The developed RP-HPLC technique lets in speedy and particular omeprazole and domperidone determinations, the goal of the current painting is to improve and extend the chromatographic circumstances, to broaden RP-HPLC method. a variety of mobility phases were tested for the duration of technique improvement, some of the numerous cell phases methanol, acetonitrile and phosphate buffer changed into discovered to be a perfect cell phase, because it provided optimal peak forms and high resolution. The go with the flow rate changed into optimized at 0.90 mL/min. The development of the isocratic elution method for omeprazole and domperidone made it perfect for quick and routine analysis. Omeprazole and domperidone linearity and correlation coefficient had been located to be 10 to 50 ug/mL 0.997, and 0.998, respectively. The restriction of detection for omeprazole and domperidone turned into discovered to be 1.78 and 3.15 and the limit of quantification changed into observed to be 544 and 956. With the assay procedure, the methodology has been recognized as accurate. The %assay become determined to be 98 and 73. The evolved technique changed into confirmed to an excellent accuracy and precision. The isocratic elution approach evolved for the dedication of omeprazole and domperidone perfectly suited for rapid and ordinary evaluation. This technique shows that right reproducibility of the effects. moreover this approach become easy, touchy, and accurate. Degradation studies had been accomplished, right here the drug stability outcomes have been within the variety of acceptance standards 85 to 115%. Moreover, this approach was easy, touchy, and correct.