Asthma In Japan Research Articles

β 2-Adrenoceptor polymorphism and asthma in Japan: application of PCR(mp)-RFLP to polymorphisms in the β 2-adrenoceptor

β 2-Adrenoceptor polymorphism and asthma in Japan: application of PCR(mp)-RFLP to polymorphisms in the β 2-adrenoceptor

Death from Asthma in Japan : Incidence, Risk Factors, and its Prevention ( "Prevention death from asthma in the west Pacific area")

Death from Asthma in Japan : Incidence, Risk Factors, and its Prevention ( "Prevention death from asthma in the west Pacific area")

Saiboku-To, a herbal extract mixture, selectively inhibits 5-lipoxygenase activity in leukotriene synthesis in rat basophilic leukemia-1 cells

Saiboku-To, a mixture of extracts from 10 medicinal herbs, has been used for the treatment of bronchial asthma in Japan. Inhibitory action of this drug on arachidonate 5-lipoxygenase (5-LO) metabolism in rat basophilic leukemia cells (RBL-1 cells) was examined. Saiboku-To significantly inhibited calcium ionophore-stimulated synthesis of cysteinyl leukotrienes (cLTs) and leukotriene B 4 (LTB 4). Inhibition appeared 10 min after addition of the substance and reached a maximal value after 3 h. Saiboku-To did not inhibit the release of [ 3H]arachidonic acid (AA) from cell membrane by calcium ionophore stimulation, or the production of cLTs and LTB 4 when LTA 4-free acid was used as the substrate. However, it significantly inhibited the production of cLTs and LTB 4 when free AA was used as the substrate. The production of thromboxane A 2 (TXA 2), a cyclooxygenase metabolite, was not inhibited when AA was used as the substrate in cell free study. These results indicate that Saiboku-To selectively inhibits 5-LO activity in the metabolic pathway of AA.

重症気管支喘息児の予後と治療

重症気管支喘息児の予後と治療

Treatment and Complications of Childhood Asthma in Japan

Recently the prevalence of asthma and emergency hospital admissions are increasing, but most childhood asthma can be controlled with appropriate therapy. Children can maintain their normal life cycle by out-patient treatment. There are two main complications of childhood asthma. One is the result of pathophysiological features and the other related to therapy. Status asthmaticus is the most serious complication and may be fatal.

Bronchial Asthma: Principles of Diagnosis and Treatment.

Part I: Definitions and Host Responses to Bronchospasm. The Genetics and Epidemiology of Asthma. Pathogenesis of Asthma: Mediators and Mechanisms. The Role of Mast Cells and Eosinophils in Asthma. Morphologic Basis of Airflow Obstruction. The Role of the Pulmonary Function Laboratory in Patients with Bronchial Asthma. The Interrelations Between Asthma, Pregnancy, and Lactation. Differential Diagnosis of Asthma in Children: Bronchial Asthma, Occult Asthma, and Pseudoasthma. Differential Diagnosis of Asthma in Adults: Bronchial Asthma, Occult Asthma, and Pseudoasthma. Part II: Patient Management. Allergic Evaluations and Management Considerations of Patients with Asthma. Clinical Laboratory Assessment of the Bronchial Asthma Patient. Radiological Considerations in Asthma. Treatment of Asthma in Children. The Pharmacological Treatment of Asthma in Adults. Management of Status Asthmaticus in Childhood. Management of Status Asthmaticus in Adults. Role of Immunotherapy in Asthma. Management of the Pregnant Asthmatic. Unconventional Therapy in Asthma. Treatment Aspects of Asthma in Japan. Treatment Aspects of International Asthma: Europe. Part III: Special Clinical Problems. Respiratory Tract Infections and Asthma. Diagnosis and Management of Exercise-Induced Asthma. Chronic Sinus Disease and Asthma. Aspirin, Related Nonsteroidal Anti-Inflammatory Agents, Sulfites, and Other Food Additives as Precipitating Factors in Asthma. Air Pollution and Asthma. Allergic Bronchopulmonary Aspergillosis. Occupational Asthma. Part IV: Living with Asthma. Anesthetic Considerations in Asthmatic Patients. Use of Prospective Disease Management to Minimize Asthma Symptoms and Maximize Potential. Asthma in School Children: Reducing the Impact on Education. Sports, Athletes, and Asthma: Winning the Fame with Asthma. The Psychology of Asthma: Implications for Treatment. Disability/Legal Issues for Asthmatics. Index .

Treatment of Bronchial Asthma in Japan

Treatment of Bronchial Asthma in Japan

CLINICAL SIGNIFICANCE OF THE HOUSE DUST MITE (DERMATOPHAG01DES PTERONYSSINUS) IN ASTHMATIC CHILDREN IN JAPAN

Clinical studies were conducted to evaluate the role of the house dust mite. Dermatophagoides pteronyssinus, as an allergen in children's asthma in Japan. Skin testing and Prausnitz-Küstner type skin testing showed good correlations between the allergenicity of house dust and the mite. A positive Prausnitz-Küstner type skin reaction to house dust was neutralized by a mite extract. Radioallergosorbent test showed good correlation between house dust and the mite (r=0.687). The mite exhibited in vitro inhibition of radioallergosorbent test to house dust. The inhalation provocation test resulted in an acute respiratory attack in one of the patients. These results suggest that the house dust mite is an important allergen in asthmatic children in Japan.

The function of the carotid body.

Carotid-body resection, or glomectomy, was introduced as a form of treatment of bronchial asthma in Japan during World War II. After the method received some acceptance in this country, several well controlled studies showed it to be ineffective, and it was the opinion of the Committee on Therapy of the American Thoracic Society in 1968 that the procedure "has no place in the treatment of patients with asthma or emphysema."1 However, seven patients on whom bilateral glomectomy had been performed provided Lugliani and his associates with the opportunity to carry out the studies reported in this issue of the Journal. . . .