Objective: To evaluate the relationship between laboratory biomarkers of severity and functional limitations analyzed by the PCFS (Post COVID Functional Scale) in COVID-19 survivors. Methods: ambispective, quantitative and longitudinal cohort study. Data collection took place in two moments: initially during hospitalization, recording the percentage of lung impairment, D-dimer, CRP (C Reative Protein), BMI (Body Mass Index), age, smoking time, mechanical ventilation (MV), MV time, lenght of hospitalization, thrombosis, use of vasoactive drugs, anticoagulants and corticosteroids. The second by applying the PCFS scale. Results: 80 individuals were included. 46 (57.5%) were female with a mean age of 52.3 years (SD 14.5) and a BMI of 27.5 kg/m2 (SD 4.4). Of these, 64 (80%) had limitations. Comparing the groups by dependent factor, functional profile, smoking time (12 vs. 28 years, p=0.041), BMI (25 vs. 28 kg/m2, p=0.036), age (43 vs. 54 years, p=0.008), D-dimer (421 vs 788 mg/L p=0.012) and CRP (2 vs 12mg/L, p=0.047) were higher in the group with limitations. In logistic regression, D-dimer and BMI remain as independent predictors of worse functional profile. Conclusion: D-dimer and BMI changes during hospital stay can modify the post-COVID-19 functional profile. Therefore, the early inclusion of individuals with changes in these markers in rehabilitation programs is an assertive strategy for COVID-19 survivors.