Diabetes Mellitus Coronary Artery Disease Research Articles

Effects of diabetes mellitus on cholesterol metabolism in man.

In view of the reported excess prevalence of atherosclerosis and cholelithiasis in diabetes, we investigated several aspects of cholesterol metabolism under metabolic ward conditions in six Pima Indians with maturity-onset diabetes mellitus. Cholesterol balance (13.5 versus 11.0 mg per kilogram per day, P less than 0.05), fecal bile acid excretion (415 versus 261 mg per day, P less than 0.05), bile acid pool size (3150 versus 1950 mg, P less than 0.05), fasting plasma cholesterol (193 versus 160 mg per deciliter, P less than 0.05) and plasma triglycerides (251 versus 150 mg per deciliter, P less than 0.05) were higher during uncontrolled hyperglycemia than during relative euglycemia on insulin. The increased plasma lipid levels and total cholesterol synthesis during hyperglycemia may contribute to the acceleration of atherosclerosis in diabetes mellitus. Gallbladder bile was significantly more saturated with cholesterol (181 per cent versus 114 per cent, P less than 0.05) during insulin treatment than during uncontrolled hyperglycemia. Bile lipid composition was thus more favorable to cholesterol precipitation and gallstone formation during insulin treatment than in the untreated diabetic state.

Atherosclerosis in diabetes mellitus. Correlations with serum lipid levels, adiposity, and serum insulin level.

A group of 101 diabetic patients containing equal numbers of patients with and without clinical atherosclerosis and 104 control subjects of similar age and sex were studied. The diabetic patients with atherosclerosis were found to have higher triglyceride and cholesterol levels, higher insulin-glucose ratios, and a higher frequency of pre-β band staining on lipoprotein electrophoresis than diabetic patients without atherosclerosis or control subjects. Diabetic patients with atherosclerosis could be discriminated better from those without atherosclerosis by the use of triglyceride levels than by the use of cholesterol levels. Segregated arbitrarily into three categories of body weight, diabetic patients with atherosclerosis had higher triglyceride levels than similarly classified diabetic patients without atherosclerosis. Basal insulin levels, triglyceride levels, and indices of body weight were highly intercorrelated in the diabetic patients with atherosclerosis. However, fasting levels of serum insulin were similar in the two groups of diabetic patients. There was no clear relationship

A phase-locked echo tracking system for recording arterial diameter changes in vivo.

A phase-locked echo tracking system for recording arterial diameter changes in vivo.

A study of myocardial infarction in women.

Excerpt It is well known that myocardial infarction occurs much more commonly in men than in women. Almost all reports on coronary artery disease in the female emphasize a history of diabetes or hy...