Aspects Of Psoriasis Research Articles

Mentally ill patients and the psychological aspects of psoriasis

Mentally ill patients and the psychological aspects of psoriasis

S008 Clinical aspects of psoriasis; Combination treatments for psoriasis

S008 Clinical aspects of psoriasis; Combination treatments for psoriasis

Leukemic cells within skin lesions of psoriasis in a patient with acute myelogenous leukemia

We report on an 81-year-old man with acute myelo-monocytic leukemia (FAB M4) and a long-standing history of psoriasis. Biopsy of psoriatic plaques revealed the coexistence of characteristic histopathologic aspects of psoriasis together with an infiltrate of blasts with features of myelo-monocytes, suggestive of a specific leukemic infiltrate within plaques of psoriasis. Immunohistologic stainings showed positivity of blasts for LN2 (CD74), MT1 (CD43), and lysozyme, consistent with a myeloid lineage of these cells. To the best of our knowledge, this is the first report on the association of psoriasis with myelogenous leukemia. The presence of leukemic cells within psoriatic skin plaques may be explained by non-specific recruitment of recirculating malignant cells to the skin. Alternatively, as psoriasis is an inflammatory disease involving granulocytes among other cell types, it may be hypothesized that leukemic cells retain to some extent their capability to respond to physiologic stimuli and enter the skin in response to specific chemotactic factors.

Psycho-social aspects of psoriasis

Psycho-social aspects of psoriasis

Metabolic aspects of psoriasis: the basis for specific therapy.

Psoriasis, like diabetes, is a multifactorial genetic disease with complex interactions of deranged metabolism. Factors that affect epidermal differentiation and proliferation include cyclic nucleotide interactions, polyamine metabolism, cell surface--cytoskeleton interactions, and arachidonic acid--prostaglandin cascade. Evidence indicates that pharmacologic manipulation of the so-called critical metabolic systems not only may help us to understand the pathophysiology of psoriasis but also may yield improved treatments for the disease.