Attending Federal Medical Centre Research Articles

The Assessment of Female Breast Cancer Tumors Using Some Biomarkers in Attendees of Federal Medical Centre, Yenagoa, Bayelsa State, Nigeria

Breast cancer has remained a major public health issue globally but predominantly affects women in developing nations. The overall survival rate of Nigerian women with breast cancer is low and patients with early breast cancer tend to have better survival than those with advanced distic basis and pathology. These changes are leading to revisions in the management of the disease with a positive impact on prognosis.The current research was done to describe the epidemiological and histopathological features of breast cancer amongst females attending the Federal Medical Center, Yenagoa, Bayelsa State, Nigeria. In this retrospective study, 178 breast specimens were used, spanned from 2010 to 2022. Results presented an age at diagnosis lower to the Western population and invasive ductal carcinoma as the main histological type. In this study, the prevalence of breast cancer amongst females attending Federal Medical Center, Yenagoa, Bayelsa State, Nigeria was analyzed using Hematoxylin and Eosin staining techniques on breast cancer samples collected over the study period. The pathophysiology of breast cancer is not very clear; however, some risk factors are. While some common risk factors are advancing age and the female gender, genetic mutations—namely BRCA 1 and 2—account for only about 10% of breast cancers. The role played by biomarkers, such as estrogen receptors, progesterone receptors, and human epidermal growth factor receptors, in the detection and management of patients with breast cancer. Human breast cancer is known to be dependent on sexual hormones for its growth, as it is derived from breast tissue that normally responds to endogenous hormones. Despite improvements in early detection and therapy, Breast Cancer remains one of the major burdens to healthcare systems and societies.

Assessment of Depression Risk Factors in Type 2 Diabetics at an Outpatient Clinic of a Tertiary Hospital in North Central, Nigeria

Background Depression and diabetes mellitus are health problems that affect people's quality of life. Some diabetic patients who are depressed may remain undiagnosed with the co- morbidity by Family Physicians. Hence there is need to draw physicians’ attention to curb this.  Aim/Objectives The objective of this study was to assess the prevalence and risk factors of depression among type 2 diabetic patients attending Federal Medical Centre's General Outpatient Clinic in Makurdi, Nigeria  Methodology This cross-sectional study included 238 diabetic patients over the age of 18 using the random sampling technique. Self-completed questionnaires were used to collect data, and clinical parameters such as height, weight, blood pressure, and fasting blood glucose levels were noted. The questionnaire collected information on the socio- demographic characteristics, relevant history and Becks Depression Inventory (BDI). Version 21 of the SPSS (Statistical Package for Social Sciences) was used to analyze the data. P-values of less than 0.05 were considered statistically significant in all analyses, which were carried out at a 5% significance level.  Results It was shown that 33.6% of people had depression. It was more common in people between the ages of 20 and 29 (50%) and in women than in men (39% vs. 25%). Mild depression was present in 56.3% of diabetic patients with depression. Depression was shown to be significantly correlated with BMI (p = 0.002), marital status (p = 0.034), gender (p = 0.026), and the kind of antidiabetic medicine taken (p = 0.036). Being overweight was substantially linked to a decreased risk of depression, according to multiple logistic regression analysis (aOR = 0.14, CI = 0.03-0.66, p = 0.013).  Conclusion/Recommendation A considerable number of diabetic patients exhibited depression. Physicians should maintain a high level of vigilance, monitor the behavior of individuals with diabetes, and screen them for depression. This approach can provide a foundation for further research.

Prevalence of Malaria among Patients attending Federal Medical Centre, Owerri, Imo State, Nigeria

The malaria parasite is a parasitic protozoan (a group of single-celled microorganisms) that inflicts humans with malaria. It is responsible for a significant proportion of the health burden of developing countries. Thus, this study aimed to evaluate the prevalence of malaria among patients attending the Federal Medical Centre Owerri, Imo State, Nigeria. A total of 150 patients consented to participate. Malaria diagnosis was performed using rapid diagnostic test kits and microscopic examination of Giemsa-stained blood film. Questionnaires were administered to gather socio-demographic data. The analysis revealed a 53% prevalence of malaria. Statistical analysis indicated associations between malaria occurrence and gender, educational level, and economic status. This study highlights the high prevalence of malaria among patients at FMC Owerri.

Molecular Characterization of Plasmid-mediated Quinolone Resistant Salmonella typhi From Patients Attending Federal Medical Center, Jabi, Abuja, Nigeria

Aims: This study investigates and reports the detection of qnr genes (plasmid-mediated quinolone resistance PMQR) in S.typhi isolated from stool of patients with suspected typhoid fever, in Federal Medical Center, Jabi, Abuja, Nigeria. Study Design: Cross sectional study. Place and Duration of Study: Department of Microbiology, Nasarawa State University, Keffi, between October 2022 and November 2023. Methodology: Salmonella typhi was isolated from stool of patients with suspected typhoid fever using standard culture and microbiological methods. Antibiotic susceptibility testing were performed using the disc diffusion method to investigate the ability of S. typhi to resist some antibiotics. Qnr genes (qnrC,qnrD,qnrS) were detected by PCR and amplification. Results: 17 out of 150 (11.3%) of the samples collected had S.typhi. Antibiotic resistance in the isolates in decreasing order were as follows: cefotaxime (100.0%), amoxicillin/ clavulanic acid (94.1%), nalidixic acid (94.1%), cefuroxime (94.1%), imipenems (88.2%), ceftriaxone/sulbactam (82.4%), ciprofloxacin (82.4%), gentamicin (58.8%), levofloxacin (47.1%) and ofloxacin (29.4%).The commonest antibiotic resistant phenotype was AUG- CTX-IMP-OFX-CN-NA-CXM-CRO-CIP-LBC at 29.4%. Multiple antibiotic resistance (MAR) was observed in 100% (17/17) of the isolates with the common MAR indices being 1.0 (29.4%), 0.7 (23.5%), 0.8 (17.6%) and 0.5 (17.6%). 33.3% of the isolates in FMCJ were positive for qnrC,qnrD,qnrS,qnrA+qnrC and qnrS+ aac(6′)-Ib-cr as all of qnrC qnrD,and qnrS genes were all expressed in the isolates. Conclusion: The S. typhi isolates showed lower resistances to ofloxacin, levofloxacin, and gentamicin, and all isolates were MAR, with resistance to 10 antibiotics being the most predominant. In addition, qnrC,qnrD, and qnrS resistance genes were all expressed in the isolates.

Prevalence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in Nigeria

The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) remains one of the most challenging pandemics in the world with fewer casualties in Nigeria despite minimal vaccine uptake. This study examines the prevalence of Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV-2) in subjects attending Federal Medical Center, Owo, Ondo State. A questionnaire based descriptive cross-sectional was conducted in 2022 among 100 patients from Federal Medical Centre in Owo, Ondo State .50 of whom had received the COIVD-19 vaccine and 50 of whom had not. For this study, men and women between the ages of 18 and 55 who appeared to be in good health were included. According to the study's findings, the prevalence of SARS-CoV-2 was detected in 5% of the population while it was absent in 95% of the rest. Two (2.00%) men and three (3.00%) women out of the five who confirmed positive for SARS CoV 2. The findings also revealed that, of the 5 participants who were tested positive for SARS CoV 2, 4 (80.00%) had not had a vaccination, while 1 (20.00%) had. Adult Nigerians who have never received the COVID-19 vaccine have a high SARS-CoV-2 antibody seroprevalence rate. Age and gender do not appear to significantly correlate with sero-positivity (p>0.05). Therefore, anti-SARS-CoV-2 antibody testing is required after vaccination since it may be necessary to achieve herd immunity. Keywords: antibody; SARS-CoV-2; Sero-prevalence; vaccine; Covid-19

Prevalence of Mycobacterium tuberculosis among HIV Patients Attending Federal Medical Centre Asaba, Delta State

Prevalence of Mycobacterium tuberculosis among HIV Patients Attending Federal Medical Centre Asaba, Delta State

Effects of age and gender on malaria knowledge among people attending Federal Medical Centre, Owerri, Imo and University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Southeast Nigeria

Malaria is responsible for most morbidity and fatality in Sub-Saharan Africa, with Nigeria having the highest proportion. This study was undertaken to evaluate the effect of age and gender on people’s knowledge towards malaria at Federal Medical Centre, Owerri, Imo and University of Nigeria Teaching Hospital, Ituku-Ozalla, Enugu, Southeast Nigeria. A hospital-based study was conducted on 500 participants attending health care. A well-structured questionnaire was administered to elicit information on socio-demographic characteristics and respondents’ knowledge on cause, signs and symptoms, and prevention of malaria. The socio-demographic variables for the respondents showed that 50.4% were male, while 49.6% were female; (34%, 66%) were < 11 years and ≥ 11 years respectively. The association of participants’ knowledge towards cause, signs and symptoms, and prevention of malaria with age was (< 11 years: Mean score = 28.8, 28.1, 34.9, SD = 3.8, 1.46, 11.2; ≥ 11 years: Mean score = 53.8, 63.3, 59.1, SD = 4.54, 0.91, 4.74) respectively. The association of respondents’ knowledge on malaria cause, signs and symptoms, and prevention with gender was (male: Mean score = 48.9, 50.47, 50.3 SD= 1.79, 0.58, 3.50; female: Mean score = 38.1, 40.9, 43.7, SD = 2.54, 1.48, 3.58) respectively. The older and the male study populace had better significant knowledge towards malaria with respect to cause, signs and symptoms, and prevention than their counterparts.

Effects of formal education on malaria knowledge among people attending Federal Medical Centre, Owerri, Imo State, Nigeria

Globally, malaria continues to be a life-threatening infectious disease in more than 100 countries. It is endemic in Africa, especially Nigeria where it is a major cause of morbidity and mortality. It affects all age brackets but more severe among children under the age of 5 and pregnant women. This study was undertaken to evaluate the knowledge of people attending health care at Federal Medical Centre (FMC), Owerri in Imo State, Nigeria on malaria with emphasis on causes, signs and symptoms, preventions, and management of the disease. The study was conducted in Federal Medical Centre, Owerri Imo state, Southeast Nigeria. This cross-sectional hospital based study was conducted on 250 participants. A well-structured questionnaire was administered to elicit information on socio-demographic characteristics and respondents’ knowledge on cause, signs and symptoms, prevention and management of malaria. The socio-demographic variables for the respondents showed that 26.0% had no formal education, whereas 74.0% had formal education. On the knowledge of causes of malaria, 67.4% of the educated study populace had sound knowledge against their counterpart that had 31.9%. Regarding knowledge of malaria signs and symptoms, the respondent without and with formal education had 40.34% and 79.7% respectively. The respondents without formal education had 38.0% against their counterpart that had 61.3% knowledge on malaria prevention. With respect to knowledge on management of malaria, those that had formal education reported 88.9% knowledge, while the participants without formal education recorded 38.8%. Generally, respondents with formal education had significantly better knowledge than those without formal education.

Biofilm Inhibitory Effects of Lactobacillus Spp Against Streptomycin-resistant Uropathogenic Escherichia Coli

The biofilm inhibitory effects of Lactobacillus spp against Streptomycin-resistant uropathogenic Escherichia coli (UPEC) were evaluated using the crystal violet test method. Lactobacillus spp were isolated from milk samples while fifty strains of Uropathogenic Escherichia coli were isolated from urine samples from Urinary Tract Infection patients attending Federal Medical Centre (FMC) Owerri, Nigeria. Ten of the E. coli strains resistant to streptomycin antibiotics were screened for their susceptibility to antibiofilm effect of Lactobacillus secondary metabolites extracts. From the result obtained, only one of the E. coli strains was susceptible while nine strains were resistant. This result shows clearly that the metabolite extracts from Lactobacillus sp were not effective in the antibiofilm activity of the E. coli strains and thus not a good candidate for the management of UTI caused by E. coli.

Comparison of the Efficacy of Haematoxylin & Eosin (H&E) and Periodic Acid Schiff (PAS) Staining Techniques in the Diagnosis of Typhoid Intestinal Perforation (TIP) among Patients Attending Federal Medical Centre, Keffi Nasarawa State, Nigeria

Aim of the Study: To compare the efficacy of H&E and PAS staining techniques in the demonstration of TIP among patients attending Federal Medical Centre Keffi, Nasarawa state. Study Design: The study is a retrospective study, a total of 129 paraffin-embedded tissue blocks of patients who were diagnosed of TIP between January 1st 2013 and December 31st 2022 were retrieved from the archives of Histopathology laboratory and examined. Ten patients (10) with incomplete data were excluded.
 Methodology: A semi structured questionnaire was used to collect demographic data. The tissue blocks were sectioned at 4um and stained using Haematoxylin and Eosin (H&E) staining technique and Periodic Acid Schiff (PAS) technique. The microscopic examination was done using x10 and x40 objectives of the Olympus light microscope.
 Results: The study showed that males were more affected with TIP than females with ratio 1.6: 1. Ages of patients ranged between 6 months-77 years with mean age of 24.8+1.87 years. The highest number of TIP cases was recorded in December. The ileal segment was the most perforated among the intestinal segments. The socioeconomic status of patients, availability of potable water supply as well as hygiene and sanitary practices were discovered to be key factors in typhoid fever infection and treatment outcomes.
 Conclusion: Although, both PAS and H&E staining techniques showed favorable features, the PAS technique gave better contrast and also revealed the perforation sites better than H&E at P<0.001. Hence, the PAS technique should be done alongside the H&E in the laboratory investigation of intestinal tissues.

Prevalence of Mycobacterium tuberculosis among HIV Patients Attending Federal Medical Centre Asaba, Delta State, Nigeria

Aim: The study aimed to ascertain the prevalence of tuberculosis among HIV-positive patients at the Federal Medical Center Asaba in Delta State, Nigeria.
 Study Design: This study engaged a cross-sectional study design to prevalence of Mycobacterium Tuberculosis among HIV Patients Attending Federal Medical Centre Asaba, Delta State.
 Place and Duration of the Study: The study was conducted in Federal Medical Center. Data collection spanned a specific duration from November, 2022 to January, 2023.
 Methodology: A total of 188 samples were obtained from known HIV patients. The patients were selected by random sampling technique. The samples were analysed using GeneXpert machine (GX2.1 model) with the nuclei acid amplification (NAA) of DNA mycobacterium tuberculosis complex (MTBC) and resistance to rifampicin. Demographic data of participants were obtained through questionnaires.
 Results: Out of 188 samples from HIV patients analyzed, MTB was detected in 13 (8.7%) patients with the highest prevalence recorded among male subjects 6(12%). Age group 19-29 was the most prevalent of MTB among the test subjects.
 Conclusion: Mycobacterium tuberculosis is widespread among HIV patients in Asaba, Delta state, according to these data. As a result, patients must be encouraged to adhere to treatment and preventive measures.

Isolation and Characterization of Coagulase Positive, Methicillin and Multi-Drug Resistant Staphylococcus and Mammaliicoccus species Isolated from Wound of Patients Attending Federal Medical Centre, Yola, Adamawa State, Nigeria

Isolation and Characterization of Coagulase Positive, Methicillin and Multi-Drug Resistant <i>Staphylococcus</i> and <i>Mammaliicoccus</i> species Isolated from Wound of Patients Attending Federal Medical Centre, Yola, Adamawa State, Nigeria

Effect of different concentrations of garlic extract on dental plaque isolates obtained from patients attending Federal Medical Center Makurdi

Instead of the traditional microbiological pathogens, the microbes that make up the mouth's resident micro-flora are what cause oral diseases like dental caries/plaque and periodontal disorders. The aim of this study was determine the effect of different concentrations of garlic extract on dental plaque isolates obtained from patients attending Federal Medical Center Makurdi. Swap samples were collected from teeth of patients and were transported to the laboratory, analysis was done on different culture media and identification of isolates was done using the Bergy’s manual of determinative bacteriology, biochemical characterization was carried following standard microbiological methods. The antibacterial activity was done using agar well diffusion method in which the garlic extract was introduced in concentrate. Concentrations of 500 mg/mL, 250 mg/mL, 125 mg/mL, 65.3 mg/mL and 35.5mg/mL were prepared and used for the susceptibility. The Isolates from results were Streptococcus oralis, Streptococcus mutans, Enterococcus feacalis and Staphylococcus aureus. The effect observed was concentration dependent as all the graphs obtained shows a linear series, the lowest inhibitory concentration shows that 250mg/ml was the lowest concentration that inhibits each of the isolates in ethanolic garlic extract while 500 mg/mL was the minimum inhibitory concentration for the aqueous garlic extract. Oral hygiene was recommended in order to help reduce the accumulation of dental plaque which usually harbours primary microbes that colonize the teeth surfaces resulting to caries and periodontal diseases. The use of mouth wash containing garlic and or toothpaste incorporated with alicin was recommended as this can help reduce the accumulation of dental plaque biofilm thereby minimising the incidence of dental caries and periodontal diseases.

Knowledge of the Risk Factors and Prevention of Deep Vein Thromboembolism Among Adults Attending Federal Medical Centre, Asaba, Delta State

Deep vein thrombosis (DVT) is a significant public health issue affecting thousands of patients globally and is accountable for a high number of hospitalizations annually. This study assessed the knowledge of the risk factors and prevention of deep vein thromboembolism among adults attending Federal Medical Centre, Asaba, Delta State. Three research questions and two hypotheses guided the study. A sample size of 420 respondents was involved in this descriptive cross-sectional study. Data were collected using structured questionnaire. Research questions were answered using frequencies and percentages. Hypotheses were tested using X2 test. Results showed that only 31.9% of participants had previous knowledge of DVT. Obesity/overweight (72.4%), long travel for more than 6 hours whether by car or plane (66.6%), and excess duration of sitting (55.7%) were the most well-known risk factors. Only about 37 (8.8%) of the respondents knew that DVT occurs when the patient relaxes most of the time in bed, and the most known symptoms were: pain and discomfort 272 (64.7%), local pain in the leg 244 (58.1%), or redness of the affected skin 213 (50.7%). The overall knowledge level of the risk factors of DVT among the respondents showed that only 2% had good knowledge, 30% had fair knowledge and 68% had no knowledge. Most of the respondents 217 (51.6%) knew that DVT is dangerous and may lead to death. The level of knowledge of the risk factors of DVT is highest among the younger aged, individuals who were employed and those who had higher level of education. Poor knowledge necessitates community education programmes about risk factors, signs and symptoms, and squeal of deep vein thromboembolism.

Prevalence of Microalbuminuria among Diabetic Patients Attending Federal Medical Centre Gusau, Nigeria

Microalbuminuria is persistent albumin excretion between 30 and 300 mg/day. In patients with diabetes, it is usually indicative of diabetic nephropathy which is the most common cause of end-stage renal disease; it is also associated with cardiovascular disease. The main objective was to determine the prevalence of microalbuminuria and its association with glycemic control, blood pressure, and duration of diabetes in type-1 and type-2 diabetic patients attending Federal Medical Center Gusau, Nigeria. This study evaluated the level of microalbuminuria among 150 diabetic patients and 50 control subjects. The urinary albumin concentration was measured by immunoturbidimetric assay. From both the control and diabetic subjects, fasting blood sugar was estimated and blood pressure was measured with an automated manometer. Prevalence of microalbuminuria (MAL) according to demographic, the incidence of variables was detected in 12 males 28 females, and &lt; 40 years of age 10 and &gt; 40 years of age 31. The Mean of Fasting Blood Glucose (FBG) was slightly higher in patients with Non-insulin Dependent Diabetes Mellitus (NIDDM) when compared to IDDM patients. There was no significant (p&gt;0.05) difference between males and females, within the group regarding age, blood pressure, and glycemic status. However, there is a statistically significant difference (p&gt;0.05) in FBG and MAL between the patients and the control. The results suggest that there is a high prevalence of microalbuminuria in patients attending Federal Medical Center Gusau which is an independent risk factor for renal and cardiovascular diseases.

Knowledge, attitude, and adherence to physical activity among hypertensive patients attending Federal Medical Center Katsina, Nigeria

Knowledge, attitude, and adherence to physical activity among hypertensive patients attending Federal Medical Center Katsina, Nigeria

PREVALENCE OF CERVICAL HUMAN PAPILLOMAVIRUS INFECTION AMONG WOMEN OF CHILDBEARING AGE IN FMC ASABA, NIGERIA

Background: Cervical Human Papillomavirus infection prevalence varies with differentenvironments. Knowledge of this will help in some cervical cancer interventions such as earlyand continuous screening. This study is aim at determining the prevalence of cervical HPVinfection among women of childbearing age attending Federal Medical Center Asaba, Nigeria.Materials and methods: A total of 99 consenting women aged between (20 -45) years wererandomly recruited and screened for HPV infection using virtual inspection by acetic acid (VIA)method. Semi-structured questionnaire was used to obtain the demographic characteristics, biodata and reproductive history of the participants. Statistical analysis was done using IBM SPSSstatistics version 21. Results: The result shows that 21(21.21%) out of 99 women thatparticipated in the study were VIA positive. 16(76.19%) out of the 21 HPV infected womenshowed cervicitis, 4(19.05%) had cervical polyps, 1 (4.16%) had invasive cervical cancer while,1(4.16%) of the participants had HPV only. Age-specific prevalence was highest among the agegroup 36 – 40 years with age groups 20 – 25 and 41-45 having the same value. Conclusions:HPV prevalence rate is high among the study population especially in women of aged between(36-40) years. Early commencement of sexual intercourse among others was associated withHPV positive. Advanced and effective method of screening is highly recommended in lowincome settings. Urgent and adequate interventions is recommended for regular HPV screeningamong women of reproductive age to reduce the spread of cervical cancer.

Prevalence of Candidiasis and Associated Site of Infection among HIV Patients Attending Federal Medical Center, Azare

Patients with Human Immunodeficiency Virus (HIV) are at the greatest risk of being infected with various opportunistic infections, as their immune systems become so weak to fight against the infectious agents. Candida species are among the commonest opportunistic pathogens affecting people with weakened immune systems. Candidiasis remains the major challenge of public health important to the HIV patients. There is scarcity of information regarding the impact of Candidiasis in public health in Northeastern part of Nigeria, especially Bauchi State. This study aimed at determining the prevalence of Candidiasis and the associated site of infection in the HIV patients. Clinical samples such as blood, urine, sputum and oral swab were collected from 300 HIV patients attending Federal Medical Center Azare, Bauchi State. The pathogens were isolated on Sabouraud Dextrose Agar and identified using Corn meal agar, Germ tube test, ChromagarCandida, Gram staining and Lactophenol cotton blue. Four Candida species were isolated among which Candida albican (51%) was the most prevalent followed by Candida glabrata (12%). The isolates colonized the oral cavity of 51.11% of the patients making oral candidiasis most common among the patients. The oral candidiasis is the most troublesome form of candidiasis among HIV patients, and has been caused mostly by Candida albican.

STATUS OF LIPID PROFILE, TRACE ELEMENTS, AND C-REACTIVE PROTEIN IN Helicobacter pylori INFECTED PREECLAMPSIA WOMEN

Status of lipid profile, trace elements and C-reactive protein (CRP) in Helicobacter pylori infected preeclampsia (PE) women were examined using patients attending Federal Medical Centre in Owerri, Nigeria. A total of 180 volunteer subjects within the ages of 18-40 years were recruited for the study. The volunteer subjects comprised of 60 PE women with H. pylori infection which served as group I, 60 PE women without H. pylori infection which as group II and 60 normotensive pregnant women (with no PE and H. pylori infection) which served as the control. Results obtained revealed varying levels of total cholesterol triglycerides, high density lipoprotein cholesterol (HDL-cholesterol), CRP, Cu and Zn observed among PE women with H. pylori infection compared to PE women without H. pylori infection and the control. Total cholesterol, triglycerides and CRP increased significantly (p&lt;0.05) in group I subjects when compared to group II subjects and the control. Trace elements significantly (p&lt;0.05) reduced in group I subjects against the control. The observation of the present study could be the status of PE women infected with H. pylori though there is need for further studies on this area to confirm the findings of the present study. This study has evaluated the lipid profile, trace elements and CRP status of H. pylori infected PE women.

Antibacterial Activities of Some Medicinal Plants on Common Multidrug-Resistant Bacterial Isolates from Some Patients Attending Federal Medical Center, Birnin Kebbi, Nigeria

Bacterial infections are among the major causes of morbidity and mortality worldwide. The development of drug resistance to most antibiotics by bacterial species are pandemic, these necessitate the urgent need to search for new antibacterial drugs from the natural sources. Hence this research was aimed at evaluating the antibacterial activity of some medicinal plants on the most commonly drug resistant bacterial isolates from some patients attending Federal Medical Center (FMC) Birnin Kebbi, Nigeria. An ethno-botanical survey was carried out within Zuru Emirate and three (3) plant samples (Lonchocarpus laxiflorus root, Mitragyna inermis root and Lawsonia inermis root) were selected based on their number of citations and limited number of reported researches on the antibacterial activities of their roots. The multidrug resistant bacterial strains (Staplococcus aureus, Escherichia coli and Psuedomonas aeruginosa) obtained from FMC, Birnin Kebbi, were taken from nutrient agar slant and sub-cultured in nutrient agar plates. The antibacterial activities of the root methanol extracts of the plants were evaluated using agar-well diffusion method. Tube dilution method was used to determine the minimum inhibitory concentration of each plant extract. The preliminary phytochemical screening of the extracts was conducted using standard methods. Alkaloids, Flavaniods, Steriods, Tannins, saponnins and Phenols, were detected in L. laxiflorus root methanol extract, Flavaniods were absent in L. inermis and Alkaloids in M. inermis root methanol extracts. The plant extracts and their combinations showed varying degrees of antibacterial activities on the test isolates. The root methanol extracts of L. laxiflorus, L. inermis, L. laxiflorus/L. inermis, L. laxiflorus/M. inermis and L. inermis/M. inermis roots presented significant increase (p&lt;0.05) in the zone of inhibition against S. aureus. Extracts of L. laxiflorus root, L. inermis root and combination of M. inermis root were able to suppress the growth of P. aeruginosa at lower dose of 25mg/ml. The antibacterial activity revealed that, the extracts exhibited dose dependent effect. L. inermis root had the highest activity and least MIC value of 12.5mg/ml against all the tested isolates. Thus, this research justified the use of these plants in traditional medicine for the treatment of bacterial infections and can also be considered as potential sources for development of new antibacterial agents that may be more effective, safe and readily accessible than the current antibiotics.