Asterric Acid Research Articles

A new spiroketal from Aspergillus terreus, an endophytic fungus in Opuntia ficusindica Mill

A new spiroketal, named aspergiketal (1) was isolated from the culture broth of Aspergillus terreus, an endophytic fungus in the stems of the plant Opuntia ficusindica Mill., together with two known compounds, physcion (2) and asterric acid (3). Their structures were elucidated by spectroscopic methods including 2D-NMR techniques.

Cyclopentenones, Scaffolds for Organic Syntheses Produced by the Endophytic Fungus Mitosporic Dothideomycete sp. LRUB20

Two new natural products, 2-hydroxymethyl-3-methylcyclopent-2-enone (1) (synthetically known) and cis-2-hydroxymethyl-3-methylcyclopentanone (2), and a known compound, asterric acid (3), were isolated from the endophytic fungus mitosporic Dothideomycete sp. LRUB20, which was isolated from the stem of the Thai medicinal plant Leea rubra. Compound 2 was separated and identified in the form of its 2,4-dinitrophenylhydrazone derivative (5). Compounds 1, 3, and hydrazone 5 exhibited mild antimycobacterial activity, both with MIC values of 200 microg/mL. Compounds 1, 3, and 4 were inactive (at 50 microg/mL) toward Vero, KB, NCI-H187, and BC cell lines. Hydrazone 5 showed only mild cytotoxicity against the Vero cell line with an IC(50) value of 21.7 microg/mL; however, it was inactive toward KB, NCI-H187, and BC cell lines. Endophytic fungi may be a source for the production of building blocks for organic syntheses.

Fungal Metabolites, Asterric Acid Derivatives Inhibit Vascular Endothelial Growth Factor (VEGF)‐Induced Tube Formation of HUVECs.

AbstractFor Abstract see ChemInform Abstract in Full Text.

Fungal metabolites, asterric acid derivatives inhibit vascular endothelial growth factor (VEGF)-induced tube formation of HUVECs.

In the search for new naturally occurring anti-angiogenic compounds, we found that a culture broth of an unidentified fungal strain B90911 exerted inhibitory activity on capillary-like tube formation of human umbilical vein endothelial cells (HUVEC) in vitro. Four active compounds were isolated by bioassay-guided separation and their structures were identified to be sulochrin (1), methyl asterric acid (2), and two new asterric acid derivatives, 3-chloroasterric acid (3), and 3,5-dichloroasterric acid (4) by spectroscopic analyses. These compounds significantly inhibited the VEGF-induced tube formation of HUVEC, suggesting that asterric derivatives could be useful for further study as anti-angiogenic agents.

New chlorinated diphenyl ethers from an Aspergillus species.

Two new chlorinated diphenyl ethers (5, 6) have been isolated from the culture broth of an Aspergillus species obtained from leaf litter, together with the known benzophenone sulochrin (1), the grisandiene geodin (2), and the diphenyl ether asterric acid (3). The structure of another metabolite, methyl asterrate (4), was confirmed by single-crystal X-ray structure analysis.

Asterric acid, a new endothelin binding inhibitor.

Asterric acid, a new endothelin binding inhibitor.

Asterric acid from Scytalidium

Asterric acid from Scytalidium

Metabolites from a Chrysosporium species.

The fungus Chrysosporium cf. merdarium Link (Carmichael) grown on potato dextrose agar produces a yellow pigment. The components of the pigment have been identified as the anthraquinones questin and questinol. The fungus also produces an unknown white metabolite and asterric acid.

940. The biosynthesis of phenols. Part II. Asterric acid, a metabolic product of aspergillus terreus thom

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