1), and a tone recognition experiment, in which they judged whether an individual tone had been part of the set or not (Experiment 2). AP listeners obtained a significantly higher percentage correct and a smaller just noticeable difference than non-AP listeners when comparing the (average) pitch of the set and the test. Remarkably, though, AP listeners did not significantly outperform non-AP listeners in individual tone recognition. These results suggest that a cognitive tone-labeling strategy, as predominantly used by AP listeners, enhances ensemble perception for music scale tones. Musically experienced non-AP listeners, however, can achieve recognition of individual tones without tone labeling at a very high level as well. Possible strategies used by the listeners in both groups were discussed.

Effects of emotion on auditory ERPs are independent of manipulated target relevance.

Emotional attention describes the prioritized processing of emotional information to help humans quickly detect biologically salient stimuli and initiate appropriate reactions. Humans can also voluntarily attend to specific stimulus features that are target-relevant. Electrophysiological studies have shown specific temporal interactions between voluntary and emotional attention, while no such studies exist for natural sounds (e.g., explosions, running water, applause). In two experiments (N = 40, each), we examined event-related potentials (ERPs) toward target relevant or irrelevant negative, neutral, or positive sounds. Target relevance was induced by the instruction to respond blockwise to either negative, neutral, or positive sounds. Emotional sounds elicited increased fronto-central N1 and P2 amplitudes and a larger late positive potential (LPP), with more sustained effects for negative sounds. Target relevance increased amplitudes during an early LPP interval (400-900 ms) but did not interact with the valence of the sounds. These results show early and late ERP modulations for natural sounds, which do not interact with the target relevance of the sound valence, in contrast to findings from the visual domain. Thus, findings indicate little temporal overlap between emotional processes and target relevance effects in the auditory domain. (PsycInfo Database Record (c) 2024 APA, all rights reserved).

Associations Between Auditory Working Memory, Self-Perceived Listening Effort, and Hearing Difficulty in Adults With Mild Traumatic Brain Injury.

Mild traumatic brain injury (TBI) can have persistent effects in the auditory domain (e.g., difficulty listening in noise), despite individuals having normal pure-tone auditory sensitivity. Individuals with a history of mild TBI often perceive hearing difficulty and greater listening effort in complex listening situations. The purpose of the present study was to examine self-perceived hearing difficulty, listening effort, and performance on an auditory processing test battery in adults with a history of mild TBI compared with a control group. Twenty adults ages 20 to 53 years old participated divided into a mild TBI (n = 10) and control group (n = 10). Perceived hearing difficulties were measured using the Adult Auditory Processing Scale and the Hearing Handicap Inventory for Adults. Listening effort was measured using the National Aeronautics and Space Administration-Task Load Index. Listening effort ratings were obtained at baseline, after each auditory processing test, and at the completion of the test battery. The auditory processing test battery included (1) dichotic word recognition, (2) the 500-Hz masking level difference, (3) the Listening in Spatialized Noise-Sentences test, and (4) the Word Auditory Recognition and Recall Measure (WARRM). Results indicated that individuals with a history of mild TBI perceived significantly greater degrees of hearing difficulty and listening effort than the control group. There were no significant group differences on two of the auditory processing tasks (dichotic word recognition or Listening in Spatialized Noise-Sentences). The mild TBI group exhibited significantly poorer performance on the 500-Hz MLD and the WARRM, a measure of auditory working memory, than the control group. Greater degrees of self-perceived hearing difficulty were significantly associated with greater listening effort and poorer auditory working memory. Greater listening effort was also significantly associated with poorer auditory working memory. Results demonstrate that adults with a history of mild TBI may experience subjective hearing difficulty and listening effort when listening in challenging acoustic environments. Poorer auditory working memory on the WARRM task was observed for the adults with mild TBI and was associated with greater hearing difficulty and listening effort. Taken together, the present study suggests that conventional clinical audiometric battery alone may not provide enough information about auditory processing deficits in individuals with a history of mild TBI. The results support the use of a multifaceted battery of auditory processing tasks and subjective measures when evaluating individuals with a history of mild TBI.

UNDERSTANDING HEARING IMPAIRMENT: CAUSES, EFFECTS, AND INTERVENTIONS

Hearing impairment is a prevalent sensory deficit affecting millions of individuals worldwide. This abstract explores the multifaceted nature of hearing impairment, encompassing its diverse causes, its profound effects on individuals' lives, and various intervention strategies. Causes of hearing impairment range from congenital factors and genetic predispositions to acquired conditions such as exposure to loud noises, infections, or aging. The impact of hearing impairment extends beyond the auditory domain, affecting communication, social interactions, and overall quality of life. Consequently, interventions play a crucial role in mitigating the challenges associated with hearing loss. This abstract provides an overview of common interventions, including hearing aids, cochlear implants, assistive technologies, and communication strategies. Understanding the complexities of hearing impairment is essential for developing comprehensive and tailored approaches to support individuals with hearing loss, fostering inclusivity, and enhancing their overall well-being.

Exploring the cognitive profiles related to unimodal auditory versus multisensory hallucinations in schizophrenia-spectrum disorders

ABSTRACT Introduction Hallucinations can be experienced across multiple sensory modalities, but psychiatric studies investigating the cognitive mechanisms of hallucinations have been somewhat restricted to the auditory domain. This study explored the cognitive profiles of individuals experiencing multisensory hallucinations (MH) in schizophrenia-spectrum disorders (SSD) and compared these to those experiencing unimodal auditory hallucinations (AH) or no hallucinations (NH). Methods Participants included SSD patients (n = 119) stratified by current hallucination status (NH, AH, MH) and nonclinical controls (NCs; n = 113). Group performance was compared across several cognitive domains: speed of processing, attention, working memory, verbal learning, visual learning, reasoning and problem-solving, social cognition, and inhibition. Results The clinical groups performed worse than NCs but differences between the clinical groups were not evident across most cognitive domains. Exploratory analyses revealed that the MH group was more impaired on the visual learning task compared to the NH (but not AH) group. Conclusions Preliminary results suggest that impaired visual learning may be related to MH. This could be attributed to the presence of visual hallucinations (VH), or greater psychopathology, in this group. However, replication is needed, as well as the investigation of other potential cognitive mechanisms of MH.