The Atlantic Meridional Overturning Circulation (AMOC) is a significant component of the global ocean system, which has so far ensured a relatively warm climate for the North Atlantic and mild conditions in regions, such as Western Europe. The AMOC is also critical for the global climate. The complexity of the dynamical system underlying the AMOC is so vast that a long-term assessment of the potential risk of AMOC collapse is extremely challenging. However, short-term prediction can lead to accurate estimates of the dynamical state of the AMOC and possibly to early warning signals for guiding policy making and control strategies toward preventing AMOC collapse in the long term. We develop a model-free, machine-learning framework to predict the AMOC dynamical state in the short term by employing five datasets: MOVE and RAPID (observational), AMOC fingerprint (proxy records), and AMOC simulated fingerprint and CESM AMOC (synthetic). We demonstrate the power of our framework in predicting the variability of the AMOC within the maximum prediction horizon of 12 or 24 months. A number of issues affecting the prediction performance are investigated.