People with serious mental illnesses die an average of 25 years earlier than people in the general population.1 An estimated 60% of this excess mortality is attributed to common preventable and treatable medical conditions, including heart disease, stroke, and diabetes. This has moved providers toward making the delivery of primary care an integral part of behavioral health services — treating people holistically rather than only “from the neck up.”2 People with serious mental illness (SMI) have a higher prevalence of cardiometabolic risk factors, including rates of obesity almost twice that of the general population3,4 The interactions between genotype and environment are complex and poorly understood. Dysfunctional mesolimbic reward patterns may lead to unhealthy food choices.5 These are often in tandem with financial constraints on patients, including living in neighborhoods where fresh fruits and vegetables are difficult to obtain. Symptoms of mental illness, including low energy and anhedonia, may lead to decreased physical activity. Lack of access to Jeanie Tse, MD, FRCPC, is Director of Integrated Health, Institute for Community Living (ICL); and Clinical Assistant Professor of Psychiatry, NYU School of Medicine. Elisa Chow, PhD, is Director of Outcomes Evaluation, ICL. Rosemarie SultanaCordero, MA, LMHC, is Clinical Coordinator, Integrated Health, ICL. Marcia Titus-Prescott, RN, is Associate Director of Integrated Health and Nursing, ICL. Ruth Chiles, RD, is Director of Nutrition, ICL. Andrew Cleek, PsyD, is Director, Urban Institute for Behavioral Health. Elizabeth Cleek, PsyD, is Vice President, Program Design, Evaluation and Systems Implementation, ICL. This work was supported by the New York State Health Foundation; the United Hospitals Fund; the New York Community Trust; and the Brooklyn Community Foundation. The authors acknowledge the contributions of Peter Campanelli, PsyD; Stella Pappas; Cynthia Williams; Shivonne Blake; Le-Nise Watson-Hudson; Drew LaStella, PhD; and Matt Wofsy, as well as numerous staff and consumers at ICL and multiple provider agencies, especially The Bridge; F.E.G.S.; and William F. Ryan Community Health Center. Address correspondence to: Jeanie Tse, MD, FRCPC, Institute for Community Living, Inc., 40 Rector St., New York, NY 10006; phone: 212-3853030; fax: 212-385-2380; email: jtse@iclinc.net. Dr. Tse, Dr. Chow, Ms. Sultana-Cordero, Ms. Titus-Prescott, Ms. Chiles, Mr. Cleek, and Ms. Cleek have disclosed no relevant fi nancial relationships. doi: 10.3928/00485713-20110921-05 Jeanie Tse, MD, FRCPC; Elisa Chow, PhD; Rosemarie Sultana-Cordero, MA, LMHC; Marcia Titus-Prescott, RN; Ruth Chiles, RD; Andrew Cleek, PsyD; and Elizabeth Cleek, PsyD