Magnitude Of Asymmetry Research Articles

Incremental Visual Occlusion During Split-Belt Treadmill Walking Has No Gradient Effect on Adaptation or Retention.

Split-belt treadmills have become an increasingly popular means of quantifying ambulation adaptability. Multiple sensory feedback mechanisms, including vision, contribute to task execution and adaptation success. No studies have yet explored visual feedback effects on locomotor adaptability across a spectrum of available visual information. In this study, we sought to better understand the effects of visual information on locomotor adaptation and retention by directly comparing incremental levels of visual occlusion. Sixty healthy young adults completed a split-belt adaptation protocol, including a baseline, asymmetric walking condition (adapt), a symmetric walking condition (de-adapt), and another asymmetric walking condition (re-adapt). We randomly assigned participants into conditions with varied visual occlusion (i.e., complete and lower visual field occlusion, or normal vision). We captured kinematic data, and outcome measures included magnitude of asymmetry, spatial and temporal contributions to step length asymmetry, variability of the final adapted pattern, and magnitude of adaptation. We used repeated measures and four-way MANOVAs to examine the influence of visual occlusion and walking condition. Participants with complete, compared to lower visual field visual occlusion displayed less consistency in their walking pattern, evident via increased step length standard deviation (p = .007, d = 0.89), and compared to normal vision groups (p = .003 d = 0.81). We found no other group differences, indicating that varying levels of visual occlusion did not significantly affect locomotor adaptation or retention. This study offers insight into the role vision plays in locomotor adaptation and retention with clinical utility for improving variability in step control.

Intra- and Inter-Limb Strength Asymmetry in Soccer: A Comparison of Professional and Under-18 Players.

(1) Background: the present study examined the isokinetic peak torque exerted by both knee extensors and flexors, anterior–posterior imbalance and the magnitude and direction of inter-limb asymmetry in professional and academy soccer players. (2) Methods: one hundred soccer players (professional = 50, elite academy = 50) volunteered to take part in this investigation. An isokinetic dynamometer was used to measure the knee extensor (quadriceps) and flexors muscle (hamstrings) torques of the limbs as well as inter-limb asymmetries—using a standard percentage difference equation. (3) Results: professional players exhibited significantly greater (effect size [ES] = large) strength levels in the quadriceps and hamstrings under both testing conditions, significantly higher (small to moderate) intra-limb ratio values for 60°·s−1 but not for the 300°·s−1 test condition, significantly (small to moderate) lower inter-limb asymmetry values for all test conditions, with the exception of the hamstrings at 60°·s−1 and the direction of asymmetry was poor to slight, indicating that limb dominance was rarely the same between groups. (4) Conclusions: this study shows that isokinetic assessments, i.e., peak torque exerted by both knee extensors and flexors and intra-limb ratio, and the subsequent inter-limb asymmetry, i.e., magnitude and direction, can differentiate between professional and academy soccer players.

Endocranial asymmetry in New World monkeys: a comparative phylogenetic analysis of morphometric data.

Brain lateralization is a widespread phenomenon although its expression across primates is still controversial due to the reduced number of species analyzed and the disparity of methods used. To gain insight into the diversification of neuroanatomical asymmetries in non-human primates we analyze the endocasts, as a proxy of external brain morphology, of a large sample of New World monkeys and test the effect of brain size, home range and group sizes in the pattern and magnitude of shape asymmetry. Digital endocasts from 26 species were obtained from MicroCT scans and a set of 3D coordinates was digitized on endocast surfaces. Results indicate that Ateles, Brachyteles, Callicebus and Cacajao tend to have a rightward frontal and a leftward occipital lobe asymmetry, whereas Aotus, Callitrichinae and Cebinae have either the opposite pattern or no directional asymmetry. Such differences in the pattern of asymmetry were associated with group and home range sizes. Conversely, its magnitude was significantly associated with brain size, with larger-brained species showing higher inter-hemispheric differences. These findings support the hypothesis that reduction in inter-hemispheric connectivity in larger brains favors the lateralization and increases the structural asymmetries, whereas the patterns of shape asymmetry might be driven by socio-ecological differences among species.

Seasonal variation of inter-limb jumping asymmetries in youth team-sport athletes

ABSTRACT The main objective of the present study was to provide seasonal variation data for inter-limb asymmetry in youth elite team-sport athletes. Fifty-nine players performed the single-leg countermovement jump (SLCMJ) and the one leg hop for distance (OLHT) tests during pre-season, mid-season and end-season. A repeated-measures analysis of variance was conducted to determine magnitude differences in asymmetry scores between time points. Kappa coefficients (κ) were calculated to determine the levels of agreement for the direction of asymmetry. When comparing inter-limb asymmetry magnitudes across the season, the SLCMJ test showed significantly higher asymmetries at mid-season in comparison with pre-season and end-season (p< 0.01, d= −1.03 for pre to mid; p< 0.01, d= 1.12 for pre to end). However, OLHT inter-limb asymmetry magnitude remained consistent throughout the season (ES range = −0.02 to −0.06). For the direction of asymmetry, levels of agreement ranged from poor to slight in the SLCMJ (k= −0.10 to 0.18) and in the OLHT (k= −0.21 to 0.18). No significant differences were found between mean asymmetry values at any time point or for either test when comparing males and females. In conclusion, jump height asymmetry during the SLCMJ was the only metric to show significant magnitude changes across the season.

Relationship between Asymmetries Measured on Different Levels in Elite Basketball Players

In this study, we investigated the association of magnitude and agreement in direction between asymmetries measured on single-joint (hip and trunk), complex movement (jumping), and skill (change of direction (CoD)) levels. The study sample comprised 43 junior- and senior-level (age = 20.5 ± 6.0 years; height = 194.5 ± 7.2 cm; body mass = 86.8 ± 10.1 kg) elite male basketball players. Both limbs/sides were tested in hip and trunk isometric strength; passive range of motion (RoM); unilateral, horizontal, and vertical jumping; and CoD tests, from which asymmetry indexes were calculated. The associations between asymmetry magnitudes were calculated with Spearman’s ρ correlation coefficient. The agreement between the direction of asymmetries on different levels was calculated with Cohen’’s Kappa (κ) coefficient. The average magnitude of asymmetry varied substantially (2.9–40.3%). Most associations between asymmetry magnitudes measured on different levels were small and statistically non-significant, with a few exceptions of moderate and large associations. Asymmetry in single-leg countermovement jump parameters was strongly associated with hip abduction maximal strength (ρ = 0.58 and 0.50, p &lt; 0.01). Agreement between asymmetry directions was slight to fair, with a few moderate exceptions. Results indicate that multiple tests are needed to obtain a comprehensive picture of athletes’ asymmetries and that universal thresholds and golden standard tests for return to play should be reconsidered and reinvestigated.

Assessing the Magnitude and Direction of Asymmetry in Unilateral Jump and Change of Direction Speed Tasks in Youth Female Team-Sport Athletes.

The direction of inter-limb asymmetries and the change of direction (COD) deficit are two aspects that have increased in recent years. The main objective of the present study was to assess the magnitude of neuromuscular asymmetries in an elite youth female team-sports sample and determine its directionality. Secondary objectives were to evaluate the relationship between COD deficit, linear speed and COD time performance. Elite female youth basketball and handball players (n = 33, age = 16 ± 1.17 y) performed the Single Leg Countermovement Jump in vertical (SLCJ-V), horizontal (SLCJ-H), and lateral (SLCJ-L) directions, the COD and the 10-m sprint. Results showed statistical differences between limbs in all the neuromuscular tests (p < 0.001). The Kappa coefficient showed poor to fair levels of agreement between tasks (K range = -0.087 to 0.233), indicating that asymmetries rarely favoured the same limb between skills. Additionally, small and non-significant correlations were found between the linear sprint capacity and the COD ability. The findings of the present study highlight the independent directionality of asymmetries across tests. The COD deficit does not appear to be much more advantageous than COD total time to measure asymmetry. Practitioners are encouraged to use a fitness testing battery to detect existing side differences and each ability should be specifically trained with functional tasks.

Assessing Inter-Limb Asymmetries in Soccer Players: Magnitude, Direction and Association with Performance.

In this study, we aimed to analyze the magnitude and direction of inter-limb asymmetries in ankle dorsiflexion range of motion (ROM), power (using iso-inertial devices), and a neuromuscular skill (change of direction). Secondarily, we aimed to determine the relationship between inter-limb asymmetry scores for each test and also between these scores and the scores for the different performance tests. Sixteen semiprofessional male soccer players (age: 25.38 ± 6.08 years; body height: 1.78 ± 0.64 m; body mass: 79.5 ± 14.9 kg) participated in this study. We calculated inter-limb asymmetries using five tests: ankle dorsiflexion ROM, change of direction (COD 180º), and iso-inertial resistance tasks in the open (leg extension strength (LE), leg curl strength (LC)) and closed (crossover step (CRO)) kinetic chain. Our results showed that asymmetry magnitudes differed between all tests with highest inter-limb asymmetries displayed during iso-inertial overloading. In addition, we observed that the direction of asymmetries varied depending on the test-specificity, and that the CRO asymmetries had a negative association with LE and CRO performance. These findings highlight the independent nature of asymmetries and that CRO could be an appropriate test to detect asymmetries related with the performance of soccer-specific actions (such as changes of direction). Practitioners are encouraged to use multiple tests to detect existing inter-limb differences according to the specific characteristics of each sport.

Interference effects on intense XUV pulse induced resonant transitions between core ionized states of helium

In the context of core-resonant ionization of helium atom the inclusion of the He–He+(2p) ionization channel sets off a quantum mechanical interference between two competing pathways, He–He+(1s)–He+(2p) and He–He+(2p) (He–He+(1s) and He–He+(2p)–He+(1s)), thereby significantly modifying the line shape of the photoelectron spectrum. The signature of this interference arises as an asymmetry in the line shape of the multi-peak photoelectron spectra. On account of the discrepancies over the magnitude of the two photon photoionization cross section for the He–He+(2p) ionization channel the calculations have been performed for three different magnitudes of this photoionization cross section and the findings confirm that asymmetry in the line shape is prevalent for all the chosen cross sections. However, the magnitude of asymmetry depends on the magnitude of the photoionization cross section for the He–He+(2p) ionization channel. It is also interesting to note that at the considered laser peak intensities in this work an additional ionization channel from excited ionic state of helium plays a significant role in influencing the line shape of the photoelectron spectrum. The effects of pulse duration on the line shape of the photoelectron spectrum and the possibility to control the interference induced asymmetry in the multi peak line shape has also been investigated.

Topological edge states in an all-dielectric terahertz photonic crystal

We present an analysis of the robustness of topological edge states in an all-dielectric photonic crystal slab in the terahertz (THz) frequency domain. We initially design a valley photonic crystal (VPC) exhibiting a nontrivial band topology. The excitation of the topological edge states in the structure is facilitated through a zigzag domain wall constructed by interfacing two types of VPCs with distinct band topologies. The robustness of the excited edge states is probed with respect to the magnitude and the sign of the asymmetry in terms of the hole diameters in the VPC, for different domain interfaces. Our study reveals that the topological edge states in the VPC structure are achieved only when the domain walls are formed by the larger air holes (i.e., asymmetry parameter has a positive value). In the case of the domain walls formed by relatively smaller air holes (i.e., asymmetry parameter has a negative value), the topological protection of the edge states is forbidden. For positive asymmetry, we demonstrate that the topological transport of THz becomes more robust with the increasing magnitude of asymmetry in the VPC structure. A robust propagation of topological edge states and strong confinement of electromagnetic fields within the domain wall are observed for asymmetry ranging from 28% to 42% in our structure. We have adopted a generic technique and therefore, the results of our study could be achieved at other frequency regimes by scaling the size parameters of the structure appropriately. At THz frequencies, such extensive analysis on the robustness of the topological edge states could be relevant for the realization of low-loss waveguides for 6G communication and other integrated photonic devices.

Improving Business-to-Business Customer Satisfaction Programs: Assessment of Asymmetry, Heterogeneity, and Financial Impact

Business-to-business (B2B) companies devote significant resources to measure customer satisfaction but lack guidance on critical aspects of implementing satisfaction programs. Accordingly, executives ask: (1) What are the key strategic attributes driving B2B customer satisfaction? (2) Are the strategic attributes satisfaction balancing, satisfaction maintaining, or satisfaction enhancing based on the pattern of asymmetry? (3) Do the sign and magnitude of asymmetry vary across industry and customer subgroups? and (4) Is there a generalizable link between satisfaction and financial performance for B2B firms? Study 1 uses qualitative and secondary research to identify and validate eight strategic attributes pertinent to B2B companies: quality of product/service, pricing, safety, sales process, project management, corporate social responsibility, communication, and ongoing service and support. Study 2 examines industry-subgroup heterogeneity in the nature of asymmetry across industries, then links satisfaction with performance (i.e., sales). Study 3 finds customer-subgroup heterogeneity in the nature of asymmetry within the customer base of a B2B service provider, then links satisfaction with performance (i.e., dollar value of purchase).

Facial asymmetry assessment in skeletal Class III patients with spatially-dense geometric morphometrics.

Quantification and visualization of the location and magnitude of facial asymmetry is important for diagnosis and treatment planning. The objective of this study was to analyze the asymmetric features of the face for skeletal Class III patients using spatially-dense geometric morphometrics. Three-dimensional facial images were obtained for 86 skeletal Class III patients. About 7160 uniformly sampled quasi-landmarks were automatically identified on each face using template mapping technique. The pointwise surface-to-surface distance between original and mirror face was measured and visualized for the whole face after robust Procrustes superimposition. The degree of overall asymmetry in an individual was scored using a root-mean-squared-error. Automatic partitioning of the face was obtained, and the severity of the asymmetry compared among seven facial regions. Facial asymmetry was mainly located on, but not limited to, the lower two-thirds of the face in skeletal Class III patients. The lower cheek and nose asymmetry were detected to have more extensive and of a greater magnitude of asymmetry than other facial anatomical regions but with various individual variations. The overall facial asymmetry index and the regional facial asymmetry indices were higher in males and patients with chin deviation. Soft tissue asymmetry is predominately presented in the lower-third of the face in skeletal Class III patients and with various variations on other facial anatomical regions. Morphometric techniques and computer intensive analysis have allowed sophisticated quantification and visualization of the pointwise asymmetry on the full face.

Directional Bilateral Asymmetry in Fish Otolith: A Potential Tool to Evaluate Stock Boundaries?

The otolith, found in both inner ears of bony fish, has mainly been used to estimate fish age. Another application that has been developing significantly in recent years, however, is the use of otolith shape as a tool for stock identification. Often, studies have directly used the shape asymmetry between the right and left otoliths. We tested the magnitude of directional asymmetry between the sagittal otoliths (left vs. right) of 2991 individuals according to their catch locations, and we selected species to evaluate whether directional asymmetry may itself be a tool to evaluate stock boundaries. Elliptical Fourier descriptors were used to describe the otolith shape. We used a flatfish, the common sole (Solea solea, n = 2431), from the eastern English Channel and the southern North Sea as well as a roundfish, the bogue (Boops boops, n = 560), from the Mediterranean Sea. Both species showed significant levels of directional asymmetry between the testing locations. The bogue otoliths showed significant asymmetry for only 5 out of 11 locations, with substantial separation between two large areas: the Algerian coast and the western part of the Italian coast. The sole otoliths showed significant asymmetry in the shape analysis (3.84–6.57%), suggesting a substantial separation between two large areas: the English and French parts of the English Channel and the southern North Sea. Consequently, directional bilateral asymmetry in otolith shape is a potential new method for stock identification.

Prenatal Developmental Trajectories of Fluctuating Asymmetry in Bat Humeri.

Fluctuating asymmetry (random fluctuations between the left and right sides of the body) has been interpreted as an index to quantify both the developmental instabilities and homeostatic capabilities of organisms, linking the phenotypic and genotypic aspects of morphogenesis. However, studying the ontogenesis of fluctuating asymmetry has been limited to mostly model organisms in postnatal stages, missing prenatal trajectories of asymmetry that could better elucidate decoupled developmental pathways controlling symmetric bone elongation and thickening. In this study, we quantified the presence and magnitude of asymmetry during the prenatal development of bats, focusing on the humerus, a highly specialized bone adapted in bats to perform under multiple functional demands. We deconstructed levels of asymmetry by measuring the longitudinal and cross-sectional asymmetry of the humerus using a combination of linear measurements and geometric morphometrics. We tested the presence of different types of asymmetry and calculated the magnitude of size-controlled fluctuating asymmetry to assess developmental instability. Statistical support for the presence of fluctuating asymmetry was found for both longitudinal and cross-sectional asymmetry, explaining on average 16% of asymmetric variation. Significant directional asymmetry accounted for less than 6.6% of asymmetric variation. Both measures of fluctuating asymmetry remained relatively stable throughout ontogeny, but cross-sectional asymmetry was significantly different across developmental stages. Finally, we did not find a correspondence between developmental patterns of longitudinal and cross-sectional asymmetry, indicating that processes promoting symmetrical bone elongation and thickening work independently. We suggest various functional pressures linked to newborn bats’ ecology associated with longitudinal (altricial flight capabilities) and cross-sectional (precocial clinging ability) developmental asymmetry differentially. We hypothesize that stable magnitudes of fluctuating asymmetry across development could indicate the presence of developmental mechanisms buffering developmental instability.

A Technical Report on Reliability Measurement in Asymmetry Studies

Bailey, CA, Sato, K, and McInnis, TC. A Technical report on reliability measurement in asymmetry studies. J Strength Cond Res 35(7): 1779-1783, 2021-Much of the current literature on asymmetry in sport performance may be biased by evaluating reliability before quantifying the asymmetry metric. This technical report aimed to evaluate the reliability of asymmetry measurements in countermovement jumps (CMJs) by providing measures before production of asymmetry metrics, after production of scalar- and vector-based asymmetry metrics, and to analyze the resulting differences that can lead to misinformed decision making. Thirteen collegiate baseball players (19.9 ± 1.3 years, 82.2 ± 10.9 kg) participated in CMJ testing on 2 force plates to evaluate symmetry index (SI) scores as scalar (asymmetry magnitude only) and vector (asymmetry magnitude and direction) quantities. Relative and absolute reliability were evaluated for peak force (PF), scalar PF SI, and vector PF SI. Results showed that reliability measures produced on the constituent force-time variable provide much more favorable results compared with evaluating reliability of the asymmetry measure itself (coefficients of variation of 10.4-15.7% vs. 63.2-1,497.1%). Findings also showed that reliability is altered depending on whether asymmetry is quantified as a scalar or vector. Asymmetry should likely be quantified as a vector for reliability purposes because that allows variability in both magnitude and direction. These findings demonstrate that inadequate evaluation of reliability in asymmetry leads to biased results. Practitioners should use caution when considering the results of asymmetry assessments as they may not be as reliable as they are often portrayed.

Unilateral vs. bilateral hamstring strength assessments: comparing reliability and inter-limb asymmetries in female soccer players

ABSTRACT The aims in the present study were to assess reliability for two unilateral and two bilateral field-based hamstring assessments and compare magnitude, direction and agreement of inter-limb asymmetry between tests and sessions. Twenty-nine female soccer players (age: 21.1 ± 4.5 years; height: 169.7 ± 5.8 cm; body mass: 66.2 ± 6.4 kg) performed three repetitions per leg of unilateral isometric 30° and 90° knee flexion (KF) tasks, and three repetitions total for a bilateral 90° isometric KF and Nordic hamstring exercise. Absolute reliability of most methods were acceptable (<10%). Relative reliability within-session was fair to excellent (ICC≥0.784; lower bound 95%CI ≥0.623). Greater variability in between-session relative reliability was observed during the unilateral tests, demonstrating poor to good (ICC = 0.698–0.798; lower bound 95%CI = 0.274–0.638). Bilateral assessments demonstrated similar ranges of poor to excellent (ICC = 0.679–0.963; lower bound 95%CI = 0.231–0.790). Agreement between-session for inter-limb asymmetry identification was slight and fair in the unilateral tests, with moderate to substantial agreement demonstrated in the bilateral. Being the most reliable within- and between-sessions, demonstrating substantial agreement in asymmetry between-sessions, the NHE would be most appropriate to identify inter-limb asymmetry and assess chronic changes in hamstring strength.

International vs. national female tennis players: a comparison of upper and lower extremity functional asymmetries.

Asymmetries have been reported to negatively impact sport performance. This study examined the magnitude and direction of whole-body functional asymmetry in international versus national female tennis players. Ten internationally and twelve nationally ranked tennis players participated. Upper extremity functional asymmetries (or side-to-side performance differences) were evaluated using handgrip strength, seated shot-put throw and plate tapping. Lower extremity functional asymmetries were determined using the single leg countermovement jump, single leg forward hop test, 6 m single leg hop test, 505 changes of direction (time and deficit), and Y-balance test (anterior, posteromedial, posterolateral). ANOVAs were used to compare the dominant (overall best or fastest result of a specific test) versus non-dominant performance values (best or fastest result of the corresponding extremity) within the internationally versus nationally ranked players. Functional asymmetry magnitudes differences (expressed as a precentage) were examined using Mann-Whitney U tests. Kappa coefficients examined the consistency as to which extremity performed dominantly across tests. Significant asymmetries for every upper and lower extremity test were found. The functional asymmetry magnitude was significantly (P=0.020) higher on the single leg forward hop test for the nationally (6.3%) versus internationally ranked players (2.9%). Kappa coefficients showed perfect levels of consistency regarding all upper extremity tests (k=1.00), indicating true limb dominance whereas more variance was found as to which lower extremity performed dominantly across tests (k range=-0.067-0.174). The included female tennis players displayed significant whole-body functional asymmetries. Poor consistency as to which lower extremity performed dominantly across tests warrants individual asymmetry monitoring.

Biomechanical Symmetry during Drop Jump Landing and Takeoff in Adolescent Athletes Following Recent Anterior Cruciate Ligament Reconstruction

This study investigated asymmetry between lower extremities during the landing and takeoff phases of a vertical drop jump (VDJ) in adolescent athletes following anterior cruciate ligament reconstruction (ACLR) and examined if performance was affected by reducing jump height. Thirty-three athletes who underwent ACLR and were referred for 3D biomechanical assessment before returning to play (mean age 15.9, SD 1.3 years; 16/33 female; mean time since surgery 7.4, SD 1.2 months) completed the VDJ while kinematics and kinetics were collected using motion capture. Lower extremity symmetry was compared between phases using paired t-tests. Jump height was calculated to measure performance. Asymmetries in ankle inversion, ankle adduction, knee adduction, hip adduction, hip adduction moment, and hip rotation moment were observed in both phases. Asymmetry was also observed in both phases for sagittal moments and power integrals at the knee and ankle and total power integral, with the magnitude of asymmetry being smaller during takeoff for power absorption/generation. Jump height was related to power generation integrals during takeoff but not to the asymmetry of power generation. Since asymmetries are translated from landing through takeoff, rehabilitation should address both phases to decrease injury risk and maximize performance after return to play.

Kinematic Analysis of Lower Limb Joint Asymmetry During Gait in People with Multiple Sclerosis

The majority of people with Multiple Sclerosis (pwMS), report lower limb motor dysfunctions, which may relevantly affect postural control, gait and a wide range of activities of daily living. While it is quite common to observe a different impact of the disease on the two limbs (i.e., one of them is more affected), less clear are the effects of such asymmetry on gait performance. The present retrospective cross-sectional study aimed to characterize the magnitude of interlimb asymmetry in pwMS, particularly as regards the joint kinematics, using parameters derived from angle-angle diagrams. To this end, we analyzed gait patterns of 101 pwMS (55 women, 46 men, mean age 46.3, average Expanded Disability Status Scale (EDSS) score 3.5, range 1–6.5) and 81 unaffected individuals age- and sex-matched who underwent 3D computerized gait analysis carried out using an eight-camera motion capture system. Spatio-temporal parameters and kinematics in the sagittal plane at hip, knee and ankle joints were considered for the analysis. The angular trends of left and right sides were processed to build synchronized angle–angle diagrams (cyclograms) for each joint, and symmetry was assessed by computing several geometrical features such as area, orientation and Trend Symmetry. Based on cyclogram orientation and Trend Symmetry, the results show that pwMS exhibit significantly greater asymmetry in all three joints with respect to unaffected individuals. In particular, orientation values were as follows: 5.1 of pwMS vs. 1.6 of unaffected individuals at hip joint, 7.0 vs. 1.5 at knee and 6.4 vs. 3.0 at ankle (p &lt; 0.001 in all cases), while for Trend Symmetry we obtained at hip 1.7 of pwMS vs. 0.3 of unaffected individuals, 4.2 vs. 0.5 at knee and 8.5 vs. 1.5 at ankle (p &lt; 0.001 in all cases). Moreover, the same parameters were sensitive enough to discriminate individuals of different disability levels. With few exceptions, all the calculated symmetry parameters were found significantly correlated with the main spatio-temporal parameters of gait and the EDSS score. In particular, large correlations were detected between Trend Symmetry and gait speed (with rho values in the range of −0.58 to −0.63 depending on the considered joint, p &lt; 0.001) and between Trend Symmetry and EDSS score (rho = 0.62 to 0.69, p &lt; 0.001). Such results suggest not only that MS is associated with significantly marked interlimb asymmetry during gait but also that such asymmetry worsens as the disease progresses and that it has a relevant impact on gait performances.

Interhemispheric Auditory Cortical Synchronization in Asymmetric Hearing Loss.

Objectives:Auditory cortical activation of the two hemispheres to monaurally presented tonal stimuli has been shown to be asynchronous in normal hearing (NH) but synchronous in the extreme case of adult-onset asymmetric hearing loss (AHL) with single-sided deafness. We addressed the wide knowledge gap between these two anchoring states of interhemispheric temporal organization. The objectives of this study were as follows: (1) to map the trajectory of interhemispheric temporal reorganization from asynchrony to synchrony using magnitude of interaural threshold difference as the independent variable in a cross-sectional study and (2) to evaluate reversibility of interhemispheric synchrony in association with hearing in noise performance by amplifying the aidable poorer ear in a repeated measures, longitudinal study.Design:The cross-sectional and longitudinal cohorts were comprised of 49 subjects (AHL; N = 21; 11 male, 10 female; mean age = 48 years) and NH (N = 28; 16 male, 12 female; mean age = 45 years). The maximum interaural threshold difference of the two cohorts spanned from 0 to 65 dB. Magnetoencephalography analyses focused on latency of the M100 peak response from auditory cortex in both hemispheres between 50 msec and 150 msec following monaural tonal stimulation at the frequency (0.5, 1, 2, 3, or 4 kHz) corresponding to the maximum and minimum interaural threshold difference for better and poorer ears separately. The longitudinal AHL cohort was drawn from three subjects in the cross-sectional AHL cohort (all male; ages 49 to 60 years; varied AHL etiologies; no amplification for at least 2 years). All longitudinal study subjects were treated by monaural amplification of the poorer ear and underwent repeated measures examination of the M100 response latency and quick speech in noise hearing in noise performance at baseline, and postamplification months 3, 6, and 12.Results:The M100 response peak latency values in the ipsilateral hemisphere lagged those in the contralateral hemisphere for all stimulation conditions. The mean (SD) interhemispheric latency difference values (ipsilateral less contralateral) to better ear stimulation for three categories of maximum interaural threshold difference were as follows: NH (≤ 10 dB)—8.6 (3.0) msec; AHL (15 to 40 dB)—3.0 (1.2) msec; AHL (≥ 45 dB)—1.4 (1.3) msec. In turn, the magnitude of difference values were used to define interhemispheric temporal organization states of asynchrony, mixed asynchrony and synchrony, and synchrony, respectively. Amplification of the poorer ear in longitudinal subjects drove interhemispheric organization change from baseline synchrony to postamplification asynchrony and hearing in noise performance improvement in those with baseline impairment over a 12-month period.Conclusions:Interhemispheric temporal organization in AHL was anchored between states of asynchrony in NH and synchrony in single-sided deafness. For asymmetry magnitudes between 15 and 40 dB, the intermediate mixed state of asynchrony and synchrony was continuous and reversible. Amplification of the poorer ear in AHL improved hearing in noise performance and restored normal temporal organization of auditory cortices in the two hemispheres. The return to normal interhemispheric asynchrony from baseline synchrony and improvement in hearing following monoaural amplification of the poorer ear evolved progressively over a 12-month period.

Commonly used clinical criteria following ACL reconstruction including time from surgery and isokinetic limb symmetry thresholds are not associated with between-limb loading deficits during running

ObjectivesWe included objective measures of gait and functional assessments to examine their associations in athletes who had recently commenced running after ACL reconstruction. DesignCross-sectional. SettingSports medicine. Participants65 male athletes with a history of ACL reconstruction. Main outcome measuresTime from surgery, isokinetic knee extension/flexion strength (60°/s), and peak vertical ground reaction force (pVGRF) measured during running using an instrumented treadmill. We also investigated if a range of recommended isokinetic thresholds (e.g. > 70% quadriceps limb symmetry index) affected the magnitude of pVGRF asymmetry during running. ResultsThere were significant relationships between quadriceps (r = 0.50) and hamstrings (r = 0.46) peak torque and pVGRF. Quadriceps peak torque explained a quarter of the variance in pVGRF (R2 = 0.24; p < 0.001). There was no association was between running pVGRF and time from surgery. Between-group differences in running pVGRF LSI% were trivial (d < 0.20) for all quadriceps and hamstring peak torque LSI thresholds. ConclusionsCurrent clinical criteria including time from surgery and isokinetic strength limb symmetry thresholds were not associated with lower pVGRF asymmetry measured during running. Quadriceps strength is important, but ‘minimum symmetry thresholds’ should be used with caution.