ATP Administration Research Articles

Value of high energy compounds in the treatment of shock

The effect of ATP administration in irreversible shock was studied in dogs. Premedication with ATP before and ATP treatment during hemorrhagic shock significantly improved survival of treated animals when compared with their matched controls. ATP administration was less effective in endotoxin shock. The protective effect of adenosine triphosphate in the prevention of irreversibility may be attributed to vasodilation, energy transfer, anticoagulation, or a combination of these mechanisms.

THE INFLUENCE OF PHOSPHORUS METABOLISM ON THE RENAL FUNCTION.

An attemt was made to observe the influence of phosphorus metabolism on the kidney function through clinical and experimental works.(1) ATP gave a rise of the renal clearance, especially dominant of PAH clearance, in the normal rabbits kidney.(2) We observed the effect of ATP, vitamin B1 and co-carboxylase on PSP test in kidney diseases. ATP improved PSP in the group suffering moderately, but not in the group seriously disturbed. When the kidney function was within normal limits, there were almost the same numbers of improved and constant rate of PSP excretion by ATP. Co-carboxylase effected on the improvement of PSP better than vitamin B1, and these effects were almost similar to that of ATP.(3) Inorganic phosphorus and Δ10P were measured for 120 min. after ATP administration to rats which were treated by potassium chromate leading to slightly or seriously disturbed kidney. In serious cases was noted low inorganic phosphorus, whereas Δ10P showed the highest rate in mild cases, but did not increase so much or did a slow return to the beginning rate in serious cases.(4) Blood pyruvic acid and α-ketoglutaric acid in the kidney disease showed a rise suggesting the disturbance of their utility. ATP, vitamin B1 and co-carboxylase made an improvement of these rates, especially vitamin B1 and co-carboxylase did a remarkable influence. However there was no definite difference of the effect between vitamin B1 and co-carboxylase.(5) The improvement of the kidney function by the activation of the glucose metabolism by ATP or co-carboxylase was most marked in moderately advanced kidney diseases. PSP test was revealed to indicate without any difficulty the reaction ability to the metabolism of the renal vessels and the tubules. Phosphate bound substances were suggested to play an important role in improving the kidney function by producing high energy phosphate bound substances, activation of phosphorilation as well as causing the smooth TCA cycle.

CLINICAL STUDIES ON ATP (ADENOSINE TRIPHOSPHATE)

In diabetic patients (41 adults), the effect of ATP injection on the carbohydrate metabolism was compared with insulin action. The results were summarized as follows. 1) By administration of ATP, blood sugar levels in diabetic patients were usually reduced, but these levels in normal subjects were unchanged by ATP administration. 2) In many cases, alimentary hyperglycemia in diabetic patients was controlled by administration of ATP, and hypoglycemic effect of insulin was raised when ATP was injected with insulin. 3) Serum inorganic phosphorus were reduced by administration of ATP and the reducing-ratio of phosphorus by intravenous injection of glucose was intensified by administration of ATP. 4) Blood pyruvic acid levels were raised by insulin injection. On the contrary, blood pyrubic acid levels were reduced by ATP injection, and the elevation of blood pyruvic acid levels by intravenous injection of glucose was also controlled by ATP injection. 5) Blood lactic acid levels were reduced by ATP injection and the elevation of lactic acid levels by intravenous injection of glucose was controlled by ATP.