Teaching materials are one of the components for improving students’ scientific literacy skills, but teaching materials that exist today, especially about thermochemical materials do not yet have the maximum content of scientific literacy. Through the research design of research and development, scientific literacy-based teaching materials have been developed in thermochemical material. The stages of research include needs-analysis, product design development, validation and analysis. Therefore, the product result and testing phase are limited to effectiveness testing. From the results of the study, it was found that science-based thermochemical teaching materials for general chemistry courses had been successfully developed with the existence of scientific literacy aspects. Moreover, the aspect are the knowledge of thermochemical material which is the aspect of science as a torso, thermochemistry in context which is an aspect of science as a process of inquiry, the high level of thinking skills which is science as a way of thinking, and attitude which is an aspect of interaction between science, technology and society. The overall feasibility validation result is 86.42%, which means the teaching material is in the valid category without revision. Moreover, the readability of teaching material products has an average readability percentage of about 83.79%, which means that teaching materials are included in the criteria to be easily understood.