AbstractMicrowave temperature sounders provide key observations in data assimilation, both in the current and historical global observing systems, as they provide the largest amount of horizontal and vertical temperature information due to their insensitivity to clouds. In the Modern-Era Retrospective Analysis for Research and Applications, version 2 (MERRA-2), microwave sounder radiances from the Advanced Microwave Sounding Unit-A (AMSU-A) are assimilated beginning with NOAA-15 and continuing through the current period. The time series of observation minus background statistics for AMSU-A channels sensitive to the upper stratosphere and lower mesosphere show variabilities due to changes in the AMSU-A constellation in the early AMSU-A period. Noted discrepancies are seen at the onset and exit of AMSU-A observations on the NOAA-15, NOAA-16, NOAA-17, and NASA EOS Aqua satellites. This effort characterizes the sensitivity, both in terms of the observations and the MERRA-2 data. Furthermore, it explores the use of reprocessed and intercalibrated datasets to evaluate whether these homogenized observations can reduce the disparity due to change in instrumental biases against the model background. The results indicate that the AMSU-A radiances used in MERRA-2 are the fundamental cause of this interplatform sensitivity, which can be mitigated by using reprocessed data. The results explore the importance of the reprocessing of the AMSU-A radiances as well as their intercalibration.