s / Drug and Alcohol Dependence 146 (2015) e118–e201 e155 Conclusions: These data suggest that increased phosphorylation of the GluA1 subunit may be a neurobiological mechanism by which MET-OX attenuates cocaine seeking. Financial Support: No outside funding. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.337 Prescription drug use in a national sample of female drivers Tara Kelley-Baker, Julie Yao, Robin Pollini Pacific Institute for Research and Evaluation, Calverton, MD, United States Aims: Prescription drug (Rx) use and driving is receiving increasing attention. Some Rx drugs are considered dangerous to use while driving. One of the largest consumer groups for these types of drugs are women. The aim this study is to examine Rx druguse among female drivers and characterize use, receipt ofwarnings regarding potential driving impairment, and perceived risks of using prescription drugs while driving. Methods:The study isnestedwithin the2013NationalRoadside Survey (NRS). The NRS uses stratified random sampling to select 60 sites in the continentalU.S. for data collection.Drivers are randomly stopped and asked to complete a survey regarding their driving, alcohol use, and drug use. Sex differences in Rx drug use, receipt of warnings, and perceived risks were examined using Chi-square tests. Results: To date, 6279 drivers consented to NRS participation (from 44 sites). Of these 5301 (84%) completed an Rx drug survey of which 2226 (42.0%) were female. Female drivers were significantly more likely than males to report using the following drugs: antidepressants (11.8% vs. 4.4%, p<0.01), sleep aids (3.6% vs. 2.2%, p<0.01), pain killers, (3.4% vs. 2.6%, p=0.04), benzodiazepines (3.3% vs. 1.0%, p<0.01), and dietary suppressants (1.7% vs. 0.5%, p<0.01). Regarding receipt ofwarnings about using drugs and driving, women more often reported receiving package warning while using sleep aids (92.9% vs. 76.9%, p=0.01). There were few sexspecific differences in perceived risks of driving while taking Rx drugs; however, significantly more women than men thought it likely that ADHD medications could affect safe driving (32.5% vs. 14.9%, p=0.05) and that muscle relaxants could lead to arrest for impaired driving (64.6% vs. 44.7%, p=0.05). Conclusions: Women were significantly more likely than men to report recent use of certain Rx drugs that could impair driving. Although the percent of women reporting warnings about use and driving was higher than for men, there remains a need to educate them as their risk perceptions related to safe driving are low. Financial Support:NationalHighwayTraffic SafetyAdministration and the National Institute on Drug Abuse. http://dx.doi.org/10.1016/j.drugalcdep.2014.09.338 A typology of prescription drug misuse: A latent class approach to contexts and risks Brian C. Kelly1, H.J. Rendina2, Brooke E. Wells2, Jeffrey T. Parsons2 1 Purdue University, West Lafayette, IN, United States 2 City University of New York, New York, NY, United