Abstract Background psoriasis is a recurring, cutaneous-articular, chronic inflammatory disease, resulting from immune and proliferative changes that affect the skin and mucosa. The worldwide incidence is 1-3% and the majority of the patients also have emotional difficulties like anxiety, depression, and sexual dysfunction. These issues along with the extent of body surface area affected have an impact on the quality of life, in particular, the sexual life, all aspects of sexual function were negatively affected by the disease process. Aim of the Work to evaluate the prevalence of sexual dysfunction among psoriatic male patients and the role of depression on sexual dysfunction. Patients and Methods the study included 60 male psoriatic patients (married sexually active with no genital abnormalities, malignancy, chronic diseases such as pulmonary, hepatic, renal, hematological, neurologic, psychosis, and similar psychiatric disorders, and not on medications that interfere with erectile function). All patients were subjected to the following: Full medical history taking, local examination of the genitalia, dermatological examination, sexual function evaluation using the Arabic version of IIEF (the international index of erectile function questionnaire) which is a validated questionnaire applied to all cases, and psychiatric evaluation using the Arabic version of Hence Hamilton Depression rating scale (HAM-D) to determine the patient’s level of depression. Results The study revealed a high prevalence of ED (86.7%) and depression (65%) among psoriatic male patients, the ED was statistically significantly affected by the severity, duration of the disease, and genital affection. Also, there was a significant correlation between ED, metabolic parameters, and depression with a significant P value. Conclusion there is a high prevalence of sexual dysfunction and depression among psoriatic male patients. Screening of sexual dysfunction among psoriatic male patients using the IIEF, depression using HAM-D, and metabolic risk factors is recommended for a better quality of life.