Association Of Self-reported Physical Activity Research Articles

Joint association of genetic risk and accelerometer-measured physical activity with incident coronary artery disease in the UK biobank cohort.

Previous research demonstrates the joint association of self-reported physical activity and genotype with coronary artery disease. However, an existing research gap is whether accelerometer-measured overall physical activity or physical activity intensity can offset genetic predisposition to coronary artery disease. This study explores the independent and joint associations of accelerometer-measured physical activity and genetic predisposition with incident coronary artery disease. Incident coronary artery disease based on hospital inpatient records and death register data serves as the outcome of this study. Polygenic risk score and overall physical activity, measured as Euclidean Norm Minus One, and intensity, measured as minutes per day of moderate-to-vigorous intensity physical activity (MVPA), are examined both linearly and by decile. The UK Biobank population-based cohort recruited over 500,000 individuals aged 40 to 69 between 2006 and 2010, with 103,712 volunteers participating in a weeklong wrist-worn accelerometer study from 2013 to 2015. Individuals of White British ancestry (n = 65,079) meeting the genotyping and accelerometer-based inclusion criteria and with no missing covariates were included in the analytic sample. In the sample of 65,079 individuals, the mean (SD) age was 62.51 (7.76) and 61% were female. During a median follow-up of 6.8 years, 1,382 cases of coronary artery disease developed. At the same genetic risk, physical activity intensity had a hazard ratio (HR) of 0.41 (95% CI: 0.29-0.60) at the 90th compared to 10th percentile, equivalent to 31.68 and 120.96 minutes of moderate-to-vigorous physical activity per day, respectively, versus an HR of 0.61 (95% CI: 0.52-0.72) for overall physical activity. The combination of high genetic risk and low physical activity intensity showed the greatest risk, with an individual at the 10th percentile of genetic risk and 90th percentile of intensity facing an HR of 0.14 (95% CI: 0.09-0.21) compared to an individual at the 90th percentile of genetic risk and 10th percentile of intensity. Physical activity, especially physical activity intensity, is associated with an attenuation of some of the risk of coronary artery disease but this pattern does not vary by genetic risk. This accelerometer-based study provides the clearest evidence to date regarding the joint influence of genetics, overall physical activity, and physical activity intensity on coronary artery disease.

Association of self-reported physical activity with cognitive function in young adults

Association of self-reported physical activity with cognitive function in young adults

Association between exercise frequency with renal and cardiovascular outcomes in diabetic and non-diabetic individuals at high cardiovascular risk

BackgroundGuidelines recommend physical activity to reduce cardiovascular (CV) events. The association between physical activity and progression of chronic kidney disease (CKD) with and without diabetes is unknown. We assessed the association of self-reported physical activity with renal and CV outcomes in high-risk patients aged ≥ 55 years over a median follow-up of 56 months in post-hoc analysis of a previously randomized trial program.MethodsAnalyses were done with Cox regression analysis, mixed models for repeated measures, ANOVA and χ2-test. 31,312 patients, among them 19,664 with and 11,648 without diabetes were analyzed.ResultsPhysical activity was inversely associated with renal outcomes (doubling of creatinine, end-stage kidney disease (ESRD)) and CV outcomes (CV death, myocardial infarction, stroke, heart failure hospitalization). Moderate activity (at least 2 times/week to every day) was associated with lower risk of renal outcomes and lower incidence of new albuminuria (p < 0.0001 for both) compared to lower exercise levels. Similar results were observed for those with and without diabetes without interaction for renal outcomes (p = 0.097–0.27). Physical activity was associated with reduced eGFR decline with a moderate association between activity and diabetes status (p = 0.05).ConclusionsModerate physical activity was associated with improved kidney outcomes with a threshold at two sessions per week. The association of physical activity with renal outcomes did not meaningfully differ with or without diabetes but absolute benefit of activity was even greater in people with diabetes. Thus, risks were similar between those with diabetes undertaking high physical activity and those without diabetes but low physical activity.Clinical trial registration: http://clinicaltrials.gov.uniqueidentifier:NCT00153101.

The association of self-reported physical activity on human sensory long-term potentiation.

Exercise has been shown to enhance synaptic plasticity, therefore, potentially affecting memory. While the mechanism(s) responsible for this relationship have been explored in animal models, current research suggests that exercise may possess the ability to induce synaptic long-term potentiation (LTP). Most of the LTP mechanistic work has been conducted in animal models using invasive procedures. For that reason, the purpose of the present experiment was to investigate whether self-reported exercise is related to human sensory LTP-like responses. Nineteen participants (MAGE = 24 years; 52.6% male) completed the study. Long-term potentiation-like responses were measured by incorporating a non-invasive method that assess the change in potentiation of the N1b component produced from the visual stimulus paradigm presented bilaterally in the visual field. Results demonstrated that those with higher levels of moderate-to-vigorous physical activity (MVPA) had a greater N1b change from baseline to the early time period assessment, r = −0.43, p = 0.06. Our findings provide some suggestive evidence of an association between self-reported MVPA and LTP-like responses. Additional work is needed to support that the potentiation of the human sensory N1b component in the observed study is due to the exercise-induced synaptic changes similar to that detailed in prior animal research.

Associations of self-reported physical activity and anxiety symptoms and status among 7,874 Irish adults across harmonised datasets: a DEDIPAC-study

BackgroundAnxiety is an adaptive response to an objective or perceived threat; however, when symptoms become severe and chronic it that can become a maladaptive anxiety disorder. Limited evidence suggests that physical activity may be associated with prevention against anxiety. This study uses data from The Irish Longitudinal Study on Ageing (TILDA) and The Mitchelstown Cohort Study to investigate cross-sectional associations between physical activity and anxiety symptoms and status among Irish adults.MethodsBoth datasets were harmonized (n = 7874). The short form International Physical Activity Questionnaire measured physical activity. Participants were classified as meeting World Health Organization physical activity guidelines (≥150 min weekly of moderate intensity physical activity, ≥75 min weekly of vigorous intensity physical activity, or ≥ 600 MET-minutes) or not. They were also divided into three groups based on weekly MET-minutes of moderate-to-vigorous physical activity (Low: 0–599; Moderate: 600–1199; High: ≥1200), and three groups based on weekly minutes of walking (Low: 0–209; Moderate: 210–419; High: 420+). Anxiety symptoms were measured by the Hospital Anxiety and Depression Scale with a score of ≥8 indicating anxiety. Binomial logistic regression, adjusted for relevant confounders examined physical activity–anxiety associations.ResultsFemales had higher rates of anxiety than males (28.0% vs 20.0%; p < 0.001). Following adjustment for relevant covariates, meeting physical activity guidelines was associated with 13.5% (95% CI: 2.0–23.7; p = 0.023) lower odds of anxiety. Moderate and High physical activity were associated with 13.5% (− 11.0–32.6; p = 0.254) and 13.6% (1.4–4.2; p = 0.030) lower odds of anxiety compared to Low physical activity, respectively. Moderate and High walking were associated with 2.1% (− 14.5–16.3; p = 0.789) and 5.1% (− 9.3–17.6; p = 0.467) lower odds of anxiety compared to Low walking, respectively.ConclusionMeeting physical activity guidelines is associated with lower odds of anxiety, but the strength of associations did not increase considerably with increased physical activity levels.

Associations of self-reported physical activity and depression in 10,000 Irish adults across harmonised datasets: a DEDIPAC-study

BackgroundDepression is a prevalent, debilitating, and often recurrent mood disorder for which successful first-line treatments remains limited. The purpose of this study was to investigate the cross-sectional associations between self-reported physical activity (PA) and depressive symptoms and status among Irish adults, using two existing datasets, The Irish Longitudinal Study on Ageing (TILDA) and The Mitchelstown Cohort Study.MethodsThe two selected databases were pooled (n = 10,122), and relevant variables were harmonized. PA was measured using the short form International Physical Activity Questionnaire. Depressive symptoms were measured by the Center for Epidemiologic Studies Depression (CES-D) questionnaire. Participants were classified as meeting World Health Organization moderate-to-vigorous PA (MVPA) guidelines or not, and divided into tertiles based on weekly minutes of MVPA. A CES-D score of ≥16 indicated elevated depressive symptoms. Data collection were conducted in 2010–2011.ResultsSignificantly higher depressive symptoms were reported by females (7.11 ± 7.87) than males (5.74 ± 6.86; p < 0.001). Following adjustment for age, sex, BMI, and dataset, meeting the PA guidelines was associated with 44.7% (95%CI: 35.0 to 52.9; p < 0.001) lower odds of elevated depressive symptoms. Compared to the low PA tertile, the middle and high PA tertiles were associated with 25.2% (95%CI: 8.7 to 38.6; p < 0.01) and 50.8% (95%CI: 40.7 to 59.2; p < 0.001) lower odds of elevated depressive symptoms, respectively.ConclusionMeeting the PA guidelines is associated with lower odds of elevated depressive symptoms, and increased volumes of MVPA are associated with lower odds of elevated depressive symptoms.

The associations of self-reported physical fitness and physical activity with sleep quality in young adults: A population-based study

Statement of problemAlthough evidence suggests that physical activity and physical fitness are associated with sleep quality, little is known about these associations in young adults. Moreover, existing results have been inconsistent and need further exploration. Thus, the main purpose of the present study was to explore the associations of self-reported physical activity and self-reported physical fitness with sleep quality. MethodsTwo-thousand and one-hundred participants (age; mean ± SD = 20.87 ± 2.11 years; 50.9% of women) years were recruited. Physical fitness, physical activity and sleep quality were assessed by previously validated questionnaires. ResultsAfter adjusting for sex, self-rated health, body-mass index, socioeconomic status, smoking status, alcohol consumption, presence or absence of chronic diseases and psychological distress, ‘lower’ levels of self-reported physical fitness and ‘insufficient’ self-reported physical activity were associated with poor sleep quality. When entered simultaneously into the model, both ‘lower’ levels of self-reported physical fitness and ‘insufficient’ self-reported physical activity remained associated with poor sleep quality. ConclusionOur results show that “lower” levels of physical fitness and “insufficient” physical activity are associated with “poor” sleep quality in a large sample of young adults. Thus, special policies and strategies that enhance physical fitness and physical activity as protective factors are warranted.

Self-Rated Health among youth and its associations with physical activity outside school, BMI and television time in an urban municipality of Portugal

This study examined associations of physical activity (PA) outside school, Body mass index (BMI) and Television time (TVT) with SRH among youth. 1121 adolescents, aged from 10-18 years old participated in this cross-sectional study. PA was obtained through a questionnaire developed by Telama et al. (1997)1. TVT was accessed by asking the participant how many hours/day did they watch tv in the preceding week. Cole et al. (2000)2 cut points for BMI [weight (kg)/ height2 (m)] were used as an indicator of children’s nutritional status. Associations of self-reported PA, TVT and BMI to SRH were assessed by gender, using Chi Squared and multivariate logistic regression controlling for mothers’ education level. High levels of physical activity (boys: OR 2.43, 95% CI 1.24 to 4.78; girls: OR 2.02, 95% CI 1.26 to 3.24) were significantly associated with better SRH in adolescents. Obese/overweight boys were less likely to report positive SRH (OR 0.41, 95% CI 0.20 to 0.81) compared to their normal-weight peers. TVT in both genders and being overweight/obese in girls was not significantly associated with SRH. Results suggest that positive SRH is associated with PA levels, in both boys and girls, and with better nutritional status in boys.

Association of self-reported physical activity with obstructive sleep apnea: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

We examined associations of mild and moderate to severe obstructive sleep apnea (OSA; apnea-hypopnea index ≥5 and ≥15, respectively) with recommended amounts of moderate-vigorous physical activity (MVPA) or vigorous physical activity (VPA) and by type of activity (i.e., recreational, transportation, and work activity). The Hispanic Community Health Study/Study of Latinos (HCHS/SOL), a multicenter population-based study, enrolled individuals from 2008 to 2011 from four U.S. metropolitan areas (Bronx, New York; Chicago, Illinois; Miami, Florida; San Diego, California). Participants in this study included 14,087 self-identified Hispanic/Latino ages 18 to 74years from the HCHS/SOL. Survey logistic regression analysis was used to compute odds ratios [OR] and 95% confidence intervals [CI], adjusting for sociodemographics, smoking status, and body mass index (BMI). Relative to being inactive, performing some MVPA (>0 to <150min/week) or meeting the recommended MVPA (≥150min/week) were associated with lower odds of mild OSA (ORs and 95% CIs 0.70 [0.61–0.82] and 0.76 [0.63–0.91], respectively), as well as moderate to severe OSA (ORs and 95% CIs 0.76 [0.62–0.93] and 0.76 [0.59–0.98], respectively). Associations of VPA with OSA were not significant. Engaging in medium or high levels of transportation activity was associated with lower odds of mild OSA (OR: 0.84, 95% CI: 0.74–0.96; OR: 0.64, 95% CI: 0.43–0.95, respectively). Performing some recreational MVPA was associated with lower likelihood of mild and moderate to severe OSA (OR: 0.82, 95% CI: 0.71–0.93; OR: 0.79, 95% CI: 0.64–0.97, respectively). Health promotion and OSA prevention efforts should encourage individuals to engage in at least some MVPA.

Association of self-reported physical activity with survival among patients with advanced non-small cell lung cancer (NSCLC).

e20664Background: Patient assessment strategies are needed to individualize treatment planning for adults receiving palliative chemotherapy for NSCLC. We evaluated the utility of a cancer-specific ...

Association of self-reported physical activity with obstructive sleep apnea: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Association of self-reported physical activity with obstructive sleep apnea: Results from the Hispanic Community Health Study/Study of Latinos (HCHS/SOL)

Associations of Daily Pedometer Steps and Self-Reported Physical Activity With Health-Related Quality of Life: Results From the Alberta Older Adult Health Survey.

The aim of this article is to examine associations of self-reported physical activity (PA) and pedometer steps with health-related quality of life (HRQoL) among a population-based sample of older adults. Adults ≥55 years (N = 1,296) were recruited through random-digit dialing and responded to a questionnaire via computer-assisted telephone interviewing methods. Questionnaires assessed demographic variables and validated measures of PA and HRQoL. Participants received a step pedometer and waist circumference tape measure via post. Compared with participants in the low-step group (0-6,999 steps/day), participants in the high-step group (>10,000 steps/day) had significantly higher scores on mental health (Mdiff = 3.1, p < .001, confidence intervals [CI] = [1.8, 4.3]), physical health (Mdiff = 3.5, p < .001, CI = [2.2, 4.7]), and global health (Mdiff = 3.5, p < .001, CI = [2.3, 4.7]). Waist circumference and body mass index did not moderate any associations of pedometer steps and PA with HRQoL. Older adults exceeding established step thresholds reported significantly higher HRQoL indices compared with those achieving lower thresholds.

Physical activity in relation to body size and composition in women in UK Biobank

PurposePhysical activity is thought to protect against obesity, but the evidence is limited and few large studies of this topic have direct, objective measures of several different anthropometric variables. We examined the association of self-reported physical activity with measures of total and central adiposity. MethodsOur cross-sectional study included 38,201 premenopausal and 94,592 postmenopausal healthy women aged 40 to 70 years in UK Biobank, recruited from 2006 to 2010. ResultsMeans for total and vigorous physical activity were 31.3 (SD, 30.8) and 9.7 (SD, 14.8) metabolic equivalent h/wk, respectively, for premenopausal and 34.4 (SD, 33.1) and 8.9 (SD, 15.6) metabolic equivalent h/wk, respectively, for postmenopausal women. Multiple linear regression models showed that in both premenopausal and postmenopausal women, body mass index, body fat mass and percentage, trunk fat mass and percentage, waist and hip circumference, and waist-to-hip ratio were lower in women with higher physical activity (P < .0001). Within each category of total physical activity, a larger proportion of vigorous physical activity was associated with lower adiposity (P < .0001). ConclusionsThese findings support the roles of a physically active lifestyle and vigorous exercise in maintaining healthy body size and composition. Higher exercise intensity may be associated with lower adiposity, beyond the influence of exercise frequency and duration.

Physical activity and body mass index as predictors of prostate cancer risk.

Physical activity and body mass index (BMI) are involved in prostate cancer etiology; possible biologic mechanisms include their effects on hormonal levels. Our aim was to investigate the relationship between physical activity, obesity, and prostate cancer. We followed a cohort of 13,109 Swedish men for 13 years and investigated the association of self-reported physical activity and BMI at baseline with prostate cancer incidence. We further analyzed whether BMI could modulate effects of physical activity. Occupational, recreational, and total physical activity were analyzed in relation to overall, localized, and advanced prostate cancer. During the study follow-up, we observed a total of 904 cases of prostate cancer (429 localized, 407 advanced, and 68 unclassified). High levels of occupational physical activity were associated with a nonsignificantly decreased risk of overall (HR 0.81, 95 % CI 0.61-1.07), localized (HR 0.75, 95 % CI 0.51-1.12), and advanced (HR 0.85, 95 % CI 0.55-1.31) prostate cancer. We found no association between high BMI and risk of prostate cancer incidence: We observed, however, a significant interaction between BMI and leisure physical activity. No association was confirmed between total physical activity and localized or advanced prostate cancer. The highest, relative to the lowest, level of occupational physical activity tended to be linked to a lower risk of prostate cancer, with a suggested dose-response relationship. We found no association between high BMI and risk of prostate cancer incidence; however, our analyses suggested an interaction between BMI and physical activity during recreational time that merits further investigation in future studies.

Self-esteem Mediates Associations of Physical Activity with Anxiety in College Women

Why physically active people report lower anxiety than those who are inactive is not well understood. This study examined whether physical self-concept and self-esteem would mediate associations of self-reported physical activity with anxiety disorder symptoms in young women, a population with elevated risk for developing an anxiety disorder. College women (N = 1036, mean ± SD = 19.7 ± 2.9 yr) completed a physical activity recall, the Psychiatric Diagnostic Screening Questionnaire, and the Physical Self-Description Questionnaire. Structural equation modeling was used to test hypotheses. Physical activity had inverse, indirect associations with symptoms of social phobia, generalized anxiety disorder, and obsessive-compulsive disorder that were expressed through its positive association with specific and global physical self-concept and self-esteem. The results were independent of similar relations with symptoms of major depressive disorder as well as the estimates of body fatness and use of psychotropic medications. These correlational findings provide initial evidence to warrant experimental efficacy trials of whether physical activity will reduce the risk of anxiety disorders in young women by positive influences on physical self-concept and self-esteem.

Relation Between Self-Reported Physical Activity Level, Fitness, and Cardiometabolic Risk

Physical activity and cardiorespiratory fitness are associated with improved cardiovascular health and reduced all-cause mortality. The relation between self-reported physical activity, objective physical fitness, and the association of each with cardiometabolic risk has not been fully described. We studied 2,800 healthy Brazilian subjects referred for an employer-sponsored health screening. Physical activity level was determined as "low," "moderate," or "high" with the International Physical Activity Questionnaire: Short Form (IPAQ-SF). Fitness was measured as METs achieved on a maximal, symptom-limited, treadmill stress test. Using multivariate linear regression analysis, we calculated age, gender, and smoking-adjusted correlation coefficients among IPAQ-SF, fitness, and cardiometabolic risk factors. Mean age of study participants was 43 ± 9 years; 81% were men, and 43% were highly active. Mean METs achieved was 12 ± 2. IPAQ-SF category and fitness were moderately correlated (r = 0.377). Compared with IPAQ-SF category, fitness was better correlated with cardiometabolic risk factors including anthropomorphic measurements, blood pressure, fasting blood glucose, dyslipidemia, high-sensitivity C-reactive protein, and hepatic steatosis (all p <0.01). Among these, anthropomorphic measurements, blood pressure, high-sensitivity C-reactive protein, and hepatic steatosis had the largest discrepancies in correlation, whereas lipid factors had the least discrepant correlation. When IPAQ-SF and fitness were discordant, poor fitness drove associations with elevated cardiometabolic risk. In conclusion, self-reported physical activity level and directly measured fitness are moderately correlated, and the latter is more strongly associated with a protective cardiovascular risk profile.

Abstract TMP46: Self-reported Physical Activity Frequency and Risk of Incident Stroke in the REasons for Geographic and Racial Differences in Stroke (REGARDS) Study

Background and Purpose: Adherence to a healthy lifestyle is known to reduce stroke risk, and regular physical activity is an important recommendation for stroke prevention. We compared the associations of self-reported physical activity (PA) with incident stroke in the REasons for Geographic And Racial Differences in Stroke (REGARDS) study. Methods: REGARDS recruited 30,239 US blacks (44%) and whites, aged 45 years or older in 2003 to 2007 who are being followed every 6 months for events. After excluding those with prior diagnosed stroke, this analysis involved 27,348 people. Participants reported their frequency of moderate-vigorous intensity PA at baseline according to three categories: none (physical inactivity), 1-3 times/week and ≥ 4 times/week. Stroke and TIA cases were identified and adjudicated during an average of 5.7 years of follow-up. Cox proportional hazards models were constructed to examine whether self-reported PA was associated with the risk of incident stroke. Results: Physical inactivity was reported by 33% of participants and was associated with a hazard ratio (HR) of 1.20 ([95% confidence intervals 1.02-1.42], p = 0.035). Adjustment for demographics (age, race, sex) and socioeconomic factors did not affect the HR, but further adjustment for traditional stroke risk factors (diabetes, hypertension, body mass index, alcohol use and smoking) completely attenuated this risk (HR 1.14 [0.95-1.37], p = 0.17). We examined the HR separately for men and women and found no significant association between PA frequency and risk of stroke although there was a trend towards increased risk for men reporting PA 0-3 times a week compared to 4 or more times a week. Conclusions: Self-reported low PA frequency is associated with increased risk of incident stroke. Any effect of PA is likely to be mediated through reduction of traditional risk factors such as hypertension, body mass index and diabetes.

Physical activity and self‐reported symptoms of insomnia, restless legs syndrome, and depression: The comprehensive dialysis study

Symptoms of sleep and mood disturbances are common among patients on dialysis and are associated with significant decrements in survival and health-related quality of life. We used data from the Comprehensive Dialysis Study (CDS) to examine the association of self-reported physical activity with self-reported symptoms of insomnia, restless legs syndrome (RLS), and depression in patients new to dialysis. The CDS collected data on physical activity, functional status, and health-related quality of life from 1678 patients on either peritoneal (n = 169) or hemodialysis (n = 1509). The Human Activity Profile was used to measure self-reported physical activity. Symptoms were elicited in the following manner: insomnia using three questions designed to capture difficulty in initiating or maintaining sleep, RLS using three questions based on the National Institutes of Health workshop, and depression using the two-item Patient Health Questionnaire. We obtained data on symptoms of insomnia and depression for 1636, and on symptoms of RLS for 1622 (>98%) patients. Of these, 863 (53%) reported one of three insomnia symptoms as occurring at a persistent frequency. Symptoms of RLS and depression occurred in 477 (29%) and 451 (28%) of patients, respectively. The Adjusted Activity Score of the Human Activity Profile was inversely correlated with all three conditions in models adjusting for demographics, comorbid conditions, and laboratory variables. Sleep and mood disturbances were commonly reported in our large, diverse cohort of patients new to dialysis. Patients who reported lower levels of physical activity were more likely to report symptoms of insomnia, RLS, and depression.

Longitudinal patterns in physical activity and sedentary behaviour from mid-life to early old age: a substudy of the Whitehall II cohort

BackgroundThere are few longitudinal data on physical activity patterns from mid-life into older age. The authors examined associations of self-reported physical activity, adiposity and socio-demographic factors in mid-life with objectively...

Physical activity, diabetes, and thyroid cancer risk: a pooled analysis of five prospective studies

PURPOSE: Although many studies have linked obesity with increased risk of thyroid cancer, few have investigated the role of obesity-related lifestyle characteristics and medical conditions in the etiology of this disease. We examined the associations of self-reported physical activity and diabetes history with thyroid cancer risk in a large pooled analysis of prospective cohort studies. METHODS: Data from five prospective studies in the U.S. (n=362,342 men, 312,149 women) were coded using standardized exposure, covariate, and outcome definitions. Hazard ratios (HR) and 95% confidence intervals (CI) for thyroid cancer were estimated using age as the time metric and adjusting for sex, education, race, marital status, cigarette smoking, body mass index, alcohol intake, and cohort. Effect modification by other risk factors (e.g., age, sex, and body mass index) and differences by cancer subtype (e.g., papillary, follicular) were also examined. RESULTS: Over follow-up (median=10.5years), 308 men and 510 women were diagnosed with a first primary thyroid cancer. Overall, subjects reporting the greatest amount of physical activity had an increased risk of the disease (HR=1.18, 95% CI:1.00-1.39); however, this association was restricted to participants who were overweight/obese (≥25kg/m(2); HR=1.34, 95% CI:1.09-1.64) as opposed to normal-weight (<25kg/m(2); HR=0.92, 95% CI:0.69-1.22; P-interaction=0.03). We found no overall association between self-reported history of diabetes and thyroid cancer risk (HR=1.08, 95% CI:0.83-1.40). CONCLUSION: Neither physical inactivity nor diabetes history was associated with increased risk of thyroid cancer. While it may have been a chance finding, the possible increased risk associated with greater physical activity warrants further investigation.