Quality Assessment Research Articles

The clinical efficacy of laser in the nonsurgical treatment of peri-implantitis: a systematic review and meta-analysis.

To systematically assess studies regarding the efficacy of lasers in the nonsurgical treatment of peri-implantitis. Electronic and manual searches were performed by two reviewers independently. Randomized controlled trials (RCTs) comparing lasers vs. mechanical debridement or air abrasive on primary outcome (probing depth (PD)) and secondary outcomes (bone loss, bleeding on probing (BOP), clinical attachment level (CAL) and plaque index (PI)) were included. Data extraction and quality assessment were conducted independently. Weighted mean difference (WMD) or standardized mean difference (SMD) and 95% confidence interval (CI) were calculated for continuous outcomes. Publication bias, leave-one-out analysis and GRADE assessment were conducted. 13 eligible publications were included in the review and 12 in the meta-analysis. Solid-state lasers significantly improved in PD (WMD = -0.39, 95% CI (-0.70, -0.09), p = 0.01, moderate-certainty evidence), BOP (SMD =-0.76, 95% CI (-1.23, -0.28), p = 0.002, moderate-certainty evidence) and CAL (WMD =-0.19, 95% CI (-0.39, -0.00), p = 0.05, moderate-certainty evidence), but not in bone loss (WMD = 0.03, 95% CI (-0.13, 0.18), p = 0.74, low-certainty evidence) and PI (SMD =-0.19, 95% CI (-0.42, 0.04), p = 0.11, moderate-certainty evidence) compared with the control group. However, the diode lasers showed no clinical advantages. No publication bias was detected, and leave-one-out analysis confirmed the robustness of findings. In the nonsurgical treatment of peri-implantitis, solid-state lasers yielded positive influence in term of PD, BOP and CAL, while diode laser provided no beneficial effect. Future well-designed large RCTs are still needed, considering the limitations of included studies. This review aimed to guide clinicians in choosing the appropriate laser for peri-implantitis, enhancing treatment strategies and attaining better outcomes.

Global prevalence and pattern of injuries in basketball players: a systematic review.

Basketball, as a widely popular sport, can be associated with a high risk of injury. This study aimed to provide a comprehensive overview of basketball-related injuries in various groups through the utilization of a systematic review methodology. An extensive search was conducted in the four valid databases using three groups of keywords up to November 2023 based on the PRISMA guidance. Two reviewers independently performed the steps of the study, including study selection, data extraction, and quality assessment. In case of any disagreements, the opinion of a third researcher was sought to achieve agreement in each step. The agreement between the reviewers was examined by computing Cohen's kappa coefficient. The quality assessment of the articles in this study was conducted using the Joanna Briggs Institute (JBI) critical appraisal tools. The prevalence range of injuries in these people was between 0.38% and 92.0%. Ankle injuries in 12 out of 28 studies (42.86%), knee injuries in 7 out of 28 studies (25.00%), head and tooth injuries in 3 out of 28 studies (10.71%), and shoulder and hand injuries in three out of 28 studies (10.71%) had the highest prevalence among various injuries. Five out of six studies (83.33%) showed a higher percentage of the injuries in males. Only a study compared the prevalence of injuries between people with various ages. These findings emphasize the need for injury prevention and management strategies, particularly targeting vulnerable areas like the ankle and knee.

Assessment of Water Quality in Pangani, Kayole and Dandora Boreholes in Nairobi County, Kenya

Assessment of Water Quality in Pangani, Kayole and Dandora Boreholes in Nairobi County, Kenya

Hydrochemical assessment of groundwater quality in the coastal belt of Sindh, Pakistan: Implications for human health

Hydrochemical assessment of groundwater quality in the coastal belt of Sindh, Pakistan: Implications for human health

Hydrochemical Assessment of Groundwater Quality in the City of Manga and the Surrounding Area, Burkina Faso, West Africa

Hydrochemical Assessment of Groundwater Quality in the City of Manga and the Surrounding Area, Burkina Faso, West Africa

Quality of information on fertility clinic websites accredited by the Latin American Network of Assisted Reproduction.

To access to reproductive health information on the Internet helps patients understand their infertility journey and make decisions about their treatment. This study aimed to evaluate the quality of fertility clinic websites accredited by the Latin American Network for Assisted Reproduction (REDLARA) using the QUality Evaluation Scoring Tool (QUEST). This observational, cross-sectional, and online study evaluated the clinic websites registered as accredited centers on the REDLARA website. The QUEST was used for the quality assessment of the websites. Data were collected from the available websites of all accredited fertility clinics between September 2023 and January 2024. A total of 173 websites from fertility clinics accredited by REDLARA were evaluated, and 152 (87.8%) clinics had functioning websites. The majority of analyzed websites were from Brazilian fertility clinics (n=58; 38.1%), followed by Mexican (n=23; 15.1%) and Argentine (n=21; 13.8%). No indication of authorship or username was observed on most websites. Some form of support for the patient-physician relationship was reported by 86.8% of websites. The mean (standard deviation±SD) of the total score obtained by all fertility clinics was 12.73±4.7 (range: 1-26). Brazil had the highest total score (mean±SD=16.03±4.6), whereas Peru had the lowest (6.42±1.7). Statistical analysis revealed a difference in the quality of websites among Latin American countries. The health information disseminated by fertility clinic websites in Latin America is of poor quality. Therefore, REDLARA should implement rules for building good-quality websites.

The difference in image quality assessment between radiographers and radiologists and its relationship with diagnostic accuracy.

Radiographers must ensure that the radiographs they produce are of sufficient quality before reporting by radiologists. However, does radiographers' perception of image quality relates to the diagnostic accuracy of radiologists? 38 unique postero-anterior (PA) chest radiographs containing either no pathology, well defined or diffuse lesions were presented to four radiologists and 24 radiographers. Image quality was rated using RadLex quality descriptors. Additionally, radiologists rated their confidence of a radiograph being were normal or abnormal on a 5-point scale. Radiographers rated visibility of anatomical structures, satisfaction with positioning, collimation and adequacy of detector dose. Modelling correlation explored relationships between radiologists' detection of pathology and radiographers' ratings. Radiographers rated image quality of 56% of radiographs as non-diagnostic or limited, compared to 30.7% by radiologists. Modelling revealed that chances of a radiograph being classified in lower quality categories by radiographers increased inversely proportionally with perceived dose, and suddenly increased when positioning was considered unacceptable. No correlation (p=0.10) was found between quality descriptors by radiographers and diagnostic accuracy of radiologists. Findings suggest that perceived "better" image quality, as defined by radiographers, may not necessarily correlate with diagnostic accuracy. This implies that radiographs repeated in clinical practice might not enhance diagnostic value. These findings raise the question which elements in the radiography or actual content (such as representation of anatomical structures) are key elements used to diagnose, which may have implications for image quality studies. Exploring the evolution of decision-making in radiographers trained to report could provide further valuable insights.

Chromium supplementation and type 2 diabetes mellitus: an extensive systematic review.

Diabetes is a global public health concern with increasing prevalence worldwide. Chromium (Cr), a trace element found in soil, water, and food, has been proposed to have a possible positive effect in glucose metabolism and diabetes mellitus prevention. However, the relationship between trivalent chromium [Cr(III)] exposure, mainly through the consumption of diet supplements, and type 2 diabetes mellitus (T2DM) remains controversial. An extensive systematic review of the current literature on randomized controlled studies (RCTs) was conducted from 1 January 2000, to January 2024 using the databases PubMed, Scopus, ScienceDirect, and Cochrane, with specific keywords and inclusion as well as exclusion criteria. After close screening of the research studies retrieved from the mentioned websites was conducted, the most related studies were included in the final systematic review. The studies were evaluated for the degree of relevance, quality, and risk bias, using appropriate quality assessment tools. Several of the included RCT studies reported possible benefits of Cr(III) supplementation, mainly in the form of chromium picolinate (CrPic), chromium yeast (CY), chromium chloride (CrCl3), and chromium nicotinate (CrN). The dosage of chromium was between 50 and 1000μg/day and it was consumed from 2 to 6months. Glycemic control markers, including FPG, insulin, HbA1C, and HOMA-IR levels, significantly decrease following chromium supplementation, mainly in studies with a longer intervention period. Supplementing with chromium (Cr) indicated that could significantly improve lipid profile by raising high-density lipoprotein and lowering triglyceride and total cholesterol while having little effect on low-density lipoprotein. However, most research findings include significant limitations, such as inconsistent dosage and type of chromium, formulation of supplements, and study duration. Further well-designed and high-quality research is needed to fully understand the role of chromium dietary supplementation and the potential risks related to its mechanisms of action, type, and dose, in the prevention and treatment of type 2 diabetes mellitus.

Factors associated with HPV vaccine acceptance and hesitancy in Africa: a systematic review protocol

IntroductionHuman papillomavirus (HPV) infection is the most prevalent sexually transmitted infection worldwide. HPV vaccination is an important tool to prevent and control HPV infection and its complications. Despite carrying the...

Are orofacial pain assessment tools for adults who cannot self-report pain suitable for dental practice? A scoping review.

This study aims to identify and appraise orofacial pain assessment tools designed to score pain in adults who cannot self-report and rate their suitability for dental practice. A protocolled systematic scoping review, in accordance with Joanna Briggs Institute methods was completed. A development panel (n=7) reviewed attributes of each tool for suitability for use in dental practice, using predefined criteria. Nine studies were included. Sample size ranged from n=22 to n=348; all participants were 65 years plus and had a cognitive impairment or dementia, excluding controls.Four tools were identified: Facial action coding system (FACS), mobilization-observation-behavior-intensity in dementia pain scale (MOBID I & II) and, orofacial pain scale-non-verbal individuals (OPS-NVI).Tools scored between two and thirteen out of twenty according to modified quality assessment criteria. No tool was deemed suitable for use in dental surgery, with the OPS-NVI scoring most favorably. No tools were deemed ideal for use within a dental clinic. Elements of some, particularly the OPS-NVI, may be adaptable for this purpose. Despite the difficulties dental practitioners face trying to assess pain in non-speaking patients, there was no suitable tool identified. Pathways need to be designed to facilitate inclusive orofacial pain assessment for those who cannot self-report pain.

Estimating the vertical profile of water quality variables in reservoirs: Application of remotely sensed data and machine learning techniques.

Water quality assessment and management of reservoirs depend on accurate, large-scale, and continuous monitoring of the vertical profile of Water Quality Variables (WQVs). Remote sensing data have been widely used to retrieve high spatiotemporal water quality data; however, their application has practically been limited to evaluating surface WQVs. In this paper, a novel and efficient approach is introduced for assessing the profile of WQVs in reservoirs that depend on stratification, by taking into account the shape of profile as prior knowledge. First, an appropriate function is fitted to the WQVs vertical profile, and second, the parameters of that function as representative of the WQVs vertical profile are estimated using machine learning techniques. The model's inputs are day, maximum depth of point, and remote sensing data. Finally, PAWN sensitivity analysis is applied to show the extent to which each input influences different parts of the vertical profile. This method is applied in the Wadi Dayqah Reservoir, the largest dam in Oman, to evaluate water temperature, dissolved oxygen, pH, and chlorophyll-a profile. The results show that the predicted profiles are properly representative of in situ measurements, with a mean absolute error of 0.28 °C, 0.25 mg/L, 0.052, and 0.33 μg/L on test data sets of water temperature, dissolved oxygen, pH, and chlorophyll-a, respectively. Finally, PAWN sensitivity analysis illustrates that satellite data not only influence the parameters representing surface WQVs but also contribute to the estimation of other curve parameters.

Acupuncture for patients with Alzheimer's disease: An evidence map of randomized controlled trials, systematic reviews, and meta-analysis.

Background: Acupuncture is an effective complementary treatment for Alzheimer's disease (AD). This review aims to summarize the available evidence provided by randomized controlled trials (RCTs) and systematic reviews (SRs) or meta-analyses (MAs) on the effect of acupuncture on AD. Objective: To systematically summarize and combine clinical research evidence on AD distribution. Methods: We conducted a comprehensive search of various databases, including PubMed, Embase, Cochrane Library, China National Knowledge Infrastructure (CNKI), Wan Fang Data, Chinese BioMedical Literature Database (CBM) and Chonqing VIP (CQVIP), from their inception to September 2023. Relevant literature about acupuncture for AD was included, and the characteristics of the evidence map were presented through charts and textual analyses. Results: In total, 117 RCTs and 17 SRs or MAs were included. The results were divided into three categories: basic characteristics of the included literature, clinical characteristics and quality assessment of the included RCTs, and clinical characteristics and quality assessment of the included SRs and MAs. Conclusions: Acupuncture as a therapeutic measure for AD has some advantages in improving cognition and quality of life; thus, it is imperative to conduct multi-center, large-scale RCTs to enhance the evidence supporting the use of acupuncture in AD. This is the first evidence map exploring acupuncture treatment for AD, providing insights into the current clinical research landscape on acupuncture treatment for AD. Furthermore, the findings of this study highlight research gaps in this field and serve as a valuable reference for guiding the planning and selection of topics for future research.

Overview of Systematic Reviews of ICIs in NSCLC With EGFR, ALK, ROS1, and RET Actionable Driver Mutations

The effectiveness and safety of immune checkpoint inhibitor (ICI) monotherapy in patients with previously treated advanced or metastatic non–small cell lung cancer with EGFR, ALK, ROS1, or RET actionable driver mutations or chromosomal rearrangements is currently uncertain. We assessed the efficacy and safety of ICIs in patients with this condition whose disease did not respond well to previous chemotherapy. We reviewed 13 systematic reviews of randomized controlled trials (RCTs). The quality assessment of these reviews revealed critical methodological flaws. All 13 systematic reviews focused on survival and progression-free survival (PFS) for patients with non–small cell lung cancer and EGFR gene mutations. The systematic reviews generally considered the same set of 4 clinical trials and did not report on other outcomes or patient groups, except for 1 review that looked at patients with different levels of anti-PD-L1 expression. We found no evidence on the efficacy and safety of ICIs in patients with ALK, ROS1, or RET mutations. Overall, the systematic reviews concluded that using ICIs alone, as a second-line therapy or beyond, does not significantly improve overall survival (OS) and PFS compared to chemotherapy in patients with non–small cell lung cancer with EGFR gene mutations. No conclusions can be made regarding the benefits of ICIs in patients with EGFR mutations based on histology or high antiprogrammed death-ligand 1 antibody expression levels. The safety of ICIs in patients with EGFR, ALK, ROS1, or RET actionable driver mutations could not be assessed because of the lack of evidence provided in the included systematic reviews.

Risk Factors of Immune-Mediated Hepatotoxicity Induced by Immune Checkpoint Inhibitors in Cancer Patients: A Systematic Review and Meta-Analysis

Immune checkpoint inhibitors (ICIs) significantly improve survival, while immune-mediated hepatotoxicity (IMH) has been reported. To evaluate the incidence and potential risk factors of IMH among cancer patients treated by ICIs, PubMed/Medline, Web of Science, Cochrane, and Embase were searched before 30 March 2024 for systematic review and meta-analysis. Odds ratios (ORs) with 95% confidence intervals (CI) were calculated. Quality assessment was completed using the Newcastle–Ottawa scale. Of 1217 articles identified, 24 consisting of 9076 patients were included, with one study being prospective and the rest retrospective. The overall incidence of any grade IMH and grade ≥ 3 secondary to ICIs was 14% and 7%, respectively. The cholestatic pattern was more prevalent than the hepatocellular and mixed patterns. The meta-analysis revealed that ICI treatment was related to reduced risk of IMH in older patients (SMD: −0.18; 95% CI: −0.33 to −0.04), individuals with higher body mass index (WMD: −2.15; 95% CI: −3.92 to −0.38), males (OR: 0.44; 95% CI: 0.27 to 0.72), and patients with lung cancer (OR: 0.58, 95%CI 0.41 to 0.83). On the other hand, patients with liver metastasis (OR: 1.80; 95% CI: 1.47 to 2.20), history of ICI treatment (OR: 3.09; 95% CI: 1.21 to 7.89), diabetes (OR: 2.19; 95% CI: 1.36 to 3.51), chronic HBV (OR: 3.06; 95% CI: 1.11 to 8.46), and concomitant use of ICIs (OR: 8.73; 95% CI: 2.41 to 31.59) increased the risk of developing IMH. This study will provide clinicians with information on potentially high-risk groups for IMH, who need to be cautiously monitored for liver function when receiving immunotherapy.

The Role of Osteocalcin in Patients with Osteoporosis: A Systematic Review

Background: Osteoporosis is the most common systemic skeletal disease worldwide. We aimed to review the latest studies related to osteocalcin and osteoporosis to clarify this relationship more precisely. Methods: A systematic literature search was performed to review studies on the effects of osteocalcin on osteoporosis, on studied published between January 2013 and January 2023. We systematically reviewed Web of Science, PubMed, ProQuest, Scopus, and Google Scholar. Results: The search yielded 4903 records, including 1063 from PubMed, 2307 from Scopus, 1084 from Web of Science, 408 from ProQuest, and 41 from Google Scholar, and twelve articles were included for data extraction and quality assessment. A significant increase in the serum level of osteocalcin was observed in postmenopausal women with osteoporosis (P<0.05), and there was a negative correlation between bone mineral density and the serum level of osteocalcin. Conclusion: Osteocalcin could be a promising marker for the diagnosis and screening of patients with osteoporosis.

Prevalence of Undernutrition and Its Contributing Factors Among Cancer Patients in Africa - A Systematic Review and Meta-Analysis of Observational Studies.

Cancer poses a significant burden in Africa, where limited resources and infrastructure compound the challenges of managing the disease. Undernutrition, a critical concern among cancer patients, can profoundly affect treatment outcomes and overall prognosis. Despite its importance, the prevalence of undernutrition among African cancer patients remains poorly understood. Five major databases were searched for observational studies that reported the prevalence of undernutrition, from inception till February 2024. Study selection, data extraction, and quality assessment were conducted by at least two independent reviewers. The NIH criteria for observational studies were used for quality assessment. A random-effects meta-analysis model was used to estimate the overall undernutrition prevalence, with subgroup analyses conducted based on country and population characteristics. Twenty-four studies involving 4,283 participants met the inclusion criteria, most studies included children (41%), followed by adults (37%), and women (19%). The overall undernutrition prevalence among African cancer patients was estimated at 32.8% (95% CI, 25.1%, 41.67%) with substantial heterogeneity observed (I² = 95.4%, P < 0.0001). Subgroup analyses revealed significant variations in prevalence across countries and population groups. Undernutrition is a serious issue among African cancer patients and requires an urgent response with targeted interventions. Tailored nutritional support strategies, considering demographic and regional contexts, are essential for improving patient outcomes.

Prevalence of childhood overweight and obesity in Malaysia: a systematic review and meta-analysis.

The incidence of childhood obesity is increasing worldwide. National surveys in Malaysia have shown similar trends. This review aimed to increase our understanding of the prevalence and associated factors of childhood overweight, obesity, and excess weight in Malaysia. A systemat-ic review and meta-analysis were conducted of studies reporting the prevalence of overweight and obesity in Malaysian children aged < 18 years. Systematic searches were conducted in Oc-tober 2023 and repeated in March 2024 of the PubMed, Scopus, and Web of Science databases. The grey literature was also included. Study selection, data extraction, and quality assessments were conducted by paired independent researchers. A meta-analysis of prevalence and 95% confidence interval (CI) using a random-effects model and heterogeneity (I2) was calculated. Publication bias was investigated using Egger's test. This review included 33 studies (N=273,710) conducted between 1996 and 2022. Overall, the childhood overweight, obesity and excess weight prevalence was 13.9% (95% confidence interval [CI], 13.0-14.8%), 11.8% (95% CI, 10.9-12.8%), and 24.0% (95% CI, 22.3-25.7%), respectively. Boys had a significant-ly higher proportion of obesity (12.5% [95% CI, 11.1-14.1%] vs. 9.1% [95% CI, 8.1-10.1%]) and excess weight (25.7% [95% CI, 23.5-28.1%] vs. 20.7% [95% CI, 18.8-22.8%]) than girls. Sarawak natives had a higher prevalence of obesity (17.7% [95% CI, 16.0-19.5%]). Annually, the obesity prevalence increased by 0.3% (95% CI, 0.1-0.6%; p=0.006) and excess weight prevalence increased by 0.6% (95% CI, 0.3-1.0%; p=0.002). Heterogeneity was high (I2>90%), and publication bias was possible (p<0.001). Variability was not significantly affected by the critical appraisal score or sample size. In conclusion, the prevalence of childhood overweight, obesity, and excess weight in Malaysia doubled over 26 years. Future studies of the prevalence of childhood excess weight should follow a standardized reference for body mass index by age to ease interstudy comparisons.

Timing Matters: A Comprehensive Meta-Analysis on the Optimal Period for Cranioplasty After Severe Traumatic Brain Injury

BACKGROUND AND OBJECTIVES: Craniectomy is a commonly performed procedure in severe traumatic brain injury (TBI) to control intracranial hypertension and reduce mortality. The optimal timing for cranioplasty after craniectomy remains a topic of debate. The aim of this study was to investigate the ideal timing for cranioplasty after severe TBI, focusing on complications associated with temporal aspects and materials used in cranioplasty. METHODS: Multiple databases, including PubMed, Embase, Cochrane, and Web of Science, were searched for studies reporting on the subject. Inclusion criteria involved randomized and observational studies comparing early and late cranioplasty procedures. Quality assessment was performed using the Methodological Index for Non-Randomized Studies scale. Results were pooled in a single-arm meta-analysis and presented as mean and 95% confidence interval. RESULTS: Early cranioplasty was associated with a lower likelihood of subdural effusion (odds ratio [OR] 0.3735 [0.1643; 0.8490], P = .0187). However, no differences were detected for the presence of infection between both groups (OR 0.7460 [0.2065; 2.6945], P = .6548). Cranioplasties performed within or equal to 3 months from the TBI incident were associated with a reduced likelihood of minor complications (OR 0.4471 [0.2467; 0.8102], P = .0080). Paradoxically, this time frame exhibited an elevated risk of hydrocephalus (OR 3.2035 [1.4860; 6.9059], P = .0030), as well as total complications (OR 1.4190 [1.0453; 1.9262] P = .0248). CONCLUSION: This comprehensive review highlights the current lack of consensus on the optimal timing for cranioplasty after severe TBI. Early cranioplasty, within 35 days, showed a reduced risk of subdural effusion, but no disparity in the odds of infection was found. A reduced incidence of minor complications was observed in the earlier approach, however with an elevated risk for hydrocephalus and total complications. The association between timing and complications, including hydrocephalus, highlights the need for further research and standardization in this critical aspect of TBI management.

Comparison of augmented reality with other teaching methods in learning anatomy: A systematic review.

Augmented reality (AR) has been investigated as an engaging educational tool that motivates undergraduate health science students to learn human anatomy. AR technology is developing rapidly, supporting medical education by presenting models of human anatomy as digital objects overlaid in the real world via mobile or head-mounted display (HMD). The purpose of this systematic review is to provide a post-pandemic analysis of AR compared with other methods for teaching anatomy and to determine the effects of AR on learning outcomes (LOs). Original research published between January 2020 and April 2024 was obtained from the WOS, Scopus, MEDLINE(Ovid), EMBASE, and PubMed databases, following PRISMA 2020 protocols. Articles included for analysis compared AR with alternative pedagogical methods of teaching undergraduate human anatomy. Studies that described AR as "mixed reality" (MR) were included, while those describing "virtual reality" (VR) were not considered. Risk of bias and limitations in individual studies were assessed using the Quality Assessment with Diverse Studies (QuADS) tool. Data were synthesized using a convergent integrated approach with LOs tabulated for visual analysis. A total of 17 articles were eligible for review: nine studies comparing AR via HMD hardware, and eight comparing mobile AR. The LOs of 12 studies were overwhelmingly reported as non-significant. Insufficient data precluded an accurate meta-analysis of LOs, and critical analysis revealed a considerable risk of bias and lack of justified methodology. While AR holds potential for supporting undergraduate students in learning anatomy, definitive outcomes from the current literature are limited by the heterogeneous nature of the studies and inconsistent use of terminology. It is recommended that future research employs professional AR technologies and incorporates the perspectives of university educators to ensure reliable outcomes that can direct the further development of AR technology in medical education.

The Role of Platelet-Rich Plasma in the Management of Ankle Osteoarthritis: A Systematic Review

Ankle osteoarthritis (OA) is characterized by intraarticular, activity-related pain. mainly with weight-bearing activities. Several nonoperative therapies remain as the first choices, but there is still no consensus on which is the most effective. This study aimed to systematically synthesize the evidence regarding the effectiveness of PRP in the management of ankle OA. Searches were conducted on PubMed, Cochrane, CINAHL, and SPORTDiscus to find relevant articles from inception to December 2023. Details regarding study characteristics, PRP procedures, and outcomes were extracted. A quality assessment was developed according to Joanna Briggs Institute’s critical appraisal tool. A total of five studies met the inclusion criteria, with 184 patients receiving PRP therapy (mean age 55.7 years, and 51.1% were female). There were three case series, one prospective cohort, and one randomized controlled trial. Pain and function were the most frequently evaluated outcomes among the selected articles. They showed significant improvements in the short-term follow-ups, mostly in patients with II-III-stage ankle OA. There is currently insufficient evidence regarding the effectiveness and safety of PRPs in the treatment of ankle OA. A paucity of high-level research in the literature was also found.