Attention-deficit/hyperactivity Disorder Rating Scale Research Articles

A comparative diagnostic study using clinical and multimodal assessment, including functional neuroimaging and oculomotricity tools, to differentiate ADHD in young patients from healthy control group.

Attention deficit hyperactivity disorder (ADHD) is a neurodevelopmental disorder that may persist into adulthood, with no established objective diagnostic tool yet. This study aims to propose a multimodal objective assessment tool involving clinical assessments, functional neuroimaging, and oculomotricity measurement for ADHD in young adults. Seventy-one medication-naïve patients and 71 healthy controls (HCs) aged 18 to 28 underwent clinical interviews, Conners' Adult ADHD Rating Scale (CAARS) questionnaire, functional near-infrared spectroscopy (fNIRS), oculomotricity task, and Conners' Continuous Performance Task (CPT) 3rd edition. Student's t-tests with Bonferroni's correction were performed to compare the performance between groups, and logistic regression was used for classification. ADHD patients had significantly lower frontal hemodynamic response during verbal fluency task (VFT) (P = 0.0003), more anticipatory eye movements during overlap task (P = 0.0006), higher latency (P < 0.0001), anticipatory (P < 0.0001), and errors (P < 0.0001) during anti-saccade task, as well as higher commission errors (P < 0.0001) and standard deviation in hit reaction time (HRT) (P = 0.0018). The multivariate logistic regression model featuring these seven parameters from the three objective tests (fNIRS-VFT, oculomotricity, and CPT) yielded an area under the receiver operating characteristic curve (AUC) value of 0.892 (95% confidence interval (CI): 0.840-0.944), with sensitivity and specificity of 80.28% and 84.51%, respectively. This multimodal assessment offered an accurate diagnostic tool for ADHD in young adults and laid the foundation for future machine-learning approaches.

Validity of the Italian Version of DIVA-5: Semi-Structured Diagnostic Interview for Adult ADHD Based on the DSM-5 Criteria

Introduction: In 2019, an updated version of the Diagnostic Interview for ADHD in Adults (DIVA-5) was developed based on DSM-5 criteria, currently validated in Korean and Farsi. The aim of this study is to validate the DIVA-5 Italian version. Methods: 132 subjects in the Adult ADHD Screening Center of AUSL-Modena, who agreed to participate in this study, were selected. Socio-demographic and clinical variables were collected. DIVA-5, Barkley Adult ADHD Rating Scale (BAARS), and Adult ADHD Self Rating Scale (ASRS-v1.1) were administered. We assessed the internal consistency of the DIVA-5 Italian version and its concurrent validity with ASRS-v1.1 and BAARS-IV. An exploratory factor analysis (EFA) was conducted to evaluate the construct validity, and a multiple linear regression to evaluate the predictive validity. Results: Our analysis indicated good internal consistence of the DIVA-5 Italian version (Cronbach’s alpha and Kuder coefficients ranged between 0.61 and 0.78). The EFA showed five factors representing specific variance. The correlation between the corresponding ADHD dimensions of DIVA-5 and BAARS was found to be statistically significant (Spearman’s coefficient ranged between 0.61 and 0.47, p = 0.000), while the correlation between the DIVA-5 dimensions and ASRS-v1.1 was statistically significant for all the dimensions except child hyperactivity/impulsivity. The multiple linear regression showed a positive association of the DIVA-5 score with the “job” variable and a negative association with “drug therapy”. DIVA-5 showed greater sensitivity for inattention in adulthood and greater specificity for hyperactivity/impulsivity in childhood. Conclusions: Our results confirm that the DIVA-5 Italian version represents a valid and reliable tool to diagnose adult ADHD.

Effects of Methylphenidate and Atomoxetine Treatment on Improvement of Motor Coordination in Children With Attention-Deficit/Hyperactivity Disorder.

To investigate the effects of methylphenidate and atomoxetine treatment on motor coordination in children with attention-deficit/hyperactivity disorder (ADHD). In this single-site, open-label, naturalistic follow-up study, 157 children (7.6±1.4 years; 139 males) with ADHD were recruited between March 2015 and May 2020 from the Department of Psychiatry, Asan Medical Center, and treated for 12 weeks with methylphenidate (n=48) or atomoxetine (n=109). Children completed the Advanced Test of Attention (ATA), and caregivers completed the ADHD Rating Scale (ARS) questionnaire and Developmental Coordination Disorder Questionnaire (DCDQ) at baseline and at 12 weeks. Paired t-tests, a mixed-effects model, and linear regression were used to compare treatment groups and assess factors influencing motor coordination changes. Methylphenidate and atomoxetine resulted in significant improvement in DCDQ fine motor/handwriting, general coordination, and total scores over 12 weeks. Fine motor/handwriting had a significant main effect for time (F1=16.64, p<0.001, η2=0.097); however, the interaction effect between group and time was not significant (F1=0.24, p=0.625, η2=0.002). Changes in parent-reported ARS inattention scores (β=-0.174, p=0.029) and auditory commission errors of ATA (β=0.191, p=0.022) were significantly associated with changes in fine motor/handwriting. Additionally, changes in parent-reported ARS inattention scores (β=-0.177, p=0.034) and rater-reported ARS inattention scores (β=-0.198, p=0.017) were significant predictors of improvements in general coordination in separate models. Methylphenidate and atomoxetine had a positive effect on motor coordination in children with ADHD. Improvement in motor coordination was associated with ADHD symptom improvement.

Resting-state microstate dynamics abnormalities in children with ADHD and co-occurring sleep problems.

Children with attention-deficit/hyperactivity disorder often experience sleep problems, exacerbating symptoms, and cognitive deficits. However, the neurophysiological mechanisms underlying such deficits remained unclear. This study aims to use resting-state microstate analysis to investigate the neurophysiological characteristics in children with ADHD and sleep problems and explore whether neurophysiological abnormalities are associated with sleep problems. Five-minute eyes-closed resting-state EEG data were collected in 34 children with both ADHD and sleep problems, 32 children with ADHD without sleep problems, and 22 healthy controls aged 6-12 years. Participants' parents completed the ADHD Rating Scale, Behavioral Rating Inventory of Executive Function, and Children's Sleep Habits Questionnaire. Five minutes of eyes-closed resting-state EEG data were collected, and agglomerative hierarchical clustering was used for microstate analysis. ANCOVAs, adjusted for sex and IQ, were used to compare ADHD symptoms, executive function, and microstate parameters across groups. Pearson partial correlations, controlling for sex and IQ, examined the association between microstate parameters and sleep problems. Children with both ADHD and sleep problems exhibited more severe inattentive (20.4±3.1 vs 18.0±3.4, p<0.05) and total symptoms (14.3±6.0 vs 13.0±5.3, p<0.05), along with greater deficits in emotional regulation (1.88±0.58 vs 1.60±0.42, p<0.05, organizational of materials 2.56±0.41 vs 2.20±0.55, p<0.05, behavioral regulation (1.88±0.40 vs 1.70±0.36, p<0.05), and global executive function (2.14±0.30 vs 1.95±0.30, p<0.05), compared to children with ADHD without sleep problems. Moreover, Both ADHD groups exhibited significantly reduced microstate D occurrence and lower transition probability from microstate C to D compared to healthy controls (all p<0.05). Additionally, no significant correlation was found between sleep problems and microstate parameters in all three groups after adjustment (all p>0.05). Children with both ADHD and sleep problems showed greater symptom severity and more pronounced executive function deficits compared to children with ADHD without sleep problems and healthy controls. Additionally, both ADHD groups showed overlapping atypical microstate parameters, suggesting children with co-occurring ADHD and sleep problems may share similar aberrant neurophysiological characteristics with children with ADHD alone. Resting-state EEG microstate parameters may serve as a sensitive tool for assessing sleep problems in children with ADHD, distinguishing them from typically developing children.

Association between prenatal tobacco exposure and attention-deficit/hyperactivity disorder related characteristics at 6 and 8 years: a birth cohort in Japan

ObjectivesTo examine the association between maternal plasma cotinine concentrations during pregnancy and attention-deficit/hyperactivity disorder (ADHD) related characteristics in children.DesignProspective birth cohort study from the Hokkaido Study on Environment and Children’s...

Attention deficit hyperactivity disorder combined subtype and Anti-Yo antibodies.

Neuroinflammation seems to be involved in ADHD pathogenesis. Recently, in this regard, some evidence suggests the possibility of an autoimmune mechanism related to anti-Purkinje cell antibodies. The aim of this paper is to confirm this evidence searching for a possible specificity for some subtype of ADHD. We studied 112 consecutive drug-naïve Caucasian ADHD outpatients, who were attending their first psychiatric examination (91 males and 21 females; median age =108.14 months; sd=34.58 months). K-SADS interview and ADHD rating scale were used for a DSM 5 diagnosis of ADHD and subtype. WISCIII and a validated list of words were used to assess a possible dyslexia. Antibodies to Yo (Purkinje cell cytoplasmic antibody type 1 [PCA-1]) were detected by indirect immunofluorescence assay. Forty-nine point one percent (55) of ADHD children were positive to Anti-Yo antibodies. A lower percentage than in previous studies. We found that in the Anti-Yo positive children, the subtype most represented was significantly the combined subtype. No significant relation was found with ADHD plus Dyslexia children. The number of ADHD subjects positive to Anti-Yo antibodies is less than in previous studies, but it remains interesting and it is more likely to find a positive child in the combined ADHD than in the other subtypes.

The interaction of ADHD traits and trait anxiety on inhibitory control.

Attention-deficit/hyperactivity disorder (ADHD) and anxiety frequently occur together; however, the cognitive outcomes of comorbid anxiety and ADHD are not straightforward. A potential explanation for conflicting results in the literature may be that different core ADHD symptoms show different interactions with anxiety depending on the task-processing demands. To address this question, we investigated whether different ADHD traits are related to different inhibitory outcomes, contingent upon the level of trait anxiety. The sample consists of 60 non-clinical university students ( age = 20.5, 53% male). Conners' Adult ADHD Rating Scale and State Trait Anxiety Inventory were used to measure ADHD traits and anxiety, respectively. The participants completed a visual Go/NoGo task with and without distractor conditions while continuous EEG was recorded. Inhibitory control was operationalized as the frontocentral N2 maximum peak amplitude elicited in response inhibition (NoGo/No Distractor), cognitive inhibition (Go/Distractor), dual inhibition (NoGo/Distractor), and control (Go/No Distractor) conditions. We analyzed the moderating effect of trait anxiety on the prediction of inhibitory control by ADHD scores for each Go/NoGo condition with the varying inhibition demands. Results showed that trait anxiety moderated the effects of total ADHD and hyperactivity-impulsivity scores, but only in the response inhibition condition (NoGo/No Distractor). These findings suggest that depending on the inhibitory demands of the task, unique cognitive outcomes may occur when different ADHD traits coexist with anxiety.

A multicenter, single-group, open feasibility study of a new individual cognitive behavioral therapy program for adult Japanese patients with attention-deficit/hyperactivity disorder: Study protocol.

Attention-deficit/hyperactivity disorder (ADHD) symptoms, including executive function, emotional regulation, and motivation, can persist into adulthood and are often associated with mental illnesses. Cognitive behavioral therapy (CBT) may help ADHD adults in Japan, but the lack of studies and the variability in group CBT approaches make its effects unclear. Japan lacks unified CBT programs and adult ADHD guidelines, making it difficult to implement international individual CBT recommendations due to cultural differences. This study will assess the feasibility of a novel CBT program for Japanese adult ADHD patients. This feasibility study will be open, nonrandomized, single-arm, multicenter study. Twelve ADHD patients aged 20-65 years who are currently receiving treatment will be included based on Conners' Adult ADHD Rating Scale (CAARS) clinical severity threshold. An intervention phase of 12-16 weeks and a 12-week follow-up will total 24-28 weeks for all participants. The intervention will use a new CBT program tailored to individual assessments. The primary objective is to determine feasibility using dropout rates, adverse events, and CAARS score changes between Weeks 1 and 16. The secondary outcomes will assess long-term effects of treatment beyond the intervention period and provide descriptive statistics on sex, depression, quality of life, and autistic scores in relation to the intervention outcomes. The full analysis set and per protocol set will be used for statistical analysis. This study is essential for the development of CBT interventions in accordance with Japan's healthcare system that are tailored to the unique needs of its population.

The efficacy of behavioral sleep intervention on sleep problems among children with attention-deficit hyperactivity disorder: A randomized controlled trial.

Attention-deficit hyperactivity disorder (ADHD), affecting 5% of global children, presents inattention, hyperactivity, and impulsivity. Sleep problems, prevalent in 70% of cases, exacerbate long-term psychosocial challenges. This study aimed to assess the efficacy of behavioral sleep intervention in alleviating sleep problems, enhancing quality of life (QoL), and reducing ADHD symptom severity among children diagnosed with ADHD. A randomized controlled trial was conducted from June 2022 to April 2023. The intervention group (n = 47) engaged in a hybrid approach, participating in both face-to-face and Zoom sessions, while the control group (n = 45) received standard care. Data collection involved administering the Children's Sleep Habits Questionnaire (CSHQ), Pediatric Quality of Life Inventory (PedsQL), and ADHD Rating Scale IV (ADHD-RS-IV). Significant enhancements were observed in CSHQ (p ≤ 0.001, effect size = 1.913), PedsQL (p ≤ 0.001, effect size = 1.862), and a notable reduction in ADHD-RS-IV (p ≤ 0.001, effect size = 1.548). These findings highlight the intervention's efficacy in improving sleep quality, QoL, and reducing ADHD symptomatology. This trial contributes substantially to understanding behavioral sleep interventions' impact on ADHD-affected children, enhancing quality of life and ADHD symptomatology. The study highlights the importance of individualized care for optimal outcomes in children with ADHD. The study's findings underscore the potential for integrating behavioral sleep interventions into routine nursing practices, offering a valuable approach to address sleep-related challenges in children with ADHD. By focusing on sleep improvement, nurses can contribute to enhancing overall well-being and emotional regulation in these children within the context of comprehensive healthcare.

Frequent Pain is Common Among 10-11-Year-Old Children with Symptoms of Attention Deficit Hyperactivity Disorder.

Adults with neurodevelopmental disorders have an increased risk for chronic pain. This study aimed to describe the prevalence of frequent and multisite pain among children with symptoms of attention deficit hyperactivity disorder (ADHD) and explore potential sex differences in pain prevalence. Children born in 2008 included in the "Halland Health and Growth Study" were invited to a follow-up (n = 1186) in 2018-19. Parents received a digital screening questionnaire, the Swanson, Nolan and Pelham Rating Scale (SNAP-IV) for ADHD, and the children answered a pain questionnaire that included a pain mannequin. The main outcome was pain experience, and children with symptoms of ADHD were compared to children without these symptoms. In this general population of 10-11-year-old Swedish children, weekly pain was reported in 52.5% of children with symptoms of ADHD combined type, compared to 36.2% of children without these symptoms (p < 0.05). Hyperactivity and impulsivity were significant contributors to the increased risk for frequent pain (OR 2.33 95% CI 1.30 to 4.17, p = 0.004), but inattention was not a significant contributor (OR 1.17 95% CI 0.74 to 1.87, p = 0.497). Multisite pain was more common among girls with hyperactivity compared to boys with hyperactivity (51.4 vs 27.9%, p = 0.036). Weekly headache and/or abdominal pain was reported by a quarter of girls with symptoms of ADHD combined type, and up to a fifth of boys, compared to 11-13% of children without these symptoms. Frequent pain was more common for children with symptoms of ADHD compared to children without symptoms of ADHD. Hyperactivity and impulsivity had a stronger association to pain than had inattention-related problems. Clinicians should be aware of the frequent occurrence and the association between pain and neurodevelopmental disorders among children, and that it could complicate both the clinical picture and the treatment.

Exploring correlations between Conners' Continuous Performance Test and subjective measures of attention deficit hyperactivity disorder symptoms in a paediatric clinical sample.

Attention deficit hyperactivity disorder (ADHD) is a childhood-onset neurodevelopmental condition characterised by inattention and/or hyperactivity-impulsivity. The ADHD symptoms are often evaluated and quantified using various assessment tools, such as the Conners' Continuous Performance Test II (CCPT-II), ADHD Rating Scale (ADHD-RS), Child Behaviour Checklist (CBCL), Clinical Global Assessment Scale (CGAS) and Clinical Global Impression Scale (CGIS). This study sought to compare CCPT-II with parent- and clinician-rated rating scales (ADHD-RS, CBCL, CGAS and CGIS) in measuring the core ADHD symptoms within the paediatric ADHD population. The data, gathered from a large-scale randomised controlled trial involving 172 children aged 6-12 years with ADHD, was pooled, and a Pearson correlation analysis was conducted. No significant correlations were observed between CCPT-II and ADHD-RS, as well as the various subscales of CBCL, CGAS and CGIS. While CCPT-II may offer insights into ADHD symptomatology, its relationship with parent- and clinician-rated rating scales such as ADHD-RS, CBCL, CGAS and CGIS appears limited. Further research is warranted to elucidate the nuances of these assessment tools and their roles in evaluating ADHD.

Investigating Attention Deficit Hyperactivity Disorder Symptoms, Emotional Dysregulation and Family Functioning in Children: A Community-Based Study in Elementary Schools in Surabaya, Indonesia.

Research on emotional dysregulation related to attention deficit hyperactivity disorder (ADHD) symptoms and its effects on family functioning in children is scarce. This is the first study conducted in Indonesia to examine the intricate relationships between ADHD symptoms, emotional regulation, and family functioning in children. A cross-sectional survey was conducted involving primary caregivers of children aged 9-13 years old across three elementary schools in Surabaya, using validated questionnaires comprising the Indonesian ADHD Rating Scale, Emotion Regulation Checklist, and Family APGAR scale. The findings revealed a positive association between ADHD features and the emotional lability/negativity subscale (ERLN) (r=0.528; p<0.001), but not the emotion regulation subscale (EREG). Moreover, family functioning positively correlated with ERLN (r= -0.269; p=0.003) and negatively correlated with EREG (r=0.331; p<0.001). Parental education emerged as a significant demographic factor, with higher education levels linked to better emotion regulation (r=0.297; p=0.001). These findings underscore the importance of addressing ADHD symptoms and emotional dysregulation in children in order to enhance family functioning and overall well-being. Implications for future research and interventions targeting emotion regulation, especially in children with ADHD and their families, are also discussed.

Symptom validity testing in adults with clinically diagnosed ADHD: comparison of the Conner’s Adult ADHD Rating Scale (CAARS) and the Self-Report Symptom Inventory (SRSI)

ABSTRACT Objectives Compared to the number of performance validity measures, the range of available symptom validity measures is limited. The Self-Report Symptom Inventory (SRSI) is a recently developed freestanding symptom validity test with promising psychometric characteristics for use on non-criminal forensic and a range of clinical populations. The goal of this study was to evaluate the utility of the SRSI for symptom validity testing in the clinical evaluation of adults with attention-deficit/hyperactivity disorder (ADHD). Methods This analogue study compared 76 German patients diagnosed with ADHD (age range 19–63 years) with typically developing individuals from the Netherlands/Germany who were assigned to either a control group (N = 58; age range 18–73 years) or a simulation group (N = 46; age range 18–57 years). All participants completed the Conners’ Adult ADHD Rating Scale (CAARS) with its two embedded validity indicators Infrequency Index (CII) and ADHD Credibility Index (ACI), the SRSI, and the Digit Span (to derive the Reliable Digit Span). Results Specificity in controls was perfect for the CAARS, but reached only about 90% for the SRSI. In contrast, sensitivity in experimental simulators ranged from 24% to 65% for the CAARS, but reached high rates of 69% to 82% for the SRSI. In the sample of patients with ADHD, the failure rate ranged from 8% to 34% (CAARS), and 33% to 47% (SRSI). Further, we found limited classification agreement between the validity measures. Conclusion The divergent results on the different validity indicators reflects the ongoing discussion on poor construct unity and clarity, and calls for more research addressing the heterogeneous construct. The utility of the SRSI to reliably distinguish between valid and invalid symptom report in the clinical evaluation of adult ADHD has to be investigated by more refined studies including both symptom and performance validity indicators.

Validation of the dispositional adult hyperfocus questionnaire (AHQ-D)

Hyperfocus (HF), or intense, deep concentration on a task, has gained significant research attention in recent years, particularly in regard to clinical populations such as Attention-Deficit/Hyperactivity Disorder (ADHD). The present work aims to provide validation of the 12-item dispositional adult hyperfocus questionnaire (AHQ-D) as a quantitative metric of HF in adults. We preregistered the study design and hypotheses. We administered the AHQ-D and several additional questionnaires to 347 adults (mean ± SD age: 33 ± 11 years; 47% female). Exploratory factor analysis revealed high factor loadings (0.57–0.81) on a single HF factor; item response theory analysis suggested that the questionnaire items had high discrimination and covered a wide range of responses; and we report strong internal consistency metrics (Cronbach’s alpha 0.93, mean split-half reliability 0.93). Replicating our previous work, HF was positively correlated with Conners’ Adult ADHD Rating Scale (CAARS) scores (r(345) = 0.53), suggesting that HF may be related to ADHD traits (though in this sample we did not specifically recruit individuals with ADHD). The AHQ-D demonstrated the hypothesized convergent validity; HF on the AHQ-D was positively correlated with HF measured using a different HF scale (r(344) = 0.69), as well as flow (r(345) = 0.12) and mind wandering (r(345) = 0.39) scores. AHQ-D HF scores showed a weak negative correlation with grit (r(345) = − 0.29). Though there was a weak negative correlation between HF and social desirability response tendency (r(345) = − 0.24), suggesting that those who care more about what others think may report less HF, there was no relationship between HF and extrasensory perception beliefs (r(345) = 0.01), suggesting that participants were not simply biased in their response tendencies. Taken together, we demonstrate strong scale metrics for the AHQ-D, the expected convergent validity, and a general lack of response bias, in addition to replicating our previous association of HF with ADHD traits. We suggest that the AHQ-D can be confidently used in future work as a valid way to measure HF in adults.

A matching-adjusted indirect comparison of centanafadine versus lisdexamfetamine, methylphenidate and atomoxetine in adults with attention-deficit/hyperactivity disorder: long-term safety and efficacy.

Aim: To compare long-term safety and efficacy outcomes of centanafadine versus lisdexamfetamine dimesylate (lisdexamfetamine), methylphenidate hydrochloride (methylphenidate) and atomoxetine hydrochloride (atomoxetine), respectively, in adults with attention-deficit/hyperactivity disorder (ADHD) using matching-adjusted indirect comparisons (MAICs). Patients & methods: Patient-level data from a centanafadine trial (NCT03605849) and published aggregate data from a lisdexamfetamine trial (NCT00337285), a methylphenidate trial (NCT00326300) and an atomoxetine trial (NCT00190736) were used. Patient characteristics were matched in each comparison using propensity score weighting. Study outcomes were assessed up to 52weeks and included safety (rates of adverse events [AEs]) and efficacy (mean change from baseline in the Adult ADHD Investigator Symptom Rating Scale [AISRS] or ADHD Rating Scale [ADHD-RS] score). Results: In all comparisons of matched populations, risks of AEs were statistically significantly lower with centanafadine or non-different between centanafadine and comparator; the largest differences in AE rates included upper respiratory tract infection (risk difference in percentage points: 18.75), insomnia (12.47) and dry mouth (12.33) versus lisdexamfetamine; decreased appetite (20.25), headache (18.53) and insomnia (12.65) versus methylphenidate; and nausea (26.18), dry mouth (25.07) and fatigue (13.95) versus atomoxetine (all p<0.05). Centanafadine had a smaller reduction in the AISRS/ADHD-RS score versus lisdexamfetamine (6.15-point difference; p<0.05) and no statistically significant difference in the change in AISRS score versus methylphenidate (1.75-point difference; p=0.13) and versus atomoxetine (1.60-point difference; p=0.21). Conclusion: At up to 52weeks, centanafadine showed significantly lower incidence of several AEs than lisdexamfetamine, methylphenidate and atomoxetine; efficacy was lower than lisdexamfetamine and non-different from methylphenidate and atomoxetine.

Adverse childhood experiences exacerbate peripheral symptoms of autism spectrum disorder in adults.

Adverse childhood experiences are potentially traumatic events with long-lasting effects on the health and well-being of patients with autism spectrum disorder (ASD). It is important to clarify which types of long-lasting autism-related symptoms are influenced by childhood experiences to design future intervention studies. However, few studies have examined the association between childhood experiences and autistic symptoms in large samples of adults with ASD and individuals with typical development (TD). In this study, we evaluate the effects of adverse childhood experiences on multiple ASD phenotypes among both individuals with ASD and those with TD. We combined questionnaire evaluations; Childhood Abuse and Trauma Scale, the Japanese version of the Autism-Spectrum Quotient, Conners' Adult ADHD Rating Scale, the Japanese version of the Impact of Event Scale-Revised, and the Japanese version of the Adolescent/Adult Sensory Profile. Individuals with ASD and those with TD (n = 205 and 104, respectively) were included. There were significant correlations between the extent of adverse childhood experiences and severity of attention-deficit/hyperactivity disorder symptoms, posttraumatic stress disorder symptoms, and hypersensitivity in both participants with ASD and those with TD. By contrast, ASD core symptoms showed no significant correlation with adverse childhood experiences in either group. These results remained consistent after adjusting for age, sex, and the estimated intelligence quotient. These findings suggest the need for a detailed disentanglement of ASD-related core and peripheral symptoms of adverse childhood experiences, which may help to appropriately set outcomes for future early interventions for the childhood experiences of individuals with ASD.

Reliability and validity of a newly developed PANDAS/PANS questionnaire

ObjectiveThis study aimed to examine the reliability and validity of a newly developed questionnaire for Pediatric Autoimmune Neuropsychiatric Disorders Associated with Streptococcal infections (PANDAS) and Pediatric Acute-onset Neuropsychiatric Syndrome (PANS). The aim was to contribute to future standardisation of screening methods for symptoms and comorbidity, as well as the measurement of symptom severity, daily life impairment, and treatment effectiveness in individuals diagnosed with PANDAS/PANS. Methods27 items from the PANDAS/PANS questionnaire concerning symptoms and comorbidities associated with PANDAS/PANS were divided into ten domains. To assess the external validity, 119 PANDAS/PANS questionnaires from a cohort of 65 children with PANDAS/PANS were correlated with three well-known validated questionnaires: the Children's Yale-Brown Obsessive-Compulsive Scale (CY-BOCS), Attention Deficit Hyperactivity Disorder Rating Scale (ADHD-RS), and the Strengths and Difficulties Questionnaire (SDQ). The internal validity of the PANDAS/PANS questionnaire was assessed by correlating the PANDAS/PANS items with the domains. ResultsInternal consistency of the PANDAS/PANS questionnaire was high, measuring moderate to very strong correlations. The external correlations for the PANDAS/PANS questionnaire showed a higher correlation with the ADHD-RS and CY-BOCS (rs ≥ 0.60) than with the SDQ (rs < 0.40). ConclusionThe validity and clinical feasibility of the PANDAS/PANS questionnaire were confirmed as an effective tool for screening symptoms, assessing symptom severity, and evaluating comorbidity and daily life impairment in individuals with PANDAS/PANS. These findings can potentially enhance the management of PANDAS/PANS patients in both clinical and research settings.

Psychometric properties of Persian version of susceptibility to driver distraction questionnaire

Background. This study aimed to investigate the validity and reliability of the Persian translation of the Susceptibility to Driver Distraction Questionnaire (SDDQ) among the inner-city drivers in Tabriz. Methods. In this cross-sectional study, 411 telephone taxi drivers from Tabriz city (northwest of Iran) and selected using a two-stage cluster random sampling were included. To produce an accurate Persian translation of the SDDQ, first, some bilingual specialists were asked to render the questionnaire into Persian from English and, then, another bilingual expert was asked to back-translate the produced Persian translation into English using a standard "forward-backward" translation procedure. The accurate content agreement of the translation with the above-mentioned versions was finally approved by the research team. Data management and analysis were performed using SPSS 26.0 and LISREL 8.80. Results. The internal consistency of the whole scale and subscales of the SDDQ was determined between 0.72 and 0.90 using Cronbach's α coefficient. The agreement between the original version and re-translation version was determined 0.66 to 1 using modified Kappa coefficient (k*). The results of the equal structural equation indicated that the construct validity of the six-factor model had a greater structural fit. Pearson's correlation coefficient between subscales and the whole-scale was found to be between 0.41 and 0.92. Furthermore, the correlation between SDDQ and Mindfulness Attention Awareness Scale (MAAS) was 0.39, while the correlation between SDDQ and Conner’s Adult ADHD Rating Scales (severity of ADHD symptoms) was 0.25 (P&lt;0.01). Conclusion. In sum, the Persian version of susceptibility to driver distraction questionnaire may have been used as a valid and reliable scale for investigating the Persian-speaking drivers in Iran. Practical Implications. SDDQ may have been used in universities and police research centers. Furthermore, it may have been applied for screening the high-risk drivers.

An exploratory investigation of the association between severities of the adverse impact of stuttering and co-occurring disorders

ABSTRACT Stuttering is a multi-dimensional disorder that affects diverse life aspects of people who stutter. This study aimed to investigate the association between severities of the adverse impact of stuttering and co-occurring disorders. Thirty adults who stutter (mean age, 37.6 ± 14.1 years; 26 males and four females) participated in this study. The Liebowitz Social Anxiety Scale (LSAS-J), Autism-Spectrum Quotient short form (AQ-10-J), and Conners’ Adult ADHD Rating Scales (CAARS) were used to assess symptoms of social anxiety disorders (SAD), autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD), respectively. The index of ratio of disfluencies (RDF) was calculated to assess cluttering. The Japanese version of the Overall Assessment of the Speaker’s Experience of Stuttering for Adults (OASES-A-J) was used to assess the adverse impact of stuttering. A moderate positive correlation was found between the LSAS-J and OASES-A-J scores. Inattention and ADHD symptoms total scores were significantly correlated with the OASES-A-J scores. The adverse impact of stuttering was associated with symptoms of co-occurring disorders, namely, SAD, ADHD, and cluttering. A negative correlation was observed between the RDF and OASES-A-J Section III score. Cluttering symptoms were associated with less communication impact in daily situations. This study sheds light on the importance of comprehensive assessments from professionals with relevant expertise for adults who stutter.

Influence of maternal attention-deficit hyperactive disorder on child dental neglect - An analytical cross-sectional study.

Attention-deficit hyperactivity disorder (ADHD) is a condition that is characterized by symptoms such as inattentiveness, hyperactivity, and impulsivity. The influence of mothers with ADHD and their attitude towards their wards' oral health has not been explored in the Indian scenario. The aim of this study was to assess the prevalence of ADHD in mother-child dyads in western Tamil Nadu and the mothers' dental neglect toward their children. The prevalence of ADHD in mothers and children was assessed using the Adult ADHD Self-report Scale screener and ADHD Rating Scale, respectively. The Child Dental Neglect Scale (CDNS) was used to assess dental neglect in children. The responses were recorded on a Likert scale and statistical analyses were done. The prevalence of ADHD in mothers and children was 10.65% and 10.57%, respectively. The impulsivity and hyperactivity type of ADHD was commonly seen in both the mothers and their children. Mothers without ADHD felt that their children maintained their oral health well. Mothers with ADHD deferred the needed dental treatment for their children. Mothers with ADHD have four times more risk of having children with ADHD. Maternal ADHD influences their child's oral health. Child dental neglect was more prevalent among mothers with ADHD.