Astringent Properties Research Articles

MANAGEMENT OF UTERINE FIBROID (SAL‘An AL-RAHIM) IN THE UNANI MEDICINE PERSPECTIVE - A CASE STUDY

Uterine fibroids, historically known as "uterine stones," represent a prevalent gynaecological condition affecting a significant proportion of women globally. This paper explores the Unani perspective on uterine fibroids, termed as “Sal‘at”, within the context of "waram Balghamī ." Drawing from classical Unani texts and contemporary case studies, it examines the etiology, classification, and treatment approaches proposed by eminent Unani scholars such as Razi, Ali Ibn-e-Abbas Majusi, and Ibn-e-Sina. Utilising herbal formulations with anti-inflammatory and astringent properties, Unani medicine aims to dissolve and expel abnormal phlegm, thereby alleviating symptoms and reducing fibroid size. A case study involving a 35-year-old woman illustrates the successful application of Unani treatment, resulting in significant symptomatic relief and fibroid resolution without surgical intervention. This research underscores the potential of Unani medicine as a holistic and effective alternative for managing uterine fibroids, advocating for its integration into modern healthcare practices.

Physico-Chemical Properties of Granular Sorbents Based on Natural Bentonite Modified by Polyhydroxocations of Aluminum and Iron (III) by Co-Precipitation.

The physicochemical and adsorption properties of granular sorbents based on natural bentonite and modified sorbents based on it have been studied. It was found that modification of natural bentonite with iron (III) polyhydroxocations (mod. 1_Fe_5 GA) and aluminum (III) (mod. 1_Al_5 GA) by the "co-precipitation" method leads to a change in their chemical composition, structure, and sorption properties. It is shown that modified sorbents based on natural bentonite are finely porous (nanostructured) objects with a predominance of pores measuring 1.5-8.0 nm, with a specific surface area of 55-65 m2/g. Modification of bentonite with iron (III) and aluminum compounds by the "co-precipitation" method also leads to an increase in the sorption capacity of the obtained sorbents with respect to bichromate and arsenate anions and nickel cations by 5-10 times compared with natural bentonite. The obtained sorption isotherms were classified as Langmuir type isotherms. Kinetic analysis showed that at the initial stage the sorption process is controlled by an external diffusion factor, i.e. refers to the diffusion of sorbent from solution into a liquid film on the surface of the sorbent. Then the sorption process begins to proceed in a mixed diffusion mode, when it limits both the external diffusion factor and the internal diffusion factor (the diffusion of the sorbent to the active centers through the system of pores and capillaries). To determine the contribution of the chemical stage to the rate of adsorption of bichromate and arsenate anions and nickel(II) cations with the studied granular sorbents, kinetic curves were processed using the equations of chemical kinetics (pseudo-second-order model). As a result, it was found that the adsorption of the studied anions by modified sorbents based on natural bentonite is best described by a pseudo-second-order kinetic model. It is shown that the use of natural bentonite for the development of technology for the production of granular sorbents based on it has an undeniable advantage, firstly, in terms of its chemical and structural properties, it is easily and effectively modified, and secondly, having astringent properties, granules are easily made on its basis, which turn into ceramics during high-temperature firing. The result is a granular sorbent with high physical and mechanical properties. Since bentonite is an environmentally friendly product, the technology of recycling spent sorbents is also greatly simplified.

Investigation of the impurity effect on the kinetics of thermal decomposition of natural gypsum at high temperatures

Natural gypsum is the most common sulfate on our planet, which is widely used in construction due to its excellent astringent properties, environmental friendliness, thermal and fire resistance, accessibility in nature and low price. Currently, the influence of modifiers, impurities and additives that can improve the strength, acoustic and thermal insulation characteristics of gypsum, which is so important in modern architecture, construction and reducing power consumption, is being increasingly studied. However, additives and impurities, controlled and uncontrolled, as in natural gypsum, can unpredictably affect the thermal stability and fire resistance of gypsum. The purpose of our work is to study the thermal characteristics of gypsum from various deposits in a wide temperature range. Our work shows that the temperature and rate of dissociation of gypsum directly depends on impurities that can change the process of its decomposition. As a result of the decomposition of natural gypsum with impurities, new phases are formed.It has been experimentally shown that the process of thermal destruction of gypsum with impurities has a complex multistage character, which is described by successive reactions of the nth order of the Avrami-Erofeev equation. It can be assumed that the reaction mechanism consists in the rapid formation of numerous nucleation centers on the surface of solid anhydrite. Kinetic parameters of thermal decomposition of gypsum of complex composition and phase formation at high temperatures are calculated. This experimental study shows the dependence of thermal stability on the amount and grade of impurities in gypsum. The results obtained contribute to the improvement of the basic concepts of the mechanism of decomposition of gypsum, as well as the explanation of some high-temperature phase formation processes in nature.

Database, prediction, and antibacterial research of astringency based on large language models

Astringency, a sensory experience causing mouth dryness, significantly impacts the taste of foods such as wine and tea, and astringent molecules may exhibit antibacterial properties. Traditional methods for predicting astringency are costly, and the connection between astringency and antibacterial activity remains largely unexplored. In this study, we present a pioneering computational approach that includes: (1) the creation of the first comprehensive astringency database comprising 238 molecules; (2) the development of a Ligand-Based Prediction (LBP) framework that combines large language models, deep learning, and traditional machine learning for enhanced molecular and peptide prediction; (3) an astringency predictor achieving 0.95 accuracy and 0.90 AUC, validated through electronic tongue measurements; (4) antibacterial predictors for molecules and peptides with accuracies of 0.92 and 0.88, respectively, revealing that 51 % of astringent molecules possess antibacterial properties; (5) accessibility of these predictors via the AstringentPD and ABPD web servers. This work not only enhances the understanding of taste-related molecules but also elucidates the relationship between astringency and antibacterial properties, setting the stage for future explorations in food science and medicinal applications.

Practical Dietary Recommendations of Persian Medicine for Pruritus: A Brief Review

This paper is a brief review of the practical dietary recommendations of Persian Medicine (PM) in the management of itching. According to our findings, PM scholars believe that the following dietary modifications help ameliorate pruritus: relative reduction of food intake, consuming tenuous foods, consumption of sweet-and-sour foods, whether natural (e.g., pomegranate juice) or man-made (e.g., oxymels), substances with astringent property, narcotics and quasi-narcotics such as a combination of dry coriander and sugar, using a group of substances called fine-humor-producing foods, laxative fruits such as tamarinds and plums, foods with sedative action including lettuce extract, watery foods containing ingredients such as barley, and increasing the share of healthy fats in the diet.

New molecular and cell-based approaches to assess food astringency and bitterness

New molecular and cell-based approaches to assess food astringency and bitterness Mouthfeel properties are crucial for human survival, nutrition, health and well-being. Unpleasant taste and mouthfeel properties in plant-based food, such as bitterness and astringency, are a challenge for food industries as flavour is key for consumer’s food choices. BeTASTy will contribute to deciphering the physiological and neural mechanisms involved in the interindividual unpleasant taste and mouthfeel perceptions through innovative molecular and cell-based approaches.

The importance of application of medicinal plants and natural products in poultry health management

Application of herbs and natural medicines have shown to have no negative side effects, with high effectiveness to improve productivity. Usage of medicinal plants can increase gut function, improve hepatic function, inhibition of prooxidant enzymes, enhance antioxidant content, improve shelf life, enhance sensorial value, better nutritive value, improve both health and consumers preference, enhance calcium and other minerals, increase vitamin B and folate, and enhance immunity. The most important medicinal plants with antiparasitic activities are green tea, guar bean, pine bark, grape seed, barberry root bark, Rangoon creeper, olive tree, and wormwood. Some other important medicinal plants in poultry industry are black pepper, nettle, shrubby sophora, Aleppo oak, garlic, red cedar, ginger, mint, tobacco, turmeric, aloe vera, etc. The application of herbal medicines can be considered as an important alternative to treating parasitic infections. In organic broiler production with application of medicinal plants, decreasing hormones, growth promoters and antibiotics should be considered as well as paying more attention to selection of appropriate organic feed management with considering higher production. This article aims to survey on the importance of application of natural products and medicinal plants in poultry industry by considering secondary metabolites such as triterpenoids, coumarins, alkaloids, tannins, and flavonoids due to their anti-inflammatory, antiparasitic, antimicrobial, antioxidant, and astringent properties.

Biological activities of Stryphnodendron adstringens bark decoction

Stryphnodendron adstringens, called ‘barbatimão’, is used in Brazilian folk medicine given its healing, astringent, anti-inflammatory, and antimicrobial properties. However, data on its safe use remain inconclusive due to controversy about the risk posed by its ethnopharmacological intake to human health. Thus, the present study aims to quantify the main classes of compounds found in S. adstringens bark powder and investigate the biological activity of ‘barbatimão’ bark decoction against pathogenic bacterial strains. We also investigated its toxic activity using the Artemia salina test and its cytogenotoxicity using the Allium cepa test. Phenols (24.5 ± 1.5 mg mL-1), tannins (15.08 ± 0.02 mg mL-1), and flavonoids (1.33 ± 0.02 mg mL-1) were quantified in the S. adstringens decoction. This decoction exhibited antibacterial activity against Gram-positive strains and toxicity against A. salina. It was not possible to observe the S. adstringens bark decoction genotoxicity in the A. cepa roots because the cell cycle stopped at the prophase, indicating the decoction’s anti-proliferation effect. S. adstringens is a plant with great herbal potential; therefore, other study models must be used to investigate its potential antibacterial and anti-proliferation applications

DkDTX1/MATE1 mediates the accumulation of proanthocyanidin and affects astringency in persimmon.

Proanthocyanidins (PAs) is a kind of polyphenols widely distributed in plants, and their astringent properties can protect plants from herbivores and regulate fruit taste. There is a great difference in PA composition between astringent (A)-type and nonastringent (NA)-type persimmon. Here, we studied the potential of DkDTX1/MATE1 in regulating PAs composition through its preferred transport in persimmon fruit. The results of fluorescence microscope showed that the DkDTX1/MATE1 green fluorescence overlapped with the blue light emitted by PA. Overexpression of DkDTX1/MATE1 in persimmon leaves not only significantly increase the concentrations of PA, but also upregulated the expression of PA biosynthesis pathway genes. Further overexpression of DkDTX1/MATE1 in persimmon fruit discs and stable genetic transformation of DkDTX1/MATE1 also led to PA concentrations increased. Molecular docking and transporter assays showed that DkDTX1/MATE1 preferentially transported catechin, epicatechin gallate and epigallocatechin gallate. DkDTX1/MATE1 mainly bound to the PA precursors via serine at position 68. Our findings indicate that DkDTX1/MATE1 play a role in the accumulation of PAs in early stage of fruit development and affects the astringency of persimmon through preferential transport PA precursors, which provided a theoretical basis for the future use of metabolic engineering to regulate the composition of PAs in persimmon.

Effects of Fermentation with Eurotium cristatum on Sensory Properties and Flavor Compounds of Mulberry Leaf Tea.

Mulberry leaf tea (MT) is a popular Chinese food with nutrition and medicinal functions. Solid-state fermentation with Eurotium cristatum of MT (FMT) can improve their quality. Differences in chromaticity, taste properties, and flavor characteristics were analyzed to evaluate the improvements of the sensory quality of FMT. After fermentation, the color of the tea infusion changed. The E-tongue evaluation results showed a significant decrease in unpleasant taste properties such as sourness, bitterness, astringency, and aftertaste-bitterness, while umami and saltiness taste properties were enhanced post-fermentation. Aroma-active compounds in MT and FMT were identified and characterized. A total of 25 key aroma-active compounds were screened in MT, and 2-pentylfuran showed the highest relative odor activity value (ROAV). A total of 26 key aroma-active compounds were identified in FMT, and the newly formed compound 1-octen-3-one showed the highest ROAV, which contributed to FMT's unique mushroom, herbal, and earthy flavor attributes. 1-octen-3-one, (E)-2-nonenal, trimethyl-pyrazine, 2-pentylfuran, and heptanal were screened as the potential markers that contributed to flavor differences between MT and FMT. E. cristatum fermentation significantly altered the sensory properties and flavor compounds of MT. This study provides valuable insights into the sensory qualities of MT and FMT, offering a theoretical basis for the development of FMT products.

The anatomical and micromorphological structure of Myrtus communis L. leaves

Myrtus communis L. is a promising medicinal plant that has garnered the attention of scientists to introduce it into industrial cultivation as a raw material source for obtaining new phytopreparations. In its chemical composition, Myrtus communis L. contains many biologically active substances, which confer upon it a range of medicinal properties including astringent, anti-inflammatory, antiviral, antibacterial, antifungal, antioxidant, antidiabetic, antiulcer, antimutagenic, gastro- and hepatoprotective properties. Published information primarily focuses on the chemical composition and pharmacological activity of common myrtle, with limited data available on its micromorphology. The aim of the work is to study the morphological and anatomical structure and to determine the general diagnostic microscopic features of common myrtle leaves. Materials and methods. The object of the research was fresh and dried plant material of common myrtle grown under room conditions. Transverse sections were fixed with Carnois fixative, dehydrated, and paraffinized. The sections were then cut using a Microm HM 325 microtome, followed by deparaffinization. Microscopic analysis of the leaf was performed using temporary preparations on a Carl Zeiss microscope, including the “AxioStar Plus” and “Primo Star”, equipped with a photo attachment for direct and reflected light microscopy. Results. The external features of common myrtle leaves include their shape, color, size, smell, and type of veining. Anatomically, the leaves exhibit a cuticle, dorsiventral mesophyll, and anomocytic stomata located on the abaxial surface. Additionally, they contain calcium oxalate crystals and druses, as well as simple hairs on the midvein and schizolisogenic secretory receptacles. Histochemical studies of these cavities indicate the presence of lipophilic substances. Conclusions. The morphological and anatomical analysis of Myrtus communis L., a representative of the myrtle genus, allowed for the identification of key diagnostic microscopic features of myrtle leaves. Further research prospects involve conducting a comprehensive set of phytochemical studies to establish standardization parameters for medicinal plant raw materials.

Combined use of kaolin and bentonite molding clays

The article compares the properties of kaolin and bentonite clays. It has been shown that kaolin clays have high fire resistance, and bentonites have high astringent properties. The experience of specialists from OJSC “MTW” in the joint use of various types of clays is considered. The combination of kaolin and bentonite in the suspension made it possible to increase the strength of the molding sand while maintaining moisture levels. The disadvantage of kaolin clay suspensions is that the moisture content increases with increasing dosage. When preparing bentonite suspensions, their short shelf life should be taken into account.

Evaluation of Antibacterial Properties of Neem Seed Oil

Neem is a potent blood purifier, detoxifier, and fever reducer according to Ayurvedic scriptures. Neem's astringent properties aid in the promotion of healing even further. Medicated neem oil is considered one of the best for treating skin conditions. Neem works well as an anti-inflammatory for discomfort in the muscles and joints. Diterpenesuginol, nimbiol (bark), triterpenes, beta-sitosterol, stigmastrol (leaf), Limonoids, Malliantriol (seed oil), Nimbendiol (seed oil), and azardiractin (seed) are among the groups of substances that have been isolated from the plant in good amounts. These compounds are sulphurous. In summary, this investigation unequivocally demonstrated the antibacterial efficacy of neem oil against bacterial strains isolated from various environments. Today, more research on antimicrobials originating from plants is required. To identify the antibacterial chemicals found in these plants and to ascertain the full range of their activity, more investigation is required. Nonetheless, the current investigation into the in vitro antibacterial assessment of specific plants serves as a foundation for future phytochemical and pharmacological research aimed at finding novel antibacterial medications.

Profiling flavor characteristics of cold brew coffee with GC-MS, electronic nose and tongue: effect of roasting degrees and freeze-drying.

Roasting is an important process in the formation of coffee flavor characteristics, which determines the quality of coffee and consumer acceptance. However, the influence of roasting degree on the flavor characteristics of cold brew coffee has not been fully described. In the present study, the flavor characteristics of cold brew coffee with different roasting degrees were compared in detail by using chromatographic and electronic sensory approaches, and the flavor changes induced by freeze-drying were investigated. Pyrazine and heterocyclic compounds were the main aroma compounds in coffee, and gradually dominated with the increase of roasting. Pyridine was consistently present in cold brew coffees of different roasting degrees and showed significant gradient of quantity accumulation. Aroma compounds such as pyrazine, linalool and furfuryl acetate were the main contributors to coffee roasting, floral and fruity flavor. Freeze-drying preserved the fruity and floral aromas of medium-roasted cold brew coffee, whereas reducing the bitterness, astringency and acidity properties that are off-putting to consumers. The higher consumer acceptance and enjoyment in medium roast cold brew coffee may be related to its stronger floral and fruity aroma. The aroma profile qualities of freeze-drying processed medium roasted cold brewed coffee were more dominant and more suitable for freeze-drying processing than medium dark roasting. Application of freeze-drying for cold brew coffee will promote the convenience of drinking. The present study provides valuable technical guidance in improving the flavor and quality of cold brew coffee, and also promotes its commercialization process. © 2024 Society of Chemical Industry.

Apple of Sedom a Ayurveda’s Gift

The beginning of civilization, human beings have worshiped plants and such plants are conserved as a genetic resource. Calotropis gigantea Linn is a well known medicinal herb commonly known as milk weed. It has been used in Unani, Ayurveda and Siddha system of medicine for years. The current study was intended to evaluate and compare the in vivo efficacy of Calotropis gigantea mouth rinse as anticariogenic agents with 0.2% chlorhexidine and Listerine mouth rincsae. All parts of the plant have been used as medicine as well as an important ingredient in a number of Unani formulations used for the treatment of various ailments. In classical Unani literature it is mentioned to have anthelmintic, appetizer, anti flatulence, astringent, tonic, expectorant, emetic, diaphoretic, anti inflammatory, sedative, wound healer, antidote and digestive properties and used in asthma, stomach ache, cholera, amenorrhea and toothache. Phytochemical constituents include giganteol, α and β calotropeol, β-amyrin, giganteol and isogiganteol etc. Calotropis gigantea has been reported for its anti asthmatic, antioxidant, antibacterial, antiviral, wound healing, antiinflammatory, antidiarrhoeal, hepatoprotective and hypoglycemic activities. In this review the main extract of Calotropis gigantea discussed.

Therapeutic Uses of Mee Tree (Madhuca longifolia)

In the past, our ancestors maintained a close relationship with the environment. They knew the value of many plants. One tree that our ancestors preserved is the Mee tree. Madhuca longifolia belonging to the family Sapotaceae, is one of those multipurpose forest tree species that provide an answer for the food, fodder and fuel. It is widely distributed in the South Asian countries, Especially in Sri Lanka. Mee tree is a large deciduous tree growing widely under dry tropical and sub-tropical climatic conditions. The tree has religious and aesthetic value in the tribal culture. The trees with best girth in forest are often Mee trees as it is protected and cared by forest dwellers. Aim of the study is to identify the therapeutic uses of this plant in Sri Lanka. Ancient classical texts were used to collect data on Mee tree especially, Medicinal plants (Indigenous and Exotic) used in Ceylon. Articles were filtered through journals, magazines and newspapers. Databases such as Google scholar, Springer and Agroforestry were used to search journal articles. The journal articles from 2010-2022 were considered as eligible for this review. Search terms such as Madhuca longifolia, Mee tree, Medicinal uses were used to search journal articles. The final summary was formulated after a thorough reading of all above materials. As the results, the plant contains Vitamins, Ethylcinnamate, Amyrin acetates, Hexacosanol, Linoleic acid, Palmitic acid and many more chemical constituents. The Mee tree has analgesic, diuretic, tonic, aphrodisiac, astringent and demulcent properties with various parts of the plant. The parts are used in certain treatments in Ayurvedic medicine. The flowers, leaves, bark, roots, and seeds of the Mee tree are used to prepare medicines for rheumatism, bronchitis, headache, skin diseases, and worm infestations. The study was concluded as, this tree was so close and familiar to the lives of the people. This tree has many benefits for mankind, and many people have been interested in preserving it. However, due to the deforestation that has taken place in the country in the last few decades, the existence of Mee trees has been severely threatened. Today, Mee tree is a scarce resource in Sri Lanka. People should aware about protecting the plant for future generation. 
 Keywords: Madhuca longifolia, Mee tree, Medicinal uses, Deforestation

A Comprehensive Review of Ethnomedicinal Uses, Phytochemistry, Pharmacology, and Toxicity of Prunus africana (Hook. F.) Kalkman from Africa.

Prunus africana, a widely utilized medicinal plant in various African ethnic communities, continues to hold significant importance in traditional healing practices. Research has identified phytochemical compounds in this plant, exhibiting diverse pharmacological activities that offer potential for pharmaceutical development. Notably, P. africana is employed in treating various ailments such as wounds, diabetes mellitus, malaria, benign prostatic hyperplasia, chest pain, and prostate cancer. Its pharmacological properties are attributed to a spectrum of bioactive compounds, including tannins, saponins, alkaloids, flavonoids, terpenoids, phytosterols, and fatty acids. Multiple studies have documented the anti-inflammatory, antimicrobial, antiandrogenic, antiangiogenic, antioxidant, antidipeptidyl peptidase-4 activity, analgesic, and astringent properties of P. africana extracts. This review offers a comprehensive compilation of ethnomedicinal applications, phytochemical composition, pharmacological effects, and toxicity assessments of P. africana, serving as a foundation for future preclinical and clinical investigations. By understanding its traditional uses and chemical constituents, researchers can target specific medical conditions with greater precision, potentially expediting the development of safe and effective pharmaceuticals. Moreover, toxicity assessments provide crucial insights into the safety profile of P. africana extracts, ensuring the development of safe pharmaceuticals to treat various diseases.

Effects of yellowing and drying treatment temperatures on the taste of autumn green tea

This study aimed to reduce the bitterness and astringency properties of autumn green tea using different yellowing and drying treatments. The results showed that as the yellowing temperature increased, the contents of tea polyphenols, gallated catechins, flavonol glycosides, and bitter amino acids decreased, while the content of soluble sugar and flavonols increased. The tea sample (YEL35 °C) subjected to yellowing treatment at 35 °C exhibited weak bitterness and astringency intensities and a relatively low content of flavonol glycosides. As the drying temperature increased, the content of gallated catechins decreased. In addition, the tea sample (DRY75 °C) subjected to drying treatment at 75 °C exhibited weak bitterness and astringency intensities, the highest contents of umami amino acids and Thea, and a relatively low content of gallated catechins. Multivariate statistical analysis revealed that vitexin-2-O-rhamnoside, pferol-3-O-rutinoside, myricetin-3-O-galactoside, and quercetin-3-O-glucoside played an important role in the astringency property of the tea. In addition, Asn, Thr, Pro, and Met were positively correlated with umami. Hence, the quality of autumn green tea was improved under optimal yellowing and drying temperatures of 35 and 75 °C, respectively.

Bidirectional regulation effect of rhubarb as laxative and astringent by metabolomics studies

Ethnopharmacological relevanceRhubarb, a prominent traditional Chinese medicine, has been employed as a potent laxative for centuries and garnered particular popularity among the youth owing to its notable efficacy in weight management. Historical records indicated that rhubarb initially exhibited robust laxative properties, but extended and consistent usage may lead to an astringent response in the later stage of long-term use. In contrast, steamed pieces of rhubarb (SR), preparing through the process of steaming with wine, have demonstrated a gentle laxative effect with no reported adverse effects. Aim of the studyOur study was designed to explore the intricate mechanisms underlying laxative and astringent properties of rhubarb through metabolomics research. Materials and methodsIn this investigation, we employed a serum metabolomics approach utilizing the UPLC-Q-Extractive-Orbitrap-MS method to delve into the contrasting laxative and astringent effects of rhubarb, as well as to unravel the mechanisms of underpinning its bidirectional regulatory influence. To commence, we assessed alterations in Evacuation Index (EI) values, intestinal hormone levels, and colon histopathology in mice to gauge rhubarb's laxative and astringent effects. Subsequently, metabolomics methodology was employed for cluster analysis through Principal Component Analysis (PCA) and biomarker identification via Orthogonal Partial Least Squares-Discriminant Analysis (OPLS-DA). Then, we delved into the distinctions in characteristic biomarkers, metabolic pathways, their association with pathological changes, and correlation heatmap for biomarkers between raw pieces of rhubarb (RR) and SR to gain insights into the potential mechanisms behind rhubarb's bidirectional regulatory effects. ResultsOur findings revealed that RR exhibited a laxative effect in the early stage and transitioned to an astringent effect in the later stage, as indicated by the EI values. In contrast, SR consistently demonstrated a mild laxative effect. Biochemical indexes and histopathological assessments unveiled that RR triggered its astringent effect by inhibiting secretion of motilin (MTL), promoting secretion of vasoactive intestinal peptide (VIP) and epinephrine (EPI), and inducing onset of inflammation. Furthermore, serum metabolomics analysis identified 59 discriminative biomarkers modulated by RR and SR. Through comprehensive analysis, we elucidated the in vivo transformation relationships among multiple endogenous metabolites. Notably, our results underscored the down-regulation of certain phosphatidylcholines (PCs), amino acids, acylcarnitines, and up-regulation of lysophosphatidylcholines (LysoPCs) played pivotal roles in the onset of gut dysfunction, intestinal inflammation, gut barrier damage, and gastrointestinal motility disorder upon prolonging RR administration, ultimately contributing to its astringent effect. Additionally, our correlation analysis elucidated that anthraquinones, stilbenes, and phenylbutanones were the pharmacodynamic material basis responsible for inducing the astringent effect of RR. ConclusionThis study provides valuable insights into the bidirectional regulatory effects of rhubarb and sheds light on its underlying mechanisms through a comprehensive metabolomics approach.

Assessment of the possibility of using the fruits of the oriental persimo (Diospyros kaki L.) as a source of filter membranes based on the tensor approach

Like all raw materials of plant origin, persimmon fruits are considered a material rich in carbohydrates. This subtropical plant grows almost throughout the entire territory of the Republic of Azerbaijan. Despite the widespread distribution of this plant in the republic, very few types of products are produced from it. The main reason why persimmon fruits are not used effectively from a production point of view is that they have astringent properties. Since fruit carbohydrates play an important role in eliminating the tart taste of persimmons, the study of the carbohydrate complex was considered as a basic condition. After fractionation of carbohydrates with a water-alcohol mixture, certain stresses arise in the filter residue, which consists of cellulose-lignin. These stresses are analyzed using tensors. It has been established that the size of the filter pores is about 0.005÷0.05 microns, and the volume of these pores is 0.062÷0.195 cm3/g. The clearance coefficient averaged 19.97 %. It is known that the outer layer of a plant cell consists of cellulose and other structural compounds. These substances determine the porosity of the material. The mass fraction of the final product of the fractional residue, more precisely cellulose, averaged 0.63 %. The use of the resulting filter membrane in the clarification of fruit juices has shown its usefulness in industry. It has been established that the selectivity of these membranes for various amino acids is 5÷18 %, and for minerals 1÷30 %. The lipid resistance of the membranes was high. It should be noted that cellulose has the ability to restore its structure and at the last stage acts only as a filter membrane. This explains the usefulness of the cellulose-lignin mixture as a membrane material