Remote patient monitoring (RPM), patient-reported outcomes (PROs), and biochemical biomarker monitoring (Mitra® devices) may be useful for early detection of major adverse cardiac events (MACE). This case report presents a patient enrolled in a precision medicine study in which RPM detected the presence of atrial fibrillation-atrial flutter (AFib-Flutter), facilitating prompt treatment. A 64-year-old male with a history of ischemic heart disease (IHD) initiated his AliveCor Kardia after noting angina which reported “possible atrial fibrillation”. Upon evaluation, AFib-Flutter was confirmed by 12-lead ECG and successfully treated. RPM was recorded continuously through (Fitbit Charge 2), weekly single-channel electrocardiogram rhythm stripe (AliveCor Kardia), PROs through weekly questionnaires, and Mitra® devices through monthly fingerpricks. The case report highlights a successful case of detecting AFib-Flutter, expediting treatment and preventing MACE. Precision medicine using RPM may be useful for detecting AFib-Flutter and improving IHD outcomes. Further research is needed. J Med Cases. 2019;10(2):31-36 doi: https://doi.org/10.14740/jmc3151w