A regional chemical transport model assimilated with daily mean satellite and ground-based aerosol optical depth (AOD) observations is used to produce three-dimensional distributions of aerosols throughout Europe for the year 2005. In this paper, the AOD measurements of the Ozone Monitoring Instrument (OMI) are assimilated with Polyphemus model. In order to overcome missing satellite data, a methodology for preprocessing AOD based on neural network (NN) is proposed. The aerosol forecasts involve two-phase process assimilation and then a feedback correction process. During the assimilation phase, the total column AOD is estimated from the model aerosol fields. The main contribution is to adjust model state to improve the agreement between the simulated AOD and satellite retrievals of AOD. The results show that the assimilation of AOD observations significantly improves the forecast for total mass. The errors on aerosol chemical composition are reduced and are sometimes vanished by the assimilation procedure and NN preprocessing, which shows a big contribution to the assimilation process.