P.L. Shupyk National University of Health of Ukraine, Kyiv, Ukraine SI "O.O. Shalimov National Institute of Surgery and Transplantology of the NAMS of Ukraine", Kiev, Ukraine The article considers the prospects of using hybrid imaging methods (PET/SPECT/CT) and quality control in nuclear medicine. The quality control system is a comprehensive measure that involves the creation and implementation of quality guidelines, quality control programs, instructions and protocols for checking control parameters. A quality control audit is a measure that allows you to verify the proper functioning of the department, identify and eliminate errors and improve the quality of patient care. All technical parameters of the devices should be checked according to standardized protocols to ensure reproduction and comparability of results. The availability of additional equipment for inspections of control parameters must be provided in advance, as well as a set of actions aimed at maintaining the quality of equipment and its timely update in order to meet modern requirements. Due to the integration of SPECT, PET and CT modules, the multimodal system is used for use in various fields of clinical medicine, in particular in oncology, cardiology, endocrinology and neurology. The comprehensive implementation of a quality management system for diagnostic tests, as an end result, allows to increase the effectiveness of these tests (not only in nuclear medicine) and to guarantee "trust" in these methods. Key words: hybrid imaging, nuclear medicine, positron emission tomography, single-photon emission computed tomography, quality control.