Associate Registry Research Articles

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Long-Term Results of Renal Transplantation in Children

During the past decade, as hemodialysis and renal transplantation have become more available, the outlook for children with irreversible renal insufficiency has changed dramatically. Prior to that time, no programs were devoted exclusively to the treatment of children with end-stage renal disease (ESRD), and a limited number of children received treatment in adult facilities. In light of very limited experience there were those who claimed1,2 that the rigors of the treatment program were so catastrophic for both child and family, and the outlook so dismal, that dialysis and transplantation should not be offered to children. Despite these warnings a program was initiated in 1967 at Childrens Hospital of Los Angeles (CHLA) to provide dialysis and transplantation for children with ESRD. The program was designed to include a component for long-term medical and psychosocial evaluation. Subsequently, other programs were developed in the United States, Canada, and western Europe. The latest report on Regular Dialysis and Transplantation of Children in Europe, 1975,3 of the European Dialysis and Transplant Association Registry included 1,111 children who were less than 15 years of age at the initiation of therapy, and the last report of the ACS/NIH Transplant Registry4 included data on 987 children, 0 to 15 years of age. In addition, numerous articles5-25 describing experience with transplantation in children attest to the increasing acceptance of this therapeutic modality for children. However, there are few reports of children surviving with a functioning graft for more than five years.13,14,21-23-25 Only the reports of DeShazo et al.21 and Weil et al.25 include data on the long-term results of renal transplantation in a large number of pediatric patients.

Registry for associates

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Registry for associates

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Association Registries as Population Estimates

Association Registries as Population Estimates

The Hallucinatory Effect of Pentazocine (Talwin)

The Food and Drug Administration approved the use of pentazocine (Talwin) in July 1967. The first report of an adverse reaction induced by this drug was received by the American Medical Association Registry on Adverse Reactions in August 1967. Since then, 20 reports have been received. Seven (35%) of these reports cited the hallucinatory effect associated with the use of pentazocine, while the others reported symptoms that included drowsiness, dizziness, inability to think, vertigo, vomiting, euphoria, incoordination exhaustion, extrapyramidal effects, confusion, rhinorrhea, hives, nausea, muscular tremor, and tightness of the chest. In the labeling of pentazocine the manufacturer has pointed out that the drug also has been associated with these adverse effects: nausea, vertigo, dizziness or lightheadedness, vomiting, euphoria, hallucinations, disorientation, weakness, muscle tremor, insomnia, and allergic reactions including edema of the face. This communication concerns the seven individuals who experienced the hallucinatory effect associated with the use of pentazocine.

Types of Cutaneous Reactions to Drugs

It has long been known that clinically recognizable adverse reactions to drugs are seen more often in the skin than in any other organ or system. This observation is substantiated by data, accumulated by the American Medical Association Registry on Adverse Reactions, which show that cutaneous manifestations have been by far the most frequently reported form of adverse reaction. One apparent reason is that skin lesions are so readily observed that both patients and physicians are quickly alerted to their possible association with a drug reaction. Because of their frequency and because their visible characteristics alone serve to separate them into a variety of specific types, cutaneous reactions play a particularly important role in the early recognition of untoward effects produced by drugs. Clinical experience has revealed propensities that certain medicaments have for causing skin reactions of a particular morphological pattern. Known associations of this nature are an important element

The American Medical Association Registry on Adverse Reactions.

Excerpt A majority of the drugs that are essential to the practice of medicine today have become available as a result of the tremendous advances in chemical and pharmaceutical research during the ...

Genetic and Environmental Factors in Dairy Sire Evaluation. I. Effects of Herds, Months, and Year-Seasons on Variance Among Lactation Records; Repeatability and Heritability

More than 39,000 Iowa Dairy Herd Improvement Association (DHIA) and Dairy Herd Improvement Registry (DHIR) Holstein lactation records provided the basic data for checking some of the parameters and assumptions currently used in dairy sire evaluation procedures in the United States. The components of variance for herds were about 32% of the total variance with both milk and milk fat records but only 17% with test. The components for months were 1.4 and 1.7% of the total variance with milk and milk fat records and only slightly higher for year-seasons. However, the interactions of herds with months and year-seasons contributed 3 to 5% of the total variance.Grouping of records according to either rolling year-seasons or fixed year-seasons was about equally suitable as a means of removing year-season variance with deviation records. However, the pooling of records from more than one year into season averages was less effective, because significant year-season variance remained in the deviations.Repeatabilities of records expressed as deviations from herd-year-season averages were .50, .47, and .72 for milk, milk fat, and test, respectively. Heritabilities, estimated as twice the regression of daughter on dam, within herd-year-seasons, were .22, .18, and .53 for milk, milk fat, and test.

DRUGS IN PREGNANCY

From the Dept. of member of the pediatrics panel of the American Medical Association Registry on Adverse Reactions

AGRANULOCYTOSIS INDUCED BY DIPYRONE, A HAZARDOUS ANTIPYRETIC AND ANALGESIC.

AN INCREASING NUMBER of reports of agranulocytosis associated with dipyrone are being received by the American Medical Association's Registry on Adverse Reactions. Between 1955 and 1959 only ten cases of leukopenia associated with this drug had been reported to the Registry from the United States, and none of these were in children. Since 1960, reports of 18 cases have been received, seven of them in children. Thirty-six percent of these patients have died. Since it is probable that many more cases of agranulocytosis occur than are reported to the Registry, these data are a cause for concern. During the same period there has been a striking increase in the use of dipyrone. Much of the dipyrone used in this country is imported; domestic production and sales figures are not available, but US Tariff Commission figures show that imports increased from none in 1958, to 220 lb in 1959; 7,164 lb

THE PREOPERATIVE DIFFERENTIAL DIAGNOSIS OF BONE TUMORS

The Clinical, Pathologic Association and Sarcoma Registry have prepared a classification of bone tumors which is easily understood by the general practitioner and conforms with surgical, pathologic and roentgenologic conceptions. For the purpose of this paper I have modified it slightly, and rearranged it so that the tumors progress from the traumatic and infectious through the benign to the most malignant types. It consists of ten groups instead of the original eight. Inflammatory lesions simulating bone tumors (osteoperiostitis): Traumatic (callous, ossifying hematoma). Syphilitic. Infectious (nonsuppurative osteitis of Garre, Brodie's abscess, tuberculosis). Osteitis fibrosa cystica; cysts. Benign osteogenic tumors: Exostosis. Osteoma. Chondroma. Fibroma. Giant-cell tumors. Angioma. Endothelioma (Ewing's tumor). Periosseous fibrosarcoma. Osteogenic sarcoma. Multiple myeloma. Metastatic tumors. With a history, clinical examination, urinalysis, Wassermann test and roentgenogram, an expert may accurately diagnose nine out of ten cases. There exists a small group, however, which defies even the most experienced until