Assess Model Performance Research Articles

Development and application of a machine learning-based predictive model for obstructive sleep apnea screening.

To develop a robust machine learning prediction model for the automatic screening and diagnosis of obstructive sleep apnea (OSA) using five advanced algorithms, namely Extreme Gradient Boosting (XGBoost), Logistic Regression (LR), Support Vector Machine (SVM), Light Gradient Boosting Machine (LightGBM), and Random Forest (RF) to provide substantial support for early clinical diagnosis and intervention. We conducted a retrospective analysis of clinical data from 439 patients who underwent polysomnography at the Affiliated Hospital of Xuzhou Medical University between October 2019 and October 2022. Predictor variables such as demographic information [age, sex, height, weight, body mass index (BMI)], medical history, and Epworth Sleepiness Scale (ESS) were used. Univariate analysis was used to identify variables with significant differences, and the dataset was then divided into training and validation sets in a 4:1 ratio. The training set was established to predict OSA severity grading. The validation set was used to assess model performance using the area under the curve (AUC). Additionally, a separate analysis was conducted, categorizing the normal population as one group and patients with moderate-to-severe OSA as another. The same univariate analysis was applied, and the dataset was divided into training and validation sets in a 4:1 ratio. The training set was used to build a prediction model for screening moderate-to-severe OSA, while the validation set was used to verify the model's performance. Among the four groups, the LightGBM model outperformed others, with the top five feature importance rankings of ESS total score, BMI, sex, hypertension, and gastroesophageal reflux (GERD), where Age, ESS total score and BMI played the most significant roles. In the dichotomous model, RF is the best performer of the five models respectively. The top five ranked feature importance of the best-performing RF models were ESS total score, BMI, GERD, age and Dry mouth, with ESS total score and BMI being particularly pivotal. Machine learning-based prediction models for OSA disease grading and screening prove instrumental in the early identification of patients with moderate-to-severe OSA, revealing pertinent risk factors and facilitating timely interventions to counter pathological changes induced by OSA. Notably, ESS total score and BMI emerge as the most critical features for predicting OSA, emphasizing their significance in clinical assessments. The dataset will be publicly available on my Github.

Enhanced Freelance Matching: Integrated Data Analysis and Machine Learning Techniques

The objective of this research is to devise a personalized recommendation system for a freelancing platform to optimize the freelancer project matching process. This enhancement is intended to improve user experience and increase the success rate of projects. The system will recommend projects to freelancers based on their skills and preferences by employing data analysis and machine learning methodologies. The research methodology adheres to the Cross Industry Standard Process for Data Mining (CRISP-DM), incorporating six stages: Business Understanding, Data Understanding, Data Preparation, Modeling, Evaluation, and Deployment. The proposed project employs a hybrid recommendation strategy, integrating Content-Based Filtering through KNearest Neighbors (K-NN) and Cosine Similarity, Collaborative Filtering via Singular Value Decomposition (SVD), and recommendations derived from Word2vec. Evaluation metrics such as precision, recall, F1 score, MAP, and MRR are utilized to assess model performance. The results, including precision scores of 0.80 for KNN and 0.728 for SVD, recall scores of 0.60 for KNN and 0.623 for SVD, and F1 scores of 0.69 for KNN and 0.671 for SVD, as well as a MAP of 0.75 and MRR of 0.80 for Word2vec, demonstrate the efficacy of the hybrid recommendation system in delivering accurate and varied project suggestions to freelancers, with a weighted average ensemble learning model emerging as the most effective solution.

Abstract PO2-02-10: Predicting the feasibility of breast conserving surgery using pre-treatment standard of care DCE-MRI: a novel clinical decision support tool for breast cancer surgical planning

Abstract Background: The decision-making process regarding breast cancer treatment options, specifically breast conserving surgery (BCS) versus mastectomy, is a complex and sensitive matter that takes into account the patient's preferences and their eligibility for BCS. A range of anatomical factors, such as tumor size, breast size, and proximity of the tumor to the skin, can influence the surgeon's recommendation regarding BCS or mastectomy. While mastectomy may be the only viable option for patients with large tumors, those with smaller tumors often have the opportunity to collaboratively decide with their surgeon on the most appropriate approach to ensure oncologic success and minimize potential cosmetic deformity. To facilitate this decision-making process, we developed a tool capable of providing informed recommendations on BCS or mastectomy based on standard of care imaging patient data. By integrating these recommendation capabilities, we aim to enhance the decision-making process and improve patient outcomes in breast cancer treatment. Methods: To assist surgeons and patients in determining a patient’s eligibility for breast conserving surgery (BCS), we developed the BCS Feasibility Score. The BCS Feasibility Score is generated from a binary classifier machine learning model and is representative of the probability that a given patient could receive BCS. The score is based solely on the output from TumorSight Viz, a software platform that uses only pre-treatment T1-weighted DCE MRI and applies a suite of deep learning algorithms to segment the patient’s disease and the surrounding breast tissues. From the multi-tissue segmentation generated using TumorSight Viz, we extracted 25 spatial morphology features to use in the model development process. The training and testing sets were a subsample of a publicly available dataset (Saha, et al, 2018). We selected patients that received either BCS or mastectomy and had a viable T1-weighted DCE MRI. Bi-lateral cases were excluded. The total training/testing set consisted of n = 749 cases, 363 of which received mastectomy and 386 who received BCS. Before model training occurred, we split 20% of the sample to use as the test set. We then trained a random forest classifier across a range of pre-set hyper-parameters, using a total of 25 features as inputs, and using 5x cross-validation in the training set. We then assessed model performance in the testing set only. Results: In the test set, 76 cases received BCS versus 74 that received mastectomy. We successfully predicted BCS in 56 out of 76 cases (74%), and mastectomy in 46 out of 74 cases (62%). Overall, we observed an AUC = 0.76 and an F1 score = 0.66, indicating moderate to strong model performance. The most important features in the model, as measured by SHAP values, included the axis aligned tumor longest dimension (mm), the closest distance between the tumor and the nipple (mm), the volume of the tumor convex hull (mL; dilated uni-centrically), and the ratio of tumor convex hull volume to breast volume. We tested the model’s performance in a fully independent holdout validation set of 579 cases. Within this validation set, 335 patients received BCS versus 244 received mastectomy. We successfully predicted BCS in 254 out of 335 cases (76%), and mastectomy in 149 out of 244 cases (61%). Overall, we observed an AUC = 0.75 and an F1 score = 0.63. Validation set performance mirrored results observed in the test set, indicating strong generalizability. In the validation set, comparing patients who underwent BCS to those who underwent mastectomy, we observed significant differences across all four of the most predictive features. Conclusion: TumorSight Viz and the BCS Feasibility Score help empower both patients and clinicians with information and tools to facilitate surgical planning decisions. Citation Format: John Pfeiffer, Bradley Feiger, Anuja Antony, Joseph Peterson. Predicting the feasibility of breast conserving surgery using pre-treatment standard of care DCE-MRI: a novel clinical decision support tool for breast cancer surgical planning [abstract]. In: Proceedings of the 2023 San Antonio Breast Cancer Symposium; 2023 Dec 5-9; San Antonio, TX. Philadelphia (PA): AACR; Cancer Res 2024;84(9 Suppl):Abstract nr PO2-02-10.

An Analysis of Convolutional Neutral Network for Image Classification

Abstract: Convolutional Neural Networks (CNNs) have emerged as a powerful tool for image classification tasks, owing to their ability to automatically learn hierarchical representations from raw pixel data. This paper presents a comprehensive analysis of CNNs for image classification, focusing on their architecture, training process, and performance evaluation metrics. The study investigates various CNN architectures, including AlexNet, GoogLeNet, and ResNet, highlighting their respective strengths and weaknesses in different scenarios. Moreover, the paper explores the impact of hyperparameters such as network depth, filter size, and pooling strategies on classification accuracy and computational efficiency. Furthermore, the training process of CNNs, encompassing data preprocessing, augmentation techniques, and optimization algorithms, is scrutinized to elucidate best practices for achieving optimal performance. Additionally, the paper discusses commonly used evaluation metrics such as accuracy, precision, recall, and F1-score, elucidating their interpretation and significance in assessing model performance. Through a systematic review of existing literature and experimental validation, this analysis aims to provide insights into the underlying mechanisms of CNNs for image classification tasks. Finally, the paper outlines future research directions, emphasizing the need for exploring novel architectures, optimizing hyperparameters, and enhancing interpretability and robustness of CNN models. Overall, this study contributes to a deeper understanding of CNNs for image classification and provides valuable guidance for practitioners and researchers in the field.

Machine Learning for Water Quality Index Forecasting

This study aims to forecast water quality in the Tumkur district, Karnataka state, India, to increase pollution levels. Various machine learning techniques, including support vector machines, regression trees, linear regression, and neural networks, are employed. The Water Quality Index (WQI) is determined using parameters such as total hardness, pH, alkalinity, turbidity, chloride, dissolved solids, and conductivity. The dataset is split into training and testing sets (80:20) to assess model performance. Support Vector Machines and Linear Regression outperform other models, achieving R2 values of 0.96 and 0.99 for training and testing, respectively. This research underscores the importance of advanced machine learning techniques for accurate water quality prediction, crucial for effective pollution reduction strategies in the region.

Importance of CD8 Tex cell-associated gene signatures in the prognosis and immunology of osteosarcoma

As a highly aggressive bone malignancy, osteosarcoma poses a significant therapeutic challenge, especially in the setting of metastasis or recurrence. This study aimed to investigate the potential of CD8-Tex cell-associated genes as prognostic biomarkers to reveal the immunogenomic profile of osteosarcoma and guide therapeutic decisions. mRNA expression data and clinical details of osteosarcoma patients were obtained from the TCGA database (TARGET-OS dataset). The GSE21257 dataset (from the GEO database) was used as an external validation set to provide additional information on osteosarcoma specimens. 84 samples from the TARGET-OS dataset were used as the training set, and 53 samples from the GSE21257 dataset served as the external validation cohort. Univariate Cox regression analysis was utilized to identify CD8 Tex cell genes associated with prognosis. The LASSO algorithm was performed for 1000 iterations to select the best subset to form the CD8 Tex cell gene signature (TRS). Final genes were identified using the multivariate Cox regression model of the LASSO algorithm. Risk scores were calculated to categorize patients into high- and low-risk groups, and clinical differences were explored by Kaplan–Meier survival analysis to assess model performance. Prediction maps were constructed to estimate 1-, 3-, and 5 year survival rates for osteosarcoma patients, including risk scores for CD8 Texcell gene markers and clinicopathologic factors. The ssGSEA algorithm was used to assess the differences in immune function between TRS-defined high- and low-risk groups. TME and immune cell infiltration were further assessed using the ESTIMATE and CIBERSORT algorithms. To explore the relationship between immune checkpoint gene expression levels and the two risk-defined groups. A CD8 Tex cell-associated gene signature was extracted from the TISCH database and prognostic markers including two genes were developed. The high-risk group showed lower survival, and model performance was validated by ROC curves and C-index. Predictive plots were constructed to demonstrate survival estimates, combining CD8 Tex cell gene markers and clinical factors. This study provides valuable insights into the molecular and immune characteristics of osteosarcoma and offers potential avenues for advances in therapeutic approaches.

Analysis of Gradient Boosting, XGBoost, and CatBoost on Mobile Phone Classification

In the ever-evolving landscape of mobile phone technology, accurately classifying device specifications is paramount for market analysis and consumer decision-making. This research conducts a comprehensive analysis of mobile phone specification classification using three prominent machine learning algorithms: Gradient Boosting, XGBoost, and CatBoost. Through meticulous dataset acquisition and preprocessing steps, including resolution normalization and price categorization, features essential for classification analysis were standardized. Robust cross-validation techniques were employed to assess model performance effectively. The study demonstrates the significant impact of normalization techniques on improving model performance across all algorithms and fold variations. CatBoost consistently emerges as the top-performing algorithm, followed closely by XGBoost, with Gradient Boosting displaying respectable performance. Notably, CatBoost consistently achieves the highest AUC values and accuracy scores, demonstrating superior performance in accurately classifying mobile phone specifications. These findings underscore the importance of preprocessing methods and algorithm selection in achieving optimal classification results. For mobile phone manufacturers, leveraging machine learning algorithms for effective classification can inform product development strategies, optimizing offerings based on consumer preferences. Similarly, for data analysts, employing appropriate preprocessing techniques and algorithmic approaches can lead to more accurate predictions and informed decision-making. Future research avenues include exploring advanced preprocessing methods, investigating alternative algorithms, and incorporating additional features or datasets to enrich the classification process. Overall, this research contributes to understanding mobile phone specification classification through machine learning methodologies, offering actionable insights for industry practitioners and researchers to address evolving market dynamics and consumer preferences.

Predictors of opioid use for rib fractures in a regional Australian hospital

BackgroundRib fractures (RFs) are the leading type of single serious injury in New South Wales trauma patients. Uncontrolled pain drives the sequelae of atelectasis, pneumonia, respiratory failure, and death in severe cases. Opioids are the mainstay of management; however, they carry numerous adverse effects. Understanding patient or injury factors which predict opioid requirement is important to tailor management. Existing evidence is limited to metropolitan trauma centres (MTCs). MethodsWe conducted an observational, retrospective, single-centre cohort study of all admissions to Albury Wodonga Health diagnosed with one or more RFs and discharged between January 1st, 2017, and December 31st, 2022, inclusive. Data collected included demographics, injury characteristics, and management, including analgesia. LASSO regression was performed to determine predictors of average daily opioid use for the first five days of admission in oral morphine equivalents (mg). R2 and root mean square error (RMSE) were calculated to assess model performance. ResultsWe included 624 patients. LASSO selected number of RFs, fracture displacement score, pulmonary contusion, new injury severity score, age, chest tube use, chronic pain history, opioid history and upper or middle lateral RF location categories as predictors. Sex, middle anterior, middle posterior, and lower RF location categories were excluded by LASSO. The out of sample R2 was 28.6 %. On the scale of log OME, the RMSE was 1.08. ConclusionThe model is effective at identifying predictors of opioid use in this regional centre, which are similar to those described in evidence from MTCs. However, the low R2 with wide prediction intervals limits its utility on an individual level.

From Block to City Scale: Greenery’s Contribution to Cooling the Urban Environment

Urban greenery is a strategy to improve the thermal environment in urban areas affected by heat islands and global warming. These phenomena can harm the citizens’ quality of life. Researchers have investigated the thermal benefits of urban vegetation, but only a few have explored its complexities across diverse urban scales. Understanding these variations is critical for precise analysis, customized solutions, efficient resource allocation, and enhancing urban living quality while promoting sustainability and climate resilience. This paper reviews 250 scientific articles about the relationship between greenspace and the urban thermal environment published between 2010 and 2023 through urban scales. It summarizes the parameters and findings of greenery’s contribution to cooling the urban environment. The data reveal that most studies concentrated on the block scale, public open spaces, neighborhoods, parks, grouped vegetation, mixed arrangements, high vegetation, spatial parameters, and the use of air temperature data to report their findings. The cooling-effect evidence shows that the block scale has an average mitigation range of 0.7–2.7 °C, the neighborhood scale of 1.1–2.9 °C, and the city scale of 0.5–2.2 °C. Furthermore, it is critical to define reliable research methods and perform thorough software validation to assess model performance and establish guidelines for urban-landscape design accurately.

A nomogram to predict cognitive function impairment in patients with chronic kidney disease: A national cross-sectional survey

BackgroundCognitive function impairment (CFI) is common in patients with chronic kidney disease (CKD) and significantly impacts treatment adherence and quality of life. This study aims to create a simplified nomogram for early CFI risk detection. MethodsData were obtained from the National Health and Nutrition Examination Survey cycles spanning from 1999 to 2002 and again from 2011 to 2014. Stepwise logistic regression was used to select variables and construct a CFI risk prediction model. Furthermore, C-statistic and Brier Score (BS) assessed model performance. Additionally, Kaplan–Meier survival curves were utilised to assess risk group-death prognosis relationships. ResultsOf the 545 participants in the CKD model development cohort, a total of 146 (26.8 %) had CFI. The final model included the variables of age, race, education, annual family income, body mass index, estimated glomerular filtration rate, serum albumin and uric acid. The model had a C-statistic of 0.808 (95 % confidence interval (CI): 0.769–0.847) and a BS of 0.149. Furthermore, the 5-fold cross-validation internal C-statistic was 0.764 (interquartile range: 0.763–0.807) and BS was 0.154. Upon external validation, the model's C-statistic decreased to 0.752 (95 % CI: 0.654–0.850) and its BS increased to 0.182. The Kaplan–Meier survival curves demonstrated that intermediate-to-high-risk participants had shorter overall survival time than low-risk participants (log-rank test: p = 0.00042). ConclusionsThis study established an effective nomogram for predicting CFI in patients with CKD, which can be used for the early detection of CFI and guide the treatment of patients with CKD.

Novel targets and their functions in the prognosis of uterine corpus endometrial cancer patients.

Aberrant mRNA expression is implicated in uterine corpus endometrial carcinoma (UCEC) oncogenesis and progression. However, effective prognostic biomarkers for UCEC remain limited. We aimed to construct a reliable multi-gene risk model using gene expression profiles. Utilizing TCGA data (543 UCEC samples, 35 controls), we identified 1517 differentially acting genes. Weighted gene co-expression complex analysis (WGCCA), hub gene screening, and risk regression analysis (RRA) were employed to determine prognosis-related genes and construct the risk model. Nomograms visualized risk scores and receiver operator characteristic (ROC) curves assessed model performance. Seven novel prognosis-related hub genes (ANGPT1, ASB2, GAL, GDF7, ONECUT2, SV2B, TRPC6) were identified. The model's concordance index (C index) by multivariate Cox regression analysis was 0.79. ROC curves yielded AUCs of 0.811 (3-year) and 0.79 (5-year), demonstrating the model's efficacy in predicting UCEC survival. Our study proposes a promising seven-biomarker risk model for predicting UCEC prognosis, offering potential clinical utility.

The value of CT radiomics combined with deep transfer learning in predicting the nature of gallbladder polypoid lesions.

Computed tomography (CT) radiomics combined with deep transfer learning was used to identify cholesterol and adenomatous gallbladder polyps that have not been well evaluated before surgery. To investigate the potential of various machine learning models, incorporating radiomics and deep transfer learning, in predicting the nature of cholesterol and adenomatous gallbladder polyps. A retrospective analysis was conducted on clinical and imaging data from 100 patients with cholesterol or adenomatous polyps confirmed by surgery and pathology at our hospital between September 2015 and February 2023. Preoperative contrast-enhanced CT radiomics combined with deep learning features were utilized, and t-tests and least absolute shrinkage and selection operator (LASSO) cross-validation were employed for feature selection. Subsequently, 11 machine learning algorithms were utilized to construct prediction models, and the area under the ROC curve (AUC), accuracy, and F1 measure were used to assess model performance, which was validated in a validation group. The Logistic algorithm demonstrated the most effective prediction in identifying polyp properties based on 10 radiomics combined with deep learning features, achieving the highest AUC (0.85 in the validation group, 95% confidence interval = 0.68-1.0). In addition, the accuracy (0.83 in the validation group) and F1 measure (0.76 in the validation group) also indicated strong performance. The machine learning radiomics combined with deep learning model based on enhanced CT proves valuable in predicting the characteristics of cholesterol and adenomatous gallbladder polyps. This approach provides a more reliable basis for preoperative diagnosis and treatment of these conditions.

Evaluating cultivar intensity and dataset size for reliable cultivar recommendation in winter wheat: A systematic research of environmental and genotype factors

AbstractCrop yield is influenced by environmental, genotype, and management factors. This study focuses on the environmental and genotype factors, specifically the concept of mega‐environments, where similar crop varieties thrive due to similar environmental conditions, and cultivar intensity, a cultivar's favorable reaction to improved growing conditions, in cultivar recommendation for winter wheat in Poland. The research aims to evaluate the potential of using cultivar intensity as a tool for cultivar recommendation and investigate the influence of dataset size on model performance. The study utilizes a dataset of winter wheat grain yield data collected over six seasons from 19 experimental stations in Poland. Various models are compared using prediction measures, such as correlation coefficient, root mean square error, and mean absolute percentage error. The results show that models combining mixed analysis of variance and linear regression perform best in terms of yield prediction, followed by models using only regression. Models based on cultivar mean in the region exhibit lower prediction ability. The impact of dataset size on prediction accuracy is found to vary depending on the model and prediction measure used. The findings highlight the importance of considering dataset size when assessing model performance and emphasize the need for reliable data in cultivar recommendation. The outcomes of this study contribute to the understanding of cultivar recommendation strategies and provide insights into the use of cultivar intensity and dataset size optimization for reliable and accurate recommendations.

PERform: assessing model performance with predictivity and explainability readiness formula

In the rapidly evolving field of artificial intelligence (AI), explainability has been traditionally assessed in a post-modeling process and is often subjective. In contrary, many quantitative metrics have been routinely used to assess a model’s performance. We proposed a unified formular named PERForm, by incorporating explainability as a weight into the existing statistical metrics to provide an integrated and quantitative measure of both predictivity and explainability to guide model selection, application, and evaluation. PERForm was designed as a generic formula and can be applied to any data types. We applied PERForm on a range of diverse datasets, including DILIst, Tox21, and three MAQC-II benchmark datasets, using various modeling algorithms to predict a total of 73 distinct endpoints. For example, AdaBoost algorithms exhibited superior performance (PERForm AUC for AdaBoost is 0.129 where Linear regression is 0) in DILIst prediction, where linear regression outperformed other models in the majority of Tox21 endpoints (PERForm AUC for linear regression is 0.301 where AdaBoost is 0.283 in average). This research marks a significant step toward comprehensively evaluating the utility of an AI model to advance transparency and interpretability, where the tradeoff between a model’s performance and its interpretability can have profound implications.

A deep learning approach for Direct Immunofluorescence pattern recognition of Autoimmune Bullous Diseases.

Artificial intelligence (AI) is reshaping healthcare, using machine and deep learning to enhance disease management. Dermatology has seen improved diagnostics, particularly in skin cancer detection, through the integration of AI. However, the potential of AI in automating immunofluorescence imaging for autoimmune bullous skin diseases remains untapped. While direct immunofluorescence (DIF) supports diagnosis, its manual interpretation can hinder efficiency. The use of deep learning to automatically classify DIF patterns, including the Intercellular Pattern (ICP) and the Linear Pattern (LP), holds promise for improving the diagnosis of autoimmune bullous skin diseases. The objectives of this study are to develop AI algorithms for automated classification of autoimmune bullous skin disease DIF patterns, such as ICP and LP. This aims to enhance diagnostic accuracy, streamline disease management, and improve patient outcomes through deep learning-driven immunofluorescence interpretation. We collected immunofluorescence images from skin biopsies of patients suspected of AIBD between January 2022 and January 2024. Skin tissue was obtained via 5-mm punch biopsy, prepared for direct immunofluorescence. Experienced dermatologists classified the images into three classes: ICP, LP, and negative. To evaluate our deep learning approach, we divided the images into training (436) and test sets (93). We employed transfer learning with pre-trained deep neural networks and conducted 5-fold cross-validation to assess model performance. Our dataset's class imbalance was addressed using weighted loss and data augmentation strategies. The models were trained for 50 epochs using Pytorch, achieving an image size of 224x224 for both CNNs and the Swin Transformer. Our study compared six CNNs and the Swin transformer for AIBDs image classification, with the Swin transformer achieving the highest average validation accuracy of 98.5%. On a separate test set, the best model attained an accuracy of 94.6%, demonstrating 95.3% sensitivity and 97.5% specificity across AIBDs classes. Visualization with Grad-CAM highlighted the model's reliance on characteristic patterns for accurate classification. The study highlighted CNN's accuracy in identifying DIF features. This approach aids automated analysis and reporting, offering reproducibility, speed, data handling, and cost-efficiency. Integrating deep learning in skin immunofluorescence promises precise diagnostics and streamlined reporting in this branch of dermatology.

Bridging the Gap Between Biological Plausibility and Practicality in Neuron Modeling: Challenges and Perspectives

Neuron modeling has been a fundamental approach in computational neuroscience for understanding the dynamics and function of the central nervous system (CNS). Over the past decades, a plethora of mathematical models, ranging from the seminal Hodgkin-Huxley model to more complex multicompartmental and stochastic models, have been developed to capture the intricate behavior of neurons and their interactions. However, despite the significant advances in modeling, there remains a substantial disconnect between the complexity of the models and their practical applicability in day-to-day medical and laboratory settings. This article explores the challenges and limitations of current neuron modeling approaches, particularly focusing on the trade-off between biological realism and computational tractability. I discuss the variability of neuronal properties within and across different regions of the brain, which poses a significant challenge for developing models that can accurately represent the full complexity of the CNS. I also highlight the computational bottlenecks associated with simulating highly detailed, which often require extensive computational resources and specialized software. Considering these challenges, we emphasize the need for a balance between biological plausibility and practicality in neuron modeling. We discuss the role of simplified models, such as the leaky integrate-and-fire (LIF) and Izhikevich models, which sacrifice some biological detail in favor of computational efficiency and ease of use. These models have proven valuable for large-scale simulations of neural networks and have provided important insights into the collective behavior of neuronal populations. Furthermore, I explore the potential of data-driven approaches, such as machine learning and artificial neural networks, in bridging the gap between biological realism and practical applicability. These approaches can learn the dynamics of neuronal systems directly from experimental data, bypassing the need for explicit mathematical models. I present a simple example using linear regression to predict neuronal firing rates based on input features, showcasing the potential of machine learning techniques in capturing the complex relationships between neuronal variables. I also highlight the need for more extensive validation of models against experimental data and the development of standardized benchmarks for assessing model performance. In conclusion, while the quest for biologically plausible neuron models has driven significant advances in our understanding of the CNS, the disconnect between model complexity and practical applicability remains a major challenge. By embracing simplified models, data-driven approaches, and interdisciplinary collaborations, we can work towards the development of more efficient and practical neuron models that can bridge the gap between biological realism and computational feasibility, ultimately facilitating the translation of theoretical insights into clinical and experimental applications.

RMDEASD: Integrating Rule Mining and Deep Learning for Enhanced Aspect-Based Sentiment Analysis Across Diverse Domains

The rapidly evolving landscape of Aspect-Based Sentiment Analysis (ABSA) in the realm of natural language processing necessitates innovative approaches to comprehend and interpret the intricate nature of sentiments expressed in textual data. Traditional ABSA methods have often struggled with the nuanced sentiments inherent in various textual sources, limited in their ability to adapt to domain-specific vernacular and context. This study introduces a novel approach that synergizes rule mining with advanced deep learning techniques, aiming to address these limitations and enhance the precision and contextual understanding in sentiment analysis. Our proposed model integrates rule-based systems with deep learning Transformers, a method recognized for its effectiveness in extracting structured, domain-specific insights. This integration results in a significant enhancement in the model's ability to capture nuanced sentiments, as demonstrated by an 8.5% increase in aspect-based sentiment analysis precision and an 8.3% improvement in accuracy over existing methods. The model employs a combination of techniques including Bi-LSTM, BiGRU-CRF with RNNs, and ontology mapping operations, forming a Hybrid Multi-Level Architecture that effectively captures both sequential data relationships and semantic context. Additionally, the model incorporates Cross-Domain Transfer Learning, utilizing BERT-based pre-trained models with added layers for contextual semantics, which has shown notable generalization capabilities across various domains. Furthermore, this study refines evaluation parameters, tailoring metrics such as domain-specific accuracy, recall, and precision to more accurately assess model performance in particular domains. This is especially pertinent in our analysis of Twitter datasets specific to industries like finance and healthcare. The inclusion of Temporal Dynamics and Aspect Summarization, using techniques like the VARMAx process, provides insights into the evolution of sentiments and aspects over time, an aspect crucial for longitudinal sentiment analysis. The comprehensive testing of our model on diverse spatial and temporal datasets reveals not only improved precision and accuracy in sentiment analysis but also a reduction in delay, demonstrating its efficiency and responsiveness. The study's findings indicate that our approach could significantly impact fields reliant on sentiment analysis, such as market analysis, public opinion research, and social media monitoring, providing a more nuanced and accurate understanding of consumer sentiments and trends. This paper's contribution lies in its innovative amalgamation of rule-based and deep learning techniques, tailored evaluation metrics, and its emphasis on temporal dynamics, setting a new precedent in the field of ABSA and opening avenues for further research and application in real-world scenarios.

A Pilot Predictive Model for Indirect Assessment of Suicidal Ideation

IntroductionIn recent years, there has been a concerning increase in suicidal thoughts and, in some countries, completed suicides, amplified by the COVID-19 pandemic. Screening for suicidal ideation (SI) in the general population is limited due to ethical, effectiveness, and feasibility concerns. Identifying individuals at risk of suicide remains a complex challenge. Our study aimed to develop a predictive model using COVID-19 data, gathering psychometric information from 1790 respondents in Slovenia via an online survey conducted between July 2020 and December 2020, with a second wave of data (ne=1200) collected from January 2022 to February 2022.ObjectivesWith 9.7% of respondents reporting recent SI in the first wave of data, our primary goal was to estimate SI indirectly using SIDAS. We examined changes in habits, demographics, coping strategies, and satisfaction in key life aspects to discreetly identify potential risk factors.MethodsWe employed four machine learning algorithms (logistic regression, random forest, XGBoost, and support vector machines) and assessed model performance using the area under the receiver operating characteristic curve (AUC). Initial assessment used a held-out dataset, followed by validation with a new cohort of 1,200 users from the late COVID-19 period.ResultsLogistic regression, random forest, and XGBoost achieved comparable AUCs, reaching 0.83 on unseen data. Our analysis revealed significant associations between Brief-COPE subscales and SI. Self-Blame emerged as a strong SI indicator, followed by increased Substance Use, reduced Positive Reframing, Behavioral Disengagement, dissatisfaction with relationships, and younger age, in both 2020 and 2022 models. The model consistently performed well, even with varying population characteristics.Conclusions These results suggest that SI presence can be reasonably estimated using selected indicators, offering promise for developing an indirect screening tool without explicit questioning about suicidal thoughts. However, individuals flagged as at-risk should undergo clinical examination, as this model serves as an initial step in identifying SI risk factors in the context of the stressful event’s (COVID-19 pandemic) impact on mental health.Disclosure of InterestNone Declared

Brain Tumour Detection and Multi‐Classification Using Advanced Deep Learning Techniques

The early detection and accurate classification of brain tumors are pivotal in enhancing treatment efficacy and patient survival rates. Traditional diagnostic methods, while effective to a degree, are often invasive and reliant on subjective interpretations. This paper introduces a novel approach using advanced deep learning techniques to automate the detection and multi-classification of brain tumors from medical imaging data. Leveraging a comprehensive dataset, we employed state-of-the-art convolutional neural networks (CNNs), incorporating innovative mechanisms such as transfer learning and attention models to refine the accuracy and interpretability of tumor identification and classification. Our methodology encompasses rigorous preprocessing, data augmentation, and a multi-faceted evaluation framework to assess model performance comprehensively. The results indicate a significant improvement over conventional methods and existing machine learning models, showcasing high precision, recall, and F1 scores across multiple tumor types. This research not only contributes to the body of knowledge in medical image analysis but also presents practical implications for integrating advanced AI technologies into clinical diagnostics, thereby potentially transforming patient outcomes through earlier and more accurate diagnoses. The discussion extends to the challenges faced, including dataset imbalances and model deployment in healthcare settings, and proposes directions for future research to further enhance model effectiveness and applicability.

Image Forgery Detection using ResNet50

Abstract: Image forgery detection is crucial in ensuring the integrity of digital media. In this study, we propose a method for detecting image tampering using Error Level Analysis (ELA) and Convolutional Neural Networks (CNNs) with a ResNet50 architecture. Leveraging the CASIA 2.0 Image Tampering Detection Dataset, which consists of authentic (Au) and tampered (Tp) images, along with metadata and annotations provided in the CASIA 2 Ground truth dataset, we develop and evaluate our model. The dataset comprises 7492 authentic images, 5125 tampered images, and 5123 files of ground truth information. ELA transformations highlight compression discrepancies, aiding in the identification of tampered regions. Our ResNet50-based CNN model, augmented with Global Average Pooling, Dense layers, and Dropout regularization, is trained using Adam optimization and binary cross-entropy loss with early stopping. Evaluation metrics, including training and validation loss/accuracy curves and confusion matrices, are used to assess model performance. The trained model is saved for future use and tested on new images to demonstrate its classification capabilities. Our approach achieves a significant level of accuracy in distinguishing between authentic and tampered images, underscoring its potential for practical image forgery detection applications and contributing to advancements in digital media forensics