IN THE course of our studies on hypopituitarism we have found that the pattern varies considerably from case to case. In women the usual picture is that described by Sheehan (1). In men there are a variety of causes for the condition. Among others,we have found two in whom it developed following head injuries. The association of the manifestations of hypopituitarism with epileptiform seizures in these two cases seems to us of sufficient interest to warrant publication. We have made rather extensive clinical and laboratory studies on both cases and have an autopsy on one. CASE REPORTS The case reports are as follows: the first patient, J. S. (unit no. 396,128), a 46 year old married Jewish factory worker, was referred to one of us (J. L.), because of a “gland condition” and convulsions. For many years—20 or more—he had suffered every 4–6 weeks with attacks, which were epileptiform in character. The attacks were not accompanied by visual, auditory or uncinate aura. The frequency of the attacks was only part...