This study reveals the adhesion of Staphylococcus aureus on the modified surface of silver-coated non-woven disposable polyethylene fabric used in hospitals to cover the patient’s bed. The bacteria Staphylococcus aureus is responsible for many Nosocomial infections. Therefore, we should take action to reduce the spread of Staphylococcus aureus. The present study is focused on a nonwoven polyethylene fabric used as a bedspread that has been plasma-treated and coated in silver to prevent the adhesion of S. aureus and its growth. Non-woven polyethylene fabric is plasma-treated for quick silver adherence before being coated with silver and treated with S. aureus. Tests for fabric characterization were performed. It includes contact angle, FTIR, and SEM.SEM, FTIR, and contact angle measurements are made on the control, plasma-treated, silver-coated, and S. aureus samples. The plasma treatment will cause the fabric to enhance its surface properties. The increased surface roughness will cause the silver to adhere rapidly. The Silver will also prevent the bacteria from multiplying. Silver's antibacterial characteristics, guarantee the destruction of the germs. A bedspread made of nonwoven polyethylene fabric with a silver coating is possible. so that the sufferers can rest comfortably. The number of nosocomial infections spread by the clothing will decline. It is possible to prevent bacterial infections in the patients and medical staff.