This study investigated the knowledge, attitude, and practices of residents in the Ho municipality towards intestinal helminth infections and their prevention. A descriptive cross-sectional study involving questionnaire administration was conducted among randomly sampled residents of the Ho municipality of the Volta Region of Ghana. A minimum sample size of 400 was calculated for subjects using Yamane's formula for population. Pearson's chi-square analysis was done to determine any relationship between sociodemographic characteristics and the categories of knowledge, attitude, and practices. Results from data analysis were computed as frequencies and percentages. P < 0.05 is considered statistically significant. Of the 400 participants, 343 (85.7%) were aware of intestinal helminths, but the majority had poor knowledge of its cause despite 50.5% (202) having good knowledge scores. Most participants (331, 82.8%) had a bad attitude toward preventing the disease. Most (335, 83.8%) of the community members still adhered to the poor practice of open defecation with the excuse of unavailable latrines, and some (143, 35.8%) believe that intestinal helminths are nothing to worry about. Health education should address the perceptions towards preventing intestinal helminthiasis and be complemented by making available public lavatories in the municipality to curb the unacceptable practice of open defecation.