Background: Asthma is a leading cause of impairment, high health-care costs and poor quality of life for those who suffer from it. Asthma is the most prevalent chronic medical illness that schoolteachers must deal with in their students, impacting more than 10% of them. Teachers may be required to supervise inhaler administration and determine the necessity for additional treatment in acute attacks. Asthma prevalence varies greatly over the world, ranging from 1 to 20% for both children and adults. Methods: The data for this cross-sectional study was acquired using a specially designed questionnaire. The questionnaire includes demographic questions as well as questions about asthma awareness and knowledge. After collection of data, it was coded and entered in the SPSS ver.20 software for analyses descriptive statistics (mean standard deviation, frequencies and percentages were computed), to measure the significance differences t test and chi-square test was used at 5% level of significance. Data was collected from the teachers of Aseer region of KSA. Ethical approval was obtained from King Khalid University, Saudi Arabia. The study duration was from January-2021 to April-2021. Results: Out of a total 759 respondents, the mean (S.D.) of the respondents were 31.6(12.8). 14.2% were male while 85.8% were females. The Cronbach alpha of the questionnaire was 0.79. We have observed that age and education have a significant impact over the prevalence of Asthma awareness. Conclusion: We should train our teachers by conducting series of seminars, webinars and workshops. We will also incorporate training the trainer sessions for teaching staff to enhance their skills to deal with asthma. Key words: Asthma, diseases, teacher, knowledge, awareness