Introduction. The high prevalence of respiratory diseases is largely due to climate change. Violation of the adaptive-compensatory capabilities of the body, causing an inadequate response of homeostatic systems, is largely determined by a person’s short-term meteorological response to dramatically changing weather conditions. Materials and methods. The study included a control group (one hundred sixty three people), individuals with bronchial asthma (BA) (221 case) and chronic obstructive pulmonary disease (COPD) (148 patients). Short-term (± 1 day) meteor reaction of the respiratory function, cardiovascular and immune systems was assessed. The day of the examination was evaluated as a synchronous meteorological reaction, 1 day before the examination - a follow-up and 1 day after - a signal reaction. There was calculated an integral indicator (Dm%) which determines the percentage of correlations (r at p<0.05) relative to the total amount (r) in the correlation matrix. Results. The compensatory capabilities of the cardio-respiratory and immune systems under the influence of weather conditions in the healthy population of the city are significantly higher than in COPD and BA cases. Day-to-day changes in weather conditions have the greatest negative impact on the respiratory system, especially in BA and COPD patients The least resistance of the organism was noted under the synchronous action of meteorological components. The greatest compensatory response was established during the signal meteoreaction. Limitations. A limitation is that the study identified a meteorological response in a specific area under a maritime monsoonal climate. Conclusion. The healthy population of the city is the most adapted to the local climate. In persons with respiratory diseases, the system of external respiratory is the most vulnerable. In the short-term consideration of the weather-induced reaction, the synchronous position exhibits the greatest negative effect on the main functional systems.