This study examines the seasonal variation of particulate matter (PM10; PM2.5) concentrations within Federal University Otuoke, Nigeria. The study is premised on monitoring and assessing PM10 and PM2.5 in the environment of the university. Dustmate and Kane 100-1 and 3.5.1 RS-1361C-Humidity/Temperature meter were used in sampling between the hours of 8am to 5pm per day in five day per week for a period of 6month which covers both the rainy and dry season. The sampled concentration of PM10 and PM 2.5 obtained was compared with the guidelines of “The National Ambient Air Quality Standard” established by U.S. Environmental Protection Agency (EPA) for compliance and regulation. Descriptive statistically methods were used in data analysis. The Results revealed that the averages PM10 are 116.71 µg/m3 and 107.25 µg/m3, while PM 2.5 records as 27.52 µg/m3 and 32.21 µg/m3 respectively. Relative humidity was also recorded 55.53 µg/m3 and 73.74 µg/m3. Similarly the results in both seasons shows the total average of PM10 as 100.19 µg/m3 and 110.07 µg/m3, PM 2.5 records 23.88 µg/m3 and 23.37 µg/m3 while relative humidity records 55.78 µg/m3 and 68.18 µg/m3 respectively. These were significantly influenced by the relative humidity of the environment of Federal University Otuoke. The study concludes that the seasonal variation of the relative humidity has an effect on the PM10 and PM2.5 concentrations and consequently the air quality of the university, hence further research into methods that will reduce particulate matter, as well as strategic environmental management policies within the university and beyond is recommended.