Modelling atmospheric composition and climate change on the global scale remains a great scientific challenge. Earth system models spend up to 85% of their total required computational resources on the integration of atmospheric chemical kinetics. We refactored a general atmospheric chemical kinetics solver system to maintain accuracy in single precision to alleviate the bottleneck in memory-limited climate-chemistry simulations and file input/output (I/O) and introduced vectorisation by intrinsic functions to increase data-level parallelism exposure. The application was validated using seven standard chemical mechanisms and evaluated against high-precision implicit methods. We reduced required integration steps by ×1.5–3-fold, in line with double precision, while maintaining numerical stability under the same conditions, accuracy to within 1%, and benefiting from halving the required memory and reducing overall simulation time by up to a factor two. Our results suggest single-precision chemical kinetics can allow significant reduction of computational requirements and/or increase of complexity in climate-chemistry simulations.