In many gear drives, one side of the flank is subjected to relatively higher load for a longer duration than the other side. Asymmetric spur gears with drive side pressure angle higher than the coast side reflects this functional difference. Conventional design criteria and procedures followed for symmetric spur gears are suitably modified and applied to predict the gear tooth bending, contact stress and power loss in asymmetric spur gears. Quasi-static gear tooth load and empirical friction coefficient formulae were applied in the past to predict the sliding power loss in asymmetric spur gears. In the present work, Finite element method is used to determine the time varying mesh stiffness of the normal contact ratio asymmetric spur gear tooth. Computed gear tooth stiffness is used to predict the dynamic load at two different speeds under non-extended contact condition. Sliding power loss during the course of meshing is analytically calculated under quasi static and dynamic load conditions. Study demonstrates the difference in sliding power loss computed based on friction formulae and empirical friction coefficient formulae under static and dynamic load.