Fatigue of materials, like alloys, is basically fatigue-crack growth in small cracks nucleating and growing from micro-structural features, such as inclusions and voids, or at micro-machining marks, and large cracks growing to failure. Thus, the traditional fatigue-crack nucleation stage (Ni) is basically the growth in microcracks (initial flaw sizes of 1 to 30 μm growing to about 250 μm) in metal alloys. Fatigue and crack-growth tests were conducted on a 9310 steel under laboratory air and room temperature conditions. Large-crack-growth-rate data were obtained from compact, C(T), specimens over a wide range in rates from threshold to fracture for load ratios (R) of 0.1 to 0.95. New test procedures based on compression pre-cracking were used in the near-threshold regime because the current ASTM test method (load shedding) has been shown to cause load-history effects with elevated thresholds and slower rates than steady-state behavior under constant-amplitude loading. High load-ratio (R) data were used to approximate small-crack-growth-rate behavior. A crack-closure model, FASTRAN, was used to develop the baseline crack-growth-rate curve. Fatigue tests were conducted on single-edge-notch-bend, SEN(B), specimens under both constant-amplitude and a Cold-Turbistan+ spectrum loading. Under spectrum loading, the model used a “Rainflow-on-the-Fly” subroutine to account for crack-growth damage. Test results were compared to fatigue-life calculations made under constant-amplitude loading to establish the initial microstructural flaw size and predictions made under spectrum loading from the FASTRAN code using the same micro-structural, semi-circular, surface-flaw size (6-μm). Thus, the model is a unified fatigue approach, from crack nucleation (small-crack growth) and large-crack growth to failure using fracture mechanics principles. The model was validated for both fatigue and crack-growth predictions. In general, predictions agreed well with the test data.