Aims And Objective: This study was conducted to assess % reduction in platelet count, prolongation of prothrombin time, activated partial thromboplastin time and relationship between CD4 count and changes in platelet count, prothrombin time and activated partial thromboplastin time. Material And Methods: Cross-sectional study was done on newly diagnosed HIV positive patients, attending ART center, Sir Takhtasinhji General Hospital, Bhavnagar in duration of one year from the ethics committee approval. Inclusion Criteria: Newly diagnosed HIV positive patients, age >18 years. Exclusion Criteria: All patients who have taken post-exposure prophylaxis. Ÿ History of previous ARTtreatment. Ÿ Drugs like aspirin, warfarin, heparin causing alteration in PTand aPTTand platelet count. Ÿ Patient with bleeding disorder like hemophilia. Ÿ Patient with liver disease. Results: Out of total 244 patients, 190 patients had CD4count (<200 cells/µL) and 54 patients had CD4count (≥200 cells/µL). From the 190 patients 36.3%, 86.3% and 94.2% showed reduction of platelet count, prolongation of prothrombin time and activated partial thromboplastin time respectively. Conclusion: Thrombocytopenia, prolonged prothrombin time and activated partial thromboplastin time is present in 28.7%, 68% and 74.6% patients respectively. Regular measurements of basic coagulation parameter could help to determine which patients are at greatest risk of disease progression, allowing these patients to be identied for closer monitoring or therapeutic interventions