The purpose of this study was to evaluate the health outcomes of 8- to 12-year-old urban-dwelling children with moderate to severe persistent asthma who participated in a modified Open Airways for Schools (OAS) asthma education program. It was hypothesized that the intervention group would have improved health outcomes when compared to control. A 2-group, 3-points-in-time method was used to conduct the study. The intervention group demonstrated significant and sustained improvement in asthma knowledge. There was no significant difference between groups for quality of life or pulmonary function. While OAS is a good program for asthma education, the program alone may not be sufficient to improve risk factors associated with poor pulmonary function. Future studies should incorporate environmental interventions.