Association Of ABO Blood Type Research Articles

ABO Red Cell Antigens, von Willebrand Factor, Factor VIII and Platelet counts among Hypertensive Patients In Kaduna Metropolis, Kaduna.

Background: von Willebrand Factor and factor VIII have been implicated in the vulnerability of causing hypertension which is related/common to some of the ABO blood group antigens. However, the precise mechanism/role of the von Willebrand Factor and factor VIII in hypertension is unknown. The study is a comparative study that is aimed to determine the association of ABO red cell antigen, von Willebrand factor, Factor VIII, and Platelets among hypertensive patients in Kaduna, Nigeria. Methods: To determine this association, fifty-five (55) hypertensive patients and 28 controls were recruited. A purposive sampling technique was employed in selecting the study participants. Determination of the ABO blood group, vWF, FVIII, and platelets was carried out to establish the frequency and the association of ABO blood type with hypertension. Results: It was established that blood group O (43%) has the highest distribution followed by A, B, and AB (6%) the least. There was no significant difference in vWF(ng/L), FVIII(pg/ml), and platelet count(109/l) between the patients and the controls (454.9 and 456.2), (242.0 and 228.4) and (238.0 and 213.0) respectively, p>0.05. The correlation studies showed a strong association between vWF and FVIII (r - 0.544, P<0.0001). There was a significant difference between males’ and females’ vWF and FVIII (P=0.0013 and 0.0029 respectively), indicating females had a higher level of vWF and FVIII, and therefore at higher risk of developing hypertension. Women should therefore be screened for these parameters as a matter of routine. Conclusion: The risk of developing hypertension based on the parameters considered in this study is independent of the ABO blood group of an individual. There is a need for further studies, to confirm or rule out these findings.

Association of ABO Blood Type with Infection and Severity of COVID-19 in Inpatient and Longitudinal Cohorts

The objectives of this study were to (1) investigate the association between human blood type and COVID-19 in both inpatient and longitudinal populations and (2) identify the association between blood type and severity of COVID-19 via presence of cellular biomarkers of severe infection in hospitalized individuals at our institution in South Florida. This study consisted of (1) a single-center retrospective analysis of 669 out of 2741 COVID-19-positive, screened patients seen from 1 January 2020 until 31 March 2021 at the University of Miami Emergency Department (ED) who tested positive for COVID-19 and had a documented ABO blood type and (2) a longitudinal SARS-CoV-2 immunity study (“CITY”) at the University of Miami Miller School of Medicine, consisting of 185 survey participants. In an inpatient setting, blood type appeared to be associated with COVID-19 severity and mortality. Blood type O sustained less risk of COVID-19 mortality, and blood type O- demonstrated less risk of developing COVID-19 pneumonia. Inpatients with O- blood type exhibited less biomarkers of severe infection than did other blood types. In a longitudinal setting, there was no association found between blood type and SARS-CoV-2 infection.

ABO blood types, but not Secretor or Lewis blood types, influence strength of antibody response to Hepatitis B vaccine in Black South African children.

Subunit vaccines for the Hepatitis B virus (HBV) have greatly reduced the prevalence of infection and morbidity through HBV-related liver cirrhosis and cancer. However, strength of immune response to vaccination varies considerably. While it is known that ABO blood types may influence HBV infection risk, the role of ABO and related blood types in strength of immune response to HBV vaccine has not been investigated. We examined 16 polymorphisms in the ABO, FUT2, and FUT3 genes and their related phenotypes for associations with strength of antibody response to HBV vaccine in Black South African infants. Anti-HBc and anti-HBs antibody levels were measured by CMIA assay 1-3months after the last dose of HBV vaccine. Prior infection occurred in 8/207 individuals (3.86%) who were removed from further study. Of the remaining 199 individuals, 83.4% individuals were strong responders (anti-HBs≥100 mIU/ml, median 973 mIU/ml), another 15.6% were weak responders (anti-HBs<100 mIU/ml, median 50 mIU/ml) and 1% were non-responders (anti-HBs<10 mIU/ml). The frequency of weak responders to HBV vaccine was not significantly affected by sex, birthweight, use of an additional booster dose of vaccine or cohort of origin. We characterised patterns of genetic variation present at the ABO, FUT2 and FUT3 loci by use of MassArray genotyping and used these data to predict ABO, Secretor and Lewis phenotypes. We observed significant association of ABO blood type with strength of antibody response to HBV vaccine in a Black South African cohort (p=0.002). In particular, presence of rs8176747G and expression of B antigen (whether in B blood type or AB blood type) was associated with decreased antibody response to HBV vaccine. Secretor and Lewis blood types were not associated with antibody response to HBV vaccine. This work increases our understanding of the impact that host genetic variation may have on vaccine immunogenicity.

Retrospective analysis on association of ABO blood type and immune checkpoint inhibitor response.

2596 Background: The presence or lack of a collection of antigenic cell surface markers on red blood cells makes up the ABO blood groups that contribute to various immunogenic neoantigens. Variations in the T-cell diversity and HLA haplotype with different blood types might affect a patient's response to Immune checkpoint inhibitors (ICIs). However, the association between the ABO blood type and ICIs is not well studied. Methods: We did a retrospective observational study to investigate the influence of ABO blood groups on patients receiving ICIs at the University of Vermont Cancer Centre. We examined the medical records of people who received ICIs as first-line therapy between January 2017 and June 2022 and collected demographic data, including age, sex, ethnicity, cancer stage, type and metastasis. We looked at overall survival and the occurrence of immune-related adverse events (irAEs) in different blood type subgroups and calculated relative risks. Results: A total of 288 cases were identified, out of which 169 had documented blood type, including 75 with A, 19 with B, 72 with O and 3 with AB blood type. The mean age was 63.71 years (Standard deviation (SD): 11.52), 58.6% were males, and ethnicity was 94.7% White, 1.2% Asian and 0.6% Hispanic. Lung cancer was most commonly identified at 41%, and 60% of total cancers were stage 4. The median ECOG status was 1 and the Charlson comorbidity index was 6. 36% of cases developed irAEs, whereas mortality was 39% during the study period. The relative risk of irAEs with blood type A and B compared to O was 0.89 and 0.83, respectively but wasn't statistically significant. The relative risk of irAEs of AB compared to O blood type was statistically significant at 2.63 (CI: 1.95-3.54). The relative risk of death in A and B blood types compared to O wasn't statistically significant. No patients in the AB blood group died. Conclusions: Clinically significant association wasn't found between different blood types and irAEs or mortality except for the increased risk of irAEs with AB compared to O. With the rapidly growing use of ICIs, prospective trials are needed to better understand the true risk of developing irAEs in patients with AB blood type. [Table: see text]

Association between ABO blood type and type I endometrial cancer: a retrospective study

This study aimed to assess the association between ABO blood type and incident of type I endometrial cancer (EC), as well as the stage and differentiation. 213 patients with type I EC and 300 healthy controls were included. As a result, the frequencies of A, B, O, and AB blood types among patients with type I EC were 51 (23.9%), 59 (27.7%), 93 (43.7%) and 10 (4.7%), respectively. There were no significant differences in age, body mass index, and other baseline covariates between groups of ABO blood types (p > .05). Logistic regression model showed that women with blood type O was more likely to develop type I EC than those with type A (odds ratio (OR): 1.66, 95% confidence interval (CI): 1.05–2.63). However, there was no significant association of ABO blood type with stage and differentiation of type I EC (p > .05). In conclusion, blood type O was the most prevalent ABO blood type among patients with type I EC and was associated with increased risk of type I EC, while ABO blood type was not significantly associated with stage or differentiation of type I EC. IMPACT STATEMENT What is already known on this subject? Previous studies have produced inconsistent findings on association of ABO blood type with EC. Those studies also did not explore the relationship between ABO blood type and stage or differentiation of type I EC. What the results of this study add? The present study showed that women with blood type O was more likely to develop type I EC than those with type A and there was no significant association of ABO blood type with stage or differentiation of type I EC. What the implications are of these findings for clinical practice and/or further research? Gynaecologists should pay more attention to women with blood type O, who should undergo more active EC screening.

Association of ABO blood types and clinical variables with COVID-19 infection severity in Libya.

The continuing COVID-19 pandemic is a coronavirus-related health emergency (severe acute respiratory syndrome coronavirus 2). Inadequate efforts are still being made to address the illness situation in Libya, and this must change. To address these issues, we looked into the demography and trend of the disease as well as the potential risk factors for infection. This study is a retrospective case-control study conducted online among 616 COVID-19 patients. The p0.05 value, odds ratios, and 95% confidence intervals were calculated and analyzed from the drawn data. Males were at high risk of COVID-19 than females (odds ratio = 1.3, 95% confidence interval: 1.042-1.622; p = 0.02). Anosmia and ageusia were more prominent in females. Patients with an "AB" blood group are significantly susceptible to infection. Adults (31 and above) are highly liable to infection. The univariate logistic regression analysis revealed that smoking is a risk factor for those above 60 years (odds ratio = 2.228, 95% confidence interval: 1.145-4.336; p = 0.018). Individuals with chronic diseases such as diabetes and/or hypertension are more prone to COVID-19 (odds ratio = 10.045, 95% confidence interval: 3.078-32.794; p = 0.000 and odds ratio = 11.508, 95% confidence interval: 3.930-33.695; p = 0.000, respectively). This study provided for the first time the demographic data and the trend of COVID-19 infection in Libya, which will assist the stakeholders and governmental bodies in planning protection strategies against the pandemic.

Allelic Variants Within the ABO Blood Group Phenotype Confer Protection Against Critical COVID-19 Hospital Presentation.

Introduction: Coronavirus disease 2019 (COVID-19) disease severity differs widely due to numerous factors including ABO gene-derived susceptibility or resistance. The objective of this study was to investigate the association of the ABO blood group and genetic variations of the ABO gene with COVID-19 severity in a heterogeneous hospital population sample from the United Arab Emirates, with the use of an epidemiological and candidate gene approach from a genome-wide association study (GWAS).Methods: In this cross-sectional study, a total of 646 participants who tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) were recruited from multiple hospitals and population-based (quarantine camps) recruitment sites from March 2020 to February 2021. The participants were divided into two groups based on the severity of COVID-19: noncritical (n = 453) and critical [intensive care unit (ICU) patients] (n = 193), as per the COVID-19 Reporting and Data System (CO-RADS) classification. The multivariate logistic regression analysis demonstrated the association of ABO blood type as well as circulating anti-A antibodies and anti-B antibodies as well as A and B antigens, in association with critical COVID-19 hospital presentation. A candidate gene analysis approach was conducted from a GWAS where we examined 240 single nucleotide polymorphisms (SNPs) (position in chr9: 136125788-136150617) in the ABO gene, in association with critical COVID-19 hospital presentation.Results: Patients with blood group O [odds ratio (OR): 0.51 (0.33, 0.79); p = 0.003] were less likely to develop critical COVID-19 symptoms. Eight alleles have been identified to be associated with a protective effect of blood group O in ABO 3'untranslated region (UTR): rs199969472 (p = 0.0052), rs34266669 (p = 0.0052), rs76700116 (p = 0.0052), rs7849280 (p = 0.0052), rs34039247 (p = 0.0104), rs10901251 (p = 0.0165), rs9411475 (p = 0.0377), and rs13291798 (p = 0.0377).Conclusion: Our findings suggest that there are novel allelic variants that link genetic variants of the ABO gene and ABO blood groups contributing to the reduced risk of critical COVID-19 disease. This study is the first study to combine genetic and serological evidence of the involvement of the ABO blood groups and the ABO gene allelic associations with COVID-19 severity within the Middle Eastern population.

Association of ABO blood type with mortality in hospitalized patients with COVID-19

Introduction. The novel SARS-CoV-2 infection (COVID-19) has generated a global crisis. It is necessary to find prognosis factors for hospitalized patients with SARS-CoV-2, that help us to understand the observed difference in disease severity in patients with similar characteristics. The aim of this study was to explore the relation between ABO groups and in-hospital mortality in Mexican patients admitted with COVID-19. Study design and Methods. We performed a retrospective study with 2369 hospitalized patients with SARS-CoV-2 confirmed infection in a tertiary referral hospital, admitted from March 27 and December 10, 2020. Results. Type A blood was associated with a lower hazard of death among COVID-19 patients compared to type O (adjusted HR=0.72, 95% IC 0.55-0.95, P-value=0.02). Conclusions We found evidence of a significant association between ABO blood type and COVID-19 in-patients’ death. The blood group A may be less likely to death during hospitalization compared with group O.

Association of ABO Blood Type with Bleeding Severity in Patients with Acute Gastroesophageal Variceal Bleeding.

Background and Objectives: ABO blood types have been implicated as potential risk factors for various hemorrhagic diseases. No study has investigated the association between gastroesophageal variceal bleeding and ABO blood types. We aimed to evaluate the impact of ABO blood types on mortality and bleeding risk in acute gastroesophageal variceal bleeding. Materials and Methods: This is a retrospective observational study. Patients presenting with acute gastroesophageal varices bleeding diagnosed by endoscopy were enrolled, and were divided by blood type into a type O group and non-type O group. The outcomes were death within 30 days and the proportion of further bleeding. We used generalized linear mixed-effects models to analyze the outcomes. Results: A total of 327 patients and 648 records of emergency room visits were included. The 30-day mortality was 14.8% (21 of 142 patients) in the type O group, and 16.2% (30 of 185 patients) in the non-type O group (p = 0.532). Further bleeding within 30 days occurred in 34 cases (12.6%) in the type O group, and in 26 cases (6.9%) in the non-type O group (p = 0.539). Conclusions: There was no significant difference in blood transfusion volume in 24 h, recurrent bleeding rates, or mortality between patients with blood type O and those with non-type O.

Association of ABO Blood Grouping and Periodontal Disease: A Literature Review

AbstractAlthough the correlation between the ABO blood group and certain systematic diseases is a well-documented fact. Few studies have explored the relationship of ABO with oral disorders including periodontal diseases (PD). This literature review aimed to assess the possible association between ABO blood grouping and PD. For this purpose, we searched online databases like PubMed and google scholar with the following terms in different combinations PD, ABO blood groups, gingivitis, the prevalence of periodontitis, aggressive periodontitis, risk factors of periodontitis, Association of PD and ABO, ABO Rh factor. English version papers describing the Oral health status are covered through research that includes clinical investigations, case studies, and retrospective studies on the subject. Historic reviews, articles with unpublished data, and letters to the editors were omitted from the survey following publications. The author thoroughly checked the titles and abstracts of the papers. The complete text was thoroughly assessed, and the relevant articles were analyzed in accordance with qualifying criteria. For further original and review research, references were further reviewed. Since our targeted subject was answered by a restricted number of original research. We identified fourteen articles describing the association of ABO blood types with PD. findings of our study concluded the genetic basis of the association of ABO blood types for the development of PD. six of the research provided here showed that the blood type O can serve as a prognostic factor for the development of PD. ABO blood types and Rhesus factors can be a risk predictors in the development of PD.

Molecular and Serological Detection of Hepatitis B Virus (HBV) and its Relation to ABO Blood Gropus in Thi-Qar Province/South Iraq

Hepatitis B Virus (HBV) infections are a significant public health problem all over the world. Among infectious disease, Hepatitis B virus is of great concern because of their prolonged viraemia and carrier or latent state. The present study aimed to determine the frequency of HBV among blood donors of Thi-Qar province and to evaluate the association of ABO blood type to HBV infections. The anti-HBc and HBs Ag technique was implemented to detect the presence of HBV, and the real-time PCR used to determinant HPV DNA in blood samples. The tube method used to detect blood group. This study was conducted on 200 serum samples from different age groups. The results showed that 3.5% of positive anti-HBc individuals, gave positive results for HBsAg by ELISA III technique and 5.5% of cases gave positive results for HBV DNA by real-time PCR. The ABO finding showed that the highest percentage of HBV infections were among patients of blood 97 (48.5%), followed by blood group B 68(34%) and blood group A 42(21%), while the lowest percentage was among patients of blood group AB 3(1.5%). The most important points concluded from the current study, that is the low infection percentage of HBV in Thi-Qar province (5.5%). And the ABO blood type may have an important role in HBV infection.

The association of ABO blood types with host susceptibility to hemorrhagic fever with renal syndrome.

Since the discovery of ABO blood types, there has been mounting evidence of the association between blood types and infectious diseases. However, so far, there is rarely available research about the potential role of ABO blood types in haemorrhagic fever with renal syndrome (HFRS) infection. Our aim was to investigate the relationship between ABO blood types and the development of HFRS infection in Qingdao, China. We carried out a retrospective study enrolling 116 HFRS patients as the case group and 373 healthy subjects as the control group. ABO blood type distribution was analysed using the Chi-square test and logistic regression analysis. Results showed that the distribution of ABO blood types between the two groups was significantly different (X2 = 18.151, P &lt; 0.05). Blood type B was less frequently observed [odds ratio (OR), 0.404; confidence interval (CI), 0.238–0.684; P &lt; 0.01], while blood type AB was more frequently observed in the case group (OR, 2.548; CI, 1.427–4.549; P &lt; 0.01). Since significantly more males were affected than females, we further analysed the data by gender as well as blood types and obtained consistent results for males. Our findings indicated that populations with blood type AB might be more prone to HFRS infection, whereas those with blood type B might be less susceptible to HFRS infection, which will help to make risk stratification in infection control.

Is there an association between ABO blood types and depressive symptoms among Japanese healthcare workers during the COVID-19 pandemic?

ABO blood types could be a biological predisposition for depression. The present cross-sectional analysis was conducted amid the second wave of COVID-19 in Japan during July 2020. We wanted to investigate the association between ABO blood types and depressive symptoms among workers (352 men and 864 women, aged 21–73 years) of a medical institution in Tokyo, Japan, which took a leading role in the response to COVID-19 in the country. A Poisson regression model with a robust variance estimator was used to estimate the prevalence ratio (PR) and 95% confidence interval (CI) for depressive symptoms associated with ABO blood types. Overall, the prevalence of depressive symptoms (using two questions employed from a Two-question case-finding instrument) was 22.0%. The adjusted PRs (95% CI) for depressive symptoms, comparing the carriers of blood type O, A, and AB with those of type B, were 0.88 (0.66, 1.18), 0.81 (0.62, 1.07), and 1.07 (0.74, 1.53), respectively. There was no difference in the prevalence of depressive symptoms between non-B and B carriers. The present study did not support the association of ABO blood types with depressive symptoms.

The association of ABO blood groups and trauma outcomes: A retrospective analysis of 3779 patients.

Background:There is currently a lack of understanding regarding the link between ABO blood types with outcomes of traumatically injured patients. The purpose of this study was to determine the association of ABO blood types with outcomes in traumatically injured patients separated by injury type.Methods:This retrospective study evaluated trauma patients at an urban, Level 1 trauma center from January 1, 2017, through December 31, 2017. Patients were excluded if they were pregnant or <16 years old. Recorded outcomes included: ABO blood group, mortality, Injury Severity Score (ISS), race, injury type, mechanism of injury, and complications. Data analysis was performed using descriptive statistics including Chi-squared, Kruskal–Wallis, and F-test calculations.Results:A total of 3779 patients were included in this study. No significant differences were present in mean age or ISS between blood types. In patients with penetrating injuries, blood type O was associated with a significant increase in mortality (P = 0.017), red blood cell transfusion (P = 0.027), and massive transfusion protocol (MTP) (P = 0.026) compared to non-O blood types. In patients with blunt injuries, blood type AB was associated with a significant increase in mortality rate compared to non-AB blood types (P = 0.03).Conclusion:ABO blood type is connected with an underlying process which affects trauma outcomes, including mortality. Blood type O is associated with increased blood transfusion, MTP, and mortality during the initial hospitalization following a traumatic penetrating injury, while blood type AB is associated with increased mortality during the initial hospitalization following a blunt traumatic injury.

Linkage of ABO blood groups with ischemic stroke

Aim: Like cancer and myocardial infarction, the cerebrovascular accident causes death and morbidity in adults. Ischemic stroke is the most common type of stroke. Predisposing conditions to other cardiovascular diseases similarly play a facilitating role for stroke. The association of ABO blood types with several illnesses as described in previous studies. In this retrospective observational study, our purpose is to show the contribution of ABO blood types in ischemic stroke patients. Our study is important because it is a rare analysis elucidating the link between ABO blood groups with IS risk in the Turkish population.Materials and Methods: 1,540 cases diagnosed with ischemic stroke and 20,863 healthy subjects determined as the control group was included in this research. Ischemic stroke cases and the healthy subjects were between 45-90 years old. Both these groups were examined for blood group analysis.Results: When the patients and healthy subjects were examined in terms of blood group distributions, the blood group type distribution within each group had similar characteristics. In terms of Rh status and Blood type distribution, Ischemic stroke cases, and the healthy subjects were not statistically different from each other.Conclusion: We were not able to show any relation between ischemic stroke and ABO blood type in our study.

Predictive value of ABO blood type with Carcinoembryonic antigen in a Nigerians population with preoperative Colorectal Cancer

Abstract Introduction/Objective Earlier studies speculated possible link between ABO blood type and risk of malignancies. Given recent increase in Colorectal cancer (CRC) cases in Nigeria amidst poor facilities for early diagnosis, unraveling measures for prevention and prognosis become critical options. This study aims at assessing the predictive association of ABO blood types with preoperative Carcinoembryonic antigen (CEA) levels and some markers of gut immunostasis among southern Nigerian population with CRC. Methods The retrospective study evaluated 200 patients, scheduled for resection surgery for CRC between July, 2018 and September 2019 in Federal medical center Yenegoa, Nigeria. The relationship between the ABO blood types and CEA, interleukins, IL(6 and 8,) and Short chain fatty acids, SCFA (butyrate and propionate) were evaluated preoperatively using immunoturbidimetric assay, ELISA, and GC-MS respectively. The mean age of the patients was 51 years. The distribution of the ABO blood types in the patients were 60 (30.1%) for A, 50 (25%) for B, 79 (39.5%) for O, and 11 (5.5%) for AB. Patients with CEA levels &amp;lt;5 ng/mL, 6-30 ng/mL, and &amp;gt;30 ng/mL were classified as CEA Group 1, group 2 and group 3 respectively. Patient’s blood types, demographic characteristics and tumor locations, were recorded. SPSS, 22 was employed for data analysis. Results We determined a significant correlation between CEA levels and IL 6 in different blood types of CRC patients. No significant correlation was observed between CEA and gender. Blood type A showed significant increase in mean levels of CEA and IL 6 when compared to blood type B and O. No significant difference was observed in the mean SCFA levels among different blood types. Conclusion ABO blood type demonstrated significant prognostic value with CEA in colorectal cancer, with blood type A being most unfavorable.

ABO groups as a risk factor for myocardial infarction in the population of Bosnia and Herzegovina.

Aim To investigate the association of ABO blood types and appearance of myocardial infarction (MI) among the population in Bosnia and Herzegovina. Methods This was a cross sectional study conducted at the Department for Cardiovascular Surgery at the Clinical Centre of the University of Sarajevo from January 1st to December 31st 2019. Patients were divided into two groups, defined by their blood type, A (N=91) and non-A (N=109). ABO blood groups were determined using standard agglutination techniques. Information regarding history of MI was taken from their medical documentation during the preparation for surgery. Results In total 200 patients were involved in this study. The study sample consisted of 151 (74.5%) males and 49 (25.5%) females. Mean age was 62.98 ± 7.73. Various risk factors associated with myocardial infarction were tobacco 92 (46.0%) and alcohol 54 (27.0%) consumption, obesity 77 (38.5%), diabetes mellitus 47 (23.5%) and hypertension 91 (45.3%). Being A blood type (OR=3.308; 95% Cl 1.317-8.311; p=0.011) and being male and having hypertension (OR=3.086; 95% Cl 1.262-7.545; p=0.013) significantly increased the risk for the development of MI among young adults. Patients with A blood type were significantly younger [median 58.0 vs. 63.0; U = 2738.5; p =0.027] when they developed MI compared to non-A blood type. Conclusion The age of myocardial infarction occurrence in the population of Bosnia and Herzegovina is lower in patients with blood group A compared to non-A blood types.

ABO Blood Group and the Risk of Esophageal Squamous Cell Carcinoma in Kashmir, a High Risk Region.

ABO blood group has been linked with a number of diseases including cancer. Association of ABO blood type with esophageal squamous cell carcinoma (ESCC) has been sparsely reported and the results are inconsistent. We undertook this study to analyze if any association exists between the ABO and Rh blood groups and ESCCrisk. We conducted a hospital-based case control study to analyze ABO and Rh blood groups in patients with histologically proven diagnosis of ESCC and compared them with healthy donors from the same population. ABO and Rh blood group status of general population was obtained from the blood bank at Sher-i-Kashmir Institute of Medical Sciences (SKIMS) and from original articles published from time to time. Chi-Square test was performed to look for statistical significance. For this study, 206 patients were prospectively enrolled. Seventy-four (35.9%) patients had blood group O. Blood groups type A and type B was found each in 59 (28.6%) patients. In 108,014 healthy donors, 35.3% had blood type O followed by type B (33.66%). There was no significant difference in any of the blood types between patients with ESCC and donors (P = 0.31). No association exists between ABO blood type and the risk of ESCC.

Association of ABO blood types with ST resolution following thrombolysis in acute ST elevation myocardial infarction.

Introduction: There is paucity of data about the possible role of ABO antigen in response to pharmacologic reperfusion therapy in ST-segment elevation myocardial infarction (STEMI) and its relationship with ST segment recovery; thus, we aimed to evaluate the association of ABO antigen with ST-segment resolution in STEMI patients treated with thrombolysis. Methods: This prospective and observational study was conducted between March 2016 and September 2017 on patients with first acute STEMI within the first 12 hours after onset of symptoms treated with thrombolysis. Myocardial reperfusion success was determined by single-lead ST-segment recovery in 12-lead ECG. Patients were considered as responders if ST-segment resolved ≥50% or were assigned as non-responders if ST-segment resolution was <50%. Univariable and multivariable analyses were performed to examine the contribution of "A" and "B" blood group antigens to ST-segment resolution and the occurrence of major adverse cardiovascular or cerebrovascular event (MACCE). Odds ratio (OR) with 95% confidence interval (CI) were reported for each variable. Results: In this study 303 patients (187 males and 116 females) with a mean age of 56.6 ± 16.8 (ranging from 39 to 87 years) were enrolled. 184 patients (60.7%) were responders and 119 patients (39.2%) were non-responders. The presence of either A (4.5 folds increase) or B (5.4 folds increase) antigen was associated with a higher likelihood of a response to thrombolytic therapy, while had not effect on the occurrence of MACCE. Conclusion: We conclude that the presence of A or B blood group antigens is associated with a better response to thrombolytic therapy in patients with acute STEMI. This finding may imply a higher likelihood for thrombotic occlusion of coronary arteries in patients who have either A or B antigen in their blood.

Association of ABO blood types and novel obesity markers in healthy adolescents.

INTRODUCTION:Association of ABO blood type with body mass index (BMI) was explored in the past studies, but literature on association of novel obesity markerssuch as total body fat and lean body mass (LBM) is scarce. The present study aimed to evaluate the relationship of ABO blood types with novel obesity markers in normal adolescents.MATERIALS AND METHODS:A cross-sectional study was done on 387 medical students. Bio-impedance analysis (BIA)-derived novel obesity markers such as body fat percent (BFP) and lean body mass (LBM) were recorded. Blood typing was done using slide-agglutination method. Mean and SD were calculated; analysis of variance and Chi-square (χ2) correlation were used to determine the relationship between ABO blood types and obesity markers.RESULTS:Highest propensity for BFP and LBM was seen in blood groups AB and B (25.09 ± 8.92 and 44.45 ± 6.91) respectively. Highly significant (P < 0.001) differences were observed in the values of BFP and LBM in normal and obese participants across ABO blood types. Prevalence of obesity did not show significant relationship (χ2 = 2.069; P = 0.913) with ABO blood types.CONCLUSIONS:Unlike BMI, novel obesity markers (BFP and LBM) significantly differ across ABO blood groups in normal and obese population. The findings suggest that ABO blood type might have role in determining body composition. This will be helpful in recognition of the participants at the risk of obesity on the basis of their blood groups.