Assistant Professor Of Biochemistry Research Articles

Cell scientist to watch – Charlotte Aumeier

ABSTRACT Charlotte Aumeier is an Assistant Professor of Biochemistry at the University of Geneva, Switzerland. After completing her PhD at the University of Bonn, Germany, studying the cytoskeleton of diatoms, Charlotte moved to the University of Grenoble, France, for a postdoc, where she became hooked on microtubules. In 2018, she established her own lab in Geneva, where she and her team work to uncover the dynamics and regulatory mechanisms of microtubule networks using a variety of approaches, including synthetic biology and non-standard model organisms. We spoke with Charlotte over Zoom to learn more about her work, her love of diatoms and how she views some of the biggest challenges of her career as her biggest advantages as a scientist.

The people behind the papers - Milica Bulajić, Divyanshi Srivastava, Esteban Mazzoni and Shaun Mahony.

Hox genes instruct positional identity along the anterior-posterior axis of the animal body. A new paper in Development addresses the question of how similar Hox genes can define diverse cell fates, using mouse motor neurons as a model. To hear more about the work, we caught up with the paper's two first authors, PhD students Milica Bulajić and Divyanshi Srivastava, and their respective supervisors Esteban Mazzoni (Associate Professor of Biology at New York University, USA) and Shaun Mahony (Assistant Professor of Biochemistry & Molecular Biology at Penn State University, USA).

The making of a lipid biochemist.

Patrick obtained his undergraduate degree at McGill University, and received his graduate training in Medicine and Biochemistry at the University of North Dakota. His postdoctoral work was conducted at the University of British Columbia. He joined the Faculty of Medicine, University of Manitoba as an Assistant Professor of Biochemistry in 1979. He was the recipient of a New Investigator Award (1979-85) from the Heart and Stroke Foundation of Canada, followed by a Scientist Award (1985-90) from the MRC/CIHR. These career awards allowed him to devote the majority of his time to research. He was promoted to Associate Professor in 1983 and Full Professor in 1986. He was cross-appointed as Professor of Pathology and participated in the teaching of General Pathology to residents. He was the founding Director of the Centre for Re-search and Treatment of Atherosclerosis at the University of Manitoba and the Winni-peg Health Sciences Centre. Administratively, he was appointed as the Professor and Head of Biochemistry and Medical Genetics (1992-1999), and an Associate Dean in the Faculty of Medicine in 1999 until his retirement in 2010.Professionally, Patrick served as President of the Canadian Biochemical Society, Chair of the Medical Research Council/Canadian Institute of Health Research New Investigator Awards Committee, Chair of the Alberta Heritage Foundation Senior Investigator Awards Committee, Vice-President of the Heart and Stroke Foundation of Manitoba, and Secretary/Treasurer of the Canadian Society for Clinical Investigation. He continues to serve on Editorial Boards of scientific journals, including the Journal of Clinical and Investigative Medicine. He was invested into the Order of Manitoba in 2011.

ATVB Named Lecture Review-Insight Into Author: Edward A. Fisher.

ATVB Named Lecture Reviews–2013 George Lyman Duff Memorial Lecture Insight Into the Author: Edward A. Fisher, MD, MPH, PhD, Department of Medicine (Cardiology), the Marc and Ruti Bell Program in Vascular Biology, and the Center for the Prevention of Cardiovascular Disease, New York University School of Medicine Neither of my parents had anything to do with science. My father worked in a pawnshop, and my mother had a vocational high school diploma in sewing. I think my initial interest in science was pretty much instinctive: isn’t everyone curious as a child? This was reinforced by excellent science teachers in the New York City public school system, especially at my high school, the Bronx High School of Science. My parents worked hard to give my brother and me educational opportunities they never had, and it turns out we both used these to become scientists, he a physical chemist. Why I chose metabolism as a field is based in part from my clinical experiences when I was a pediatrics resident at Duke. We had a chief of metabolism, Jim Sidbury, who was very inspiring. We talked at length about some of the patients with metabolic disorders, and he encouraged me to get the hard science training needed to understand biochemical mechanisms, to make more accurate diagnoses, and to improve treatments. He also pointed me to a joint graduate program at MIT and the Harvard-affiliated hospitals in metabolism, and in one of my first year courses, I attended a lecture by Jan Breslow on lipoproteins, which led to my joining his lab. I already mentioned two mentors, Jim Sidbury and Jan Breslow, who also became role models as highly successful physician-scientists in the area of metabolic disease. When I became an assistant professor of biochemistry at the Medical College of Pennsylvania, Julian Marsh, …

Claude D Arnaud, Jr, MD (1929–2016): ASBMR Loses a Founding Father

Claude D Arnaud, Jr, MD (1929–2016): ASBMR Loses a Founding Father

APRI/P3NP: CAN IT BE AN ACCURATE MARKER FOR NONINVASIVE EVALUATION OF LIVER FIBROSIS IN CHRONIC HCV.

31Jul 2016 APRI/P3NP: CAN IT BE AN ACCURATE MARKER FOR NONINVASIVE EVALUATION OF LIVER FIBROSIS IN CHRONIC HCV. Mervat Essam , Ahmed Yamany , Asmaa Hanafy , Nadia Morcos , Dina Seoudi and Mohamed Sherif Mogawer. Lecturer of Internal Medicine, Faculty of Medicine, Cairo University, Egypt. Master degree of Biochemistry, Faculty of Science, Ain shams University, Egypt. Professor of Biochemistry, Faculty of Science, Ain shams University, Egypt. Assistant professor of Biochemistry, Faculty of Science, Ain shams University, Egypt. Professor of Internal Medicine and Hepatology, Faculty of Medicine, Cairo University, Egypt.

Interview: Enriching The Pore

Professor Hagan Bayley speaks to Hannah Stanwix, Assistant Commissioning Editor Professor Hagan Bayley received his Bachelor of Arts degree in Chemistry from the University of Oxford (Oxford, UK) in 1974. He holds a PhD in Chemistry from Harvard University (MA, USA) and completed a postdoctoral fellowship at the Massachusetts Institute of Technology (MA, USA). In 1981, Professor Bayley moved to Columbia University (NY, USA) as an Assistant Professor of Biochemistry. He subsequently worked at the Worcester Foundation for Biomedical Research (MA, USA) and in 1997, Professor Bayley moved to Texas A&M University (TX, USA) to become a Professor of Chemistry and Head of the Department of Medical Biochemistry & Genetics. Professor Bayley returned to the University of Oxford in 2003 and is currently the Professor of Chemical Biology. Professor Bayley is a Fellow of the American Association for the Advancement of Science, a Fellow of the Society of Biology (London, UK) and a Fellow of the Royal Society (London, UK). He has received numerous awards including the Royal Society of Chemistry 2009 Chemistry World Entrepreneur of the Year. Professor Bayley is the founder of Oxford Nanopore Technologies Ltd., a private company based in Oxford (UK). Professor Bayley has authored over 150 peer-reviewed papers, over 40 book chapters and review articles, as well as numerous patents.

Dietary Goal Attainment Measures and Psychosocial Factors among Mexican Americans and Non-Hispanic Whites with Type 2 Diabetes

Diabetes education programs need improved measures of goal setting for dietary control of diabetes. Additionally, measures of patient experiences with dietary goal setting are needed to better prepare patients for diabetes self-management. Measures of dietary goals and strategies were investigated via survey of 100 Mexican Americans and non-Hispanic whites with type 2 diabetes at a community clinic. Analyses tested novel goal measures as stages of change and goal attainment with a food plan compared to a traditional measure of food plan adherence. Ethnic groups varied in some reported experiences with goal setting education and goal attainment, but did not differ in most clinical characteristics of diabetes. Results indicated that different measures of goal setting vary in their psychosocial predictors, suggesting changes in how health care providers use and monitor goal setting for patients. At the time this research was conducted, Dr. Briggs Early was a doctoral candidate in the Department of Food Science and Human Nutrition at Washington State University. She is currently an Assistant Professor of Biochemistry and Nutrition at Pacific Northwest University of Health Sciences – College of Osteopathic Medicine, and a certified diabetes educator, and insulin pump trainer in Yakima, Washington.

Howard N. Sloane (1932–2010)

​HowardHoward N. Sloane, colleague, friend, and mentor, died October 2, 2010. Howard was 78 years old. He is survived by his wife of 35 years, Judith Crandall-Sloane, his children Gary, Jeff, and Wendy, and his eight grandchildren. Howard was a moving force throughout his career in advancing the field of applied behavior analysis, helping to launch the careers of others, and helping innumerable children and their families. Howard will be remembered for his many contributions to the field and for his unyielding humanity. Howard received his PhD in psychology from Pennsylvania State University in 1959. His early work as a postdoctoral student at Walter Reed Hospital and later as an assistant professor of biochemistry at John Hopkins School of Public Health focused on the effects of diet on behavior. He was a research professor at the University of Illinois from 1964 to 1965. In 1966, Howard moved to Utah for an academic position in the Department of Educational Psychology at the University of Utah. He partially retired in 1992 to become the Executive Director of the Cambridge Center for Behavioral Studies, a position he held until 1995. Then he fully retired and moved to California, where he served on several boards, was an active consultant, and was the Executive Director of the California Association for Behavior Analysis from 2004 to 2005. Howard's contributions to the field of applied behavior analysis are pioneering. In 1964, he joined a group of young professionals who became legends in applied behavior analysis at the University of Washington's Institute for Child Development under the direction of his longtime friend Sidney Bijou. This group included Don Baer, Mont Wolf, Todd Risley, Jim Sherman, Ivar Lovaas, Ron Hawkins, Jay Birnbrauer, Hayne Reese, Robert Wahler, and others. This interaction and his friendship with Sidney Bijou were shaping forces for Howard's career, which translated into shaping forces for the field. Howard was amazingly productive, with hundreds of scholarly publications of articles, books, software, and professional presentations. However, it was not just the number of publications but their impact that has been so important to the field. His edited book with Barbara MacAulay, Operant Procedures in Remedial Speech and Language Training, was an early seminal book in applied behavior analysis, as was his later book, Applied Behavior Analysis in Education: A Structured Teaching Approach. Possibly, his best known book that advanced applied behavior-analytic techniques to the general population was his classic, The Good Kid Book. This book was born out of a series of individually written pamphlets teaching parents how to manage 16 of childhood's most common problem behaviors, from tantrums to shyness. The Good Kid Book is a classic, still in print after 32 years and still widely popular with parents and families. Helping others was one of Howard's most outstanding characteristics, whether it was helping new professionals entering the field or helping children and their families. I owe a great debt to Howard for his mentoring and support, as do others such as George Endo, Elaine Clark, Gina Green, Richard Young, Richard West, and Charlie Greenwood. Howard opened professional doors for us and gently pushed us through. Howard was also instrumental in starting high-quality behavior-analytic services for children and their families both nationally and internationally. He was a consultant for the U.S. State Department for International Development in India. He was a cofounder of the Utah Partners program that brought services to children with autism in Bolivia. He and his wife Judy organized and ran a summer reading camp that brought high-quality direct instruction services to hundreds of struggling learners. Howard was one of the original founders of the Behavior Modification Center in Salt Lake City, Utah, which evolved into the Pingree Center for Children with Autism that has served thousands of children with autism and their families. In his classic essay, “What is Behavior Analysis?,” Howard wrote, “Applied behavior analysis attempts to improve individual and social conditions.” Simply put, that is what Howard's career was all about.

Douglas Weibel: Using Microfluidics for Microbiology

The ubiquity of microorganisms is unparalleled in any other known organism. These creatures surround our outsides and colonize our insides, a fact that has been known for centuries. However, despite their prevalence and long study, many of their characteristics still remain largely unexplained, including how proteins organize within microbial cells and how microbes interact with each other and with their environments. Many of the techniques used to study microorganisms are nearly as old as the knowledge of microorganisms themselves. Seeking new ways to look at microbiology, Douglas Weibel, Ph.D., an assistant professor of biochemistry at the University of Wisconsin-Madison, turned to chemistry. He and his colleagues are using novel microfluidic methods to develop new ways to culture bacteria and small molecules to control the function of proteins in vivo. By combining chemistry with microbiology, Weibel and his team hope to shine new light on this old field.

Transition States

Transition States

Vitamin D: Mode of Action and Biomedical Applications

Vitamin D: Mode of Action and Biomedical Applications Get access Mark R. Haussler, Ph D Mark R. Haussler, Ph D Assistant Professor of Biochemistry at the College of Medicine, The University of Arizona, Tucson, Arizona 85724. Search for other works by this author on: Oxford Academic PubMed Google Scholar Nutrition Reviews, Volume 32, Issue 9, September 1974, Pages 257–266, https://doi.org/10.1111/j.1753-4887.1974.tb00970.x Published: 01 September 1974

David Bruce Dill: A Man of Many Seasons and Environments—Committed to Life, Heat, and Altitude

Section editor’s note: This paper on the professional life of Dr David Bruce Dill is a departure from the typical ‘‘Lessons From History’’ commentary on a classic original scientific article relevant to wilderness medicine. It is hoped that readers will find this short vignette of Dr Dill, a personality who contributed so much to the field of environmental physiology, enjoyable and informative reading. David ‘‘Bruce’’ Dill (1891‐1986) was widely and affectionately known throughout his life as a scientist, colleague, and friend. As a pioneer in the fields of exercise and environmental physiology, physiochemical properties of blood, and aging, he made significant and lasting contributions. The 20 years Dill spent as research director of Harvard’s renowned Fatigue Laboratory was an era of highly productive research in high-altitude, tropical, and desert environments. His pursuit of research and passion for life lead him to many environments, starting in his early years at Harvard and continuing until his 95th year. Born in Kansas, Dill was raised by relatives after the death of his parents and ultimately moved to California. He was graduated from Occidental College in Los Angeles with a bachelors of science degree in chemistry and received a masters of arts degree and a PhD in chemistry from Stanford University. Through his association with his doctoral advisor, Professor C. L. Alsberg, he obtained a National Research Council Fellowship (1925‐1927) at Harvard University with Lawrence J. Henderson. 1 While at Harvard, Dill was introduced to many scientists, establishing many lasting friendships. He worked with A. V. Bock during research on physiochemical properties of blood at the Massachusetts General Hospital, and their professional and personal relationship continued in the following years. In 1927, through the encouragement of A. V. Hill, both Dill and Bock wrote an update of Bainbridge’s monograph, The Physiology of Muscular Exercise . 2 This publication is considered pioneer work that made a lasting contribution to the field of exercise physiology. It was Dill’s association with L. J. Henderson that led

Reversible Phosphorylation and Kinase Cascades: the Work of Edwin G. Krebs

Reversible Phosphorylation and Kinase Cascades: the Work of Edwin G. Krebs

An interview with Professor Robert J. Lefkowitz, M.D. Interview by Vicki Glaser.

Robert J. Lefkowitz, M.D., is James B. Duke Professor of Medicine and Professor of Biochemistry at the Duke University Medical Center. He has been an Investigator of the Howard Hughes Medical Institute since 1976. Dr. Lefkowitz received a Bachelor's degree from Columbia College and an M.D. degree from Columbia University College of Physicians and Surgeons. After serving an internship and one year of general medical residency at the College of Physicians and Surgeons, he served as a Clinical and Research Associate with Drs. Jesse Roth and Ira Pastan at the National Institutes of Health. He then completed his medical residency and research and clinical training in cardiovascular disease at the Massachusetts General Hospital, Boston. During this time, he continued his research in the laboratories of Dr. Edgar Haber and was a teaching fellow at Harvard Medical School. On completing his training, he was appointed Associate Professor of Medicine and Assistant Professor of Biochemistry at the Duke University Medical Center.

A change of heart. Finding the right balance.

Glenda Gillaspy, Assistant Professor of Biochemistry, Virginia Polytechnic Institute and State University Along the way to becoming an Assistant Professor of Biochemistry at a public land-grant university, I explored a career briefly as a faculty member at a liberal arts institution. I want to

BIOCHEMISTRY'S SECRET AGENTS

IRON-SULFUR CLUSTERS MAY BE THE secret agents of biochemistry. Once thought to be involved only in moving electrons from place to place within cells, these fairly common inorganic cofactors of proteins are now revealing another, more active, side. Increasingly, biochemists are learning that these clusters are directly involved in some of the more challenging chemical reactions that take place in cells. One of the most recent examples of the diversity of these clusters' chemistry comes from the laboratory of Joseph T. Jarrett, assistant professor of biochemistry and biophysics at the University of Pennsylvania School of Medicine, Philadelphia. In a pair of papers published last month, Jarrett and his colleagues identify two distinct types of iron-sulfur clusters in the enzyme that completes the synthesis of the vitamin biotin. One cluster, they show, is the source of the sulfur atoms that are incorporated into biotin. The other, they and others believe, plays ...

PROTEINS BY DESIGN

A collaborative group of researchers has designed a series of proteins that fold into a right-handed superhelical twist never observed in natural proteins. The core of one of the proteins matches its blueprint with incredible accuracy—varying from the design by less than the radius of a hydrogen atom. This ability to engineer structures so accurately suggests it may soon be possible to design and build proteins to order for applications such as catalysis and molecular recognition. Previously, scientists were able to make such accurate structural predictions only when they were creating modified versions of already known protein structures. The study was carried out by Massachusetts Institute of Technology graduate student Pehr B. Harbury (now assistant professor of biochemistry at Stanford University) and MIT biology professor Peter S. Kim, also of Howard Hughes Medical Institute and the Whitehead Institute for Biomedical Research, Cambridge, Mass.; MIT assistant professor of chemistry Bruce Tidor; and gr...

Modified DNA molecule mimics transfer RNA

Biochemists at North Carolina State University, Raleigh, have designed a short segment of modified DNA with a structure so similar to one of the binding regions of yeast transfer RNA (tRNA) that it can block tRNA binding to ribosomes. Since such binding is an essential step in synthesis of proteins, the copycat DNA is a potential new type of antibiotic. The DNA mimic interacts with ribosomes in the same way natural tRNAs do in reading the genetic code for amino acids, so if s unlikely that mutant bacteria could develop with resistance to this type of antibiotic, explains biochemistry professor Paul R Agris, who led the team that synthesized the DNA mimic [ Nature Struct Biol. , 3 ,38 (1996)]. And because the molecule is composed of DNA, rather than RNA, it's less easily degraded by the nucleases present in cells. Other members of the research team are Mufeed M. Basti, now an assistant professor of biochemistry at ...

Mitochondrial DNA Studies Help Identify Lost Victims of Human Rights Abuses

MITOCHONDRIAL DNA (mtDNA) extracted from the teeth and bones buried in clandestine graves is allowing investigators to identify victims of government-sanctioned murder in several countries. By comparing mtDNA sequences of possible living relatives with DNA extracted from teeth found in two mass graves in Guatemala, T. Christian Boles, PhD, assistant professor of biochemistry, Brandeis University, Waltham, Mass, is helping forensic anthropologists confirm the identities of five of the victims. The skeletons are believed to be the remains of 12 men who were taken from the village of San Jose Pacho Lemoa by a "civilian patrol" the night of February 14, 1982. The next morning, villagers found what appeared to be two freshly dug graves in a nearby ravine. For more than 10 years after the massacre, the villagers did not disturb the graves, nor did they talk about the disappearance of the men or the gunshots they heard during that