Association Of Serum Lipid Profile Research Articles

Association of serum lipid profile and diabetes mellitus among middle aged Lithuanian adults

Aim: The aim of the study was to assess the differences of lipidogram parameters between diabetes mellitus (DM) group and non-diabetic group of middle aged Lithuanian adults participating in Lithuanian High Cardiovascular Risk primary prevention programme.

Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

Association of serum lipid profile and family history of coronary heart disease among middle aged Lithuanian adults

Association of serum lipid profile and dietary habits among middle-aged Lithuanian adults

Aim: The aim of the study was to assess the effect of diet on serum lipid profile values among middle-aged Lithuanian adults in Lithuanian High Cardiovascular Risk (LitHiR) primary prevention program.

Association of serum lipid profile and physical activity among middle aged Lithuanian adults

Aim: The aim of the study was to determine the differences of serum lipid profile between sufficient and insufficient physical activity groups, consisting of middle aged Lithuanian adults participating in Lithuanian High Cardiovascular Risk primary prevention programme.

A comparative study of serum lipid profile of women with preeclampsia and normotensive pregnancy

Introduction: Preeclampsia is associated with substantial risks for the fetus and the mother. Women with preeclampsia have a significant difference in lipid parameters compared to normal pregnancy. The association of serum lipid profile with gestational proteinuric hypertension is highly suggested to reflect a new diagnostic tool. Materials and Methods: The present study is a prospective case–control comparative study done over a period of 2 years, i.e., from October 2015 to July 2017. The study takes into account 100 normotensive pregnant women (control group) and 100 pre-eclamptic women (study group) in their third trimester of pregnancy. Serum total cholesterol (TC), triglycerides (TGs), low-density lipoprotein-cholesterol (LDL-C), high-density lipoprotein-C (HDL-C), and very LDL-C (VLDL-C) were estimated in both groups. Aims: The study aims to analyze the lipid profile in normotensive pregnant patients, to analyze the lipid profile in pregnancy-induced hypertension patients, and to investigate the alteration in lipid profile in both groups. Results: There was a significant rise in serum TC, TGs, LDL-C, VLDL-C, and a significant decrease in HDL-C in the study group as compared to controls. Conclusion: Altered lipid profile also has a potential role in the genesis of endothelial dysfunction and expression of preeclampsia. Early detection of these lipid parameters may help pregnant patients by preventing maternal and fetal complications in preeclampsia and is going to aid in better management of preeclampsia.

우리나라 성인에서 혈청 지질성분비가 허혈성 심장질환 발생에 미치는 위험도 평가: 코호트 연구

본 연구에서는 우리나라 30세 이상 성인들의 허혈성심장질환(ischemic heart disease, IHD) 발생률을 계산하고, 지질지표(콜레스테롤, 중성지방, 고밀도지단백콜레스테롤, 저밀도지단백콜레스테롤)가 허혈성심장질환 발생에 미치는 위험도를 파악하고자 19개 대학 및 종합병원의 건강검진센터에서 검진을 받은 417,642명을 대상으로 1993년 9월부터 2009년 6월까지 평균 8.5년동안 허혈성심장질환의 발생을 추적관찰하였다. 자료수집은 검진자들에 대한 설문조사지를 이용하였고, 허혈성심장질환의 발생여부는 국민건강보험공단의 데이터베이스에서 확인하였다. 발생률은 발생밀도로 계산하였고, 혈청지질 지표에 따른 허혈성심장질환의 발생 위험도는 콕스의 비례위험 회귀모형을 이용하여 연령, BMI, 생활양식을 보정한 상태에서 성별에 따른 위험요인별 위험비와 95% 신뢰구간을 계산하였다. 연구결과 TC/HDL 비의 증가에 따라 IHD의 발생 위험비는 남자에서 1.21배에서 1.84배까지, 여자는 1.26배에서 1.86배까지 증가하였으며, TG/HDL 비의 증가에 따른 IHD의 발생 위험비는 남자에서 1.17배에서 1.49배까지, 여자는 1.42배에서 1.97배까지, LDL/HDL 비에 따라 IHD의 발생 위험비는 남자에서 1.26배에서 1.82배까지, 여자는 1.26배에서 1.68배까지 증가하였다. 결론적으로 혈청지질지표는 심혈관질환의 중요한 위험요인으로 총콜레스테롤, 저밀도지단백콜레스테롤, 중성지방은 혈중 농도가 높을수록, 고밀도지단백콜레스테롤은 낮을수록 IHD의 위험이 높아지는 것으로 나타났고, TC/HDL 비, TG/HDL 비, LDL/HDL 비에서 단독의 지질지표보다 위험도가 더 높게 나타나는 경향이 있었다. 따라서 추후 허혈성 심장질환의 예방 및 관리에는 혈청지질지표의 비도 감안하여야 한다. This study conducted to investigate incidence rate and association of serum lipid profiles with incidence of ischemic heart disease. Study subjects consisted of 417,642 adults aged 30 years and over, who underwent physical examination and responded to questionnaire from health examination center of 19 university general hospitals. Hazard ratio of risk factor for ischemic heart disease (IHD) were calculated by Cox's proportional hazard regression model adjusted for ages, BMI and lifestyle (drinking, smoking and exercising). For TC/HDL ratio, hazard ratio of IHD in male increased from 1.21 times to 1.84 times increase with TC/HDL ratio, and that in female also increased from 1.26 times to 1.86 times. For TG/HDL ratio, hazard ratio of IHD in male increased from 1.17 times to 1.49 times increase with TG/HDL ratio, and that in female also increased from 1.42 times to 1.97 times. For LDL/HDL ratio, hazard ratio of IHD in male increased from 1.26 times to 1.82 times increase with LDL/HDL ratio, and that in female also increased from 1.26 times to 1.68 times. In conclusion serum lipid indexes are the significant risk factors for cardiovascular diseases. The higher the concentration of TC, LDL and TG is, the lower the concentration of HDL is, hazard ratio for IHD increased. Ratio of TC/HDL, TG/HDL and LDL/HDL were also verified to be significant risk factors for IHD.

Association of serum lipid profile with distant metastasis in breast cancer patients

In order to investigate whether the presence of distant metastases is associated with serum lipid abnormalities. The fasting serum lipid profile and various clinicopathological data of 324 breast cancer patients with and without synchronous distant metastases were collected and analyzed. The serum lipid profile, including total cholesterol (TC), triglycerides (TG), low-density (LDL-C) and high-density lipoprotein cholesterol (HDL-C) was determined. The nutritional status, the serum albumin was measured and body mass index (BMI) was calculated. Univariate analysis and multiple logistic regression analysis were carried out to investigate the association of serum lipid profile with distant metastases. Univariate analysis showed that the distant metastasis rate was significantly higher in the breast cancer patients with an higher level of serum TC, TG, LDL-C, and LDL-C/HDL-C ratio (P < 0.05). Multiple logistic regression analysis showed that higher serum levels of TC, LDL-C and LDL-C/HDL-C ratio were independent risk factors for distant metastasis in breast cancer (OR = 2.324, 2.648 and 4.862, respectively). Hyperlipidemia is significantly associated with the distant metastasis in breast cancer patients. Monitoring of serum lipid profile may be helpful to predict the occurrence of distant metastasis in breast cancer patients.

Association of serum lipid profiles with inflammation in autoimmune diseases

Association of serum lipid profiles with inflammation in autoimmune diseases

1P-0010 Association of serum lipid profile and mortality in a cohort of 3,499 urban Thais: The electricity generating authority of Thailand (EGAT) study

1P-0010 Association of serum lipid profile and mortality in a cohort of 3,499 urban Thais: The electricity generating authority of Thailand (EGAT) study