Goal – the main purpose of this article is to substantiate the organizational capabilities of the formation of digital bioclusters in the Brest region. In this regard, the issues of building supply chains during the period of technological structure change are considered, especially on the basis of bioproduct specifics, since they become the most relevant in the general spectrum of scientific problems of economic theory and practice. Research methodology – the authors of the study focused on descriptive and monographic methods, cluster analysis and assessment of institutional effectiveness. Score/results – in this article, the authors present conclusions and results on the systematization of the whole complex of problems in the formation of supply chains of bioproducts and the possibility of the formation of bioclusters in the Brest region. Originality/value – the article presents original original material, since it is published for the first time and has a high potential for practical application, which leads to the presence of a corresponding added value within the framework of the study and confirms its scientific value.