Vaccine hesitancy and conspiracy beliefs are social issues of growing concern which have arisen particularly during the COVID-19 pandemic. The aim of this study was to investigate the multifaceted relationship between a hesitant attitude towards vaccination, conspiracy thinking, fear of infection, and the dimensions of epistemic trust, mistrust, and credulity. 297 Italian adult participants completed an online survey during the pan-demic time frame which included self-report questionnaires that measured the variables of interest. Group differences pertaining to prior vaccination behavior in scores of con-spiracy beliefs about vaccines and vaccine hesitancy were explored. A negative associa-tion was found between years of education and both vaccine hesitancy and conspiracy beliefs about vaccines, and a positive one with epistemic trust; higher education may protect the individual from misinformation and help in discerning between real knowledge and fake or imprecise news. A mediation model was developed between ep-istemic stance, vaccine conspiracy belief, vaccine hesitancy, and COVID-19-specific variables: the affective dimension (fear of contagion) and the behavioral one (number of vaccine doses). The model demonstrates how certain structural characteristics, such as epistemic credulity and skepticism towards vaccine benefits, may indirectly affect the number of COVID-19 vaccine doses taken through fear of contracting the virus. The re-sults support the value of exploring vaccine hesitancy and conspiracy beliefs in relation to epistemic trust dimensions, specifically in the post-pandemic era, and are discussed in light of the recent literature.
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