Post-extubation dysphagia is a common yet under-recognized condition in intubated patients, which can lead to severe complications. The awareness and attitudes of Intensive Care Unit (ICU) nurses towards post-extubation dysphagia play a critical role in early detection and management of the condition, improving patient outcomes. Objective: To assess the awareness and attitudes of ICU nurses regarding post-extubation dysphagia in intubated patients. Methodology: This cross-sectional study was conducted at the Intensive Care Unit of Sheikh Zayed Hospital, Rahim Yar Khan, from June 2023 to June 2024. One hundred nurses working full-time in general and specialized ICUs were included. Data were collected using a 28-item questionnaire divided into two sections. The first section collected demographic information, while the second assessed knowledge and attitudes toward post-extubation swallowing disorders using 20 specific questions. Statistical analysis, including multivariate analysis, was performed to identify factors associated with knowledge and attitude scores. Results: The average total standard score was 60.87 ± 14.31. The mean knowledge score was 7.54 ± 2.99, with a standard score of 75.40 ± 29.9. The average attitude score was 8.10 ± 2.01, with a standard score of 81.0 ± 20.1. Multivariate analysis revealed that age group 31-35, job title, and job satisfaction were significantly associated with higher knowledge scores. In contrast, attitude scores were significantly associated with sex, job title, age group, and department. Conclusion: The knowledge and attitudes of ICU nurses regarding post-extubation dysphagia in intubated patients are unsatisfactory. Professional training and educational programs are needed to improve critically ill patients' awareness and management of this condition.