Classification Assessment Research Articles

Prevalence of frailty and association with patient centered outcomes: A prospective registry-embedded cohort study from India

PurposeWe aimed to study the prevalence of frailty, evaluate risk factors, and understand impact on outcomes in India. MethodsThis was a prospective registry-embedded cohort study across 7 intensive care units (ICUs) and included adult patients anticipated to stay for at least 48 h. Primary exposure was frailty, as defined by a score ≥ 5 on the Clinical Frailty Scale and primary outcome was ICU mortality. Secondary outcomes included in-hospital mortality and resource utilization. We used generalized linear models to evaluate risk factors and model association between frailty and outcomes. Results838 patients were included, with median (IQR) age 57 (42,68) yrs.; 64.8% were male. Prevalence of frailty was 19.8%. Charlson comorbidity index (OR:1.73 (95%CI:1.39,2.15)), Subjective Global Assessment categories mild/moderate malnourishment (OR:1.90 (95%CI:1.29, 2.80)) and severe malnourishment (OR:4.76 (95% CI:2.10,10.77)) were associated with frailty. Frailty was associated with higher odds of ICU mortality (adjusted OR:2.04 (95% CI:1.25,3.33)), hospital mortality (adjusted OR:2.36 (95%CI:1.45,3.84)), development of stage2/3 AKI (unadjusted OR:2.35 (95%CI:1.60, 3.43)), receipt of non-invasive ventilation (unadjusted OR:2.68 (95%CI:1.77, 4.03)), receipt of vasopressors (unadjusted OR:1.47 (95%CI:1.04, 2.07)), and receipt of kidney replacement therapy (unadjusted OR:3.15 (95%CI:1.90, 5.17)). ConclusionsFrailty is common among critically ill patients in India and is associated with worse outcomes.Study registration: CTRI/2021/02/031503.

Implementing materials fragmentation in the Life Cycle Assessment of orbital spacecraft

Space debris are a primary environmental concern for the sustainability of space mission activities. When considering terrestrial applications, the Life Cycle Assessment represents a widely standardised technique for estimating the environmental impacts of human activities; however, its implementation in the space-related value chain is still in an early stage. In this study, the implications of two alternative materials in the development of a CubeSat structural bus are investigated with reference to the well-established categories for the Life Cycle Impact Assessment. Moreover, the potential impact of these materials on the orbital environment is quantified by the evaluation of the number of generated fragments upon collision for different significant low Earth orbits. The results of this study allow to quantify the impact of alternative design solutions for space systems on the terrestrial environment as well as the degradation of the orbital resources as a result of the space debris generation.

Comparative life cycle assessment of flooring options for sustainable buildings

Purpose This study aims to quantify and compare the environmental impacts of Marble-stone and Kota-stone flooring options widely used for buildings in India. The study discusses the possibility of carbon sequestration through Bamboo cultivation in India. Design/methodology/approach The study has followed a standard life cycle assessment (LCA) framework based on ISO 14040 guidelines. Three distinct phases have been compared on midpoint and endpoint assessment categories – raw material, polishing and disposal. Primary data has been collected from the construction site in India, and secondary data has been collected from the Ecoinvent 3.0 database. Previous studies have been referred to discuss and calculate the area of bamboo cultivation required to sequestrate the generated carbon from the flooring. Findings The study has found that endpoint category damage to resources, and midpoint categories of climate change, metal depletion and agricultural land use are highly impacted in building floorings. The study has also found that the Marble-stone floor generates higher environmental impacts than the Kota-stone floor in most of the midpoint and endpoint impact categories. This difference is significant in the raw material phase due to the different compositions of stones. The study also found that Bamboo has excellent potential to act as a carbon sink and mitigate the generated carbon. Research limitations/implications This study excludes human labour, cutting and distribution of floor tiles made of Marble-stone and Kota-stone. The researcher can use the study to evaluate, compare and benchmark the various building flooring options from the environmental perspective. The study aids to the body of knowledge available on the various building flooring options by presenting the LCA or the environmental impacts generated by two flooring options. It is expected that the architects and builders can use these results to develop carbon-neutral buildings. This study provides a methodology for governments, constructors, builders and individuals to evaluate, compare and benchmark the various construction materials from the environmental perspective by computing the environmental impacts throughout the life cycle of the materials. Originality/value This study compares two widely used building flooring options using the LCA methodology and evaluates the potential of bamboo cultivation near the buildings for carbon sinks. The study is unique because it shows the environmental impacts of two flooring options and the carbon sequestration method to mitigate/absorb the generated environmental impacts in or around the building itself through bamboo cultivation. This study may set the foundation for carbon-neutral buildings.

Artificial intelligence scoring of liver biopsies in a phase II trial of semaglutide in nonalcoholic steatohepatitis.

Artificial intelligence-powered digital pathology offers the potential to quantify histological findings in a reproducible way. This analysis compares the evaluation of histological features of NASH between pathologists and a machine-learning (ML) pathology model. This post hoc analysis included data from a subset of patients (n=251) with biopsy-confirmed NASH and fibrosis stage F1-F3 from a 72-week randomized placebo-controlled trial of once-daily subcutaneous semaglutide 0.1, 0.2, or 0.4mg (NCT02970942). Biopsies at baseline and week 72 were read by 2 pathologists. Digitized biopsy slides were evaluated by PathAI's NASH ML models to quantify changes in fibrosis, steatosis, inflammation, and hepatocyte ballooning using categorical assessments and continuous scores. Pathologist and ML-derived categorical assessments detected a significantly greater percentage of patients achieving the primary endpoint of NASH resolution without worsening of fibrosis with semaglutide 0.4mg versus placebo (pathologist 58.5% vs. 22.0%, p < 0.0001; ML 36.9% vs. 11.9%; p =0.0015). Both methods detected a higher but nonsignificant percentage of patients on semaglutide 0.4mg versus placebo achieving the secondary endpoint of liver fibrosis improvement without NASH worsening. ML continuous scores detected significant treatment-induced responses in histological features, including a quantitative reduction in fibrosis with semaglutide 0.4mg versus placebo ( p =0.0099) that could not be detected using pathologist or ML categorical assessment. ML categorical assessments reproduced pathologists' results of histological improvement with semaglutide for steatosis and disease activity. ML-based continuous scores demonstrated an antifibrotic effect not measured by conventional histopathology.

Investigation of the relationship between oral motor feeding development and gross motor development between preterm and term infants at 10- to 12-month postnatal age

BackgroundImmature central nervous system, extended stay in the neonatal intensive care unit, and sensory experience deficiency may contribute to oral and gross motor delay in preterm infants. Current study aimed to investigate oral and motor development in preterm infants.MethodsTwenty-nine preterm infants and 28 term infants were evaluated within the scope of the study. Oral motor feeding development was assessed with the Schedule for Oral Motor Assessment, and motor development was evaluated with the Alberta Infant Motor Scale. All analyses were performed using SPSS 22. The study was approved by the Gazi University Clinical Researches Ethics Committee (no: 25901600–23).ResultsThere was a correlation between the Schedule for Oral Motor Assessment categories (solid, semisolid, cracker, puree, bottle, and cup) and the Alberta Infant Motor Scale score (p < 0.05). There was a significant difference between groups in the Schedule for Oral Motor Assessment’s solid, semisolid, cracker, and puree categories and total score (p < 0.05). There was a significant difference between groups regarding the Alberta Infant Motor Scale score (p < 0.05).ConclusionPreterm infants come behind their term peers in motor and oral motor feeding performance. These two areas of development can influence each other. For this reason, oral motor feeding problems should be emphasized as well as motor problems in physiotherapy rehabilitation evaluations.

Utility of the Neonatal Early-Onset Sepsis Calculator in a Low-Risk Population.

To compare early-onset sepsis (EOS) risk estimation and recommendations for infectious evaluation and/or empiric antibiotics using a categorical risk assessment versus the Neonatal Early-Onset Sepsis Calculator in a low-risk population. Retrospective chart review of late preterm (≥350/7-366/7 weeks' gestational age) and term infants born at the Brooke Army Medical Center between January 1, 2012 and August 29, 2019. We evaluated those born via cesarean section with rupture of membranes (ROM) < 10 minutes. Statistical analysis was performed to compare recommendations from a categorical risk assessment versus the calculator. We identified 1,187 infants who met inclusion criteria. A blood culture was obtained within 72 hours after birth from 234 (19.7%) infants and 170 (14.3%) received antibiotics per routine clinical practice, using categorical risk assessment. Respiratory distress was the most common indication for evaluation, occurring in 173 (14.6%) of patients. After applying the Neonatal Early-Onset Sepsis Calculator to this population, the recommendation was to obtain a blood culture on 166 (14%), to start or strongly consider starting empiric antibiotics on 164 (13.8%), and no culture or antibiotics on 1,021 (86%). Utilizing calculator recommendations would have led to a reduction in frequency of blood culture (19.7 vs. 14%, p < 0.0001) but no reduction in empiric antibiotics (14.3 vs. 13.8%, p = 0.53). There were no cases of culture-proven EOS. This population is low risk for development of EOS; however, 19.7% received an evaluation for infection and 14.3% received antibiotics. Utilization of the Neonatal Early-Onset Sepsis Risk Calculator would have led to a significant reduction in the evaluation for EOS but no reduction in antibiotic exposure. Consideration of delivery mode and indication for delivery may be beneficial to include in risk assessments for EOS. · Cesarean section with rupture of membranes at delivery confers low risk for EOS.. · Respiratory distress often triggers an EOS evaluation.. · Delivery mode should be considered in EOS risk..

Life Cycle Assessment (LCA) of Solid Waste Management Systems in African Countries: A Systematic Review

Life cycle assessment (LCA) is a vital tool for evaluating the environmental burden of solid waste. This study investigated the outcomes of selected studies that applied the LCA methodology in assessing the environmental consequences of solid waste management (SWM) systems in Africa. Thirteen process-based LCA studies on SWM were reviewed, drawing from established criteria in databases such as SCOPUS, Elsevier, and Google Scholar. These studies were distributed across various African countries, with three conducted in Mauritius and Nigeria each, two in Zimbabwe and South Africa each, and one in Tanzania, Ghana, and Uganda, respectively. The evaluated parameters included aspects such as goal and scope, functional unit, system boundary, impact assessment categories, and sensitivity analysis. The findings revealed that majority of the studies employed similar waste management scenarios to determine the most environment-friendly, yet they differed considerably in some parameters. Climate change and global warming were the most assessed impact categories. Municipal solid waste (MSW) and plastic waste were the leading waste categories. MSW typically comprises paper, bottles, metal, plastics, glass, organics, and mixed waste proportions. The study also stated that the lack of reliable data on solid waste was a significant challenge faced by African countries in LCA studies. The paper’s findings highlighted that a significant number of the studies, particularly in Nigeria, did not incorporate sensitivity analysis into their assessments, a crucial component for result interpretation. Consequently, the study emphasizes the importance of conducting more LCA research studies in African countries to produce pertinent data on SWM.

Quantitative MYD88 L265P Analysis Represents a Powerful Tool for Assessing Disease Response and Evaluating Clinical Trial Performance in Waldenstrom's Macroglobulinemia

Serum IgM measurements represent the current standard for assessing changes in disease burden in Waldenström's Macroglobulinemia (WM). Many agents used to treat WM can significantly affect serum IgM levels without impacting the underlying burden of clonal lymphoplasmacytic cells thereby producing discordant findings. Such agents can raise (CD20-directed monoclonal antibodies, IMiDs), or lower (BTK-, proteasome-, MTOR- inhibitors) serum IgM levels, and impact categorical response assessment. Somatic mutations in MYD88 are found in 95-97% of WM patients, and support tumor growth through activation of multiple pro-survival pathways that include HCK/BTK, SYK and ERK. Nearly all MYD88 mutations in WM are of the L265P variant. Previous studies by us and others have shown that serial quantitative measurements of both bone marrow (BM) and peripheral blood (PB) MYD88 L265P (c.978 T&amp;gt;C) by allele-specific PCR can be used to assess changes in underlying BM disease burden (Blood 121:2051-2058; Leukemia 28:1698-1704). However, the utility of using quantitative allele-specific MYD88 L265P (qMYD88 L265P) analysis has not been studied in prospective clinical trials. As such, we performed a comprehensive study of qMYD88 L265P response assessment utilizing BM and PB CD19-selected tissue across 5 prospective clinical studies in WM: Ixazomib, Dexamethasone and Rituximab (IDR; NCT02400437) Ibrutinib monotherapy (IBR; NCT02604511); Venetoclax monotherapy (VEN; NCT02677324); Ibrutinib plus Ulocuplomab (IBR/ULO; NCT03225716); and Ibrutinib plus Venetoclax (IBR/VEN; NCT04273139). Changes in MYD88 L265P ΔCt were assessed as reported above with ΔCt = Mutant Ct - Wild-type Ct, and higher ΔCt values indicating a lower mutant allele burden, with each ΔCt unit reduction representing a 50% decrease in mutant MYD88 L265P burden. Changes in MYD88 L265P ΔCt were compared to changes in underlying BM disease burden and categorical response assessment using the current (IWWM-11) response criteria (Semin Hematol. 60:97-106). Across all five trials, BM (r=0.52; p&amp;lt;0.001) and PB (r=0.43; p&amp;lt;0.001) MYD88 L265P ΔCt changes from baseline were highly correlated at best response with corresponding changes in underlying BM disease burden determined by repeat BM biopsies. As shown in Fig. 1, comparing changes from baseline in BM MYD88 L265P ΔCt assessments across studies showed marked differences, with greatest reductions observed in patients treated with IBR/VEN, IDR, and VEN alone, than for those treated with IBR alone or IBR/ULO. Similar findings were also observed for corresponding PB MYD88 L265P ΔCt assessments from baseline, with changes in PB MYD88 L265P ΔCt strongly correlating with those of BM MYD88 L265P ΔCt findings across all 5 clinical trials (r=0.67; p&amp;lt;0.001), thereby signifying the ability to use PB MYD88 L265P ΔCt assessments to evaluate treatment responses. We next compared findings from BM and PB MYD88 L265P ΔCt to changes from baseline in serum IgM levels across all 5 trials. At best response, major categorical responses denoted by &amp;gt;50% reduction in serum IgM using IWWM-11 criteria showed commensurate decreases in BM and PB MYD88 L265P ΔCt from baseline in patients receiving IBR/VEN, IDR and VEN alone ( Fig. 2). In contrast, minimal changes in BM and PB MYD88 L265P ΔCt from baseline were observed at best response for most major responders on IBR or IBR/ULO, including individuals who achieved very good partial responses denoted by &amp;gt;90% decrease in IgM by IWWM-11 criteria. In this first prospective evaluation of BM and PB qMYD88 L265P response assessment, we show that both BM and PB L265P qMYD88 analysis can provide more accurate assessment of treatment related changes in disease burden over the current standard of IgM response assessment alone, and can be used to more robustly evaluate clinical trial performance byidentifying treatments or regimens that produce more meaningful tumor reductions in WM patients.

Development of Learning Video to Introduce Panting Musical Instrument in Bina Desa Program Anjir Pasar Kota II

The development of a Panting Music learning video in the MBKM Bina Desa Independent Program of FKIP ULM 2022 in Anjir Pasar Kota II Village aims to produce a product in the form of a Panting Music instrument introduction video learning media and describe the feasibility of the developed learning video. The 4D development model includes the Define, Design, Develop, and Disseminate phases. The researcher employed data collection techniques for this development, including structured observations, unstructured interviews with the village chief, questionnaires systematically distributed to the experts and participants, and documentation in photos to complement the research data. Data analysis was conducted quantitatively and descriptively. The developed media went through stages of validation, with the language validated by a language expert with a "Very Feasible" assessment category at a 95% rating, media validation by a media expert with a "Feasible" assessment category at an 85% rating, and content validation by a subject matter expert with a "Feasible" assessment category at an 80% rating. The next phase involved testing the media with students, resulting in a "Very Feasible" student responses category at a 92% rating, indicating that students could recognize and learn to play the Panting Music instrument.

Utilization of the Edupreneurship Monitoring Information System (SIMO-Edu) to Improve the Performance of Vocational High School (SMK) Collaborations, Partners and the Community in the Edupreneurship Process

This study aims to apply a monitoring information system model (SIMO-EduPKK in the edupreneurship process to improve the performance of collaboration between vocational high schools (SMK), partners and the community as well as to build partner trust in ordering SMK products. The edupreneuship monitoring information system model is designed to be able to facilitate the operational process of cooperation and monitoring of product manufacturing so that the edupreneuship process can run well and as a vehicle for introducing SMK products to the wider community. Researchers use the system development life cycle (SDLC) approach with the waterfall model method to develop a system to obtain an analysis that is in accordance with user needs in producing an information system and monitoring the edupreneurship process that is effectively used in enhancing cooperative relations between all related parties. The results of the research based on measuring questionnaires to teachers majoring in culinary management partners and the community show that the monitoring information system developed is effectively used in the process edupreneuship based on the response value given by teachers to the assessment category on related aspects through a questionnaire using the scala Likert was 96.15%, and the assessment from partners and the community was 95.31%, both of which were in the very practical category.

Return to work post spinal cord injury through a comprehensive rehabilitative program: A case series

Context Spinal cord injury (SCI) can impair bodily functions and limit an individual’s ability to maintain or gain steady employment. Vocational rehabilitation programs have been shown to effectively facilitate individuals with a SCI to return to work, however, further research is needed on the implementation, outcomes, and feasibility of such programs including with the integration of healthcare. Objective The objective of this single-group study was to assess the effectiveness of a comprehensive vocational rehabilitation program, as measured by improvements in employment, work confidence, life satisfaction, and quality of life for individuals with a SCI. Methods Four individuals with a SCI participated in the vocational rehabilitation program. Participants were assigned responsibilities within their department of interest and attended weekly meetings with the vocational rehabilitation team to address barriers, discuss resources and education, and set professional goals. Completion of pre and post-test assessments was required to evaluate the program’s impact on participants’ work readiness and overall well-being. Results Each participant worked with an interdisciplinary team on an individualized work-plan (over 100 h of employment) with necessary accommodations for successful rehabilitation. Participants reported beneficial changes in multiple post-program assessment categories including physical, social, and emotional functions, with all reporting a general improvement in physical strength upon completion of the program. Conclusion Our findings suggest that a comprehensive vocational rehabilitation program can be effective in facilitating individuals with SCI to gain greater functional independence and confidently pursue employment. Further studies are crucial to advance the knowledge required to implement a successful rehabilitative program.

In-situ Printability Maps (IPM): A new approach for in-situ printability assessment with application to extrusion-based bioprinting

3D Bioprinting is an emerging field with many highly valuable applications. The most common and versatile technology is extrusion-based bioprinting, which requires extensive experimental campaigns to achieve appropriate quality of the bioprinted constructs when new bioinks or complex geometrical constructs need to be considered. This paper presents a new approach to easily guide operators and scientists to evaluate the probability of successful bioprinting in a defined window of the process parameters, starting from a small experimental campaign and relying on in-situ quality data. The proposed method consists of defining printability maps based on a probabilistic approach. These maps assess the printing outcome considering a specified acceptable deviation from the nominal geometry, which is predefined by the end-user depending on the application at hand. Even if shown with reference to extrusion-based bioprinting, the proposed method can be used with any other bioprinting process and any quality index, including categorical assessment classification. Eventually, the paper shows how the map can be combined with different quality criteria (e.g., productivity, cell viability) to define the appropriate setting, depending on the application at hand. Furthermore, the map provides a practical tool for rapid material printability assessment and robust process optimization. It offers an enhanced visual representation of the process domain, acceptable region boundaries, and their resilience to variation and uncertainties. Eventually, in-situ printability maps represent a further leap for the advancement of bioprinting toward the digital transformation, aiming at increasing the controllability and scalability of the bioprinting process.

Abstract 16906: Impact of ECPELLA Support on Mid-Term Survival and IABP-Shock II Score in Patients With Refractory Cardiogenic Shock Due to Acute Coronary Syndrome

Introduction: The prognosis remains extremely poor for acute coronary syndrome (ACS) with cardiogenic shock (CS) who required VA-ECMO. The IABP-SHOCK II score is a simple tool, and has demonstrated a high predictive ability for assessing the prognosis of patients with CS. Objective: To evaluate the impact of ECPELLA on intermediate-term survival compared to VA-ECMO with IABP support in patients with ACS and refractory CS and to assess the utility of the IABP-SHOCK II score in predicting outcomes for patients requiring VA-ECMO support. Methods: From January 2012 to December 2022, we enrolled 90 consecutive patients with ACS-CS who received VA-ECMO. Patents were divided into two groups; 44 patients received ECPELLA, and 46 patients received VA-ECMO with IABP. We assessed IABP-SHOCK II score and 180-day all-cause mortality. Results: There were no significant differences in age, rate of male sex, coronary risk factors, ST-elevated ACS, LMT lesion, extracorporeal cardiopulmonary resuscitation, and IABP-SHOCK II score between two groups. Kaplan-Meier analysis revealed that ECPELLA was associated with a significantly higher 180-day survival rate (p = 0.001). The patients were categorized into three groups based on the IABP-SHOCK II score: low (0-2), intermediate (3-4), and high (5-9). The IABP-SHOCK II risk score successfully stratified only the ECPELLA group into different risk categories for 30-day prognostic assessment. Conclusions: ECPELLA was associated with favorable mid-term survival compared to VA-ECMO with IABP support. Additionally, the IABP-SHOCK II score proved to be a useful tool for predicting mortality in patients treated with ECPELLA.

Teacher Preferences for Formative Assessment: Leveraging Findings for Future Professional Development Resources

Classroom-based formative assessment is invoked as an essential component of effective teaching, but there is no widely agreed-upon approach for targeted professional development. This survey of secondary school teachers examined 3 issues: (a) can McTighe and Ferrara’s assessment framework provide a psychometrically tenable way to classify formative assessment techniques, (b) does their framework offer a viable approach to professional development; and (c) could their framework be applied in strengths-based professional development. Analyses of the teachers’ self-reported skills showed (a) high levels of internal consistency across categories of formative assessment, (b) STEM and Humanities teachers could be grouped via discriminant analysis based on reported levels of skill in 3 categories of formative assessment, and (c) scenarios are presented to demonstrating a strength-based approach. The findings indicate that McTighe and Ferrara’s framework provides a psychometrically tenable way to categorize formative assessment techniques and provide professional development. Future research should include K-6 teachers.&#x0D; &#x0D; Received: 25 July 2023 / Accepted: 13 October 2023 / Published: 5 November 2023

An avian Modified Glasgow Coma Scale as a prognostic indicator in raptors with head trauma.

To develop a Modified Glasgow Coma Scale (MGCS) for use in raptors presenting with head trauma and assess the agreement of the MGCS scores between examiners with varying backgrounds, and to assess the prognostic value of the avian MGCS in raptors with head trauma. 156 native raptorial species. All raptors received an MGCS assessment within 8 hours of their presentation, between January 1, 2018, and December 31, 2019. For the first objective, the assessment was performed by a veterinary student, a wildlife veterinarian, and a board-certified or resident veterinary neurologist. Each animal received a score in 3 categories (motor activity, level of consciousness, and brain stem reflexes) and an overall score. For the second objective, the MGCS scoring was performed by the intaking clinical team member and survival after 48 hours was documented. Agreement between the 3 individual scores was assessed via Cronbach α and intraclass correlation. There was excellent-good agreement in all 3 assessment categories as well as the overall score. Univariate associations between survival and demographic factors were determined using the χ2 test. Overall, raptors with a total MGCS of < 10 were less likely to survive than those with a score > 12. An avian-specific MGCS demonstrated good-excellent agreement among raters of various backgrounds in assessing raptors with head trauma. Additionally, this study showed that an avian-specific MGCS may be correlated with the probability of survival within the first 48 hours after presentation to rehabilitation facilities in raptors with head trauma.

Prevalence of the alternative model of personality disorders diagnoses in populational and at-risk samples, gender and age groups comparisons, and normative data for the LPFS-SR and PID-5.

The Alternative Model of Personality Disorders (AMPD), introduced in Section III of the Diagnostic and Statistical Manual of Mental Disorders (DSM-5; American Psychiatric Association, 2013), was proposed as a new operationalization of personality disorders (PDs) aiming to overcome the several limitations of the traditional symptom-based model (Waugh et al., 2017; Zimmerman et al., 2019). In the AMPD, PDs are defined by two-dimensional criteria (the level of personality functioning and maladaptive personality traits), but as a hybrid model, it also allows for categorical assessment of PDs (i.e., "hybrid types") to facilitate continuity with clinical practice. The present study aimed to provide normative data for two widely used instruments assessing Criterion A (Level of Personality Functioning Scale-Self-Report; Morey, 2017) and B (Personality Inventory for DSM-5; Krueger et al., 2012) in a large populational French-Canadian sample. Regarding the categorical assessment, Gamache et al. (2022) recently tested scoring approaches for extracting the PD hybrid types from dimensional measures of the AMPD. In the present study, these approaches were used to estimate prevalence rates for these PD hybrid types in two samples. In the populational sample, results showed that prevalence rates varied from 0.2% (antisocial PDs) to 3.0% (trait-specified PDs), with an overall prevalence of 5.9% to 6.1% for any PD hybrid type. Prevalence was higher in men than in women in the populational sample, but the contrary was observed in the at-risk sample. Prevalence was higher in younger adults than in middle-aged and older adults. (PsycInfo Database Record (c) 2023 APA, all rights reserved).

Integrated Exposure–Response of Dupilumab in Children, Adolescents, and Adults With Atopic Dermatitis Using Categorical and Continuous Efficacy Assessments: A Population Analysis

BackgroundWhile the majority of patients with atopic dermatitis (AD) achieve disease control with dupilumab treatment, there is variability in which patients achieve clear disease. The predictors of these responses are currently unclear. Integrated models were developed to evaluate the exposure–response (E-R) relationship of dupilumab in children, adolescents, and adults with AD.MethodsData from six Phase II and III clinical studies were pooled (2,366 adults [> 18 years], 243 adolescents [≥ 12 to < 18 years] and 359 children [≥ 6 to < 12 years]) for model development. Efficacy was assessed using the Eczema Area and Severity Index (EASI) and Investigator’s Global Assessment (IGA). Indirect response models were applied to link measures of efficacy and functional serum dupilumab concentrations. The covariates on individual placebo-corrected response were assessed. Clinical trial scenarios were simulated to compare E-R relationships across age groups. Safety was not explored.ResultsAfter correcting for differences in placebo response and dupilumab exposure: 1) older age, higher body weight, lower baseline thymus and activation-regulated chemokine, and Asian race were associated with slightly lower EASI response, and no clear covariates were identified on IGA response; 2) clinical trial simulations generally showed slightly higher response at a given dupilumab concentration in children compared to adults and adolescents with severe and moderate AD.ConclusionsThe collectively tested covariates explain some of the variability in dupilumab response in patients with AD. Patients in all age groups showed adequate response to dupilumab; however, children showed slightly higher drug effects compared to adults and adolescents at equivalent concentrations.

К вопросу о персонализме лингвофилософии отца Павла Флоренского: современные рецепции

This paper considers some provisions of Father Pavel Florensky's philosophy of language (and more broadly, the philosophy of the symbol) from the perspective of its reception in contemporary historical-philosophical and linguophilosophical studies. It is shown that the problematization of the question of personalistic or imperpersonalistic nature of Florensky's philosophy can be carried out in several perspectives: critical, apologetic, constructivist. As an example of critical reception we considered the theses of S. S. Khoruzhy, who noted the absence of a developed anthropology in Florensky's symbolist discourse and evaluated his philosophy of the symbol as impersonalistic. It is shown that Khoruzhy's categorical assessment requires correction in the perspective of a more detailed analysis of the intention concept in Florensky's philosophy. The paper also considered the apologetic reception of S. M. Polovinkin, who revealed the personalistic content of Florensky's philosophy (including the philosophy of language) by considering the inherent subject-object unity and asserting the fundamental importance of the volitional aspect ("striving") in the realization of the connection between man and objective reality (symbolic-creation). As an example of creative reconstruction we considered the works of L. A. Gogotishvili, who proposed to consider the status of "ego" in Florensky's linguophilosophy from two points of view: on the one hand, as a condition for expressing transcendental meaning in immanent forms; on the other hand, as a guarantee of communicative intension and attention, connecting the personal "ego" with the word and image. This reconstruction of Florensky's ideas was labeled by Gogotishvili with the term "round" discourse. It is shown that Gogotishvili's reception is novative and developing Florensky's ideas in the linguophilosophical perspective. In conclusion, it was suggested that Gogotishvili's concept of "round" discourse and the possibility of communicative interpretation of Florensky's linguophilosophy lies in his epistemology related to the idea of personalization of cognizable reality.It is concluded that the absence of a detailed comprehension of the problematics of communicativity and intensionality in Florensky's philosophical discourse, on the one hand, reveals his vulnerability to criticism (accusation of impersonalism), on the other hand, allows for a creative reconstructive reception associated with the actualization of not always obvious potentialities of personalism in Florensky's thought.

Development of Inquiry-Based Environmental Knowledge Modules and Islamic Values

This study aims to assess the feasibility of inquiry-based environmental knowledge modules and Islamic values according to expert assessments. This type of research is research and development which refers to the ADDIE model. The research instrument is in the form of validation sheets from 2 media experts, 3 science material experts, and 2 Quran and tafsir material experts with four assessment categories. The data of this research are observation sheets and questionnaires which are analyzed using descriptive analysis. The results showed that the feasibility of inquiry-based environmental knowledge modules and Islamic values assessed by media experts was in the feasible category (79%), science material substance experts were in the feasible category (80%) and the substance of the Qur’an and interpretation material experts were in the feasible category (74%). Thus, it can be concluded that the inquiry-based environmental knowledge module and Islamic values can be used in the learning process.Keywords: module, environmental knowledge, inquiry, Islamic values

Reflective Practices of Pre-Service Teachers: Self-reflections on Micro Teaching

This study aims to reveal pre-service teachers' (PSTs) self-reflections on micro-teaching practices. The study was conducted with a qualitative approach. The participants of the study consisted of 117 PSTs from 9 different branches who took the Micro-teaching (Elective) course at the faculty of education of a state university in Türkiye in the 2021-2022 academic year. According to the aim of the study, PSTs did micro-teaching practices. The micro-teaching practices were video-recorded and watched by the PST. The practice was evaluated by the PSTs peers and delivered to the PST in writing. The qualitative data of the study were obtained with the "Self-reflection Form" prepared by the researchers. This form consists of two open-ended questions about the strengths and weaknesses that pre-service teachers realized during the microteaching practice. The data were analyzed by content analysis method. It was found that PST described their strengths and weaknesses in planning, process, and assessment categories. PSTs emphasized their weaknesses more than their strengths for the planning category. In the category of planning, pre-service teachers stated that their strengths were that they were able to prepare lesson plans with well-rounded activities and integrity, and their weaknesses were that they could not manage their time properly and that they realized that the activities and examples were not suitable for the grade level. In the category of processing, they emphasized strengths more than weaknesses. The PSTs consider themselves strongest in lesson management and stated that they need to improve their diction, voice, and oratory skills. The assessment was the least opinioned category by the PSTs. For the assessment of the lesson, PSTs thought that they achieved the outcome by focusing on the teaching process, which was considered successful.