Association Of High-density Lipoprotein Cholesterol Levels Research Articles

Relationship between high-density lipoprotein cholesterol levels and endothelial function in women: a cross-sectional study

ObjectivesThe purpose of this study was to evaluate the relationship between high-density lipoprotein cholesterol (HDL-C) levels and endothelial function in women.DesignCross-sectional study.Setting22 university hospitals and affiliated clinics in Japan.Participants1719 Japanese...

Association of total cholesterol and HDL-C levels and outcome in coronary heart disease patients with heart failure.

The aim of the study was to evaluate associations of total cholesterol (TC) and high density lipoprotein cholesterol (HDL-C) levels with prognosis in coronary heart disease (CHD) patients with heart failure (HF).Patients who were angiographical-diagnosis of CHD and echocardiographical-diagnosis of left ventricular ejection fraction (LVEF) < 45% were enrolled. Baseline characteristics were collected and association of TC and HDL-C levels with rehospitalization for HF and all-cause mortality was assessed.A total of 118 patients were recruited. Mean age was 58.6 ± 10.9 years and male accounted for 65%. Mean LVEF was 39.5 ± 4.0%. Twenty-eight patients were rehospitalized for HF and 6 patients were dead. In patients with poor prognosis, lower body mass index (BMI), TC, HDL-C and albumin while higher high sensitivity C-reactive protein (Hs-CRP) was observed. TC was positively correlated with BMI and albumin, and HDL-C was inversely correlated with Hs-CRP. The associations of TC level and rehospitalization for HF and all-cause mortality were attenuated but consistently significant through model 1 to 4, with odds ratio (OR) of 0.97 (95% confidence interval [CI]: 0.92–0.99). Associations of HDL-C level and rehospitalization for HF and all-cause mortality were also consistently significant through model 1 to 4, with OR of 0.95 (95% CI: 0.90–0.98). Strength of association was attenuated prominently in model 3 after adjusted for Hs-CRP, and no change was observed after further adjusted for BMI and albumin.Higher baseline TC and HDL-C levels are associated with better outcome in CHD patients with HF.

Could Low Hdl-Cholesterol Levels Be an Unvalued Predictor of Cancer Risk?: A Retrospective Case Study

Background: The relationship between serum lipid profile levels and cancer risk remained uncertain. Recently, it had been reported a significant inverse association between high-density lipoprotein cholesterol (HDL) and the risk of incident cancer that was independent of low-density lipoprotein cholesterol (LDL), age or sex. Objective: The aim of our study was to evaluate the behavior of HDL in cancer patients and in healthy population. Methods: We created a retrospectively search strategy in the laboratory information system (LIS). We filtered and searched those patients with CEA within 5 - 20 ng/ml and any value of HDL and corroborated the presence of cancer (Group 1 (G1)) or not (Group 2 (G2)). Moreover, we searched a control group (patients in outpatient oncology clinic) to observe the values of HDL. Comparisons and statistical logistic regression models were applied to link the levels of this biomarkers and cancer risk. Results: We examined 852 valid patients, median age 62 (50 - 73) years. Within the search strategy group, G2 showed highest levels of HDL (54 (43 - 67) mg/dl) and lowest CEA levels (6.7 (5.7 - 8.4) ng/ml) comparing with G1: HDL (47 (37 - 60) mg/dl) and the CEA (7.9 (6.2 - 10.9) ng/ml); p < 0.001. The values in control group were: the lowest HDL levels (41 (29 - 54) mg/dl) and CEA (25.2 (6.1 - 124.5) ng/ml); p < 0.001, between oncologic patients and the search strategy group. On logistic regression multivariate analysis, we obtained: r²: 0.092; p < 0.001; HDL [OR: 0.983 (0.974 - 0.993), (p = 0.001)] and CEA [OR: 1.115 (1.060 - 1.174), (p < 0.001)] and they were confirmed as independent predictors of cancer. Conclusion: Our findings confirmed the inverse association of HDL levels between healthy * Both authors contributed equally. # Corresponding author.

Response to Letter Regarding Article, “Statin Use in Patients With Extremely Low Low-Density Lipoprotein Levels Is Associated With Improved Survival”

HomeCirculationVol. 117, No. 9Response to Letter Regarding Article, “Statin Use in Patients With Extremely Low Low-Density Lipoprotein Levels Is Associated With Improved Survival” Free AccessLetterPDF/EPUBAboutView PDFView EPUBSections ToolsAdd to favoritesDownload citationsTrack citationsPermissions ShareShare onFacebookTwitterLinked InMendeleyReddit Jump toFree AccessLetterPDF/EPUBResponse to Letter Regarding Article, “Statin Use in Patients With Extremely Low Low-Density Lipoprotein Levels Is Associated With Improved Survival” Nicholas J. Leeper, MD, Reza Ardehali, MD, PhD, Emil M. deGoma, MD and Paul A. Heidenreich, MD, MS Nicholas J. LeeperNicholas J. Leeper Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif Search for more papers by this author , Reza ArdehaliReza Ardehali Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif Search for more papers by this author , Emil M. deGomaEmil M. deGoma Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif Search for more papers by this author and Paul A. HeidenreichPaul A. Heidenreich Department of Medicine, Stanford University School of Medicine, Palo Alto, Calif Search for more papers by this author Originally published4 Mar 2008https://doi.org/10.1161/CIRCULATIONAHA.107.744243Circulation. 2008;117:e175Anderson and Salgado offer the hypothesis that increases in high-density lipoprotein (HDL) cholesterol may explain in part the benefit of statins that we observed in patients with extremely low low-density lipoprotein (LDL) values. Although we cannot answer the question directly, we have examined the association of HDL cholesterol levels and outcome in this cohort.1 We found that low HDL cholesterol remains a risk factor for death and ischemic heart disease events in this group with an LDL cholesterol <60 mg/dL. This association between HDL and outcome in patients with low LDL cholesterol was recently confirmed in a separate population.2 Thus, we agree that the likely benefit of statins in patients with low LDL cholesterol may be due in part to an increase in HDL cholesterol.DisclosuresNone. References 1 deGoma EM, Leeper NJ, Heidenreich PA. Clinical significance of high-density lipoprotein cholesterol in patients with low low-density lipoprotein cholesterol. J Am Coll Cardiol. 2008; 51: 49–55.CrossrefMedlineGoogle Scholar2 Barter P, Gotto AM, LaRosa JC, Maroni J, Szarek M, Grundy SM, Kastelein JJ, Bittner V, Fruchart JC; Treating to New Targets Investigators. HDL cholesterol, very low levels of LDL cholesterol, and cardiovascular events. N Engl J Med. 2007; 357: 1301–1310.CrossrefMedlineGoogle Scholar Previous Back to top Next FiguresReferencesRelatedDetails March 4, 2008Vol 117, Issue 9 Advertisement Article InformationMetrics https://doi.org/10.1161/CIRCULATIONAHA.107.744243 Originally publishedMarch 4, 2008 PDF download Advertisement SubjectsMetabolism