Asymmetric Body Research Articles

Motion of asymmetric bodies in two-dimensional shear flow

At low Reynolds numbers, axisymmetric ellipsoidal particles immersed in a shear flow undergo periodic tumbling motions known as Jeffery orbits, with the orbit determined by the initial orientation. Understanding this motion is important for predicting the overall dynamics of a suspension. While slender fibres may follow Jeffery orbits, many such particles in nature are neither straight nor rigid. Recent work exploring the dynamics of curved or elastic fibres have found Jeffery-like behaviour along with chaotic orbits, decaying orbital constants and cross-streamline drift. Most work focuses on particles with reflectional symmetry; we instead consider the behaviour of a composite asymmetric slender body made of two straight rods, suspended in a two-dimensional shear flow, to understand the effects of the shape on the dynamics. We find that for certain geometries the particle does not rotate and undergoes persistent drift across streamlines, the magnitude of which is consistent with other previously identified forms of cross-streamline drift. For this class of particles, such geometry-driven cross-streamline motion may be important in giving rise to dispersion in channel flows, thereby potentially enhancing mixing.

Modeling of the optimal deceleration for the rotatory motion of asymmetric rigid body

This paper investigates a minimum time of the 3D slowing rotatory motion of free asymmetric rigid body under the influence of a rotatory moment of viscous friction and a gyrostatic one. It is considered that the body center of mass coincides with the origin point of two Cartesian frames. The law of optimal control for the slow body’s rotation is formulated, and the associated time and phase paths are evaluated. The achieved novel results are obtained and plotted for two new cases in some graphical representations to detect the good effects of the gyrostatic moment. The comparison between our results and the previous one shows great consistency between them in the absence of influence of the gyrostatic moment, in which the differences between them are discussed. Therefore, the attained results generalized those which were obtained in previous works. The relevance of this work is due to its practical applications, especially for the gyroscopic theory applications in maintaining stability and determining the ordination of aircraft and submarine vehicles.

Classical and Quantum Controllability of a Rotating Asymmetric Molecule

We study both the classical and quantum rotational dynamics of an asymmetric top molecule, controlled through three orthogonal electric fields that interact with its dipole moment. The main difficulties in studying the controllability of these infinite-dimensional quantum systems are the presence of severe spectral degeneracies in the drift Hamiltonian and the nonsolvability of the stationary free Schrödinger equation, which lead us to apply a perturbative Lie algebraic approach. In this paper we show that, while the classical equations given by the Hamiltonian system on $$\mathrm{SO}(3)\times {\mathbb {R}}^3$$ are controllable for all values of the rotational constants and all dipole configurations, the Schödinger equation for the quantum evolution on $$L^2(\mathrm{SO}(3){,{\mathbb {C}}})$$ is approximately controllable for almost all values of the rotational constants if and only if the dipole is not parallel to any of the principal axes of inertia of the asymmetric rigid body.

Semi-Regular Precession of an Asymmetrical Rigid Solid Body Filled with a Liquid

Semi-Regular Precession of an Asymmetrical Rigid Solid Body Filled with a Liquid

Estimation of the probability of two consecutive passages through resonance during the descent of an asymmetric rigid body in a rarefied atmosphere

A two-frequency nonlinear system of ordinary differential equations is considered. This system describes the perturbed motion of a rigid body with considerable asymmetry in a rarefied atmosphere. It is known that when the frequencies of this system of equations coincide, the phenomena of capture or passage through the principal resonance, which have a random nature, are possible. In this case, the probability of a passage through the resonance is calculated from the initial conditions on the separatrix. The objective of this study is to obtain an expression for estimating the probability of two consecutive passages through the resonance regions during the descent in the rarefied atmosphere of Mars of a rigid body with significant geometric and aerodynamic asymmetry.

Phased contests allow rapid hierarchy formation in paired bumble bee workers

A primary approach to establishing hierarchy is through contests, in which conflicts are settled using various behavioural patterns. Although dominance ranks in a hierarchy are determined by quality-related innate factors, how the inequality of competitors is assessed and triggers the formation of a hierarchy by means of behavioural interactions remains unclear. Here, we report the sequence of aggressive behaviours that mediates the onset of hierarchy formation in eusocial bumble bee workers by continuously monitoring pairwise contests. Sequential analysis characterized the dynamics of the behavioural repertoire during hierarchy formation in Bombus terrestris ; this was organized in phases associated with a divergence in dominance rank and included mutual pumping (a dorsoventral abdominal movement), bilateral physical contact and unilateral strikes. Escalated bilateral aggression served as a mutual assessment strategy and caused a rapid divergence in rank in evenly matched contests. Head butting was subsequently performed by dominants, suggesting it is a badge of higher rank. The behavioural progression was also similar in two other Bombus species despite interspecific variation in behavioural patterns. Size asymmetry reduced the duration of bilateral aggression, while age advantages over callow workers eliminated bilateral aggression. These results suggested potential roles of mutual assessment by ritualized fighting in hierarchy formation in queenless bumble bee societies. • When bumble bee workers form a hierarchy, fighting behaviours are arranged in phases. • Bilateral aggression is used to assess rivals, leading to a rapid divergence in ranks. • Mutual assessment may be a strategy to solve workers' conflicts across Bombus species. • Asymmetric body size and age profoundly affect contest phases.

Stability of a Uniform Rotation of an Asymmetric Rigid Body in a Resisting Medium under a Constant Moment

Stability of a Uniform Rotation of an Asymmetric Rigid Body in a Resisting Medium under a Constant Moment

Oscillation of a balanced hollow cylinder on an inclined plane

The static and dynamic properties of an asymmetric rigid body are studied using a Lagrangian approach. The body consists of a thin-walled cylinder balanced by a point mass attached to its inner surface. When resting on an inclined plane, stable and unstable equilibrium points are found, and oscillations about the stable point are studied for different angles of inclination and different values of the balancing mass. The analysis illustrates the utility of Lagrangian mechanics, and the derived results can be experimentally verified using simple materials.

Review on Medical Implantable Antenna Technology and Imminent Research Challenges.

Implantable antennas are mandatory to transfer data from implants to the external world wirelessly. Smart implants can be used to monitor and diagnose the medical conditions of the patient. The dispersion of the dielectric constant of the tissues and variability of organ structures of the human body absorb most of the antenna radiation. Consequently, implanting an antenna inside the human body is a very challenging task. The design of the antenna is required to fulfill several conditions, such as miniaturization of the antenna dimension, biocompatibility, the satisfaction of the Specific Absorption Rate (SAR), and efficient radiation characteristics. The asymmetric hostile human body environment makes implant antenna technology even more challenging. This paper aims to summarize the recent implantable antenna technologies for medical applications and highlight the major research challenges. Also, it highlights the required technology and the frequency band, and the factors that can affect the radio frequency propagation through human body tissue. It includes a demonstration of a parametric literature investigation of the implantable antennas developed. Furthermore, fabrication and implantation methods of the antenna inside the human body are summarized elaborately. This extensive summary of the medical implantable antenna technology will help in understanding the prospects and challenges of this technology.

Prenatal Sildenafil treatment prevents postpartum neuroinflammation in the Dahl‐SS/Jr model of superimposed preeclampsia

Superimposed preeclampsia is diagnosed in women with chronic hypertension who develop preeclampsia (proteinuria or end organ symptoms) after the 20th week of gestation. Superimposed preeclampsia can be detrimental to both the mother and fetus. Pregnant Dahl-SS/Jr rats display chronic hypertension and kidney dysfunction and exhibit many clinical findings of preeclampsia patients including hypertension, proteinuria, placental hypoxia, increased sFlt-1 & TNF-alpha, and fetal growth restriction. Sildenafil, a phosphodiesterase-5 inhibitor, has been studied as a potential therapeutic in preeclampsia patients, and we have shown that sildenafil treatment in the Dahl-SS/Jr improves maternal and fetal outcomes. Thus, we tested the hypothesis that the Dahl-SS/Jr rat model of superimposed preeclampsia will have increased neuroinflammation, evidenced by increased microglia density and frequency of activated microglia in the postpartum period, which will be attenuated by sildenafil treatment. Dahl-SS/Jr virgins (DV, n=8), prior pregnant (DP, n=9), and prior pregnant treated (DS, n=5) rats were used. DS rats received 50mg/kg/day of sildenafil from gestational day (GD)10 until delivery. DP and DS rats were mated again at 4.5 months old for a second pregnancy, receiving sildenafil (50mg/kg/day) as before. At 3.5 months postpartum, brains were harvested and processed for immunofluorescence staining. Anterior brain sections were cut into 20 µm thick sections and stained for microglia using ionized calcium-binding adapter molecule 1 (Iba-1). Z-stacks (0.5μm steps) were obtained using a confocal microscope, and microglia density, soma size, and morphology in the hippocampus and cortex were analyzed using Image J. Microglia morphology was quantified as follows: Type 1 microglia had small cell bodies and long, thin (ramified) processes. Type 2 microglia included those with asymmetrical cell body and long processes, Type 3 had rounded cell bodies and shorter, thicker processes, and Type 4 included those with round, enlarged cell bodies and short to no visible processes. In the hippocampus, DS rats had smaller microglia soma [DV: 65±2, DS: 58±5, DP: 68±2µm2; p= 0.06], with no difference in microglia density. Prenatal Sildenafil prevented hippocampal microglia activation with decreased type 3 activated microglia [DS: 85±4, DP: 95±2, DV: 86±4%, p= 0.01] as well as increased surveying type 2 microglia [DS: 13±4, DP: 5±2, DV: 12±4%, p= 0.01]. No significant microglia morphology change was found in the cortex. Our results support the hypothesis that superimposed preeclampsia induces postpartum hippocampal microglia activation which is prevented by prenatal sildenafil treatment. Ongoing and future studies will determine whether microglia activation occurs during pregnancy and whether postpartum neuroinflammation is associated with cognitive impairment.

Agonistic interactions with asymmetric body size in two adult-age groups of the annual killifish Millerichthys robustus (Miller & Hubbs,1974).

In this study, the author evaluated two adult age groups of the Mexican rivulus Millerichthys robustus with body size asymmetries to determine the strategies used by an annual killifish during agonistic interactions of different ontogenetic stages. To achieve this goal, the author first characterized the ethogram of agonistic interactions of M. robustus composed of seven behavioural units in males and five behavioural units in females. The author then analysed agonistic interaction strategies used by males and females with body size asymmetries in two groups of different adult ages that represent different ontogenetic stages: (a) just after sexual maturity was reached, at 5 weeks of age, and (b) near natural death, at 24 weeks of age. The agonistic behaviour patterns of M. robustus were compatible with the logic of mutual assessment. Large males had an advantage during their interactions in both age groups, winning all of the encounters. Nonetheless, there was more aggression in 5-week-old fish encounters. In addition, small 24-week-old fish were more aggressive than small 5-week-old fish. These changing strategies may be because of the cost-benefits required during a fight at each ontogenetic stage. In the female encounters, size did not predict winners, as both small and large fish won a similar number of encounters, and some contests remained unresolved regardless of age group. There was a tendency for small females of any age to risk more than males in fights to maintain reproductive fitness.

Maternofetal inflammation induced for 2 wk in late gestation reduced birth weight and impaired neonatal growth and skeletal muscle glucose metabolism in lambs.

Intrauterine stress impairs growth and metabolism in the fetus and offspring. We recently found that sustained maternofetal inflammation resulted in intrauterine growth-restricted (MI-IUGR) fetuses with asymmetric body composition, impaired muscle glucose metabolism, and β-cell dysfunction near term. These fetuses also exhibited heightened inflammatory tone, which we postulated was a fetal programming mechanism for the IUGR phenotype. Thus, the objective of this study was to determine whether poor growth and metabolism persisted in MI-IUGR lambs after birth. Polypay ewes received serial lipopolysaccharide or saline injections in the first 2 wk of the third trimester of pregnancy to produce MI-IUGR (n = 13) and control (n = 12) lambs, respectively. Lambs were catheterized at 25 d of age. β-Cell function was assessed at 29 d, hindlimb glucose metabolism at 30 d, and daily blood parameters from day 26 to 31. Glucose metabolism was also assessed in flexor digitorum superficialis (FDS) muscle isolated at necropsy on day 31. Asymmetric body composition persisted in MI-IUGR neonates, as these lambs were lighter (P < 0.05) than controls at birth and 31 d, but body and cannon bone lengths did not differ at either age. FDS muscles from MI-IUGR lambs were smaller (P < 0.05) and exhibited reduced (P < 0.05) glucose oxidation and Akt phosphorylation but similar glucose uptake compared with controls when incubated in basal or insulin-spiked media. Similarly, hindlimb glucose oxidation was reduced (P < 0.05) in MI-IUGR lambs under basal and hyperinsulinemic conditions, but hindlimb glucose utilization did not differ from controls. Circulating urea nitrogen and cholesterol were reduced (P < 0.05), and triglycerides, high-density lipoprotein cholesterol, and glucose-to-insulin ratios were increased (P < 0.05) in MI-IUGR lambs. Glucose and insulin concentrations did not differ between groups during basal or hyperglycemic conditions. Although circulating monocyte and granulocyte concentrations were greater (P < 0.05) in MI-IUGR lambs, plasma tumor necrosis factor α (TNFα) was reduced (P < 0.05). FDS muscle contained greater (P < 0.05) TNF receptor 1 (TNFR1) and IκBα protein content. These findings indicate that maternofetal inflammation in late pregnancy results in fetal programming that impairs growth capacity, muscle glucose oxidation, and lipid homeostasis in offspring. Inflammatory indicators measured in this study appear to reflect heightened cytokine sensitivity in muscle and compensatory systemic responses to it.

Particle-in-cell simulations of the Cassini spacecraft’s interaction with Saturn’s ionosphere during the Grand Finale

ABSTRACT A surprising and unexpected phenomenon observed during Cassini’s Grand Finale was the spacecraft charging to positive potentials in Saturn’s ionosphere. Here, the ionospheric plasma was depleted of free electrons with negatively charged ions and dust accumulating up to over 95 per cent of the negative charge density. To further understand the spacecraft–plasma interaction, we perform a three-dimensional Particle-In-Cell study of a model Cassini spacecraft immersed in plasma representative of Saturn’s ionosphere. The simulations reveal complex interaction features such as electron wings and a highly structured wake containing spacecraft-scale vortices. The results show how a large negative ion concentration combined with a large negative to positive ion mass ratio is able to drive the spacecraft to the observed positive potentials. Despite the high electron depletions, the electron properties are found as a significant controlling factor for the spacecraft potential together with the magnetic field orientation which induces a potential gradient directed across Cassini’s asymmetric body. This study reveals the global spacecraft interaction experienced by Cassini during the Grand Finale and how this is influenced by the unexpected negative ion and dust populations.

Food intake, growth, and expression of neuropeptides regulating appetite in clown anemonefish (Amphiprion ocellaris) exposed to predicted climate changes

The clown anemonefish (Amphiprion ocellaris) is a common model species in studies assessing the impact of climate changes on tropical coral fish physiology, metabolism, growth, and stress. However, the basic endocrine principles for the control of food intake and energy homeostasis, under normal and elevated sea temperatures, in this species remain unknown. In this work, we studied food intake and growth in clown anemonefish reared at different temperatures and with different food availability. We also analyzed expression of genes in the melanocortin system, which is believed to be involved in the control of appetite and feeding behavior. These were two paralogues of pomc: pomca and pomcb; two paralogs of agrp: agrp1 and agrp2; and one mc4r-like. Groups of juvenile clown anemonefish were exposed to four experimental treatments combining (orthogonal design) two rearing temperatures: 28 °C (T28; normal) and 32 °C (T32; high) and two feeding regimes: one (1 M; 08:00) or three (3 M; 08:00, 12:00, 15:00) meals per day, fed to satiety by hand. The results showed that high temperature (T32) did not affect the average growth rate but induced a stronger asymmetrical individual body weight of the fish within the population (tank). Lower feeding frequency (1 M) resulted in lower growth rates at both rearing temperatures. Fish reared at high temperature had higher total daily food intake, which correlated with a lower expression of pomca, supporting an anorexigenic role of this gene. High temperature combined with restricted feeding induced higher agrp1 levels and resulted in a higher food intake in the morning meal compared to the control. This supports an orexigenic role for agrp1. mRNA levels of agrp2 responded differently from agrp1, supporting different roles for the paralogues. Levels of mc4r-like inversely correlated with fish body weight, indicating a possible size/stage dependence of gene expression. In conclusion, our results indicate that the melanocortin system is involved in adjusting appetite and food intake of clown anemonefish in response to elevated temperature and low food availability.

Single-nucleotide polymorphisms responsible for pseudo-albinism and hypermelanosis in Japanese flounder (Paralichthys olivaceus) and reveal two genes related to malpigmentation.

Paralichthys olivaceus is the kind of cold-water benthic marine fish. In the early stages of development, the symmetrical juveniles transform into an asymmetrical body shape through metamorphosis for adapting benthic life. After that, one side of the fish body is attached to the ground, and the eyes turn to the opposite side which is called ocular side. The body color also appears asymmetry. The skin on the ocular side is dark brown, and the skin on the blind side is white without pigmentation. Pseudo-albinism and hypermelanosis have been considered distinct body color disorders in flatfish. Pseudo-albinism and hypermelanosis in Paralichthys olivaceus are due to abnormal or uneven pigment distribution, due to the interaction of hereditary and environmental factors, rather than a single-nucleotide mutation of a specific gene. Here, we report three single-nucleotide polymorphisms (SNPs) responsible for both pseudo-albinism and hypermelanosis, which are located on two body color-related genes involved in melanogenesis-related pathways. c.2440C>A (P. V605I) and c.2271-96T>C are located on the Inositol 1,4,5-trisphosphate receptor type 2-like (ITPR2) (Gene ID: 109624047), they are located in exon 16 and the non-coding region, respectively, and c.2406C>A (P.H798N) is located in exon 13 of the adenylate cyclase type 6-like (AC6) gene(Gene ID: 109630770). ITPR2 and AC6 expression, which both participate in the thyroid hormone synthesis pathway associated with pseudo-albinism and hypermelanosis in P. olivaceus, were also investigated using qRT-PCR. In hypermelanotic fish, there were relatively higher levels of expression in ITPR2 and AC6 mRNA of hyper-pigmented skin of blind side than that of non-pigmented skin on the blind side and pigmented skin on the ocular side, while in pseudo-albino fish, expression level of ITPR2 and AC6 mRNA in pigmented skin of ocular side was significantly higher than that in non-pigmented skin both ocular and blind side. The results indicated that the expression of the two genes in abnormal parts of body color is positively correlated with pigmentation, suggesting that the influence of abnormal expression of two genes on the pigmentation in abnormal parts of body color deserves further study.

Particular Extremals in the Optimal Control Problems of the Reorientation of an Asymmetric Rotating Body

The optimal control problem regarding the reorientation of an asymmetric rigid body has been investigated. The integral-quadratic functional consistent with the inertial symmetry of the body, which characterizes the total energy consumption, has been chosen as the criterion. Control is considered to be the main moment of applied external forces. An explicit description of a family of extremals for an arbitrary asymmetric rigid body has been obtained. The idea of constructing such extremals is based on the study of spatio-temporal deformations for solutions of Euler differential equations of a rigid body’s free rotation.

258 Deficits in growth, muscle mass, and body composition following intrauterine growth restriction persisted in lambs at 60 d of age but were improved by daily clenbuterol supplementation

Abstract Intrauterine growth restriction (IUGR) reduces neonatal muscle growth and alters body composition in livestock. Our objective was to determine the effect of IUGR on juvenile growth and assess the benefits of treatment with clenbuterol (β2 adrenergic agonist) in IUGR offspring. Heat stress-induced IUGR lambs were born 28% lighter (P &amp;lt; 0.05) than controls. At 60 d of age, unsupplemented IUGR lambs had reduced (P &amp;lt; 0.05) bodyweight (BW), average daily gain, and crown-rump length compared to controls, but clenbuterol-supplemented IUGR lambs did not differ from controls. Crown circumference, body girth, and cannon bone length did not differ among groups. Bioelectrical impedance in live lambs and carcasses estimated that lean mass and mass of multiple muscle groups were reduced (P &amp;lt; 0.05) in unsupplemented IUGR lambs but not clenbuterol-supplemented IUGR lambs compared to controls. Estimated protein, fat, and protein/fat were likewise reduced (P &amp;lt; 0.05) in unsupplemented but not clenbuterol-supplemented IUGR lambs. Loin-eye area in chilled carcasses was 30% smaller (P &amp;lt; 0.05) in unsupplemented IUGR lambs but 19% larger (P &amp;lt; 0.05) in clenbuterol-supplemented IUGR lambs compared to controls. Proximate analysis revealed greater (P &amp;lt; 0.05) fat and reduced (P &amp;lt; 0.05) protein and protein/fat in loin muscles from unsupplemented but not clenbuterol-supplemented IUGR lambs compared to controls. At necropsy, hindlimbs, hearts, and flexor digitorum superficialis muscles tended to be lighter (P ≤ 0.09) and lungs and kidneys were lighter (P &amp;lt; 0.05) in IUGR lambs. Kidney weight was further reduced (P &amp;lt; 0.05) in clenbuterol-supplemented IUGR lambs. Brain/BW tended to be reduced (P ≤ 0.09) and lung/BW and kidney/BW were reduced (P &amp;lt; 0.05) in IUGR lambs, but lung weight and lung/BW were greater (P &amp;lt; 0.05) in clenbuterol-supplemented compared to unsupplemented IUGR lambs. We conclude that poor growth and asymmetric body composition previously observed in IUGR neonates persists in juveniles, but daily treatment with clenbuterol recovered growth and improved body composition in IUGR lambs.

Direct and inverse secondary resonance effects in the spherical motion of an asymmetric rigid body with moving masses

Secondary resonance effects in the spherical motion of a heavy asymmetrical rigid body with moving masses are reviewed in the case close to the Lagrange top. It is known that perturbations acting on the body, particularly a small displacement of the center of mass with respect to axis of symmetry and a small perturbing moment in a connected system of coordinates, lead to non-resonant evolutions of angular velocity. These evolutionary phenomena are called direct secondary resonance effects. They are visible in a dynamic system consisting of an asymmetric rigid body and several masses fixed relative to the body. However, the presence of moving masses connected to a rigid body by springs may lead to the stabilization of the angular velocity of the body. This dynamic phenomenon should be attributed to the inverse secondary resonance effect. The aim of this paper is to study the characteristic direct and inverse secondary resonance effects in a perturbed spherical motion of a rigid body with fixed and moving masses. The method of integral manifolds and the averaging method are used for the asymptotic analysis of the secondary resonance effects. The paper presents the numerical results of modeling the direct and inverse resonance effects.

Compassionate use of everolimus for refractory epilepsy in a patient with MTOR mosaic mutation

The MTOR gene encodes the mechanistic target of rapamycin (mTOR), which is a core component of the PI3K-AKT-mTOR signaling pathway. Postzygotic MTOR variants result in various mosaic phenotypes, referred to in OMIM as Smith-Kinsgmore syndrome or focal cortical dysplasia. We report here the case of a patient, with an MTOR mosaic gain-of-function variant (p.Glu2419Lys) in the DNA of 41% skin cells, who received compassionate off-label treatment with everolimus for refractory epilepsy. This 12-year-old-girl presented with psychomotor regression, intractable seizures, hypopigmentation along Blaschko's lines (hypomelanosis of Ito), asymmetric regional body overgrowth, and ocular anomalies, as well as left cerebral hemispheric hypertrophy with some focal underlying migration disorders. In response to the patient's increasingly frequent epileptic seizures, everolimus was initiated (after approval from the hospital ethics committee) at 5 mg/day and progressively increased to 12.5 mg/day. After 5 months of close monitoring (including neuropsychological and electroencephalographic assessment), no decrease in seizure frequency was observed. Though the physiopathological rationale was good, no significant clinical response was noticed under everolimus treatment. A clinical trial would be needed to draw conclusions, but, because the phenotype is extremely rare, it would certainly need to be conducted on an international scale.

The Esmolfe-Matança granite (Penalva do Castelo, central Portugal): A keystone to understand the ascent and emplacement of magmas under low tectonic stress

The Esmolfe–Matança ilmenite-type granite is analyzed using petrography, microstructures, anisotropy of magnetic susceptibility and microfracturing. The granite occurs in two separated bodies outcropping in distinct villages, Esmolfe and Matança, which are located in the termination of the Juzbado-Penalva do Castelo (JPCSZ) and Dúrico-Beirão (DBSZ) shear zones. The petrography shows a progressive textural overprint from magmatic, through high-, medium- and low-T solid-state deformation microstructures. The presence of dominantly magmatic microstructures and the absence of deformation patterns at macroscopic scale, may indicate an emplacement under low tectonic stress. The directional magnetic data indicates a magma ascending and emplacement conditioned by the JPCSZ and DBSZ. The magma passive intruded upwards, along the confluence zone between the JPCSZ and DBSZ, and it spread laterally forming an asymmetric laccolithic body. The DBSZ worked as physical barrier in Esmolfe, avoiding the spreading of the magma to the north, leading to the rotation of the magnetic lineations and foliations, drawing onion-type trajectories. In Matança the magnetic lineations and foliations are dominantly NW-SE oriented in the western side, and ENE-WSW oriented in the eastern side, parallel to the JPCSZ regional trend. The fluid inclusions planes demonstrated three distinct brittle deformational events linked to the rotation of σ1.