Editorials1 November 1973Isoenzymes of Creatine Phosphokinase and Diagnosis of Myocardial InfarctionROBERT ROBERTS, M.D., BURTON E. SOBEL, M.D.ROBERT ROBERTS, M.D.Search for more papers by this author, BURTON E. SOBEL, M.D.Search for more papers by this authorAuthor, Article, and Disclosure Informationhttps://doi.org/10.7326/0003-4819-79-5-741 SectionsAboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissions ShareFacebookTwitterLinkedInRedditEmail ExcerptSerum creatine phosphokinase isoenzymes have become a focus of intensive investigation, abetted by the recent development of sensitive techniques. The isoenzymes are likely to become particularly useful in the assessment of acute myocardial infarction (1) for reasons perhaps best appreciated by considering both the virtues and the limitations of total serum creatine phosphokinase as a diagnostic criterion.Elevation of creatine phosphokinase was recognized to be a manifestation of acute myocardial infarction by Dreyfus and co-workers in 1960 (2). Subsequently, its specificity was disputed because assay methods varied among institutions and because available procedures were relatively insensitive or subject to influence...