Abstract
Transition States
Highlights
My interest in chemistry came early through the apparently common male interest of blowing things up
The chinchilla house was anathema to Goldie because the chinchillas had a sink and running water before similar conveniences were installed in her kitchen
Glycerol was one of the component chemicals, and with a few judicious additions from the pharmacy and the help of Encyclopedia Britannica, I attempted the synthesis of nitroglycerine in our basement
Summary
I read most of the books in our school library during study hall time and much of both the Americana and Britannica Encyclopedias Goldie wanted her children to attend college, and like other South Dakota natives, I was entitled to enter the South Dakota State College of Agricultural and Mechanical Arts, our land-grant college where I enrolled as a chemistry major. As the 2-year master’s program neared its end, I noticed an ad in the Harvard Medical School Library for international research scholars to study biochemistry at the Australian National University in Canberra. Morrison was an excellent enzymologist, an experimental perfectionist, and an expert in kinetic derivations He developed a substantial body of work on slow-tight binding inhibitors during the time I spent in his laboratory, a topic that has remained of interest in our continuing research on transition state analogues. As the role of the N-ribosyltransferases became implicated in the regulation of cellular adenylate pools and precursors for nucleic acid synthesis, the National Institutes of Health (NIH) began to support the work and has provided almost continuous support for our research for over 30 years
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